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( Dae Suk Kim ),( Dongyun Shin ),( Minseok Lee ),( Hyunjoong Jee ),( Tae Gyun Kim ),( Sung Hee Kim ),( Do Young Kim ),( Soo Min Kim ),( Min Geol Lee1 ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Circulating inflammatory cytokines and markers are increased in patients with psoriasis. Recent studies have shown that a higher red blood cell distribution width (RDW) is associated with disease activity in various disorders. Objectives: Our objective was to investigate whether RDW is increased in psoriasis patients, and to evaluate its association with disease severity. Methods: We conducted a retrospective study of psoriasis patients seen in single hospital in Korea. Demographic data, hematologic parameters and disease severity were collected. Results: A total of 261 psoriasis patients and 102 healthy controls were included in our study. The RDW value was significantly increased in psoriasis patients compared to healthy control (p=0.037). Compared to mild psoriasispatients (PASI<7), moderate to severe patients (PASI≥7) showed significantly higher RDW values (p=0.044). RDW did not show significant correlation with PASI (p=0.358). When patients were divided into two groups according to their RDW value (<14.6% and ≥14.6%), the mean value of PASI was not significantly different (p=0.219). Conclusion: Patients with psoriasis showed increased RDW values compared to healthy controls. It was also higher in moderate and severe disease group than mild group. RDW values were increased in psoriasis patients and it is possible that RDW value reflects the inflammatory status of psoriasis, but this needs to be evaluated in near future.
Lee, Byung Yang,Seo, Sung Min,Lee, Dong Joon,Lee, Minbaek,Lee, Joohyung,Cheon, Jun-Ho,Cho, Eunju,Lee, Hyunjoong,Chung, In-Young,Park, Young June,Kim, Suhwan,Hong, Seunghun Royal Society of Chemistry 2010 Lab on a chip Vol.10 No.7
<P>We developed a carbon nanotube (CNT)-based biosensor <I>system</I>-<I>on</I>-<I>a</I>-<I>chip</I> (SoC) for the detection of a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing circuits in a single chip, which was made possible by combining several technological breakthroughs such as <I>efficient signal processing</I>, <I>uniform CNT networks</I>, and <I>biocompatible functionalization of CNT</I>-<I>based sensors</I>. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia, a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors, modulated the conductance signals to the CNT-based sensors. This is a major technological advancement in the integration of CNT-based sensors with microelectronics, and this chip can be readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC systems for neural networks.</P> <P>Graphic Abstract</P><P>Uniform arrays of carbon nanotube (CNT)-based biosensors were integrated with CMOS signal-processing circuits into a CNT-biosensor system-on-a-chip (SoC) for the detection of glutamate, a neurotransmitter. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b916975j'> </P>
Hyunjoong Kim(Hyunjoong Kim),Dongjin Lee(Dongjin Lee) 물리치료재활과학회 2023 Physical therapy rehabilitation science Vol.12 No.4
Objective: Clinical practice guidelines for chronic low back pain (LBP) strongly recommend thrust manipulation; however, its effectiveness for acute and subacute nonspecific LBP is controversial. Therefore, the aim of this systematic review and meta-analysis was to synthesize the immediate or short-term effects of thrust manipulation on pain in patients with acute and subacute LBP. Design: Asystematic review and meta-analysis. Methods: A literature search was performed in international databases (CINAHL, Embase, MEDLINE, PubMed) in June 2023. Search terms were set according to PICOSD (participants, intervention, comparison, outcomes, study design). Risk of bias (RoB) assessment was performed using the RoB tool and quantitative analysis was performed using RevMan 5.4. The effect measure was standard mean difference (SMD) and the analysis model was random effect model. Results: The database was searched for 249 studies and six randomized controlled trials (RCTs) were finally synthesized after independent review by researchers. Only pain intensity was found to have a significant effect on pain intensity and disability (p<0.05). The pooled results showed a small effect size for pain intensity in acute to subacute LBP with thrust manipulation in sixRCTs(SMD= -0.44; 95% CI, -0.80 to -0.08) and a large effect size for disability in three RCTs (SMD= -0.96; 95% CI, -2.67 to 0.76). Conclusions: In conclusion, this review provides evidence supporting the effectiveness of thrust manipulation in reducing pain intensity and disability in patients with acute and subacute LBP. It highlights the potential benefits of incorporating thrust manipulation as a treatment option for LBP.
