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제약단지 인접 지역 지표수의 잔류 의약물질 생태위해성평가
박수현(Suhyun Park),강하병(Habyeong Kang),신혜수(Hyesoo Shin),유일한(Ilhan Ryoo),최경호(Kyungho Choi),고영림(Younglim Kho),박경화(Kyunghwa Park),김경태(Kyungtae Kim),지경희(Kyunghee Ji) 한국환경보건학회 2020 한국환경보건학회지 Vol.46 No.1
Objectives: Limited information is available on the presence and associated ecological risks of pharmaceutical residues in aquatic environments near pharmaceutical manufacturing areas in Korea. In this study, we investigated the current state of pharmaceutical contamination and its associated ecological risks in streams near a pharmaceutical manufacturing complex. Methods: Seven pharmaceuticals (acetaminophen, clarithromycin, diclofenac, diphenhydramine, ibuprofen, mefenamic acid and roxithromycin) were measured in water samples collected from the streams near a harmaceutical manufacturing complex. A predicted no-effect concentration (PNEC) was derived using either the assessment factor method or species sensitivity distribution method. In addition, a hazard quotient for each pharmaceutical was calculated by dividing its measured environmental concentration by its PNEC. Results: Samples collected downstream from the wastewater treatment plant (WWTP) had higher concentrations of pharmaceuticals than those collected from the reference site (upstream). Moreover, pharmaceutical concentrations were greater in ambient water than in the final effluent from the WWTP, which suggested that non-point sources were contributing to the contamination of the ambient water environment. Some of the target pharmaceuticals exhibited a hazard quotient >1, indicating that their potential ecological effects on the aquatic environment near the pharmaceutical industrial area should not be ignored. Conclusion: This study demonstrated that the pharmaceutical manufacturing area was contaminated with residual drugs, and that there was a possible non-point source near the WWTP effluent discharge area. The results of this study will aid in the development of management plans for pharmaceuticals, particularly in hotspots such as pharmaceutical industrial sites and their vicinities.
Design of HTS Toroidal Magnets for a 5 MJ SMES
Seyeon Lee,Kyung-Pyo Yi,Sang Ho Park,Ji-Kwang Lee,Woo-Seok Kim,Chan Park,Joon-Han Bae,Ki-Chul Seong,Ilhan Park,Kyeongdal Choi,Songyop Hahn IEEE 2012 IEEE transactions on applied superconductivity Vol.22 No.3
<P>A 2.5 MJ Superconducting Magnetic Energy Storage System (SMES) is being developed as a national R&D project in Korea. It is in 2nd phase of total 3 phases program. In phase 1, we developed a 600 kJ SMES which had the maximum storage over 1 MJ. Its magnet was an HTS solenoid, whereas the HTS magnet for phase 2 is a toroid which is composed of 28 HTS double pancake coils. The final target of phase 3 is to develop a 5 MJ SMES, which will start from next year. The operating temperature of the HTS magnet will be below 20 K by conduction cooling. In this paper, we present and compare conceptual designs of the magnet in the shape of toroid and the configuration of serial connection of two 2.5 MJ toroids. The most important design criterion is to minimize the total length of HTS conductors.</P>
Lim, Ilhan,Park, Joon Yeun,Kang, Hye Jin,Hwang, Jae Pil,Lee, Seung Sook,Kim, Kyeong Min,Choi, Tae Hyun,Yang, Sung Hyun,Kim, Byung Il,Choi, Chang Woon,Lim, Sang Moo S. Karger AG 2013 Acta haematologica Vol.130 No.2
<P>Abstract</P><P><B><I>Aims:</I></B> It was the aim of this paper to identify prognostic factors in patients with relapsed or refractory B-cell non-Hodgkin's lymphomas, treated by radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab (<SUP>131</SUP>I-rituximab). <B><I>Methods:</I></B> Twenty-four patients were enrolled prospectively and were treated with unlabeled rituximab 70 mg and a therapeutic activity (median 7.3 GBq) of <SUP>131</SUP>I-rituximab. Contrast-enhanced <SUP>18</SUP>F-FDG PET/CT scans were performed before and after 1 month of RIT. Tumor sizes and maximum standardized uptake values (SUV<SUB>max</SUB>) of scans were measured. <B><I>Results:</I></B> Four of the 24 patients survived. High SUV<SUB>max</SUB> in a pretreatment scan was found to be related to poorer overall survival (OS) and progression-free survival (p = 0.04 and 0.02, respectively). Furthermore, a large tumor size in a pretreatment scan was associated with poorer OS but not with progression-free survival (p < 0.01 and p = 0.07, respectively). By multivariate analyses, a high SUV<SUB>max</SUB>, a large tumor size in a pretreatment scan and diffuse large B-cell lymphoma histology were significantly associated with poorer OS [p = 0.04/hazard ratio (HR) = 3.54, p < 0.01/HR = 5.52, and p = 0.02/HR = 3.38, respectively). <B><I>Conclusion: </I></B>SUV<SUB>max</SUB> and tumor size determined by a pretreatment <SUP>18</SUP>F-FDG PET/CT result as significant predictors of OS in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma treated by RIT.</P><P>Copyright © 2013 S. Karger AG, Basel</P>
Position-selective metal oxide nano-structures using graphene catalyst for gas sensors
Lee, Aram,Park, Jinheon,Choi, Kyoung Soon,Lee, Jouhahn,Yoo, Ilhan,Cho, In Sun,Ahn, Byungmin,Seo, Hyungtak,Choi, Jae-Young,Yu, Hak Ki Elsevier 2017 Carbon Vol.125 No.-
<P>The thermal transport growth of various metal oxide (MOx) nanostructures using graphene as a catalytic layer was studied. Graphene was synthesized by Cu-catalyzed chemical vapor deposition and transferred onto a SiO2-covered Si substrate using bubble transfer methods. Due to the catalytic activity of the atomic-thick carbon layer, control of the position of the MOx nanostructures as well as the growth parameters, such as nucleation density and growth rate, could be achieved. The position-selective and density-controlled MOx nanostructures were evaluated for hydrogen gas sensor applications, where different responses were obtained with hydrogen molecules. (C) 2017 Elsevier Ltd. All rights reserved.</P>