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      • 입제의 수면처리에 의한 주요수도해충의 동시방제

        최승윤,배상희,송유한,Choi Seung Yoon,Bae Sang Hee,Song Yoo Han 한국응용곤충학회 1970 한국식물보호학회지 Vol.9 No.1

        본 시험은 유기인계 살충제인 Terracur P입제 및 Lebaycid 입제와 유기염소계 살충제인 상감마입제$(\gamma-BHC 입제)$를 수면시용 하였을때 수도요해충인 이화명충, 끝 동매미충, 애멸구 및 흰둥멸구에 대한 동시방제가능성과 방제적기를 구명하고 약제간의 방제효과를 비교코저 실시하였다. 얻어진 시험결과는 다음과 같다. 1) 약제처리후 부화직후 이화명충 접종 시험에 있어서 상감마와 Terracur P는 높은 살충율을 보였으나 Lebaycid의 살충율은 낮았다. 約 $50\%$ 살충력 잔효일수에 있어서 상감마는 8-14日이었고 Terracur P는 6일간이었다. 2) 당초 계획된 방제적기에 관한 정보는 얻을 수 없었다. 즉 주어진 일간격이 좁아 유의한 차를 얻을 수 없었다. 3) 1,2화기 이화명충에 대한 방제효과는 Terracur P=상감마>Lebaycid의 순이었다. 4) Terracur P와 Lebaycid 입제의 처리는 끝동매미충의 방제효과가 좋았으나 상감마$(\gamma-BHC 입제)$의 방제효과는 기대할 수 없었다. 끝동매미충에 대한 Terracur P와 Lebaycid입제의 잔효력은 30일 이상이었다. 5) 애멸구와 흰등별구에 대한 시험은 충의 서식밀도가 낮기 때문에 약제간 방제효과를 얻을 수 없었다. 6) 공시약제중 Terracur P와 Lebaycidd입제는 이화명충과 끌동매미충의 동시방제제로서 사용할 수 있을 것 같다. This experiment was conducted to find out the simultaneous control effect of granulated insecticides on the several major rice insect pests in Korea. The granulated insecticides used were Terracur P$5\%$ (one of the phosphoric insecticides), Lebaycid $5\%$, and Sang-gamma (gamma-BHC) $6\%$. Those insecticides were broadcasted by hand on the paddy field at the ratio of 3kg. in June and 4kg. in August per 10 a, and the date of insecticidal application was based on the maximum moth occurrence of the rice stem borer in 1969. The rice insect pests tested in this study were rice stem borer (Chilo suppressalis W.), green rice leafhopper (Nephotettix bipunctatus cincticeps U.), smiller brown planthopper (Laodelphax striatellus F.), and white back planthopper (Sogotella furcifera H.). For the study of residual effectiveness of the insecticides, the rice stem borer larvae just hatched from the eggs were installed on the sheath of rice plants collected from the paddy field after insecticidal treatment, and the mortality was made at 48 hours after installation. High mortality was observed in Terracur P and Sang-gamma treatments and low mortality in Lebaycid treatment. The duration of residual effects giving about 50% mortality was about 14 days in Sang-gamma and about 6 days in Terracur P treatments. The study on the effectiveness of the insecticides to the rice stem borer in the paddy field was made by the number of dead blades and white heads of the rice plants injured by the larvae, and the number of survival larvae in the straws after crop harvest. The order of insecticidal effectiveness to the rice stem borer was Terracur P=Sang-gamm>Lebaycid. The study on the effectiveness of the insecticides to the leafhoppers and planthoppers in the paddy field was made by the population density by sweeping (5 times) at the given day intervals after treatments. Terracur P was highly effective for the control of the green rice leafhoppers and Lebaycid was moderately effective, but Sang-gamma seemed not to be effective. The effectiveness of the insecticides tested to the planthoppers was not clear, and it seemed to related with the low insect population density. Study on the determination of proper timing of insecticidal application was not also made clear, and it seemed to be short in the range of day intervals in the insecticidal application. For the study on the control effects of the rice insect pests, rice yield per 100 hills per plot was observed. There was no statistically significant difference among the treatments in rice yields, but the order of yield (Terracur P>Sang-gamma>Lebaycid>Control) was paralleled with the tends of control effects above mentioned. In a view point of simultaneous control of the rice stem borers and green rice leafhoppers by the application of granulated insecticides, Terracur P and Lebaycid were more effective than Sang-gamma which have been used.

