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Jaejun Choi,Ryeonghyeon Kim,Junseock Koh 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.7
Multivalent macromolecular interactions underlie dynamic regulation of diverse biological processes in ever-changing cellular states. These interactions often involve binding of multiple proteins to a linear lattice including intrinsically disordered proteins and the chromosomal DNA with many repeating recognition motifs. Quantitative understanding of such multivalent interactions on a linear lattice is crucial for exploring their unique regulatory potentials in the cellular processes. In this review, the distinctive molecular features of the linear lattice system are first discussed with a particular focus on the overlapping nature of potential protein binding sites within a lattice. Then, we introduce two general quantitative frameworks, combinatorial and conditional probability models, dealing with the overlap problem and relating the binding parameters to the experimentally measurable properties of the linear lattice-protein interactions. To this end, we present two specific examples where the quantitative models have been applied and further extended to provide biological insights into specific cellular processes. In the first case, the conditional probability model was extended to highlight the significant impact of nonspecific binding of transcription factors to the chromosomal DNA on gene-specific transcriptional activities. The second case presents the recently developed combinatorial models to unravel the complex organization of target protein binding sites within an intrinsically disordered region (IDR) of a nucleoporin. In particular, these models have suggested a unique function of IDRs as a molecular switch coupling distinct cellular processes. The quantitative models reviewed here are envisioned to further advance for dissection and functional studies of more complex systems including phase-separated biomolecular condensates.
무선 인터넷 환경에서의 공간 객체 영상 정보 검색 시스템의 설계 및 구현
유재준(JaeJun Yoo),최지훈(JiHoon Choi),최정단(JeongDan Choi) 한국정보과학회 2004 한국정보과학회 학술발표논문집 Vol.31 No.2Ⅲ
최근에 지리 정보를 검색, 관리, 분석할수 있는 지리 정보시스템(Geographic Information System, GIS)의 사용이 확대됨에 따라 단순한 수치지도 정보 이외에 좀 더 현실적이고 사실적인 정보를 제공해 줄 수 있는 시스템에 대한 요구가 커지고 있으며, 이동 통신 기술의 발달과 모바일 단말의 급속한 확산으로 인하여 지리 정보 시스템의 모바일 시스템화가 급속히 진행 중이다. 이러한 현상에 맞추어 무선 인터넷 환경에서 공간 객체의 실제 영상 정보를 보여주는 시스템의 필요성이 대두 되고 있다. 현장에서 공간 객체에 대한 영상 정보를 검색할 수 있는 시스템은 현실적 모습 및 상대에 대한 정보를 실시간으로 제공해 줄 수 있어, 공간객체의 실제 모습이 필요한 여러 분석 이나 의사결정이 필요한 분야에서 효율적으로 이용될 수 있다. 공간 객체의 실제 영상 정보를 제공하기 위해 현재 영상을 고려 하는 지리 정보시스템이 개발중이기는 하나, 이러한 시스템들은 무선 인터넷 환경을 고려하지 않고 있어, 현장에서 공간 객체에 대한 영상을 효율적으로 얻기에는 적합하지 않다. 본 논문에서는 무선 인터넷 환경에서의 공간객체에 대한 영상 정보 검색 시스템을 설계하고 구현한다. 이를 위해 1)수치지도 및 영상, 그리고 그 매핑 정보의 구축 방안을 제시한다. 그리고, 2)제안된 시스템을 전체적으로 설계 및 구현함으로써, 그 유용성을 보인다.
