알레르기 ; 알레르기 환자에서 한방 이외의 대체 요법의 사용 현황에 대한 다기관 조사

이현정 ( Hyun Jung Lee ),이재현 ( Jae Hyun Lee ),이용원 ( Yong Won Lee ),김철우 ( Cheol Woo Kim ),동헌종 ( Hun Jong Dhong ),박해심 ( Hae Sim Park ),조영주 ( Young Joo Cho ),조진희 ( Jin Hee Cho ),조상헌 ( Sang Heon Cho ),편복양 ( 대한내과학회 2011 대한내과학회지 Vol.80 No.1

목적: 한국에서 알레르기 질환 치료를 위한 한방 치료뿐만 아니라 대체 요법이 많이 이용되고 있으며, 그 현황에 대하여 다기관 조사를 시행하였다. 방법: 10개의 대학병원 외래로 내원한 647명의 알레르기 환자를 대상으로 설문조사를 시행하였으며, 이 중 510명이 한방 이외의 대체 요법에 응답하였다. 이환되어 있는 알레르기 질환은 천식(50.0%), 알레르기 비염(36.0%), 아토피 피부염(36.0%), 그리고 두드러기(9.3%)였다. 각각 환자들에게 12 문항의 설문조사를 시행하였으며, 한방 이외의 대체 요법의 사용 빈도 및 종류, 대체 요법에 의지하게 된 이유, 비용, 그리고 치료효과에 대한 의견을 물어 보았다. 결과: 16.7%의 알레르기 환자에서 한방 이외의 다른 대체 요법을 받았으며, 평균 1.6종의 한방 이외의 대체 요법을 받았다. 가장 많이 의지하는 대체 요법은 민간 식이요법 (48.6%)이었고, 그 다음이 아로마 요법(23.8%), 지압(14.3%), 건강 호흡법(7.6%), 마인드 컨트롤(5.7%), 목욕요법(5.7%) 순이었다. 대체 요법을 받은 환자 중 마인드 컨트롤(50%), 식이요법(50%), 그리고 건강 호흡법(75%)의 경우 치료 효과가 만족스럽다는 응답이 높았으며, 목욕요법, 아로마 요법, 그리고 지압은 만족도가 각각 33.3%, 28.0%, 26.7%로 저조하였다. 대체 요법 사용자의 63.6%가 5회 미만의 대체 요법을 받았고, 91.8%가 1년 이내로 치료받았으며, 1인당 평균 연 37 만원을 지출하였다. 대체 요법을 선택한 가장 큰 이유는 체질이 개선될 수 있을까 해서(44.2%)였으며, 대체 요법이 몸에 부담이 없어서(31.4%), 면역기능이 강화되어서(22.9%) 순으로 나타났고, 15.7%는 양약치료가 도움이 되지 않아서 대체 요법을 선택하였다고 응답하였다. 결론: 한국에서 알레르기 환자의 상당수가 한방뿐만 아니라 여러 가지의 대체 요법을 사용하고 있음을 알 수 있었다. 대체 요법의 사용 빈도가 증가하고 그 종류가 다양함을 고려할 때, 의료진은 대체 요법의 현황에 대하여 정확히 인지하고 이에 대해 관심을 가지고 환자를 대하여야 하며 올바른 알레르기 질환 치료법에 대해 환자뿐만 아니라 의료인에게 교육하는 것이 필요하다. Background/Aims: The use of unproven complementary/alternative medicine (CAM) to treat allergies is popular in Korea. We conducted a multicenter survey of the current use of CAM other than herbal medication in Korean allergy patients. Methods: This study enrolled 510 adults with allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, and chronic urticaria, from ten hospitals. They underwent a structured questionnaire interview and clinical assessment of the prevalence, motivation, costs, and subjective assessment of CAM. Results: Of the patients, 16.7% used at least one type of CAM to treat their allergic diseases. Common types of CAM were diet (48.6%), aroma therapy (23.8%), massage (14.3%), breathing exercises (7.6%), baths (5.7%), and mind control (5.7%). The therapeutic effects of CAM included improved in patients using mind control (50%), diet (50%), breathing exercises (75%), and baths (33.3%), but worse in patients using aroma therapy (28%), and massage (26.7%). About 36.4% of the patients used CAM more than four times per year, and the average cost per CAM user was 370,000 won/year. The main reason for trying CAM was `hope to improve my constitution`. Conclusions: CAM is used widely for treating allergic diseases in Korea. Detailed knowledge of CAM and patient education are important. Further studies of the clinical efficacy of CAM are needed. (Korean J Med 2011;80:68-77)

원-달러 선물계약과 NDF계약의 헤징효율성 비교

윤원철 ( Won Cheol Yun ),안현진 ( Hyun Jin An ) 한국파생상품학회 2004 선물연구 Vol.12 No.2

Cutaneous neoplasms with overlying scalp alopecia

( Hyun Wuk Cha ),( Kyung Hea Park ),( Han Jin Jung ),( Hyun Jung Lim ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2011 초록집 Vol.49 No.20

[P172] A case of plexiform fibrohistiocytic tumor on finger Asan Medical Center, University of Ulsan College of Medicine

( Hyun Ji Kang ),( Young Jae Kim ),( Chong Hyun Won ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ),( Woo Jin Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Plexiform fibro histiocytic tumor (PFHT) is an intermediate malignant mesenchymal neoplasm which mainly occurs in children and young adults. We report a 45-year-old woman presented with a skin-colored nodule on the right fourth finger diagnosed as plexiform fibro histiocytic tumor. This case is a specialized PFHT due to its late adulthood onset and histopathologic feature.