      • 백서의 적출된 기도평활근에서 Ketamine의 이완효과

        윤석화,김윤희,김상수,이상묵 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

        The effects of anesthetics on airway smooth muscle tone are important in the management of patients with asthma. Airway epithelial cells and vascular endothelial cells modulate the tone of the underlying smooth muscle by releasing relaxing factors such as prostanoids and nitric oxide (NO). Ketamine, at concentrations achieved with the usual clinical doses, has a direct relaxant effect on airway smooth muscle. In the present study we evaluated whether the relaxant effect of ketamine depend on any of the epithelium-derived relaxing factors. Isolated rat tracheal preparations mounted in water-jacketed organ baths filled with modified Tris Tyrode buffer solution with 100% oxygen at 37˚C for recording isometric contractile force. In the first experimental step, Tracheae, in the absence and in the presence of epithelium, were contracted with acetylcholine(10^-8M-10^-3M), and we plotted concentration -response curve for the Ach. And then we examined the inhibitory effect of ketamine(10^-5 and 10^-4M) on the concentration-response curve for Ach. In the second experimental steps, we studied the effect of N-omega-nitro L-arginine methylester(L-NAME) on the relaxant activity of ketamine(10^-6-10^-3M) on trachea contracted by 10^-5M Ach. In the result, 1) Removal of the tracheal epithelium did not change the response to Ach. 2) 10^-5M ketamine not significantly changed, but 10^-4 M ketamine shifted to the right the concentration-response curves for Ach in both intact and denuded epithelium rings. 3) L-NAME did not influence the relaxant effect of ketamine on trachea contracted by 10^-5 M Ach. These results indicate that ketamine-induced tracheal smooth muscle relaxation is epithelium-independent and may be is mediated by inhibition of Ca^++ influx in nonspecific way.

      • LiNb_3O_8의 고주파 유전특성

        윤상옥,윤종훈,심상흥,강기성 국립7개대학공동논문집간행위원회 2002 공업기술연구 Vol.2 No.-

        Recently many Microwave devices have been newly developed as the demands for mobile communication and satellite broadcasting have been increased. Microwave dielectrics can be use in dielectric resonator, duplexer filter, VCO, GPS antenna and so on. The dielectric properties required for such application are high dielectric constant(ε_r), high Q value and low temperature coefficient of resonant frequency(τ_f). These requirement correspond to necessities for size reduction, excellent frequency selectivity, good temperature stability of devices. This study was focussed on the improvement and understanding for low-temperature sinterbility and microwave dielectric properties in LiNb_3O_8 compositions. The main topics of this study was the relationship between sinter behavior and microwave dielectric properties on LiNb_3O_8 system. As a result, the dielectric constant and Q×f_0 increased linearly with increase in the sinter density. The dielectric constant is about 34 and the Q×f_0 at a microwave frequencies is over 58000.

      • KCI우수등재
      • Classification of Product Knowledge : A Conceptual Discussion

        Yoon, Sung-Wook,Lisa L. Scribner 東亞大學校 經營大學 2004 經營硏究 Vol.- No.17

        Subjective product knowledge is now a new construct, but in fact has been defined and measured in a plethora of ways. Existing subjective knowledge measures range from a single item (Peracchio and Tybout 1996) to multi-item scales (Flynn and Goldsmith 1999). Regardless of whether the instruments use single or multiple indicators, they simply measure consumers' overall subjective knowledge and treat the construct as unidimensional. As previously discussed, consumer product knowledge is a multidimensional construct (Alba and Hutchinson 1987; Biswas and Sherrell 1993). This multidimensionality should not be confined to measuring objective knowledge. In other words, it equally applies to subjective knowledge. Throughout this paper it was pointed out discrepancies in findings (e.g., relationship between knowledge and search) that are mainly due to the dearth of valid, multidimensional instruments. Unfortunately, such a scale does not exist. Therefore, future research should develop a scale that captures multidimensional aspects of consumer knowledge. Theory-driven, multidimensional subjective knowledge scales should prove useful to marketing practitioners as well. An essential in consumer-oriented markets is understanding the consumer. Part of understanding consumers is understanding how much they know. For instance, a marketer of a new, highly technological product can administer a multidimensional subjective project knowledge scale to learn about the perceived knowledge distribution of his target market. If it is discovered that the target market is largely comprised of novices, the marketer may want to educate the potential consumers in terms of the terminology associated with the product, the product's attributes, the purchasing procedures, and the different uses for the product. Promotional campaigns can be orientated accordingly. If educating the consumer is not of concern, then the marketer may want to place more emphasis on peripheral cues in advertising. A marketer may find him/herself in the situation where most of the target market for his/her product is high on the knowledge continuum. This marketer, for example, will experience more liberties in terms of terminology of message arguments.

      • The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection

        Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

        Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.

      • KCI등재

        Apoptosis and necroptosis‑inducing effects of arctigenin on nasal septum carcinoma RPMI‑2650 cells in 2D and 3D culture

        Yoon‑Jin Lee,Kwan‑Sik Park,Byoung Joon Baek,Kyong‑Ae Lee,Sang‑Han Lee 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

