A Case of Urethral Stent for Recurrent Urethral Stricture and Penile Prosthesis for Erectile Dysfunction

Jung, Gyung-Woo,Song, Young-Jin,Park, Young-Ho,Kwon, Heon-Young,Yoon, Jin-Han 동아대학교의과대학 1992 동아의대학술지 Vol.4 No.1

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

정지궤도 위성과 지구국간 광통신 링크의 전송속도 해석

한종석,정진호,김영권,Han, Jong-Seok,Jung, Jin-Ho,Kim, Yung-Kwon 한국전기전자학회 1997 전기전자학회논문지 Vol.1 No.1

정지궤도 위성과 지구국간 광통신을 대기상태와 앙각의 함수로써 해석할 수 있는 한모델(Han's model)을 제시하였다. 한모델에서는 대기상태를 맑은날, 구름낀 날, 안개, 헤이즈, 비, 눈의 여섯가지 전형적인 상태로 구분한다. 비트오류을 $10^{-7}$을 만족하는 데이터 전송속도를 한모델을 이용하여 상향링크와 하향링크에 대해 해석하였다. 상향링크시의 포인팅손실이 하향링크시의 대기에 의한 공간 가간섭 저하보다 크기 때문에 데이터 전송속도는 하향링크 보다 오히려 상향링크시에 제한됨을 알 수 있었다. Han's model, which is able to analyze optical communication between earth station and geo-satellite as a function of atmospheric conditions and elevation angles. is presented. In Han's model, atmospheric conditions are roughly classified into six basic types; clear sky, cloud, haze, fog, rain and snow. Data rate satisfying for the BER below $10^{-7}$ is analyzed by Han's model in case of up-link and down-link, respectively. Data rate is more limited by up-link than by down-link because the pointing loss caused by atmosphere on the up-link is greater than the spatial coherence degradation caused by atmosphere on the down-link.

골프선수들의 심리적(PSIS) 비교 분석에 관한 연구

한정훈,배진희,최영수 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose of this study was to compare the PSIS factors and to development the norms of golf players in competition. Subjects were 180 golf players. For PSIS adopted Mahoncy(1989) was used in this research. The main findings of this study were as follows. First, there was significant mean difference in the confidence factor between university and business players, however there were no differences in other factors. Second, there was significant mean difference in the confidence factor among under 3.48th, 3.49th~9.65th years by career, however there were no differences in other factors. Third, there was significant mean difference in the confidence factor between one and none by representative career, however there were no differences in other factors. Fourth, there were 11~26 norm scores of university players and 17~28 norm scores of business players in the anxiety factor. Fifth, there were 6~20 norm scores of university players and 7~18 norm scores of business players in the concentration factor. Sixth, there were 12~27 norm scores of university players and 16 ~27 norm scores of business players in the confidence factor. Seventh, there were 4~20 norm scores of university players and 10~23 norm scores of Eighth, there were 9 ~23 norm scores of university players and 10~23 norm scores of business players in the motivation factor. Ninth, there were 5~18 norm scores of university players and 9~18 norm scores of business players in the team emphasis factor.

