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함현식,강삼룡 明知大學校 産業技術硏究所 1984 産業技術硏究所論文集 Vol.3 No.-
The aims of this paper are : (1) to review the techniques to measure the metal dispersion of the supported metal catalysts, (2) to review the experimental results of sintering of supported metal catalysts, (3) to present the methods used to correlate the sintering data, and (4) to discuss the mechanistic models proposed for the sintering process. The experimental results presented will be restricted to supported Group Ⅷ metals ; the majority of the data being for platinum supported on alumina or silica.
L-Asparaginase가 Mouse의 肝細胞에 미치는 影響
鄭鎬三,李圭植,尹康默 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.1
L-asparaginase hydrolysis L-asparagine which is essential amino acid for tumor cells to produce an antitumorous effect. On the other hand, it was reported that this drug provoked cytotoxic effect following the inhibition of protein synthesis and that this was a consequence of the exhaustion of L-asparagine in the normal cell. Therefore, the authors have demonstrated the toxicity of L-asparaginase on the hepatic parenchymal cell observing with light and electron microscope: Male mice of ICR strain were used in this experiment and the weight of experimental animals was around 20gm. The animals were divided into two groups, the control and the L-asparaginase treated groups and subdivided into the 6th, 12th and 24th hours groups. L-asparaginase 2,500 I.U./kg, in the water for injection was injected intraperitoneally for the animals of L-asparaginase treatment group. The animals of control group were given water for injection only. The experimental animals were sacrificed at the 6,12 and 24 hours after an administration of L-asparaginase or water for injection. The liver specimens were stained with hematoxylin oesin, methyl green-pyronin and oil red 0 method and observed them under the light microscope. And the ultrathin sectioned specimens were stained with uranyl acetate and lead citrate and observed with the JEM 100B electron microscope. The results obtained were as follows: 1. Cellular swelling accompanied with the vesicular or vacuolar formation, reduction or disappearance of the pyroninophilic granules and fat infiltration were observed in the hepatic parenchymal cells of the L-asparaginase treated mouse. 2. Dilatation, sacculation and fragmentation of the cisternae of RER were accompanied with dissociation of membrane bound ribosomes, and proliferation of SER associated with depletion of glycogen particles were observed. And formation of numerous primary lysosomes, secondary lysosomes, autophagic vacuoles, multivesicular bodies and irregular sized lipid droplets were recognized in the hepatic parenchymal cells of the L-asparaginase treated mouse. Consequently, it is suggested that intraperitoreal injection of L-asparaginase would include the cellular degeneration of the hepatic parenchymal cells in the mouse.
Synthesis of epialeuritolic acid
Kang, Sam-Sik,Woo, Won-Sick The Pharmaceutical Society of Korea 1986 Archives of Pharmacal Research Vol.9 No.3
The triterpenoid isolated from the seeds of Phytolacca plants was confirmed to be acetylaleuritolic acid rather than acetylepialeuritolic acid by direct comparison with synthetic compounds.
Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix
KANG, Sam Sik,KIM, Ju Sun,SON, Kun Ho,KIM, Hyun Pyo,CHANG, Hyeun Wook 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
A mixlure of cerebrosldes, called poke-weed cerebrosldes, was purified from Phytoluccae Radix (Phytolaccaceac) and characterized as I-O-B-D-glucopyranosides of phytosphingosine type ceramides comprised of a common long chain base (2S,3S,4R,8Z)-2-amino-8-octadecene-1,3,4-trlol and fatty acids. The fatty acyl chain of ceramide moieties was determined as (2R)-2-hydroxypentacosanoic acid, (2R)-2-hydroxylignoceric acid, (2R)-2-hydroxybehenic acid. (2R)-2-hydroxypalmitic acid, and palmltic acld. The poke weed cerebroside inhlbited the cyclooxygenase-2 dependent phase of prostaglandin D_(2) generation in bone marrow-derived mast cells in a concentration dependent manner with an IC_(30) of 6.2 ㎍/ml.
Platelet Anti-Aggregation of Paeony Root
Sam Sik Kang,Ju Sun Kim,Eun Mi Kim,Hye Sook Yun-Choi 한국생약학회 1992 생약학회지 Vol.22 No.4
Paeony root was extracted and fractionated for the identification of the platelet anti-aggregatory components. And gallic acid methylester was isolated as the major component from the active sub-fraction F302.
NMR Assignments of Two Furofuran Lignans from Sesame Seeds
Kang, Sam-Sik,Kim, Ju-Sun,Jung, Jee-Hyung,Kim, Young-Hee The Pharmaceutical Society of Korea 1995 Archives of Pharmacal Research Vol.18 No.5
Two furofuran lignans, sesamolin and sesangolin were isolated from the seeds of Sesamum indicum and S.angolense, respectively. Detailed analysis of the $^1H-and^{13}C-NMR$ spectra of these lignans was carried out by the application of two-dimensional $^1H-^1/H\; COSY\; and^1/H^{13}C$ multiple-bond, multiple-quantum spectroscopic correlation techniques.
Flavonoids from the Leaves of Polygonum Sachalinense Fr. Schm.(Ⅰ)
Sam-Sik Kang(강삼식) 한국생약학회 1981 생약학회지 Vol.12 No.4
From the leaves of Polygonum sachalinense Fr. Schm. (Polygonaceae) quercetin, mp 316∼8°, and avicularin, mp 216∼6°, [α]^D_(20)-152°, were isolated and characterized by spectral data. Both are first isolation from this plant.
Identification of Anthocyanins from a Black Soybean, Geomjeongkong 1
Sam Sik Kang,Sang Jun Han,Su Noh Ryu 한국육종학회 2003 한국육종학회지 Vol.35 No.2
Three anthocyanins were isolated from the acidif ied ethanol extract of black soybeans (Glycine max M. cv. Geom jeongkong 1) using preparative high-performance liquid chrom atography. The anthocyanins were characterized as delphinidin 3-glucoside (D3G), c