<i>In vitro</i> and <i>in vivo</i> evaluation of a novel polymer-free everolimus-eluting stent by nitrogen-doped titanium dioxide film deposition

Park, Dae Sung,Bae, In-Ho,Jeong, Myung Ho,Lim, Kyung Seob,Sim, Doo Sun,Hong, Young Joon,Lee, So-Youn,Jang, Eun Jae,Shim, Jae-Won,Park, Jun-Kyu,Lim, Han Chul,Kim, Han Byul Elsevier 2018 Materials Science and Engineering C Vol.91 No.-

<P><B>Abstract</B></P> <P>Inflammation and thrombosis are linked to the use of polymer-based drug-eluting stents (DES). The aim of this study was to develop a polymer-free everolimus (EVL)-eluting stent using nitrogen-doped titanium dioxide (N-TiO<SUB>2</SUB>) and verify its efficacy by <I>in vitro</I> and <I>in vivo</I> assessment in a porcine coronary model. Various analytical approaches such as scanning electron microscopy and atomic force microscopy, electron spectroscopy, Fourier transform infrared spectrometry and contact angle measurement were employed for the characterization. As a part of biocompatibility assessment, platelet adhesion and smooth muscle cell (SMC) proliferation were examined. Bare metal stent (BMS), N-TiO<SUB>2</SUB> stent, everolimus-eluting N-TiO<SUB>2</SUB> (N-TiO<SUB>2</SUB>-EVL) stent, and commercialized EVL-eluting stent (EES) were randomly placed in forty coronary arteries in twenty pigs. After four weeks of implantation, the stents were subjected to histological and quantitative analysis. The N-TiO<SUB>2</SUB> film used in this study was well coated without any cracks or peeling. Surface hydrophilicity (88.8% of angle decrement) could be associated with the decrease in surface roughness post N-TiO<SUB>2</SUB> deposition (37.0%). The platelet adhesion on the N-TiO<SUB>2</SUB> surfaces was less than that on the BMS surface. The proliferation of SMC was suppressed in the N-TiO<SUB>2</SUB>-EVL group (30.2%) but not in the BMS group. In the animal study, the percent area restenosis was significantly decreased in the N-TiO<SUB>2</SUB>-EVL group compared to that in the BMS group. The results (BMS; 47.0 ± 11.00%, N-TiO<SUB>2</SUB>-EVL; 31.7 ± 10.50%, and EES; 29.1 ± 11.21%, <I>n</I> = 10, <I>p</I> < 0.05) were almost at par with those of the commercialized EVL-eluting stent. The introduction of N-TiO<SUB>2</SUB> deposition during fabrication of polymer-free DES may be an efficient accessorial process for preventing in-stent restenosis and thrombosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> N-TiO<SUB>2</SUB> surfaces can help to reduce the platelet adhesion. </LI> <LI> In porcine model, N-TiO<SUB>2</SUB> everolimus decreased in-stent restenosis and fibrin deposition. </LI> </UL> </P>

In-hospital mortality in patients with STEMI admitted during off hours

( Sung-Soo Kim ),( Myung Ho Jeong ),( Jeong Gwan Cho ),( Young Keun Ahn ),( Jong Hyun Kim ),( Shung Chull Chae ),( Young Jo Kim ),( Seung Ho Hur ),( In Whan Seong ),( Taek Jong Hong ),( Dong-hoon Choi 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Conflicting results exist on the outcome of off hours PCI in ST elevation myocardial infarction (STEMI). However, there were only a few studies that have focused on the clinical characteristics and outcomes of off hours PCI in STEMI. So, we studied the clinical characteristics and hospital mortality in STEMI patients treated with primary PCI during regular hours (weekdays 9:00 AM to 6:00 PM) versus off hours Weekdays 6:01 PM to 8:59 AM, weekends, and holidays) in Korea Acute Myocardial Infarction Registry. We analyzed in hospital and one year mortality among 5,665 consecutive ST segment elevation myocardial infarction patients treated with primary PCI between November 2005 to January 2008. Total 2,848 (50.2%) patients were treated during off hours. Baseline finding were similar, although regular hours patients were older. Median symptom to balloon time (304 min, IQR 175 to 750 vs. 270 min, IQR 145 to 551, p=0.001) were longer for regular hours primary PCI. Median door to balloon time (71min, IQR: 48 to 132 vs. 59 min, IQR 39 to 110 min, p=0.001) were longer for off hours pPCI. Also, Cardiac enzyme such as Max CK-MB (212.1±299.3 vs 194.7±303.4, p=0.031) and max TnI (72.6±239.5 vs. 58.9±94.4, p=0.013) were increased in off hours pPCI. However, unadjusted in hospital (6.0% off hours vs. 6.0% regular hours, p=0.946) and one year cardiac mortality (11.3% off hours vs. 11.7% regular hours, p=0.661) were comparable. In multivariate analysis, off hours primary PCI did not predict an adverse outcome. In conclusion, when primary PCI was performed within an appropriate reperfusion strategy, the clinical effectiveness of either off hours or regular hours pPCI is comparable.

