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조상헌 ( Sang Heon Cho ) 대한내과학회 2009 대한내과학회지 Vol.76 No.3
Cough is an important defensive reflex of the respiratory tract needed to clear and protect the airways; however, it may become exaggerated and interfere with quality of life. Chronic cough is one of the most common symptoms leading to referral to secondary or tertiary hospital. The purpose of this article is to review the most common causes of chronic cough and to provide a comprehensive algorithms for clinician in evaluating and treating the patient with chronic cough. After excluding the possibility of smoking, angiotensin converting enzyme inhibitor or other specific abnormality in chest radiography as a cause of chronic cough, upper airway cough syndrome (UACS), previously named as postnasal drip syndrome, asthma, nonasthmatic eosinophilic bronchitis (NAEB), and gastroesophageal reflux disease (GERD) are the most common causes of chronic cough and these conditions may be present alone or in combination. Chronic cough can be cured in most people by treatment of these underlying causes of chronic cough. (Korean J Med 76:252-259, 2009)
종설 : 기관지천식 가이드라인의 변화: 2006 개정 GINA 가이드라인 중심
조상헌 ( Sang Heon Cho ) 대한내과학회 2007 대한내과학회지 Vol.72 No.3
Asthma is a serious global health problem. People of all ages in countries throughout the world are affected by this chronic airway disorder that, when uncontrolled, can place severe limits on daily life and is sometimes fatal. The prevalence of asthma is increasing in most countries, especially among children. Asthma is a significant burden, not only in terms of health care costs but also of lost productivity and reduced participation in family life. In 2002, the GINA Report stated that "it is reasonable to expect that in most patients with asthma, control of the disease can, and should be achieved and maintained". To meet this challenge, in 2005, Executive Committee recommended preparation of a new report not only to incorporate updated scientific information but to implement an approach to asthma management based on asthma control, rather than asthma severity. Recommendations to assess, treat and maintain asthma control are provided in the new GINA Report revised in 2006. Here, we summarize the main concepts and major changes of the new GINA guideline. (Korean J Med 72:245-255, 2007)
Ranitidine과 Famotidine이 Theophylline 대사에 미치는 영향의 약동학적 비교연구
조상헌 ( Sang Heon Cho ),조영주 ( Young Joo Cho ),김미경 ( Mi Kyeong Kim ),권오정 ( O Jung Kwon ),이춘택 ( Choon Taek Lee ),이상도 ( Sang Do Lee ),민경업 ( Kyung Up Min ),김유영 ( You Young Kim ),김호순 ( Ho Soon Kim ),신현택 ( Hy 대한결핵 및 호흡기학회 1990 Tuberculosis and Respiratory Diseases Vol.37 No.1
한국인 성인 천식 한자의 Theophyline 대사에 관한 약동학적 연구
조상헌(Sang Heon Cho),조영주(Young Joo Cho),민경업(Kyung Up Min),김유영(You Young Kim),김호순(Ho Soon Kim),신현택(Hyun Taek Shin Pharm) 대한내과학회 1991 대한내과학회지 Vol.41 No.4
N/A To evaluate pharmacokinetic parameters and maintenance dose of theophylline in Korean adult asthmatics, we estimated total body clearance by nonlinear computer analysis according to age and sex after continuous infusion of aminophylline in 82adult asthmatics (age range 20-81 years old). Eight men were smokers. In nonsmoking male and female patients, the total body clearance of patients over 55years old was significantly lower than that of patients under 55years old(p<0.05). In nonsmoking male patients, the total body clearance was 44.2±9.9 ml/hour/kg in patients under 55years old and 33.2±8.2 ml/hour/kg in patents over 55years old. In nonsmoking female patients, it was 44.1±13.6ml/hour/kg in patients under 55years old and 34.1±8.2 ml/hour/ kg in patients over 55years old. The regression equations between total body clearance and age were total body clearance (ml/hour/kg)= 0.403×Age+59.698 in male (r=0.50, p<0,05) and 0.546×Age+67.462 in female (r=0.61, p<0.05). The total body clearance of smoking male was increased by 27% compared to that of nonsmokers of same age group. There was no significant diference between clearance of Korean adult asthmatics and that of western people reportec1 by Hendeles and Antal. And there was no difference according to gender in same age groups. Even though we can calculate serum theophylline concentration from above equations, variability of total body clearance is so wide that regular estimation of serum theophylline concentration is recommended.