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( Hyunil Kim ),( Jin Woo Kim ),( Hong Jun Park ),( Su Young Kim ),( Hyun-soo Kim ),( Gwang Ho Baik ),( Sung Chul Park ),( Sang Jin Lee ),( Tae-hwa Go ) 대한소화기학회 2022 Gut and Liver Vol.16 No.1
Background/Aims: Endoscopic submucosal dissection (ESD) is a curative treatment modality for early gastric neoplasms; however, ESD can be a time-consuming process. To overcome this pitfall, we developed the one-step knife (OSK) approach, which combines an endoscopic knife and injection needle on a single sheath. We aimed to evaluate whether this approach could reduce the ESD procedure time. Methods: This single-blinded randomized multicenter trial at four tertiary hospitals from June 2019 to June 2020 included patients aged 19 to 85 years undergoing ESD. Patients were randomly assigned to two groups (OSK or conventional knife [CK]). The injection time, total procedure time, resected specimen size, submucosal fluid amount, degree of device satisfaction, and adverse events were evaluated and compared between groups. Results: Fifty-one patients were analyzed (OSK: 25 patients and CK: 26 patients). No baseline differences were observed between groups, with the exception of a higher portion of males in the OSK group. The mean injection time was significantly reduced in the OSK group (39.0 seconds) compared to that in the CK group (87.5 seconds, p<0.001). A decrease of more than 10 minutes in the total procedure time (18.0 minutes vs 28.1 minutes, p=0.055) in the OSK group compared to the CK group was observed. Second-look esophagogastroduodenoscopy revealed two delayed bleeding cases in the OSK group that were easily controlled by endoscopic hemostasis. Conclusions: OSK reduced the injection time and showed a decrease in total procedure time compared with the CK approach. OSK can be a feasible tool for ESD, especially in difficult cases. (Gut Liver 2022;16:44-52)
Kim, Minha,Jang, Yong-Jun,Jung, Ho-Sung,Song, Woochang,Kang, Hyunil,Kim, Eung Kwon,Kim, Donguk,Yi, Junsin,Lee, Jaehyeong American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.5
<P>Aluminum-doped zinc oxide (AZO) thin films were deposited on glass and polyimide substrates using radio frequency magnetron sputtering. We investigated the effects of the oxygen gas ratio on the properties of the AZO films for Cu(In, Ga)Se-2 thin-film solar cell applications. The structural and optical properties of the AZO thin films were measured using X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), and UV-Visible-NIR spectrophotometry. The oxygen gas ratio played a crucial role in controlling the optical as well as electrical properties of the films. When oxygen gas was added into the film, the surface AZO thin films became smoother and the grains were enlarged while the preferred orientation changed from (0 0 2) to (1 0 0) plane direction of the hexagonal phase. An improvement in the transmittance of the AZO thin films was achieved with the addition of 2.5-% oxygen gas. The electrical resistivity was highly increased even for a small amount of the oxygen gas addition.</P>
Kim, Bongjun,Lee, Jong-Ho,Jin, Won Jong,Kim, Hong-Hee,Ha, Hyunil,Lee, Zang Hee Elsevier 2018 european journal of pharmacology Vol.823 No.-
<P>Rheumatoid arthritis (RA) is a chronic autoimmune disease that is characterized by uncontrolled joint inflammation and destruction of bone and cartilage. Previous studies have shown that C-X-C motif chemokine 10 (CXCL10) has important roles in RA development and that blocking CXCL10 expression effectively inhibits arthritis progression in animal models. However, clinical study using anti-CXCL10 monoclonal antibody (MDX-1100) to block CXCL10 expression in patients with RA did not show significant effectiveness. Therefore, we turned our attention to C-X-C motif chemokine receptor 3 (CXCR3), which is a receptor for CXCL9, CXCL10, and CXCL11, to treat RA. In the present study, administration of JN-2, our newly developed CXCR3 antagonist, ameliorated the progression of arthritis in a collagen-induced arthritis animal model. JN-2 also inhibited CXCR3-induced cell migration and pro-inflammatory cytokine expression of bone marrow-derived macrophages and CD4(+) T cells in vitro. In addition, we found that CXCL10 formed an auto-amplification loop through activation of NF kappa B. Furthermore, Phosphorylation of p65 at serine 536 played an important role in the auto-amplification of CXCL10. Overall, the present results demonstrated that JN-2 decreased inflammation by inhibiting CXCR3-enhanced cell migration and pro-inflammatory cytokine expression, which then ameliorated arthritis progression.</P>
Synthesis of Carbon Nanowalls by Microwave PECVD for Battery Electrode
Kim, Sung Yun,Shin, Seung Kwon,Kim, Hyungchul,Jung, Yeun-Ho,Kang, Hyunil,Choi, Won Seok,Kweon, Gi Back The Korean Institute of Electrical and Electronic 2015 Transactions on Electrical and Electronic Material Vol.16 No.4
The microwave plasma enhanced chemical vapor deposition (PECVD) system was used to grow a carbon nanowall (CNW) on a silicon (Si) substrate with hydrogen (H<sub>2</sub>) and methane (CH<sub>4</sub>) gases. To find the growth mechanism of CNW, we increased the growth time of CNW from 5 to 30 min. The vertical and surficial conditions of the grown CNWs according to growth time were characterized by field emission scanning electron microscopy (FE-SEM). Energy dispersive spectroscopy (EDS) measurements showed that the CNWs consisted solely of carbon.
Kim Kangmin,Kim Chulsoo,Kwon Seokhun,Choi Wonseok,Kang Hyunil 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1
Background Carbon nano wall (CNW) characterized by a large specific surface area were used, and graphite slurry was applied through a casting process to improve durability. Methods To improve adhesion between the current collector (copper foil) and CNWs, a titanium nitride (TiN) layer was deposited using the RF magnetron sputtering method. CNWs were then grown by injecting methane (CH4) and hydrogen (H2) using a microwave plasma enhanced chemical vapor deposition (PECVD) system. The casting process was performed by making the height of the graphite slurry uniform. Afterwards, heat treatment process was performed at 70℃, 75℃, and 80℃ on a hot plate to improve durability. Field emission scanning electron microscope (FE-SEM) and energy-dispersive X-ray spectroscopy (EDS) were used to confirm the presence of CNWs in the casting process. A Raman spectroscopy was used to analyze the structural properties of anode materials. The improvement in the durability of the anode material was confirmed by analyzing the electrochemical properties. Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) were performed to characterize the lithium-ion battery. Results The cyclic voltammetry (CV) of the graphite slurry was measured at 20 cycles, which increased by about 8 cycles compared to other temperatures. As a result of electrochemical impedance spectroscopy, the Rct value was 25 Ohm at 75℃ heat treatment, which was about 4 times smaller than other temperatures.