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윤미옥,강신정,이수정,최현철,김호정,박창훈,홍세령,김지선,김길수 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-
의약품의 약효를 안전하게 나타내기 위해서는 정확한 용량의 복용이 중오하다. 정해진 용법 ·용량에 따라 투여를 하더라도 1회 복용단위당 항량이 균일하지 않으면 복용자의 의지에' 관계없이 과량 혹은 유효량에 디치지 못하는 양을 복용하게 되므로 복용단위당 유효성분의 균질성은 매우 중요하다. 이에 국내 시판 의약품 중 경구용 성형제제를 대상으로 중랸과 항랑의 균질성 평가 및 상관성에 대한 기초적 연굴를 통하여 함량군일성시험의 규긱 설정에 관한 기준을 마련하고자 하였다. 국내 시판 중인 총 560롯트의 경구용 성형제제에 대하여 주성분의 수 함량 등에 따라 븐류하고 함량시험, 중량편차, 함량균일성시험을 실새하여 중량편차와 함량균일성의 상관계수를 구하였으며, 상관성분석을 통하여 각 분류한 군에서 상관성 있는 것으로 나타난 롯트의 비을을 살펴보았다. 주성분 함유량 2% 미만, 혹은 2 mg 미만인 제제에서는 함량균일성으로의 관리가 필요한 것으로 나타났으며, 제형에 따라서는 당의정에서 상패적으로 상관성 있는 롯트의 수가 적게 나타나 함량균일성으로의 관리가 필요한 것으로 나타났다
External Stimuli-Responsive Melanin-Like Nanoparticles for Photoacoustic Imaging-Guided Therapy
Lee, Sunho,Lee, Hohyeon,Han, Hyounkoo,Yoo, Hongkeun,Kim, Haemin,Chang, Jin Ho,Kim, Hyuncheol American Scientific Publishers 2018 Science Of Advanced Materials Vol.10 No.5
<P>Photoacoustic (PA) imaging potential for biomedical applications, such as image-guide therapy, has been accelerated by exogenous contrast agent development, because of its real-time functional imaging and non-ionizing. The goal of this study was to develop melanin-like nanoparticles (MeINPs) for amplified PA imaging and pH stimuli-responsive local drug delivery. MeINPs were produced with dopamine hydrochloride and included catechol and quinone functional groups on the surface. pH sensitive MeINPs (pH-MeINPs) were synthesized by reversibly blocking free primary amines. pH-MeINPs are stable in pH > 7; however, in slightly acidic conditions (pH 5.6), pH-MeINPs are aggregated, resulting in the amplification of PA signals. Additionally, the chemotherapeutic agent, doxorubicin (DOX), was bound onto the surface of pH-MeINPs by pi-pi and hydrogen bonding. Finally, pH-MeINPs conjugated onto the surface of a 1-2-mu m sized microbubble (MB) for an externally ultrasound-controlled release of pH-MeINPs around a local tumor site. In addition, the efficient delivery and penetration of released pH-MeINPs into tumor cells can be expected because of the sonoporation of microbubbles. Results showed that under the exposure of ultrasound, DOX-pH-MeINPs were released from the microbubbles and delivered into cells more efficiently, compared to the ultrasound non-exposed control group, because of the sonoporation. The pH-MeINPs released the loaded DOX more effectively in acidic than neutral conditions. Therefore, MB-DOX-pH-MeINPs could be applied to tumor-specific PA amplification strategies; DOX-pH-MeINPs nanoparticles could be released around a tumor site with focused ultrasound, and then control DOX release locally in tumors in response to stimuli such as low pH and reactive oxygen species.</P>
Lee, Sang Un,Asami, Yukihiro,Lee, Dongho,Jang, Jae-Hyuk,Ahn, Jong Seog,Oh, Hyuncheol American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.5
<P>Two new oxepin-containing (<B>1</B> and <B>2</B>) and two diketopiperazine-type alkaloids (<B>3</B> and <B>4</B>) have been isolated from an EtOAc extract of the marine-derived fungus <I>Aspergillus</I> sp. SF-5044. The structures of these metabolites were determined through analysis of NMR and MS data, along with Marfey’s method. Compound <B>1</B> showed weak growth inhibitory activity against a small panel of cell lines.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-5/np100880b/production/images/medium/np-2010-00880b_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np100880b'>ACS Electronic Supporting Info</A></P>
Q-switching of a diode-pumped Nd:YVO4 laser with a closely folded resonator
Hyuncheol Lee,Yongwoo Lee,Chonghoon Kwak,Jinhyuk Kwon,Jonghoon Yi,Yong-Sik Lim 한국광학회 2005 Current Optics and Photonics Vol.9 No.2
A diode-pumped Nd:YVO4 laser is developed. The laser has a closely folded resonator. The laser beam in two arms of the folded resonator passes the same acousto-optic modulator. The laser output power and pulsewidth dependence on a Q-switching frequency were measured. It is found that the newly proposed geometry provides an effective means for reducing the pulsewidth while maintaining almost the same output power compared with the usual folded resonator, where the beam in one arm of the resonator passes the acousto-optic modulator.
