Effects of Long-acting Injectable 3-Monthly Paliperidone Palmitate on the Clinical and Social Performance of Patients with Schizophrenia

Jihoon Oh(Jihoon Oh),Jihye Oh(Jihye Oh),Dong Wook Kim(Dong Wook Kim),HyunChul Youn(HyunChul Youn),Sae-Hoon Kim(Sae-Hoon Kim),Soo In Kim(Soo In Kim),In Won Chung(In Won Chung),Kuan Shu Wang(Kuan Shu Wa 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Objective: To investigate the effects of long-acting injectable 3-monthly paliperidone palmitate on the clinical and social functioning of patients with schizophrenia. Methods: This study enrolled patients with schizophrenia receiving long-acting injectable 1-monthly paliperidone palmitate for at least 4 months and who subsequently received 3-monthly paliperidone palmitate. Accordingly, 418 patients were followed up for 24 weeks. Their clinical symptoms and social functioning were measured using the Clinical Global Impression-Severity of Illness and Personal and Social Performance scales. Results: The Personal and Social Performance total score was significantly higher after 3-monthly paliperidone palmitate treatment than at baseline (baseline vs. week 24: 54.3 ± 18.0 vs. 61.0 ± 14.5 [mean ± standard deviation]; p < 0.001; Wilcoxon signed-rank test); the proportion of patients in the mildly ill group (scores 71−100) also increased significantly (baseline vs. week 24: 16.5% vs. 20.6%; p < 0.001; McNemar-Bowker test). The mean Clinical Global Impression-Severity of Illness score decreased significantly (baseline vs. week 24: 3.7 ± 1.0 vs. 3.4 ± 0.9; p < 0.001; Wilcoxon signed-rank test), as did the proportion of patients in the severely ill group (baseline vs. week 24: 4.1% vs. 2.1%; p < 0.001; McNemar-Bowker test). Conclusion: Continuous 3-monthly paliperidone palmitate treatment significantly enhances the personal and social performance of patients with schizophrenia and reduces the proportion of those with severe illness. These findings suggest that long-acting injectable antipsychotic administration at intervals longer than 1 month might improve the social functioning of and promote return to activities of daily living in patients with schizophrenia.

Recent Trends on Crystalline Porous Materials for Efficient Hydrogen Isotope Separation

Hyunchul Oh(오현철) 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.1

A Development of Digital Solution for Automated Quality Test Management at Road Construction Site

HyunChul Oh,YoungHwan Shin,SungOh Byun,KiHyun Baek 한국도로학회 2022 한국도로학회 학술대회 발표논문 초록집 Vol.2022 No.10

Mitigation of LH₂ tank boil-off losses via adsorption of H₂ on metal–organic frameworks

Hyunchul Oh 한국표면공학회 2023 한국표면공학회 학술발표회 초록집 Vol.2023 No.11-1

토의민주주의 이론의 쟁점

오현철(Hyunchul Oh) 한국정치학회 2006 한국정치학회보 Vol.40 No.5

이 글의 목적은 대의민주주의의 유력한 대안으로 논의되고 있는 토의민주주의론의 이론적 쟁점들을 분석하는 것이다. 논문에서 다양한 쟁점들을 인식론적, 정치적, 도덕적 쟁점으로 구분하였고 각각의 범주를 다시 세분하였다. 인식론적 쟁점은 토의의 목적과 정당화 방식, 정치적 쟁점에서는 의사결정의 문제와 토의의 병리학, 도덕적 쟁점에서는 차이의 문제와 포괄적 관점의 배제를 중심으로 검토하였다. 분석 결과 토의민주주의론은 이론적으로 다양한 관점이 존재하며, 토의민주주의에 대한 비판과 우려는 토의민주주의를 지나치게 협소하게 바라보는 관점 혹은 토의민주주의의 목적에 대한 오해에 근거했거나, 토의민주주의의 일부의 관점을 확대해석한 결과임을 알 수 있었다. 그리고 토의민주주의적 실천이 쟁점들에 대한 이론적ㆍ경험적 해결 방안임을 확인하였다. 마지막으로 인식론적 엄밀성을 보완하는 연구, 토의적 의사결정 방안 연구, 토의민주주의의 제도화에 관한 연구를 앞으로의 이론적 과제로 제시하였다. The purpose of this essay is to analyze controversial issues on deliberative democracy. To select the meaningful issues, three distinct categories are considered; epistemic, political, moral. There are controversial issues on deliberative democracy. They are the purpose of deliberation, method of justification, problems of decision-making, pathologies of deliberation, difference and exclusion. Many theorists including difference politics, social choice theory and liberalism have criticized these issues as the problems and failures of deliberative democracy. This essay considers how deliberative democracy can process these issues concerning mutually contradictory assertions of democracy. At first I classify the purpose of deliberation and method of justification into epistemic category, problems of decision-making and pathologies of deliberation into political category, difference and exclusion into moral category. After analyzing the issues, I argue the basic misunderstandings on deliberative democracy stem from the pluralism of deliberative theories, and the plural aspects can coexist with the deliberative democratization. At last I conclude that close attention must be paid to the institutionalization of the ideas of Deliberative Democracy.