Method for Measuring Advertising Effect of Digital Signage by Joining Advertising System and Mobile Phone Application

Hyun-Jin LEE,Hwa-Suk KIM,Dong-Hun LEE,Uk JANG,Eun-Il KIM,Kee-Seong CHO,Won RYU 한국콘텐츠학회 2012 한국콘텐츠학회 종합학술대회 논문집 Vol.2012 No.12

[P285] A case of disseminated Mycobacterium avium complex infection in an immunocompromised patient

( Won-ku Lee ),( Sung-min Park ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Mycobacterium avium intracellulare complex (MAC) includes 2 genetically similar organisms: Mycobacterium avium and Mycobacterium intracellulare. Mycobacterium avium complex (MAC) is a ubiquitous pathogen, widely distributed in the environment including water, soil and animals. Disseminated MAC occurs in cell-mediated immunodeficiency and is mostly described in the setting of advanced HIV disease. To our knowledge, this is a rare case of disseminated MAC in a non-AIDS patient in Korea. A 64-year-old female presented with 2-week history of soft fluctuating mass on scalp. She had past history of MAC infection, pulmonary tuberculosis, Sweet syndrome and undifferentiated connective tissue disease.The bacterium culture from her skin was identified as MAC. This was also isolated from CT guided aspiration of psoas abscess and sputum. A diagnosis of disseminated MAC infection was established based on the laboratory and clinical findings. The patient was initially treated with clarithromycin, ethambutol, and rifabutin as a result of the drug-sensitivity test. Due to poor response, treatment with amikacin and cycloserin was added with successful clinical resolution. Clinicians should be alert for the diagnosis of MAC infection in diverse clinical conditions. Despite the severity of this infection, with timely diagnosis effective treatment is available.

CASE REPORT : Empyema caused by Clostridium perfringens

( Hyun Sun Park ),( Chul Min Jung ),( Jang Won Choi ),( Yoon Ki Hong ),( Woo Jin Kim ) 영남대학교 의과대학 2015 Yeungnam University Journal of Medicine Vol.32 No.1

Pleuropulmonary diseases caused by Clostridial species infections are rare, but have a mortality rate of up to 30%. Furthermore, older people are at greater risk of developing invasive clostridium infections, and the majority of reported cases of clostridium empyema have been attributed to iatrogenic trauma or aspiration. The authors report a case of spontaneous empyema caused by Clostridium perfringens. A 72-year-old woman was admitted to Kangwon National University Hospital for empyema. The patient had no history of trauma, a dental procedure, or aspiration, and was treated using empirical antibiotics and by drainage of pleural fluid. Bacteria species that cause empyema are usually not detected, but on the 4th day of admission, C. perfringens was isolated from the pleural space. The patient was continuously treated with antibiotics for C. perfringens and drainage, and was discharged 25 days after admission with almost a fully recovered status. Increased awareness of Clostrium species infection in the elderly is needed to ensure appropriate treatment.

[P349] A case of squamous cell carcinoma arising from epidermal cyst on buttock

( Won Choi ),( Kyoung Geun Lee ),( Byoung Yong Koh ),( Ki Bum Myung ),( Seung Hyun Cheong ),( Hyung Jin Hahn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Epidermal cysts are common benign tumor of the skin. They are slow growing, round, firm intradermal or subcutaneous tumor and occur most commonly on the trunk, face and scalp. Interestingly, when an epidermal cyst ruptures and its contents are released into the dermis, foreign body reaction occurs. As a result, multinucleated giant cells may form a keratin granuloma and lead to a pseudocarcinomatous hyperplasia, which is thought to be a stimulant of squamous cell carcinoma (SCC) formation. From a review of the literature, malignant transformation of epidermal cysts is very rare and its incidence rate is known to be 0.011 -0.045%. An 82-year-old woman presented with painful, 2cm-sized subcutaneous nodule on left buttock for two years. Excisional biopsy specimens were taken from the skin lesion on buttock. In microscopic view, numerous keratinous materials were released from ruptured cysts. The specimen was consisted of well-differentiated squamous cells with atypical nucleus and mitotic figures. In mid dermis, horn pearl and the numerous multinucleated giant cells were also seen. On immunohistochemical staining, CK5/6 were positive. Also, Ki-67 and p53 were largely confined to basal portion of epithelium. The patient was diagnosed with a rare case of SCC arising from epidermal cyst based on histological finding and was later treated with complete excisional biopsy. Herein we report a rare case of SCC arising from epidermal cyst.