濟州道 柑橘業의 成長과 構造的 特質에 關한 考察

許仁玉 濟州敎育大學校 1976 論文集 Vol.6 No.-

In consequence of search and analysis for the solution of problems after inquiring into the history of citrus industry in Jeju-Do and the characteristics it preserves, it follows; 1) In 1975 the total area in which citrus trees were planted, covered 10,930 hectares and the fruit production amounting to 81,105 T/M took the second placemext to apple of all the fruit production in Korea. 2) Natural species of citrus had long been growing, so the first introduction of improved species took place in the twentieth century, its full-scale growth starting in the 1960, s, which resulted in an increase of 428 times in its production within a span of fifteen years. 3) The background the industry thus rapidly progressed can be ascribed to favorable condition of geographic location, maintenance of price stabilization under protection of the Government and technical inneovation in the growing knowhow. 4) The structural characteristics of citrus industry in Jeju-Do. ① Species structure shows the unitary one, where by the labor force and shipment have to be concentrated within a short span. ② As the average area per household growing is no more than 0.5 hectare, there follows low productivity compared to the operating investment and care, which results in difficulties for the planned shipment for marketing. ③ There many newly established orchards in which the age of citrus trees is mostly under no more than ten years, and thus a rapid increase is estimated in the future production.

Temporal trends and in-hospital outcomes of primary percutaneous coronary intervention in nonagenarians with ST-segment elevation myocardial infarction

( Joon Young Kim ),( Myung Ho Jeong ),( Yong Woo Choi ),( Yong Keun Ahn ),( Shung Chull Chae ),( Seung Ho Hur ),( Taek Jong Hong ),( Young Jo Kim ),( In Whan Seong ),( In Ho Chae ),( Myeong Chan Cho ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Background/Aims: Data regarding the outcomes of primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in nonagenarians are very limited. The aim of the present study was to evaluate the temporal trends and in-hospital outcomes of primary PCI in nonagenarian STEMI patients. Methods: We retrospectively reviewed data from the Korea Acute Myocardial Infarction Registry (KAMIR) from November 2005 to January 2008, and from the Korea Working Group on Myocardial Infarction (KorMI) from February 2008 to May 2010. Results: During this period, the proportion of nonagenarians among STEMI patients more than doubled (0.59% in KAMIR vs. 1.35% in KorMI), and the rate of use of primary PCI also increased (from 62.5% in KAMIR to 81.0% in KorMI). We identified 84 eligible study patients for which the overall in-hospital mortality rate was 21.4% (25.0% in KAMIR vs. 20.3% in KorMI, p = 0.919). Multivariate analysis identified two independent predictors of in-hospital mortality, namely a final Thrombolysis in Myocardial Infarction (TIMI) flow < 3 (odds ratio [OR], 13.7; 95% confidence interval [CI], 3.2 to 59.0; p < 0.001) and cardiogenic shock during hospitalization (OR, 6.7; 95% CI, 1.5 to 30.3; p = 0.013). Conclusions: The number of nonagenarian STEMI patients who have undergone primary PCI has increased. Although a final TIMI flow < 3 and cardiogenic shock are independent predictors of in-hospital mortality, primary PCI can be performed with a high success rate and an acceptable in-hospital mortality rate.

