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백서의 말초신경 통증 모델에서 신경결찰 전 말초에 주입된 Bupivacaine 이 기계적 통각과민의 발현에 미치는 영향
정용보(Yong Bo Chung),임중우(Joong Woo Leem),정은정(Eun Jung Chung),이정찬(Jung Chan Lee),최윤(Yoon Choi) 대한통증학회 2001 The Korean Journal of Pain Vol.14 No.1
N/A Background: Although several mechanisms of causalgia, which results from a partial injury to the peripheral nerve trunk, have been proposed, whether or not antidromic impulses from the injured neurons contribute to the development of the mechanical hyperalgesia has not been studied. The purpose of this experiment is was to investigate the role of antidromic impulses to the peripheral sensory receptor site on the development of mechanical hyperalgesia in a rat model of peripheral neuropathy. Methods: Rats were prepared with tight ligation of by tightly ligating the left fifth and sixth lumbar spinal nerves. The effect of bupivacaine pretreatment on the development of mechanical hyperalgesia was evaluated by injecting 0.5% bupivacaine (0.3 ml) into the plantar surface of the left hind paw before the skin incision was made. For the control group, normal saline (0.3 ml) was injected instead of bupivacaine. To measure the mechanical hyperalgesia, paw withdrawal thresholds were measured using a series of von Frey hairs. Mechanical hyperalgesia was measured a the day before, and 1, 2, 3, 4, 7, and 14 days after the surgery. Results: The control group showed decreased withdrawal thresholds from the day after the surgery (the values were 14.0 ± 0.5, 8.9 ± 1.3, 8.4 ± 1.6, 6.9 ± 1.2, 8.8 ± 1.5, 10.5 ± 1.3, and 8.6 ± 1.3 g; at -1, 1, 2, 3, 4, 7, and 14 days after the surgery, respectively). However, withdrawal thresholds of the bupivacaine-pretreated group showed increased withdrawal thresholds for three days after the surgery (14.5 ± 0.3, 12.6 ± 1.4, 12.7 ± 1.1, 10.5 ± 1.3 g; at 1, 1, 2, 3 days after the surgery). Conclusions: Our result suggests that antidromic impulses to the peripheral sensory receptors are at least partly responsible for the initial development of mechanical hyperalgesia in a rat model of peripheral neuropathy.
임상연구 : 수술 후 환자에서 기계식 통증자가조절기의 안전성 및 유효성에 관한 임상연구
정용보 ( Yong Bo Jeong ),이무송 ( Moo Song Lee ),최병문 ( Byung Moon Choi ),진지현 ( Ji Hyun Chin ),노규정 ( Gyu Jeong Noh ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.2
Background: The disposable patient-controlled analgesia (PCA) devices are convenient for portability and management. An ideal PCA can be developed as an electronic device with various functions of safety and control. Recently, Accumate 1000(R). was developed as an electronic pump in Korea, and has passed the relevant laboratory criteria of safety and efficacy. We conducted a clinical study on the safety and efficacy when the device is applied to patients. Methods: Fentanyl 1,500μg, ketorolac 180 mg, and ondansetron 8 mg were used for PCA. Continuous infusion rate, bolus dose, and lockout time were set at 1 ml/h, 1 ml, and 15 min, respectively. Fifty patients were monitored for 48 h. The safety of Accumate 1000(R). was evaluated by backflow and siphonage, auto-clamp function, and lockout time intraoperatively. The efficacy was evaluated by the accuracy of bolus and total infused dose, and the satisfaction rates of patients and users. Results: Backflow and siphonage did not occur, and the auto-clamp function was excellent. There was no bolus infusion during lockout time, and the bolus dose was infused accurately after lockout time. For the accuracy of the total infused dose, the mean and median value of performance error between the infused and target doses were -0.55%, and -0.29%, respectively. Noise, button sense, and convenience of cable were rated as satisfactory by 90%, 78%, and 84%, of patients respectively. Conclusions: The safety and efficacy of Accumate 1000(R) were established by clinical trial. We can provide patients with the more precise and optimal analgesia. The history of drug infusion can be used as research data. (Korean J Anesthesiol 2007; 52: 161~5)
불소가스를 이용한 Polypropylene의 표면의 친수성 개질
이병기,이영석,정용보,최정봉,노재성 한국공업화학회 2001 한국공업화학회 연구논문 초록집 Vol.2001 No.-
범용수지 중에서 중핵을 이루고 있는 polypropylene은 기계적 강도, 내열성, 내약품성, 내수성, 전기 절연성 등 각종 물성 및 성형가공성이 우수하여 일상생활에 널리 사용되고 있다. 또한 저비중으로 인한 경량화와 재활용의 용이성 등으로 인해 다른 고분자 소재에 비해 수요가 급격히 증가하는 추세이다. 또한 시멘트 모프타르 및 콘크리트가 시멘트 모르타르 및 콘크리트가 건조나 냉각에 의해 수축될 때 구속에 의해 발생하는 인장응력 및 균열을 제어하고 인성의 증가와 충격, 마모, 피로에 대한 저항성을 증대시켜 재료의 내구성을 향상시키기 위하여 polypropylene 섬유가 사용되고 있다. 그러나 폴리프로필렌은 결정성이 높고 수소성의 탄화수소 구조를 가지고 있으므로 접착력이 약한 단점을 지니고 있다. 이러한 polypropylene의 표면을 친수성으로 개질하기 위하여 plasma modification, surface-graft polymerization, chemical reaction 및 flame treatment 등이 연구되고 있다. 최근 불소가스와 산소가스의 혼합가스를 이용한 oxyfluorination에 대한 연구가 많이 진행되고 있다. 따라서 본 연구에서는 불소-산소의 혼합가스를 이용하여 polypropylene을 친수성으로 개질하는데 있어 도입된 특성기의 관찰을 통한 기초연구를 진행하였고, oxyfluorination에 의해 친수성으로 개집된 polypropylene을 시멘트 모르타프의 보강섬유로 활용한 응용연구를 진행하였다.