고온 인산염 유기 전해질에서의 TiO² 나노구조 형성 원리와 응용

오현철 ( Hyunchul Oh ),이영세 ( Young Sei Lee ),이기영 ( Kiyoung Lee ) 한국공업화학회 2017 공업화학 Vol.28 No.4

전기화학 방법을 이용한 이산화티타늄 나노구조에 대한 기존 연구는 불소 이온을 함유한 전해질에서의 산화반응으로 형성된 나노튜브가 연구의 주를 이루고 있다. 최근, 불소 이온이 아닌 고온 인산염이 함유된 글리세롤계 전해질의 개발로 관련 연구가 활발히 진행되고 있다. 본 총설은 이러한 전해질을 활용하여 다양한 이산화티타늄 나노구조를 형성하는 연구 동향에 대해 다루고 있다. 새로운 양극산화법을 통해 형성된 이산화티타늄 나노구조는 기존의 나노튜브에 비하여 비표면적이 넓고 결정성과 접착력이 우수하여 여러 응용분야에 활용가치가 높다. 이에 본 총설에서는 새로운 양극산화법을 이용한 나노구조의 형성 원리, 특성에 대한 개괄적 접근 뿐만 아니라 실제 응용분야에서의 소재 성능을 기존 나노튜브 구조와 비교한 결과 등을 망라하여 자세히 소개하고 있다. In the present review, we provide an overview of the research trend of anodic TiO₂ nanostructures. To date, most anodic TiO₂ nanostructure formation has focused on the fluoride ion electrolyte system to form nanotube layers. Recently, a novel approach that describes the formation of thick, self-organized TiO₂ nanostructures was reported. These layers can be prepared on Ti metal by anodization in a hot organic/K₂HPO₄ electrolyte. This nanostructure consists of a strongly interlinked network of nanosized TiO₂, and thus provides a considerably higher specific surface area than that of using anodic TiO₂ nanotubes. This review describes the formation mechanism and novel properties of the new nanostructures, and introduces potential applications.

주요 설교환경으로서 회중 분석과 세대별 설교를 위한 실천적 제안

오현철 ( Hyunchul Oh ) 한국복음주의신학회 2015 성경과신학 Vol.75 No.-

본 연구는 설교자가 회중을 명확하게 이해할 때 회중의 영적, 물리적 필요를 채워줄 수 있는 설교를 수행할 수 있다는 확신 가운데 19세기 말 독일의 회중연구와 20세기 후반 미국 그리고 최근 한국에서 회중에 대한 관심이 높아지고 있음을 논증하였다. 이후 설교에 영향을 미치는 주요 설교환경으로 회중에 대한 이론적 논의를 전개하고, 그 이론에 근거해 40대를 중심으로 한세대별 설교에 대한 실천적 제안을 시도하였다. This study has begun with a conviction that preacher is able to fulfill congregation’s spiritual and physical needs only when he or she is good enough to understand them. Having thought that, this determined the increasing interest on congregation from Germany in 19th century through USA in 20th to Korea nowadays. This thesis then developed the theoretical discuss on congregation as a major preaching context that effects to preaching. After that, this suggested four practical proposals for forties as a generation based preaching.

Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235- induced Growth Inhibition of Colorectal Cancer Cells

Iljoong Oh,Hyunchul Cho,Yonghoon Lee,Minseok Cheon,Deokbae Park,Youngki Lee 한국발생생물학회 2016 발생과 생식 Vol.20 No.1

Molecular targeting for the altered signaling pathways has been proven to be effective for the treatment of many types of human cancer, including colorectal cancer (CRC). The dual phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor BEZ235 has shown to exhibit potent antitumor activity against solid tumors. Autophagy is a cellular lysosomal catabolic process to maintain metabolic homeostasis, which has been known to be induced in response to many therapeutic agents in cancer cells. This process is negatively regulated by mTOR and often acts as prosurvival or prodeath mechanism following cancer therapeutics. The current study was designed to investigate the antiproliferation activity of BEZ235 and to evaluate the role of autophagy induced by BEZ235 using HCT15 CRC cells bearing ras oncogene mutation. We found that BEZ235 decreases cell viability, which was mostly dependent on G1 arrest of cell cycle via suppression of cyclin A expression. BEZ235 affects PI3K/Akt/mTOR signaling pathway by increasing the phosphorylation of AKT at Ser473 and RAS/RAF/MEK/ERK pathway by decreasing the phosphorylation of ERK at Tyr204. BEZ235 also stimulated autophagy induction as evidenced by the increased expression of LC3-II and abundant acidic vesicular organelles (AVOs) in the cytoplasm. In addition, the combination of BEZ235 with autophagy inhibitor chloroquine, a known antagonist of autophagy, counteracted the antiproliferation effect of BEZ235. Thus, our study indicates that autophagy induced in response to BEZ235 treatment appears to act as cell death mechanism in HCT15 CRC cells.

의사소통행위 이론에 기반한 민주시민역량 개념 연구

오현철(OH, Hyunchul) 한국사회과교육연구학회 2020 사회과교육 Vol.59 No.2

이 논문은 민주시민역량 개념을 학생들의 사회참여 활동과 관련지어 제시하고자 한다. 기존 연구성과들이 민주시민역량 개념을 포괄적이고 일반적인 관점에서 제시한 것과 달리, 이 논문은 사회참여에 초점을 맞추어 이론적 차원에서 제시한다. 이론적 작업을 위해 하버마스가 의사소통행위론에서 의사소통의 타당성 요건으로 제시한 진실성, 진리성, 정당성, 이해가능성을 출발점으로 삼는다. 민주시민교육의 목표로 의사소통행위 역량의 함양을 제시하고, 하위 핵심역량으로 자아성찰역량, 정보활용역량, 가치판단역량, 상호작용역량을 제시하였다. 위의 핵심역량들을 활용하여 선행 연구들이 제안한 다양한 역량 개념들을 재구성함으로써, 구체적인 상황에 필요한 다양한 역량들을 4개의 역량 개념으로 구성할 수 있음을 보여준다. 그리고 이러한 접근이 현실 교육에서 무리 없이 적용될 수 있음을 최근의 토론수업 사례를 제시하여 보여준다. The purpose of this paper was to present democratic citizens’ competence to be nurtured through democratic citizenship education in schools, focusing on students’ social participation activities. Unlike the existing research achievements presented from a comprehensive and general perspective on democratic citizenship education and competence, this paper features the competence to influence social participation of students on a theoretical level. For the theoretical work, the truthfulness, truth, rightness, and understandability presented by the Habermas as the feasibility requirements for communication in the theory of communicative action were used as starting points. The communicative action competence was presented as a meta competence of democratic citizenship education. The concepts of competence in response to the validity claims of the Harbermas presented four key sub-competence: self-reflection, information use, value-judgment, and interaction. Using four core competencies, the various competency concepts proposed by the preceding studies were compared and explained in practice. And I showed a recent discussion class that my views can be applied without undue force in real-life education

창조와 과학, 어떻게 설교할 것인가?

오현철(Hyunchul Henry Oh) 창조론오픈포럼 2008 창조론오픈포럼 Vol.2 No.2

After briefing the history of creation movement in Korea and the U.S., the author presents how to deal with the issues of creation and science in preaching. As a homilectic scholar, he proposes the creation message should be focused on what the Bible says, not for debate but for apologetic purpose.