Celay/In-Ceram, Conventional In-Ceram, Empress 2 전부도재관의 변연적합도에 관한 비교 연구

양재호,여인성,이선형,한중석,이재봉,Yang, Jae-Ho,Yeo, In-Sung,Lee, Sun-Hyung,Han, Jung-Suk,Lee, Jai-Bong 대한치과보철학회 2002 대한치과보철학회지 Vol.40 No.2

There have been many studies about marginal discrepancy of single restorations made by various systems and materials. But many of statistical inferences are not definite because of sample size, measurement number, measuring instruments. etc. The purpose of this study was to compare the marginal adaptations of the anterior single restorations made by different systems and to consider more desirable statistical methods in analysing the marginal fit. The in vitro marginal discrepancies of three different all-ceramic crown systems (Celay In-Ceram. Conventional In-Ceram. IPS Empress 2 layering technique) and one control group (PFM) were evaluated and compared. The crowns were made from one extracted maxillary central incisor prepared with a 1mm shoulder margin and $6^{\circ}$ taper walls by milling machine. 10 crowns per each system were fabricated. Measurements or a crown were recorded at 50 points that were randomly selected for marginal gap evaluation. Non-parametric statistical analysis was performed for the results. Within the limits of this study, the following conclusions were drawn: 1 Mean gap dimensions and standard deviations at the marginal opening for the maxillary incisor crowns were $98.2{\pm}40.6{\mu}m$ for PFM, $83.5{\pm}18.7{\mu}m$ for Celay In-Ceram, $104.9{\pm}44.1{\mu}m$ for conventional In-Ceram, and $45.5{\pm}11.5{\mu}m$ for IPS Empress 2 layering technique. The IPS Empress 2 system showed the smallest marginal gap (P<0.05). The marginal openings of the other three groups were not significantly different (P<0.05). 2 The marginal discrepancies found in this study were all within clinically acceptable standards ($100\sim150{\mu}m$). 3. When the variable is so controlled that the system may be the only one, mean value is interpreted to be the marginal discrepancy of a restoration which is made by each system and standard deviation is to be technique-sensitivity of each one. 4. From the standard deviations. the copy-milling technique (Celay/In-Ceram) was not considered to be technique-sensitive in comparison with other methods. 5. Parametric analysis is more reliable than non-parametric one in interpretation of the mean and standard deviation. The sample size of each group has to be more than 30 to use parametric statistics. The level of clinically acceptable marginal fit has not been established. Further studies are needed.

In_0.5(Ga_1-xAl_x)_0.5P/GaAs 이중 이종접합 구조의 Contactless Electroreflectance에 관한 연구

김정화,조현준,배인호,Kim, Jeong-Hwa,Jo, Hyun-Jun,Bae, In-Ho 한국진공학회 2010 Applied Science and Convergence Technology Vol.19 No.2

Metal-organic chemical vapour deposition (MOCVD)법으로 성장된 $In_{0.5}(Ga_{1-x}Al_x)_{0.5}P$/GaAs 이중 이종접합 구조의 특성을 contactless electroreflectance (CER) 분광법으로 조사하였다. CER 측정은 변조전압($V_{ac}$), 온도 및 dc 바이어스 전압($V_{bias}$)의 함수로 수행하였다. 상온에서는 5개의 신호가 관측되었는데, 이 신호들은 각각 GaAs, $In_{0.5}Ga_{0.5}P$, $In_{0.5}(Ga_{0.73}Al_{0.27})_{0.5}P$, $In_{0.5}(Ga_{0.5}Al_{0.5})_{0.5}P$ 및 $In_{0.5}(Ga_{0.2}Al_{0.8})_{0.5}P$ 전이에 관련된 것이다. CER 스펙트럼의 온도 의존성으로부터 Varshni 계수 및 평탄인 자를 구하였다. 그리고 인가전압에 따른 신호의 진폭은 순방향 바이어스 전압 인가시 점차로 감소하나, 역방향 바이어스 전압 인가시에는 반대의 경향을 보였다. We have investigated the contactless electroreflectance (CER) properties of $In_{0.5}(Ga_{1-x}Al_x)_{0.5}P$/GaAs double heterostructures grown by metal-organic chemical vapour deposition (MOCVD). The CER measurements on the sample were studied as a function of temperature, modulation voltage ($V_{ac}$), and dc bias voltage ($V_{bias}$). Five signals observed at room temperature are related to the GaAs, $In_{0.5}Ga_{0.5}P$, $In_{0.5}(Ga_{0.73}Al_{0.27})_{0.5}P$, $In_{0.5}(Ga_{0.5}Al_{0.5})_{0.5}P$, and $In_{0.5}(Ga_{0.2}Al_{0.8})_{0.5}P$ transitions, respectively. From the temperature dependence of CER spectrum, the Varshni coefficients and broadening parameters were determined and discussed. In addition, we found that the behavior of the CER amplitude for the reverse bias is larger than that of the forward.