        Backgrounds Arctigenin derived from the seeds of Arctium lappa Linnaeus is known as an anticancer drug candidate by targeting various pathways involved in anticancer therapy. Methods Using 2D monolayer and 3D spheroid culture systems in nasal septum carcinoma RPMI-2650 cells, the effects of arctigenin and dexamethasone on cell viability, ROS levels, ATP level, mitochondrial function, apoptosis and necroptosis were examined. Results The combination treatment of both compounds induced strong cytotoxicity, accompanied by increases of sub-G0/ G1 peak, annexin V-PE-positive cells, and ROS levels, loss of mitochondrial membrane potential, and decrease of cellular ATP content. These changes were observed as simultaneous induction of DNA damage, apoptosis, and necroptosis. A series of changes by arctigenin and dexamethasone were efficiently restored by decreasing ROS levels or supplementing ATP. Treatment of 3D spheroids with arctigenin and dexamethasone decreased cell viability in the spheroids, but it was slightly resistant than cells under 2D conditions. In addition, this phenomenon was accompanied by an increase in mediators for both apoptosis and necroptosis. Conclusion Results of this study suggest that the apoptosis and necroptosis-inducing effects of arctigenin are associated with ATP depletion due to oxidative mitochondrial dysfunction.

      • Piezoelectric Materials: All‐Solution‐Processed Flexible Thin Film Piezoelectric Nanogenerator (Adv. Mater. 45/2012)

        Chung, Sung Yun,Kim, Sunyoung,Lee, Ju‐,Hyuck,Kim, Kyongjun,Kim, Sang,Woo,Kang, Chong‐,Yun,Yoon, Seok‐,Jin,Kim, Youn Sang WILEY‐VCH Verlag 2012 ADVANCED MATERIALS Vol.24 No.45

        <P>An all‐solution‐processed flexible piezoelectric nanogenerator, composed of polycrystalline ZnO thin film and functional polymer layers such as P3HT/PCBM and PEDOT:PSS, generates energy through a mechanical rolling and muscle stretching system. On page 6022, Youn Sang Kim, Sang‐Woo Kim, and co‐workers show that this all‐solution‐processed nanogenerator is feasible as a piezoelectric patchable device and is promising for use in future energy harvesters such as wearable human patches and mobile electronics. </P>

      • KCI등재

        코로나19 대응 거버넌스의 성공 요인에 관한 탐색적 연구: 성과중심적 거버넌스 모형을 활용하여

        윤기웅(Yoon, Ki-Woong),공동성(Kong, Dong-Sung) 한국정부학회 2020 한국행정논집 Vol.32 No.3

        본 연구는 코로나19 방역 모범국이라는 평가를 받는 한국의 코로나19 대응 전략 및 성공 요인을 살펴보는 데 그 목적이 있다. 코로나19 감염병은 사회재난 중 하나로 정부가 중심이 되는 공공거버넌스의 영역이라고 볼 수 있다. 따라서 본 연구는 공공거버넌스 유형 중 하나인 성과중심적 거버넌스 모형을 활용하여 코로나19 방역의 성과(확진자와 사망자의 통제 가능 여부)에 영향을 미치는 요인들을 탐색적으로 분석한다. 분석결과 거버넌스 맥락, 정권, 행정적 준비단계, 성과향상 실행메커니즘에 포함되는 다양한 요인들이 한국의 코로나19 방역의 성과에 이바지한 것으로 나타났다. 구체적으로 살펴보면, 첫째, 거버넌스 맥락 차원에서 2015년 메르스 대응실패 이후 이루어진 법령 개정, 중앙집권체계, 정보통신기술발달 등 방역 활동에 우호적인 외부환경 요소들이 방역의 성과향상에 기여하였다. 둘째, 정권 차원에서 방역당국에 대한 대통령의 적극적 지원과 범정부적 조직/인사/예산지원은 방역당국이 효과적으로 방역에 집중할 수 있도록 하는 밑거름이 되었다. 셋째, 행정적 준비단계 차원에서 구체적으로 마련된 표준운영절차(SOP)와 담당자에 대한 교육/훈련을 통한 역량 강화는 방역 일선 담당자들의 일사불란한 대처를 가능하게 했다. 넷째, 성과향상 실행메커니즘 차원에서 방역당국은 주어진 상황 및 여건에 맞춘 적절한 대비를 하였을 뿐만 아니라 신속한 진단검사 및 역학조사를 통해 확진자를 조기 발견하여 적시에 감염병 확산을 차단할 수 있었다. 결론적으로 피해복구 단계를 제외한 예방, 대비, 대응 단계에서 적절한 조치가 이루어졌고, 이로 인해 비록 미흡한 점이 일부 있기는 하나 한국의 코로나19 방역이 어느 정도 성공적으로 작동하였다고 볼 수 있다. South Korea is being evaluated by global media and experts for its successful response to coronavirus disease 2019 (COVID-19). The purpose of this study is to examine the Korean government’s response strategy and success factors for COVID-19 using the performancebased/managerial governance model which was presented by Kong & Yoon(2018b). It found that various factors, such as governance context, governance regime, pre-governance and execution mechanisms, all together contributed to South Korea’s success in responding to COVID-19. These findings can be considered to be of theoretical significance in that they expanded the applicability of the public governance model proposed by Kong & Yoon. In addition, the case of South Korea, which has harmoniously achieved the two conflicting goals of controlling infectious disease and minimizing economic damage, provides many practical implications for how other countries should cope in the future.

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