Parkin Interacts with the PDZ Domain of Multi-PDZ Domain Protein MUPP1

Won Hee Jang(장원희),Young Joo Jeong(정영주),Sun Hee Choi(최선희),Won Hee Lee(이원희),Mooseong Kim(김무성),Sang-Jin Kim(김상진),Sang-Hwa Urm(엄상화),Il Soo Moon(문일수),Dae-Hyun Seog(석대현) 한국생명과학회 2014 생명과학회지 Vol.24 No.8

세포표면 수용체와 통로가 적절히 기능하려면 특정 세포 내 위치로 배치되고 조절되어야 한다. PSD95/Dlg/Zo-1 (PDZ) 도메인은 이러한 배치와 조절을 매개하는 다양한 단백질들을 인식하고 이 단백질들이 서로 결합하는데 관여한다. MUPP1은 13개의 PDZ domain을 가지는 단백질로서 여러 구조 단백질 및 신호전달 단백질과 상호결합하지만, MUPP1이 어떻게 안정화되며, 어떻게 신호전달과정에 관여하는지에 대해 아직 명확히 밝혀지지 않았다. 본 연구에서 MUPP1의 PDZ 도메인과 상호 작용하는 단백질을 규명하기 위하여 효모 two-hybrid 방법을 이용하였고, Parkin이 MUPP1과 결합하는 것을 확인하였다. Parkin은 E3 ubiquitin ligase로서, Parkin 유전자의 기능상실 돌연변이는 autosomal recessive juvenile parkinsonism을 일으키는 것으로 알려져 있다. Parkin은 MUPP1의 12번째 PDZ domain과 결합하지만, 다른 PDZ 도메인과는 결합하지 않았다. Parkin의 C-말단부위는 II 형 PDZ-결합모티프를 가지고 있는데, 이 모티프가 MUPP1과의 결합에 필수적임을 확인하였다. HEK-293T 세포에 MUPP1과 Parkin을 동시에 발현하여 발현위치를 확인한 결과 세포내의 같은 위치에서 발현하였다. 또한 Parkin은 MUPP1을 강하게 유비퀴틴화 하였다. 이러한 결과들은 MUPP1이 Parkin의 기질이며, Parkin에 의한 유비퀴틴화에 의해 MUPP1의 기능 혹은 안정성이 조절될 수 있음을 시사한다. The localization to specific subcellular sites and the regulation of cell surface receptors and channels are crucial for proper functioning. Postsynaptic density-95/Disks large/Zonula occludens-1 (PDZ)-domain is involved in recognition of and interaction between various proteins, by which the localization and the regulation are mediated. Multi-PDZ domain protein 1 (MUPP1) contains 13 PDZ domains. MUPP1 serves a scaffolding function for structure proteins and signaling proteins, but the mechanism how MUPP1 is stabilized and signalized has not yet been elucidated. We used the yeast two-hybrid system to identify proteins that interact with PDZ domains of MUPP1. We found an interaction between MUPP1 and Parkin. Parkin is an E3 ubiquitin ligase. Loss-of-function mutations of Parkin gene are known to cause an autosomal recessive juvenile parkinsonism. Parkin bound to the 12th PDZ domain, but not to other PDZ domains of MUPP1. The C-terminal end of Parkin has a type II PDZ-association motif, which was essential for the interaction with MUPP1 in the yeast two-hybrid assay. When co-expressed in HEK-293T cells, Parkin co-localized with MUPP1. When co-expressed with ubiquitin in HEK-293T cells, MUPP1 has been strongly ubiquitinated by Parkin. These findings collectively suggest that MUPP1 is a novel substrate of Parkin and its function or stability could be modulated by Parkin-mediated ubiquitination.

Resistance mechanisms to chlorantraniliprole in diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae)

Hyun Kyung Kim,Won Jin Kang,Dae-Hoon Jeong,Hyun-Na Koo,Gil-Hah Kim 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.04

The diamondback moth (DBM), Plutella xylostella, is a globally distributed and important economic pest. Chemical control is the primary approach to regulate populations of this pest. Chlorantraniliprole is the first commercial insecticide that belongs to the new chemical class of diamide insecticides. In this study, the resistant strain was observed 1578-fold resistance to chlorantraniliprole. Point mutation (G4946E) in ryanodine receptor (RyR) showed a high frequency. Enzyme assays indicated that glutathione S-transferase (GST) activity in the resistant strain was 2.4 times higher compared with the susceptible strain, whereas no difference was seen for P450 and esterase. In addition, the expression of two GSTs genes was up-regulated. These findings pave the way for the complete understanding of the mechanisms of diamide insecticides resistance in insects.