생쥐의 심장발생과정에서 세포증식과 세포고사의 역할

김어진,김효수,서정욱,김어진,김효수,서정욱 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.12

인삼첨가 Long Life면의 조직감과 관능적 특성

정재홍,심창주,신영,권효진,이규희,오만진 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.5

인삼이 밀가루의 아밀로그래프에 의한 호화 성질과 파리노그래프에 의한 반죽 성질에 미치는 영향을 조사하였다. 인삼첨가 LL면의 조직감과 관능적 특성에 미치는 영향을 분석하기 위하여 밀가루에 대하여 인삼을 5.0∼10% 첨가하여 LL면을 제조한 뒤 면의 조직 특성 분석 및 조리시험을 하고 관능검사를 하였다. 인삼을 첨가하면 아밀로그래프의 호화개시 온도를 3.1℃ 지연시켰으며, 최고 점도를 40B.U 감소시켰다. 파리노그래프의 흡수율은 1.2% 증가하였으며, 반죽의 안정도는 인삼의 첨가로 2.0분 길게 측정되었다. Hunter L값은 인삼 첨가량이 증가할수록 낮아졌으며, Hunter a, b값은 반대로 측정되었다. 인삼첨가 LL면의 층밀림 압출력은 첨가량의 증가에 따라 높아져 10.0%의 첨가는 대조구 18.65(㎏f)보다 2.3(㎏f) 높은 23.95(㎏f)로 측정되었으며, 경도도 대조구보다 5.4(㎏f) 높게 측정되었다. 인삼첨가 LL면의 무게 증가는 인삼의 첨가량이 증가할 때 다소 높게 나타났으나. 부피 증가는 오히려 높게 나타나 조직이 다소 치밀한 것으로 나타났다 용출량은 인삼량의 증가에 따라 약간 감소하였다. 미생물은 인삼의 첨가량이 증가할수록 줄어들어서 장기 저장이 가능하였다. 관능 검사 결과는 인삼첨가 LL면이 4.2 및 4.0으로 비교적 좋은 점수를 얻었다. 이같이 LL면 제조시 인삼 첨가량은 7.0%의 수준이 효과가 컸다. The influence of ginseng on the paste or gelatinization properties by amylograph and mixing properties by farinograph of wheat flour, and on quality properties, color, cooking quality, textural and sensory properties, and reducing microbial population of LL (Long Life) noodles was studied. The contents of ginseng used were from 5% to 10% based on flour weight. The viscosity property of wheat flour with ginseng was increased the initial pasting temperature but the amylograph peak viscosity were decreased in vice versa. The farinograph absorption, stability and breakdown were increased by ginseng. The whiteness of LL noodles manufactured with ginseng was lower than that of control. The shear extrusion force and hardness of LL noodles manufactured with ginseng were shown much higher value than those of control. At cooking quality examination of LL noodles manufactured with ginseng, weight of cooked LL noodles was decreased but volume was appeared in vice versa. Extraction amounts of LL noodles manufactured with ginseng during cooking were much smaller than those of control. Total counts of microorganism of LL noodles manufactured with ginseng were decreased during storage at 30℃. Sensory properties of cooked LL noodles which was manufactured with ginseng showed quite acceptable. Based on the cooking and sensory evaluation test, addition of 7.0% ginseng to wheat flour may be suitable for processing LL noodles.

자연과 수업에서 Vee Diagram 의 적용에 대한 연구

정진우,송보용,김효남 한국교원대학교 과학교육연구소 1994 청람과학교육연구논총 Vol.4 No.1

The purpose of this study is to analize the effect of Vee Diagram on the ability of scientific investigation, scientific attitude, cognitive ability in elementary school. For this study, 68 sixth grade students were selected and they were divided into two group: one is the experimenal group with Vee diagram instruction, the other is the control group with conventional instruction. Data were collected from the samples to know effect of Vee Diagram instruction and compared the experimental group with the control group. The result of analysis is as follows: 1. The vee diagram instruction is better than the conventional instruction for improving the scientific inquiry skills. 2. The vee diagram instruction does not show statistically meaningful difference to the conventional instruction for improving the scientific attitude. 3. The vee diagram instruction is better than conventional instuction for improving scientific knowledge. The results indicated that Vee diagram instruction is effective in learning strategy for improving scientific attitude.

인공신경망 이론을 이용한 충주호의 수질예측

정효준,이소진,이홍근 한국환경과학회 2002 한국환경과학회지 Vol.11 No.3

This study was carried out to evaluate the artificial neural network algorithm for water quality forecasting in Chungju lake, north Chungcheong province. Multi-layer perceptron(MLP) was used to train artificial neural networks. MLP was composed of one input layer, two hidden layers and one output layer. Transfer functions of the hidden layer were sigmoid and linear function. The number of node in the hidden layer was decided by trial and error method. It showed that appropriate node number in the hidden layer is 10 for pH training, 15 for DO and BOD, respectively. Reliability index was used to verify for the forecasting power. Considering some outlying data, artificial neural network fitted well between actual water quality data and computed data by artificial neural networks.