In_xGa_1-xN/GaN 다중양자우물 구조의 광학적 성질 연구

김기홍,김인수,박헌보,배인호,유재인,장윤석,Kim, Ki-Hong,Kim, In-Su,Park, Hun-Bo,Bae, In-Ho,Yu, jae-In,Jang, Yoon-Seok 한국진공학회 2009 Applied Science and Convergence Technology Vol.18 No.1

$In_xGa_{1-x}N$/GaN 다중양자우물 구조의 EL 특성을 온도와 주입전류 변화에 따른 특성을 조사하였다 저전류와 고전류 주입시 EL 효율의 온도 의존 변화는 매우 다르게 나타나는데, 이러한 온도와 전류의 변화에 의한 독특한 EL 효율의 변화는 내부전기장의 존재 하에 순방향 바이어스에 기인한 외부전기장의 영향인 것으로 볼 수 있다. 그리고 $In_xGa_{1-x}N$/GaN 다중양자우물 구조에서 In 성비의 증가는 발광파장위치의 적색이동을 보였다. 15K에서 주입 전류의 증가에 따라 녹색 양자우물 구조는 80 meV와 청색 양자우물 구조는 22 meV의 청색 편이를 하였다. 이는 전류의 증가에 의해 단위 시간당 생성되는 캐리어 수가증가하게 되고 그에 따라 subband가 급격히 채워지는 band filling 현상이 일어나게 되어 짧은 파장에서 재결합이 증가하기 때문이다. 그리고 청색과 녹색 다중 양자우물구조의 짧은 파장 쪽으로의 편이 차이는 In 농도에 기인한 것으로 In 농도가 높으면 양자우물 깊이가 증가되어 더 강한 양자속박효과가 작용하여 캐리어 구속력이 증가하기 때문 것으로 볼 수 있다. Temperature and injection current dependence of electroluminescence(EL) spectral intensity of the $In_xGa_{1-x}N$/GaN multi-quantum wells(MQW) have been studied over a wide temperature range and as a function of injection current level. It is found that a temperature-dependent variation pattern of the EL efficiency under very low and high injection currents shows a drastic difference. This unique EL efficiency variation pattern with temperature and current can be explained field effects due to the driving forward bias in presence of internal(piezo and spontaneous polarization) fields. Increase of the indium content in $In_xGa_{1-x}N$/GaN multiple quantum wells gives rise to a redshift of 80 meV and 22 meV for green and blue MQW, respectively. It can be explained by carrier localization by potential fluctuation of multiple quantum well and MQW structures also shows a keen difference owing to the different indium content in InGaN/GaN MQW.