Lee Minhye,Cha Gilyong,Kim Dongki,윤미용,Jang Daehyuk,Lee Sunyoung,Kim Song Hyun,Kim Hyuncheol,Kim Soonyoung 대한방사선방어학회 2023 방사선방어학회지 Vol.48 No.1
Background: Aptamers are currently being used in various fields including medical treatments due to their characteristics of selectively binding to specific molecules. Due to their special characteristics, the aptamers are expected to be used to remove radionuclides from a large amount of liquid radioactive waste generated during the decommissioning of nuclear power plants. The radiological effects on the aptamers should be evaluated to ensure their integrity for the application of a radionuclide removal technique. Materials and Methods: In this study, Monte Carlo N-Particle transport code version 6 (MCNP6) and Monte Carlo damage simulation (MCDS) codes were employed to evaluate the radiological effects on the aptamers. MCNP6 was used to evaluate the secondary electron spectrum and the absorbed dose in a medium. MCDS was used to calculate the DNA damage by using the secondary electron spectrum and the absorbed dose. Binding experiments were conducted to indirectly verify the results derived by MCNP6 and MCDS calculations. Results and Discussion: Damage yields of about 5.00×10-4 were calculated for 100 bp aptamer due to the radiation dose of 1 Gy. In experiments with radioactive materials, the results that the removal rate of the radioactive 60Co by the aptamer is the same with the non-radioactive 59Co prove the accuracy of the previous DNA damage calculation. Conclusion: The evaluation results suggest that only very small fraction of significant number of the aptamers will be damaged by the radioactive materials in the liquid radioactive waste.
Lee, Dong-Sung,Ko, Wonmin,Yoon, Chi-Su,Kim, Dong-Cheol,Yun, Jinju,Lee, Jun-Kyung,Jun, Ki-Young,Son, Ilhong,Kim, Dong-Woung,Song, Bong-Keun,Choi, Seulah,Jang, Jun-Hyeog,Oh, Hyuncheol,Kim, Sungchul,Kim, Hindawi Publishing Corporation 2014 Evidence-based Complementary and Alternative Medic Vol.2014 No.-
<P>The brain is vulnerable to oxidative stress and inflammation that can occur as a result of aging or neurodegenerative diseases. Our work has sought to identify natural products that regulate heme oxygenase (HO)-1 and to determine their mechanism of action in neurodegenerative diseases. KCHO-1 is a novel herbal therapeutic containing 30% ethanol (EtOH) extracts from nine plants. In this study, we investigated the antineuroinflammatory effects of KCHO-1 in lipopolysaccharide- (LPS-) treated mouse BV2 microglia. KCHO-1 inhibited the protein expression of inducible nitric oxide synthase (iNOS), iNOS-derived nitric oxide (NO), cyclooxygenase- (COX-) 2, and COX-2-derived prostaglandin E2 (PGE<SUB>2</SUB>) in LPS-stimulated BV2 microglia. It also reduced tumor necrosis factor-<I>α</I> (TNF-<I>α</I>), interleukin-1<I>β</I> (IL-1<I>β</I>), and IL-6 production. This effect was correlated with the suppression of inhibitor of nuclear factor kappa B-<I>α</I> (I<I>κ</I>B-<I>α</I>) phosphorylation and degradation and nuclear factor kappa B (NF-<I>κ</I>B) translocation and DNA binding. Additionally, KCHO-1 upregulated HO-1 expression by promoting nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in mouse BV2 microglia. Tin protoporphyrin (SnPP), an HO activity inhibitor, was used to verify the inhibitory effects of KCHO-1 on proinflammatory mediators and proteins associated with HO-1 expression. Our data suggest that KCHO-1 has therapeutic potential in neurodegenerative diseases caused by neuroinflammation.</P>
