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Involvement of Immune Responses in the Efficacy of Cord Blood Cell Therapy for Cerebral Palsy
Kang, Mino,Min, Kyunghoon,Jang, Joonyoung,Kim, Seung Chan,Kang, Myung Seo,Jang, Su Jin,Lee, Ji Young,Kim, Sang Heum,Kim, Moon Kyu,An, SeongSoo A.,Kim, MinYoung Mary Ann Liebert 2015 STEM CELLS AND DEVELOPMENT Vol.24 No.19
<P>This study evaluated the efficacy of umbilical cord blood (UCB) cell for patients with cerebral palsy (CP) in a randomized, placebo-controlled, double-blind trial and also assessed factors and mechanisms related to the efficacy. Thirty-six children (ages 6 months to 20 years old) with CP were enrolled and treated with UCB or a placebo. Muscle strength and gross motor function were evaluated at baseline and 1, 3, and 6 months after treatment. Along with function measurements, each subject underwent (18)F-fluorodeoxyglucose positron emission tomography at baseline and 2 weeks after treatment. Cytokine and receptor levels were quantitated in serial blood samples. The UCB group showed greater improvements in muscle strength than the controls at 1 (0.94 vs. -0.35, respectively) and 3 months (2.71 vs. 0.65) after treatment (Ps<0.05). The UCB group also showed greater improvements in gross motor performance than the control group at 6 months (8.54 vs. 2.60) after treatment (P<0.01). Additionally, positron emission tomography scans revealed decreased periventricular inflammation in patients administered UCB, compared with those treated with a placebo. Correlating with enhanced gross motor function, elevations in plasma pentraxin 3 and interleukin-8 levels were observed for up to 12 days after treatment in the UCB group. Meanwhile, increases in blood cells expressing Toll-like receptor 4 were noted at 1 day after treatment in the UCB group, and they were correlated with increased muscle strength at 3 months post-treatment. In this trial, treatment with UCB alone improved motor outcomes and induced systemic immune reactions and anti-inflammatory changes in the brain. Generally, motor outcomes were positively correlated with the number of UCB cells administered: a higher number of cells resulted in better outcomes. Nevertheless, future trials are needed to confirm the long-term efficacy of UCB therapy, as the follow-up duration of the present trial was short.</P>
Spatial Distribution of Dislocations in Relation to a Substructure in High-Quality GaN Film
Yang, Mino,Kim, Chong-Don,Kim, Hee-Goo,Yang, Cheol-Woong Cambridge University Press 2013 Microscopy and microanalysis Vol.19 No.5
<B>Abstract</B><P>The dislocation distribution of high-quality single-crystal gallium nitride (GaN) films grown by the hybrid vapor phase epitaxy was analyzed. This study examined the domain structure of GaN from the dislocation distribution on the macroscale by optical microscopy. The surface structure of GaN consisted of domains with microcolumns as the substructure. The inner domains contained a lower density of dislocations but a large number of these dislocations were observed along the domain boundaries. The existence of a domain boundary structure doubly increased the total dislocation density.</P>
비예혼합 난류 화염의 난류와 복사의 상호작용 및 매연 생성에 대한 수치적 연구
우민호(Mino Woo),김태훈(Taehoon Kim),김용모(Yongmo Kim),김후중(Hoo-Joong Kim) 한국연소학회 2009 KOSCOSYMPOSIUM논문집 Vol.- No.38
Numerical simulation results are presented for axisymmetric, nonluminous turbulent confined jet flame. The turbulence-chemistry interaction is represented by the laminar flamelet model together with the presumed PDF approach which easily implements the variable thermo-chemical properties and the complex soot source terms from the information of detailed chemical kinetic model. The radiative transfer equation is solved using spherical harmonic P-1 approximation. In the present study, the Turbulence-Radiation interaction(TRI) is taken into account in context with the flamelet concept. The soot formation and oxidation processes are modeled by the two variable approach which realistically accounts for soot nucleation, coagulation, surface growth and oxidation. The numerical and physical models used in this study successfully predict the essential features of the combustion processes and soot formation characteristics in the turbulent non-premixed flame field.
Woo Mino,Gu Yunjang,Kim Gyeong-Min,Kim Minkyum,Kim Hee Soo,Lim Dong-Ha 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.1
This study aims to numerically analyze the ceramic and metallic monoliths as a catalyst substrate of selective catalytic reduction (SCR) system in marine applications. The representative elementary volume of each catalyst substrate was chosen and pressure drop through the volume was numerically calculated to estimate the parameters for the porous model. The fi xedbed experiment using a powder catalyst of 3V7MO/TiO 2 was conducted in the way to estimate the global one-step reaction kinetics. Thus, the NO conversion from both ceramic and metallic monolith catalysts was calculated by a porous model with a simplifi ed reaction mechanism to numerically investigate the fl ow and thermal characteristics within the two types of catalyst substrate. As an extreme condition, an external heat loss with an ambient temperature of 300 K was set to the reactor wall. Predicted results indicate that the NO conversion performance of ceramic monolith is better in general due to the lower heat loss from the cold wall. However, it is found that there is a trade-off relationship between the residence time and the external heat loss. Heat management such as thermal insulation plays an essential role to maximize the benefi ts of using metallic monolith as a catalyst substrate for practical marine applications.