기획논문 : 인조반정(仁祖反正)과 남명학파(南冥學派) ; 인조반정(仁祖反正)과 정인홍(鄭仁弘)의 정치철학적 재평가

권인호 ( In Ho Kwon ) 南冥學硏究院 2011 南冥學 Vol.16 No.-

이른바 ‘인조반정(광해군 15년; 인조 1년; 1623년 3월)’ 후에 정인홍(1535-1623)의 ‘산림정치’를 이귀(1557-1632) 등 쿠데타의 주역들이 당시 송익필(1534-1599)과 이이(1536-1584)의 제자인 김장생(1548-1631)을 불러내어 흉내 내었다. 인조반정은 그 성격 상 서인의 왕위찬탈과 정치 쿠데타(Coup d`Etat)의 성격이 강하다. 이후 그들의 밀약대로 ‘무실국혼, 숭장산림’으로, 조선조 말기까지 서인-노론-세도정치로 이어져 망국의 주요한 원인이 되었다고 본다. 정인홍은 인조반정에 의해 역적으로 몰려 참형을 당한 인물이다. 이 사건의 289년 후인 대한제국 순종 융희 2년(1908년 4월 30일)에야 칙명으로 영의정으로 신원복작이 되었다. 모든 역사가 ‘승자의 자기변명과 정당화’라고 하지만, 또한 ‘역사는 과거와 현재의 끊임없는 대화’라는 역사철학적 의견도 있다. 그렇기 때문에 역사적 재평가는 계속되어야 한다. 과거 한국과 중국의 역사에서 부왕(황이) 죽고 어린 왕(황제)이 즉위하여 그 모후가 섭정했을 때, 대개의 경우 외척들이 발호하여 정치와 경제가 파탄하여 민중의 삶이 도탄에 빠지고 끝내 망국으로 치달았던 일반적인 모습을 보게 된다. 광해군 시대의 계모후인 인목왕후 연안 김씨와 그 배후 정치세력의 성격은 이미 많은 문제점을 노출하였다. 조선의 태종 이방원은 태조 이성계의 일곱 왕자 가운데 유일하게 고려 말에 문과에 급제한 총명한 사람이다. 이성계의 역성혁명과 왕업을 도우고 아들 세종을 성군으로 만드는 기틀을 마련한 영명한 군주였다. 그는 형제와 외척들(여흥 민씨, 청송 심씨)을 제거하고 계모후인 신덕왕후의 정릉을 도성 밖으로 이장했다. 그렇지만 후대에 감히 어떤 이가 태종을 인륜도덕을 어긴 ‘폐모살제’를 운운하며 욕하는 이가 있으며, 세조 또한 유사한데도 그 누가 이를 빌미로 왕위찬탈의 역모를 하여 성공한 것을 정당하게 기록했던가? 정인홍은 유교적 민본적 정치 학문사상과 지방관으로서 당대 최고의 선정관과 중앙 조정에서의 추상같은 공정성과 청렴함 경연에서 훌륭한 학자의 풍모가 있었다. 그리고 임진왜란 때 의병 창의하여 ‘출장입상’의 경륜과 ‘출처대의’를 올바로 평가해야 한 오히려 도덕정치와 내치외교에서 철저하게 실패한 인조와 그 반정공신들 및 그 후예들의 정치행태는 새롭게 비판적으로 평가되어야 한다. ‘잘못된 임금은 放伐할 수 있다’는 것이 맹자의 ‘폭군일부론’이며 혁명론이다. 그것이 정당하려면 반정세력들이 유교의 민본과 정치에서 혁명의 당위성이 있어야 한다. 그렇지 못하면 북송 때 사마광은 ‘맹자의 ’역위‘와 ’혁명론‘은 왕위 찬탈과 역적들의 구실이 될 것으로 비판 하였다.먼저 ‘앞의 왕이 ’걸주‘처럼 폭군이고 뒤의 왕이 ’탕무‘처럼 현군이라야 가할 것’이라고 일찍이 주희는 이야기 한 바가 있다. 과연 인조반정이 그랬던가? After the King Injo Restoration, Yi, Gui(1557~1632), including participants of the coup, imitated Jeong, In-hong`s politics of Sallim with Kim, Jang-saeng(1548~1631), a fellow pupil. The King Injo Restoration was a political coup d`Etat and a usurpation the throne by Soin. Soin`s coup was the first chain of Soin, Noron and In-raw gorvernment, moreover, it was the major reason of the fall of Joseon dynasty. Jeong, In-hong was the person who was beheaded by false charges. After 289 years, Great Han Empire Sunjong[純宗] Yoonghi [隆熙] 2nd year(April 30th, 1908), he was rehabilitated as the prime minister of the Joseon dynasty by emperor. Someone says that every scene of history was "self-vindication and justification of winners", but there is the historical philosophical opinion of "History is an unending dialogue between the present and the past." In Korean and Chinese history, when a former queen[empress] acted as regent for the young king after a king or emperor was dead, mostly, the maternal relatives dominated the political situation, as a result, the people and dynasty[empire] fall into extreme distress. In the reign of Gwanghaegun, there was many problems of the queen as king`s stepmother, Inmok Queen Kim`s speech and her de facto power. King Taejon, Lee, Bang-won was an intelligent person and he was the only person who was pass the civil service examination among seven sons of King Taejo, Lee, Seong-gye in goryo dynasty. He helped father`s dynastic revolution and made his son, King Sejong, as a sage king. He purged his brothers and maternal relatives(Yeoheung Min`s family, Cheongsong Sim`s family) and change the burial site of the queen as king`s stepmother, Shindeok Queen Kang`s royal tomb to out of a capital city. Nevertheless, was there a person who dared to abuse King Taejong by reason of ``deposing mother queen and killing brother``? Was there a person who succeeded in usurpation and restoration against King Sejo, similar to King Taejong. Jeong, in-hong became the best mayor of the day and he was equipped impartiality and integrity in royal court and he had a scholarly appearance in Gyeongyeon[經筵] with his Confucian and democratic thought of politics. We should estimate his raising an army in the cause of justice based on the thought of ‘To become a general outside, to become a prime minister inside`` and ``Enter the government service and Live in seclusion``. On the contrary, we should estimate critically King Injo, the coup confederates and the successors those failed in ethical politics, internal administration and diplomacy desperately. ``The wrong King could be punished``, that was the Mengzi`s thoughts of ``A tyrant is an ordinary man`` and revolution. Revolution or restoration should have Confucian and democratic legitimacy. In other words, the changing of Providence should be admitted by public sentiment. In the age of Northern Song, Ssu-ma Kuang criticized that Mengzi`s thougnt of changing the throne and revolution will be a excuse for traitors who try to usurp the throne. So Zhu Xi said that ``It is possible when the former king must be a tyrant like Jie Zhou[桀紂] and the latter king must be a wise king like Tang Wu[湯武]``. Was The King Injo Restoration really as Zhu Xi said?