Analytical method for determination of <sup>41</sup>Ca in radioactive concrete
Lee, Yong-Jin,Lim, Jong-Myoung,Lee, Jin-Hong,Hong, Sang-Bum,Kim, Hyuncheol Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.4
The analysis of <sup>41</sup>Ca in concrete generated from the nuclear facilities decommissioning is critical for ensuring the safe management of radioactive waste. An analytical method for the determination of <sup>41</sup>Ca in concrete is described. <sup>41</sup>Ca is a neutron-activated long radionuclide, and hence, for accurate analysis, it is necessary to completely extract Ca from the concrete sample where it exists as the predominant element. The decomposition methods employed were the acid leaching, microwave digestion, and alkali fusion. A comparison of the results indicated that the alkali fusion is the most suitable way for the separation of Ca from the concrete sample. Several processes of hydroxide and carbonate precipitation were employed to separate <sup>41</sup>Ca from interferences. The method relies on the differences in the solubility of the generated products. The behavior of Ca and the interfering elements such as Fe, Ni, Co, Eu, Ba, and Sr is examined at each separation step. The purified <sup>41</sup>Ca was measured by a liquid scintillation counter, and the quench curve and counting efficiency were determined by using a certified reference material of known <sup>41</sup>Ca activity. The recoveries in this study ranged from 56 to 68%, and the minimum detectable activity was 50 mBq g<sup>-1</sup> with 0.5 g of concrete sample.
Lee, Junyeong,Hwang, Hyuncheol,Min, Sung-Wook,Shin, Jae Min,Kim, Jin Sung,Jeon, Pyo Jin,Lee, Hee Sung,Im, Seongil American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.3
<P>Although organic field-effect transistors (OFETs) have various advantages of lightweight, low-cost, mechanical flexibility, and nowadays even higher mobility than amorphous Si-based FET, stability issue under bias and ambient condition critically hinder its practical application. One of the most detrimental effects on organic layer comes from penetrated atmospheric species such as oxygen and water. To solve such degradation problems, several molecular engineering tactics are introduced: forming a kinetic barrier, lowering the level of molecule orbitals, and increasing the band gap. However, direct passivation of organic channels, the most promising strategy, has not been reported as often as other methods. Here, we resolved the ambient stability issues of p-type (heptazole)/or n-type (PTCDI-C13) OFETs and their bias-stability issues at once, using DNA-base small molecule guanine (C<SUB>5</SUB>H<SUB>5</SUB>N<SUB>5</SUB>O)/Al<SUB>2</SUB>O<SUB>3</SUB> bilayer. The guanine protects the organic channels as buffer/and H getter layer between the channels and capping Al<SUB>2</SUB>O<SUB>3</SUB>, whereas the oxide capping resists ambient molecules. As a result, both p-type and n-type OFETs are simultaneously protected from gate-bias stress and 30 days-long ambient aging, finally demonstrating a highly stable, high-gain complementary-type logic inverter.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2015/aamick.2015.7.issue-3/am507354p/production/images/medium/am-2014-07354p_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am507354p'>ACS Electronic Supporting Info</A></P>