전기자극 스트레스 또는 심리갈등 스트레스가 흰쥐 비장 임파구 증식과 Interleukin-2 생산능에 미치는 영향

한상진,김정목,양병환 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.2

The purpose of this study was to examine the relastionship between stress and immunologic function as a possible mechanism of stress and disease process. The authors investigated how the psychological stress induced by avoidance-avoidance conflict model or physical stress of electric shock do impact the immune function, measuring proliferation and interleukin-2(IL-2) production of rat splenic lymphocytes stimulated with various mitogens such as concanavalin-A(Con-A). phytohemagglutinin-M(PHA) and phorbol 12-myristate l?-acetate+calcium inophore A23187(PMA+A23187). In this experiment, female Sprag-Dawley rats were used an subjects. Animals were separated into 4 group according to different stress conditions. Conflict group received psychological conflict stress with electric shock depending on the coping behaviour and Yoked group was not in psychological conflict situation but received as same amount of electric shock as conflict group. Skinner-Box control group was immobilized without electric shock and Home-cage control group had no stress condition. The results are as follows : 1) There is significant difference in lymphocyte proliferation in case of Con-A and PMA+A 23187 between Skinner-Box control group and Yoked group at the high current condition. 2) There is significant difference in IL-2 production in case of PHA and PMA+A23187 between Skinner-Box control group and Yoked group. 3) There is more significant difference in lymphocyte proliferation in case of all of mitogens, Con-A. PHA and PMA+A23187 between Yoked group and Conflict group regardless of high or low current condition. 4) There is significant difference in IL-2 production in case of PMA+A23187 between Yoked group and Conflict group. This results suggest that psychological stress could reduce the immue function more profoundly than physical stress and also means the importance of coping and appraisal in the stress-immunology relationship.

운동성 산화 스트레스와 항산화비타민의 보충이 말초단핵세포의 NF-kB 활성에 미치는 영향

진영수,박건구,박준영,김미정,이왕록,김혜영,이한준,박은경 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

Reactive oxygen species(ROS) are implicated in the pathogenesis of a wide variety of human diseases. Numerous studies indicate that ROS may serve as common intracellular molecules that contribute to the process of nuclear factor(NF)κB activation in response to a diverse stimuli. In our laboratory, we have demonstrated tat antioxidants could reverse the decline of immune function caused by exercise-induced ROS. Furthermore, it in necessary to understand a mechanism underlying ROS-dependent disorder in biological system. Recent studies have been shown that several gene expression were regulated by oxidants, antioxidants and other determinants of the intracellular reduction-oxidation(redox) state. In this process, NF-κB have been shown to play a important role. The purpose of the present investigation was to evaluate the effect of exercise-induced oxidative stress and antioxidnt supplementation on NF-κB activation in peripheral mononuclear cells. Forty male SD rats(4 weeks old) were randomly divided into noraml diet group and antioxidants(ATO) supplement group, and then ATO groups were treated with antioxidants(VE: 2001U/kg, VC: 50mg/rat, β-carotene: 300mg/kg, vitamin B6: 250㎍/100g, selenomethionine: 0.1mg/kg) for 16 weeks. After 16 weeks breeding at each condition, each group divided into two groups: Control group(CR) fed generally, Exercise group(CE) fed generally and followed by acute exercise 16 weeks later. Antioxidant Antioxidants and Exercise group(AE) fed with antioxidants and followed by acute exercise. The activation of NF-κB binding activity was increased after exhaustive exercise bout in both group. In addition, pretreatment of ATO group with the antioxidants mixture lead to the inhibition of NF-κB binding activity. This results suggest that NF-κB activation should be further studies in response to a variety of exercise.