심장수술 시 농축적혈구, 자가수혈기 혈액, 체외 순환기 혈액에서의 유리 혈색소 농도 비교

송장호,구승우,백종화,정용보,이정순,최인철 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.5

Background: Intraoperative autotransfusion or residual blood in a cardiopulmonaty bypass (CPB) circuit has been used to reduce the need for an homologous blood transfutsion during cardiac surgery. However, it may contain some free hemoglobin released from damaged cells. The load of blood containing free hemoglobin may cause renal dysfunction. We measured the amount of free hemoglobin in backed blood, cell saver blood and CPB blood to evaluate what is the least hemolytic blood transfused in cardiac surgery. Methods: This study was performed in 20 patients undergoing cardiac surgery. In each patient, the banked blood, intraoperative salvaged blood with a cell saver and CPB residual blood were sampled at the end of the operation. The concentration of free hemoglobin, hemoglobin and platelet counts were measured in these blood samples and percent of hemolysis was calculated (%hemolysis = [free hemoglobin] / .free hemogloben + hemoglobin]) Results: In salvaged blood with a cell saver, CPB residual blood and banked blood, hemoglobin concentrations were 20.1 ± 2.7 g/dl, 8.0 ± 1.1 g/dl, and 22.2 ± 2.7 g/dl, respectively. Free hemoglobin concentrations were 336.6 ± 239.5 mg/dl, 49.2 ± 26.8 mg/dl, and 279.5 ± 167.5 mg/dl respectively. Platelet counts were 26.1 ± 22.2 × 10^3/mm^3, 116.8 ± 56.5 × 10^3/mm^3, and 94.9 ± 43.6 × 10^3/mm^3 respectively. % Hemolysis were 1.6 ± 1.1%, 0.6 ± 0.4%, and 1.2 ± 0.7% respectively. In the comparison between the salvaged blood with a cell saver and CPB residual blood, free hemoglobin concentration, % hemolysis, and platelet counts had positive correlations (r = 0.8, 0.7, and 0.6). Conclusions: In twenty cardiac surgeries, CPB residual blood had a lower free hemoglobin level than the other two blood groups. The platelet counts in CPB residual blood were higher than those in cell saver blood but did not differ from those in banked blood. Therefore, CPB residual blood was the least hemolytic blood among the three blood groups when a transfusion was performed in cardiac surgery. (Korean J Acesthesiol 2002; 43: 588~593)

수종의 식물섬유의 급이가 고콜레스테롤 혈증 흰쥐의 지질 대사에 미치는 영향 : 1.간장의 지질성분 및 지방산 조성 Lipid Component and Fatty Acid Composition in liver

이호신,서인숙,김우준 麗水水産大學校 産業技術硏究所 1995 産業基術硏究所 論文集 Vol.4 No.-

This study was designed to observe the effects of feeding dietary fiber on the improvement of the lipids and the fatty acid metabolism in liver in dietary hypercholesterolemic rats. Experimental groups with 5% level of cellulose(A group as control group), chinese cabbage root(B group), tora stalk(C group) and sweet potato stalk(D group) were adminstered to the male rats of the Sprague-Dawley for 4 weeks. The results obtaind are as follows. Concentrations of total cholesterol, triglyceride and phospholipid in liver were significantly lower in the all experimental groups than in the control group, particularly, the lowest in the B group. Concentrations of free cholesterol and cholesteryl ester in liver were lower in the B group than in the other groups. In the fatty acid composition of total lipid, phospholipid, triglyceride and cholesteryl ester in liver, oleic acid in the MUFA was major fatty acid. From the above result, the feeding of chinese root was effective on the improvment of the lipid composition in liver.