Hyunjoong Kim,Seonghyeok Song,Sangbong Lee,Seungwon Lee 물리치료재활과학회 2021 Physical therapy rehabilitation science Vol.10 No.1
Objective: Joint mobilization for arthrokinematics altered by the positional fault of chronic ankle instability (CAI) is an effective intervention for stabilization. In this study, we compared the effects of ankle dorsi flexion range of motion (DFROM) and dynamic balance ability (DBA) in CAI patients via passive joint mobilization (PJM), a method traditionally performed in previous studies, and active joint mobilization (AJM), a method that can have a greater effect on cortical excitability with spontaneous movements. Design: Single-blind two-arm randomized controlled trial Methods: A total of 30 participants were registered: 15 each to the PJM and AJM groups. Each participant received a total of 10 intervention sessions, 10 minutes per session, 5 times a week for 2 weeks. PJM used Maitland s mobilization method to apply joint mobilization with talus in the posterior direction and AJM used an angular joint motion to induce patient s voluntary motion of medial malleolus anterior gliding and lateral malleolus posterior gliding, respectively. DFROM of the ankle was measured by using tape and DBA was evaluated by using the balance system. Results: Significant improvement was observed after intervention in both the PJM and AJM groups except for the DBA-anterior and DBA-right variables of the PJM group. There were statistically significant differences between the AJM and PJM groups in the DFROM, DBA-anterior, DBA-posterior, and DBA-right variables. Conclusions: The overall improvement of DFROM and DBA was found to be more effective in joint mobilization including voluntary movement. When it is accompanied by voluntary movement, it further affects the neuromuscular system of the ankle.
An opportunistic scheduling algorithm using aged CSI in massive MIMO systems
Lee, Hyunjoong,Park, Sangkyu,Bahk, Saewoong Elsevier 2017 COMPUTER NETWORKS - Vol.129 No.1
<P><B>Abstract</B></P> <P>In time-division duplex (TDD) massive multiple-input multiple-output (MIMO) systems, the spatial multiplexing gain cannot be fully achieved since available pilot resources at each channel coherence time interval are limited. In this paper, we propose an Opportunistic user Scheduling algorithm, termed <I>OpSAC</I>, that uses Aged Channel state information (CSI) to increase spatial multiplexing gain without incurring additional pilot overhead. Assuming the base station (BS) employs two popular precoders of maximum ratio transmission (MRT) and zero-forcing (ZF), we first derive their closed-form lower bounds on the achievable sum-rate under channel aging. According to the analysis results, we develop a heuristic solution that estimates the amount of channel variation for each user by using correlation of CSI samples, and exploits channel conditions to opportunistically schedule more users by using aged CSI, thereby enhancing spectral efficiency. Through numerical analysis and simulation we confirm that the proposed lower bounds are very tight, and show the impact of channel aging on the performance of massive MIMO systems. In addition, it is shown that <I>OpSAC</I> achieves near-optimal performance and considerably outperforms the conventional user scheduling algorithm that uses current CSI only.</P>
A Sub-1.0-V On-Chip CMOS Thermometer With a Folded Temperature Sensor for Low-Power Mobile DRAM
Hyunjoong Lee,Daeyong Shim,Cyuyeol Rhee,Mino Kim,Suhwan Kim IEEE 2016 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS PART 2 E Vol.63 No.6
<P>As Dynamic Random Access Memory (DRAM) supply voltages drop below 1 V with the scaling down of the process, it becomes increasingly difficult to construct a temperature sensor with sufficient accuracy to control self-refresh, without occupying significant area or consuming increased power. In this brief, we propose an on-chip CMOS thermometer with a temperature sensor, the output of which is divided into segments by a folding scheme. The slopes of these segments can be arranged to be the same or adjusted separately, as desired for the output. Implemented in a 29-nm DRAM process, the sensor operates from -40 degrees C to 95 degrees C at the supply voltage of 0.8 V, with a temperature sensitivity of -3.1 mV/degrees C between -40 degrees C and 35 degrees C, and -2.1 mV/degrees C between 35 degrees C and 95 degrees C. It has an area of 0.0016 mm(2) and consumes less than 0.144 mu W.</P>
Charge Amplifier With an Enhanced Frequency Response for SPM-Based Data Storage
Hyunjoong Lee,Jong-Kwan Woo,Hyo-Jin Nam,Won-Hyeog Jin,Moongi Jeong,Young-Sik Kim,Jin-Koog Shin,Suhwan Kim IEEE 2010 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS PART 2 E Vol.57 No.9
<P>Storage systems based on scanning probe microscopy incorporate an array of thermopiezoelectric cantilevers that require charge amplifiers with a wide frequency response but low power consumption. We use an improved frequency compensation method to enhance the in-band frequency response without requiring any additional power. Measurements show that the prototype chip draws the same 68 A at 1.8 V as an unmodified design but has a closed-loop frequency response that is ten times greater. The chip was fabricated in a 0.18-m standard CMOS process, and the charge amplifier core occupies 0.042 mm<SUP>2</SUP>.</P>