유증기 회수설비 유무에 따른 주유소 근로자들의 요중 trans, trans-Muconic acid, Hippuric acid에 관한 연구
최재준 ( Jaejun Choi ),원종욱 ( Jong Uk Won ),김치년 ( Chi Nyon Kim ),노재훈 ( Jaehoon Roh ) 한국산업보건학회 2014 한국산업보건학회지 Vol.24 No.2
Objectives: This study aims to investigate the excretion aspect of urinary t, t-MA and hippuric acid by measuring concentrations of urinary metabolites according to the use of gasoline vapor recovery system. Materials:In order to analyze urinary metabolites, samples from the 23 gas station workers ten gas stations in the Seoul and Gyeonggi Province area were collected once daily after work. In addition, a survey was conducted on work factors and lifestyle habits as factors affecting the concentration of urinary metabolites. Results: The average concentrations of t, t-MA and hippuric acid after work were 0.124±0.177 mg/g creatinine and 0.557±0.251 g/g creatinine among workers at gas stations where gasoline vapor recovery systems were installed. The average concentrations of t, t-MA and hippuric acid were 0.160±0.113 mg/g creatinine and 0.682±0.619 g/g creatinine among workes at gas stations where gasoline vapor recovery systems were not installed. Average concentrations were higher at gas stations where a gasoline vapor recovery system was not installed, but the differences were not statistically significant differences. Urinary t, t-MA and hippuric acid average concentrations of smokers and non-smokers were higher in the gas stations where gasoline a vapor recovery system was not installed. T, t-MA as a factor evaluation affecting the concentration of urinary metabolites was not statistically significant in all factors, while hippuric acid was statistically significant only for age(p=0.024). Conclusions: The average concentrations of urinary t, t-MA and hippuric acid were higher in gas stations where gasoline vapor recovery systems were not installed compared to gas stations where such a system was installed. There needs to be an assessment of biological monitoring according to refueling activity considering skin absorption of benzene and toluene and presence of gasoline vapor recovery system.
Development of <SUP>123</SUP>I nuclide production apparatus using <SUP>124</SUP>Xe
JaeJun Yoo,HyunWoo Jung,JunYong Choi,SangKwon Bang,Seyoung Oh,KwonSoo Chun,DongHoon Lee,ByungIl Kim 한국정보통신학회 2015 2016 INTERNATIONAL CONFERENCE Vol.7 No.1
<SUP>123</SUP>I has a short half-life compared to <SUP>131</SUP>I for a diagnostic radiopharmaceutical of the thyroid, so it is a very good drug for reducing the radiation exposure for the patient and emitting gamma rays which is suitable for diagnostic image. In this paper, we have developed a device that can produce the 123I after 30MeV proton was irradiated into the <SUP>124</SUP>Xe target for nuclear reaction. Because <SUP>124</SUP>Xe gas is expensive, we have applied the collection and storage technology for <SUP>124</SUP>Xe reuse after proton irradiation. The developed device is composed of a total of six devices. Target system for the <SUP>124</SUP>Xe and proton nuclear reaction, water cooling system for cooling high heat generated in the target chamber when the beam irradiation, helium circulation system to remove heat generated in the window foil, <SUP>123</SUP>I helium supply manifold for supplying helium into the <SUP>124</SUP>Xe collection device and helium circulation system, the gas process manifold for collection and storage and removing impurities of the expensive <SUP>124</SUP>Xe gas and lastly wash process manifold for recovering <SUP>123</SUP>I. Because of devices dealing with gas, it was designed and manufactured after verification by simulation for volume, vacuum, temperature and pressure of <SUP>124</SUP>Xe moving path precisely. It was also manufactured after we have verified the reliability and the possibility of the device via thermal analysis for the heat generated in nuclear reactions. Each device was controlled by using the siemens PLC for valves, heaters, motors, temperature sensors, pressure sensors, flow sensors, and vacuum sensor. In order to remotely control the device with computer, user interface was used by PcVue program for monitoring and controlling the device conveniently and easily. Through this study, we have owned voluntarily nuclide production equipment technology which was dependent on foreign production equipment and import substitution effect by the domestic production. So, we can apply this technique for the development of various new species of nuclides in future.
JaeJun Yoo,KyoungBok Sung,JungDan Choi,ByoungTae Jang 한국항해항만학회 2006 한국항해항만학회 학술대회논문집 Vol.2 No.-
In this paper, we design a prototype service in Telematics environment for providing safety warning notification at crooked roads efficiently using wireless sensor network. Through this study, we 1) analyze several requirements to be satisfied in the services, 2) design and implement the service architecture based on the requirements.