교정선의 종류, 결찰방법, 타액의 유무에 따른 마찰력의 비교연구

한정숙,이진우,차경석 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.2

치아에 부착된 bracket이 교정선을 따라 이동할때 필연적으로 bracket과 교정선, 결찰재 사이에 마찰력이 발생된다. 이에 저자는 동일한 bracket내에서 교정선의 종류, 결찰방법, 건조와 타액상태에 따른 마찰력 차이, 타액의 윤활제로서의 기능을 살펴보기 위해 본 연구를 시행하게 되었다. 본 실험에 사용된 bracket은 .018"× .025" slot의 상악 견치용 standard edgewise bracket(RMO. USA)이며, 교정선은 .016" , .016" × .022" 크기의 Cobalt-chromium(Elgiloy . RMO. USA), Nickel-titanium(Ni-Ti) (ORTHOLLOY : Goldstar Cable Co. KOREA), Beta- titanium(TMA : ORMCO Co., USA)의 2가지형태의 3종을 이용하여 활주할때의 마찰력을 만능시험기(Instron, M 1000 EC)를 사용하여 계측하여 다음과 같은 결론을 얻었다. 1.각각의 동일조건하에서 교정전의 재질에 따른 마찰력은 Co-Cr, Ni-Ti, β-Ti순으로 증가하였다. 단, 타액상태에서 elastomeric으로 결찰한 .016" 군에서는 예외이다. 2.각 조건하(건조/타액상태, .016" /.016" × .022" ) 에서 결찰방법에 따른 마찰력은 elastomeric보다 stainless steel 결찰에서 더 크게 나타났다(p<0.05). 3.각각의 교정선과 결찰방법에서 타액 유무에 따른 마찰력은 stainless steel로 결찰한 .016" Co-Cr, Ni-Ti, β-Ti는 타액상태에서 감소하나, stainless steel로 결찰한 .016" × .022" Co-Cr, Ni-Ti, β-Ti는 타액상태에서 증가하였다(p<0.05). 4.각 조건하(건조/타액상태, elastomeric/stainless steel결찰) .016" 과 .016" × .O22" 교정선 사이의 마찰력은 .016" × .022" 교정선에서 증가하였다(p<0.05). The purpose of this study was fourfold - to evaluate the general laws of friction applied to orthodontic conditions, to compare archwire materials under these controlled conditions, to compare ligation method, and to measure the effect of the artificial saliva on friction with these materials Three wire alloys (Cobalt-chromium, Nickel-titanium, Beta-titanium) in two size wires (.016" ,.016" × .022" ) were examined respect to the bracket (0.18 × .025" standard), and two ligature material (stainless steel, elastomeric) in dry and wer conditions The result were as follows, 1.The order of frictional force against alloy materials was Co-Cr (lowest), Ni-Ti, and β -Ti(highest) - with the exception of elastomeric ligation under wet conditions. 2.S.S. ligation gave rise to significantly greater friction than elastomeric ligation did. 3.Testing in the presence of saliva, rather than in dry conditions, decreased the frictional force for S.S. ligation with .016" Co-Cr, Ni-Ti, β -Ti. but, increased the frictional force for 5.5. ligation with .016" × .022" Co-Cr, Ni-Ti, β-Ti. 4.016" ×.022 " wire generated more friction than .016" wire.

3-레벨 반브리지로 구성된 SSSC의 동특성 분석

정진규,백승택,한병문 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

This paper proposes an SSSC based on 3-level half-bridge inverters. The dynamic characteristic of the proposed SSSC was analyzed by EMTP simulation, assuming that the SSSC is inserted in the transmission line of the one-machine-infinite-bus power system. The proposed SSSC has six 3-level half-bridge inverters per phase, which poperates in PWM mode. The proposed SSSC generates a quasi-sinusoidal output voltage by 90 degree phase shift to the line current. The proposed SSSC does not require the coupling transformer for voltage injection, and has a flexibility in operation voltage by increasing the number of series connection.

남북의 통일을 대비한 초등 체육교육의 비교분석 방안연구

한정훈,배진희 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

It is obvious that, based on the fact that south Korea and north Korea have took the different ways respectively in the different ideologies and political systems from each other for the period of half a century since the Korean peninsula was divided into south and north after the liberation of Korea, they have seriously become different in all aspects, including politics, economy, society, culture and etc. and the educations in both have been also gradually getting different without overcoming the difference. Therefore this study is to compare and analyze the ideologies and object, the policy and the change of the curriculum of physical education in primary school of both. In the way of study, the physical education of both was compared and analyzed based on the treatise related to previous studies owing to difficulties in access to the materials. Chapter 2 has showed the ideology and the object, chapter 3 the policy, chapter 4 the change of curriculum, chapter 5 the system of curriculum, chapter 6 the comparison of physical education of primary schools in south and north korea. The conclusion has been showed in chapter 7. Consequently, it can be considered that the educations in both of south and north korea have had a great effect on the political systems of both: the education of south korea has success-fully contributed to the economic development of the liberal democracy and that of north korea has been successful for maintenance of the political system based on Kim Il-Seong's unique ideology. To narrow the gap of differences between south korea and north korea, it was suggested that the exchange of the children's sports activities which are most basic in education is a short cut.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.