Yang, Mino,Lee, Jun-Ho,Kim, Hee-Goo,Kim, Euna,Kwon, Young-Nam,Kim, Jin-Gyu,Yang, Cheol-Woong Cambridge University Press 2013 Microscopy and microanalysis Vol.19 No.5
<B>Abstract</B><P>Distribution of wax in laser printer toner was observed using an ultra-high-voltage (UHV) and a medium-voltage transmission electron microscope (TEM). As the radius of the wax spans a hundred to greater than a thousand nanometers, its three-dimensional recognition via TEM requires large depth of focus (DOF) for a volumetric specimen. A tomogram with a series of the captured images would allow the determination of their spatial distribution. In this study, bright-field (BF) images acquired with UHV-TEM at a high tilt angle prevented the construction of the tomogram. Conversely, the Z-contrast images acquired by the medium-voltage TEM produced a successful tomogram. The spatial resolution for both is discussed, illustrating that the image degradation was primarily caused by beam divergence of the Z-contrast image and the combination of DOF and chromatic aberration of the BF image from the UHV-TEM.</P>
마이크로리엑터를 이용한 금속폼 기반 DOC에서의 촉매 화학 반응에 대한 연구
우민호(Mino Woo),김구환(Kuhwan Kim),김후중(Hoojoong Kim),이정민(Jeongmin Lee),이병하(Byungha Lee) 한국자동차공학회 2009 한국자동차공학회 학술대회 및 전시회 Vol.2009 No.11
An alternative metal foam substrate for diesel exhaust after treatment applications has been recently researched and characterized. The present paper focuses on the potential of the metal foam technology as an efficient DOC substrates on real conditions. The target platform is a mid-size passenger car and the methodology includes both modeling and experiments. The lab-scale reactor called Micro-Reactor system has been provided to analyze binary reaction and complex reaction. To analyze metal foam substrate, the alternative model which reaction rate and transfer coefficients are not based on early honeycomb monolith is required. Based on experimental result, the reaction rate and activation energy of each binary reaction are established, and the light-off results of the real gas composition are compared to experimental conversion data. The main binary reactions of DOC such as CO, HC and NO are experimented to establish the reaction kinetics. And the contribution and limitation of this binary reactions are studied in the calculation and experimentation of real gas condition. In this paper, we focus on making basic transfer and reaction rate using the model based on 1D plug flow type rather than full CFD model. And the model use CHEMKIN library to obtain gas properties of chemical species.
직접적분법을 이용한 C₂H₄/Air 비예혼합 난류연소의 매연생성 모델링
김태훈(Taehoon Kim),우민호(Mino Woo),김용모(Yongmo Kim) 한국연소학회 2010 KOSCOSYMPOSIUM논문집 Vol.- No.40
The Direct Quadrature Method of Moments (DQMOM) has been presented for the solution of population balance equation in the wide range of the multi-phase flows. This method has the inherently interesting features which can be easily applied to the multi-inner variable equation. In addition, DQMOM is capable of easily coupling the gas phase with the discrete phases while it requires the relatively low computational cost. Soot inception, subsequent aggregation, surface growth and oxidation are described through a population balance model solved with the DQMOM for soot formation. This approach is also able to represent the evolution of the soot particle size distribution. The turbulence-chemistry interaction is represented by the laminar flamelet model together with the presumed PDF approach and the spherical harmonic P-1 approximation is adopted to account for the radiative heat transfer.
김태훈(Taehoon Kim),우민호(Mino Woo),김용모(Yongmo Kim) 한국연소학회 2010 한국연소학회지 Vol.15 No.4
The Direct Quadrature Method of Moments (DQMOM) has been presented for the solution of population balance equation in the wide range of the multi-phase flows. This method has the inherently interesting features which can be easily applied to the multi-inner variable equation. In addition, DQMOM is capable of easily coupling the gas phase with the discrete phases while it requires the relatively low computational cost. Soot inception, subsequent aggregation, surface growth and oxidation are described through a population balance model solved with the DQMOM for soot formation. This approach is also able to represent the evolution of the soot particle size distribution. The turbulence-chemistry interaction is represented by the laminar flamelet model together with the presumed PDF approach and the spherical harmonic P-1 approximation is adopted to account for the radiative heat transfer.