국가수준의 과학에 관련된 정의적 특성의 평가체제 개발

김효남,정완호,정진우 한국교원대학교 과학교육연구소 1998 청람과학교육연구논총 Vol.8 No.1

학생들의 과학적 소양을 기르는데에는 과학과 관련된 정의적 특성이 중요한 역할을 한다. 과학적 태도, 자연과 과학에 대한 가치, 호기심과 관심 등의 과학과 관련된 정의적 특성이 대부분의 과학교육 목표에 포함되고 있다. 이 연구에서는 과학과 관련된 정의적 특성의 평가체제와 문항을 개발하였다. 인식, 흥미와 과학적 태도의 세 개의 주범주와 16개의 소범주로 평가체제가 구성되었다. 평가체제의 타당도는 10명의 과학교육학자들에 의하여 검증되었다. 48개의 평가 문항을 문항반응분석과 문항· 검사 상관계수를 고려하여 총 64 문항 중에서 선정하였다. 크론바하 알파계수는 인식과 흥미에서 0.83이고, 과학적 태도에서는 0.86이었다. 검사의 결과는 다음과 같다. 첫째, 과학과 관련된 정의적 특성에서 남학생이 여학생 보다 더 높은 점수를 나타내었다. 둘째, 초등학생이 중등학생보다 더 높은 과학과 관련된 특성 점수를 나타내었다. 마지막으로 도시지역의 학생이 시골지역의 학생보다 더 높은 과학과 관련된 특성 점수를 보여 주었다. Science-related affective domain is considered as a very important domain for achieving students' scientific literacy. Most science educational objectives include some objectives about affective domain such as scientific attitudes, values, curiosity, interests and concerns about nature and science. In this research, the evaluation framework and items of science-related affective domain were developed. The evaluation framework consists of three main categories such as cognition, interest and scientific attitudes and 16 subcategories. The validity of the evaluation framework is tested by ten science educators. Forty-eight items are selected among item pool by considering item response analysis and item-test correlation coefficient. The Cronbach α of the tests is 0.83(cognition and interest) and 0.86(scientific attitudes). The results of the test are as follows. First, boys got higher scores than girls. Second, elementary students got higher scores than secondary students. Finally, students in urban areas showed higher scores than those in rural areas.

초·중·고 학생들의 과학 정의적 특성 추이 분석을 위한 종단적 연구

김효남,정완호,정진우,양일호,김영신 한국교원대학교 과학교육연구소 1999 청람과학교육연구논총 Vol.9 No.1

이 연구는 우리 나라 학생들의 과학의 정의적 특성의 성취 수준을 종단적으로 분석하여 국가 수준에서 과학교육 성과를 가늠해 봄으로써, 과학교육의 질을 향상시킬 수 있는 과학교육 정책의 기초자료를 제공하는데 그 목적이 있다. 이를 위하여 1997년 2월에 초중고학생 3603명, 1999년 3월에 초중고학생 4737명을 대상으로 과학의 정의적 특성을 조사하였다. 본 연구의 결과는 학교급별 과학의 정의적 특성의 성취 수준이 초등학교에서 중학교까지 통계적으로 유의미하게(p<.05) 하락 한 후 고등학교에서 상승하는 것으로 나타났다. 또한, 남학생이 여학생보다 통계적으로 유의미하게 높게 나타났다(p<.05). 남녀간의 성취수준의 차이는 학년이 올라갈수록 감소하는 것으로 나타났다. 지역별로는 소도시보다 대도시가 높게 나타났으며, 시간이 지날수록 그 차이가 커지는 것으로 나타났다. 1997년과 1999년의 성취 수준을 비교해보면 1999년의 성취수준이 통계적으로 유의미하게 낮게 나타났다. 또한, 국가수준의 과학에 대한 성취도를 분석할 수 있는 모니터 과정이 계속적으로 이루어지길 기대한다. The purpose of this study was to longitudinally analyze Korean students' trend on science-related affective characteristics and provide descriptive data for improving the quality of Korean science education. In this longitudinal study, 3603 students and 4737 students were sampled in elementary and secondary schools, respectively in January 1997 and March 1998. The result showed that students' affective characteristics were decreased with statistical significance(p<0.05) during elementary and junior high school periods, but students' affective characteristics were increased during high school period. Affective characteristics of male were significantly higher than those of females' (p<0.05). Difference on affective characteristics between female and male students was being decreased by increasing grades. Students' affective characteristics in metropolitan areas were significantly higher than those in regional areas and difference between them was increased in 1999 comparing to 1997. The students' affective characteristics in 1999 were lower than those in 1997 totally.

HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.

矢狀分割骨切斷術에 依한 顎矯正術의 統計學的 硏究

辛曉根,陳宇政,李俊禮,金晤煥,李炫尙 大韓顎顔面成形再建外科學會 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.2

Recently, combined with social complexity, increment of medical demand and supply and the change of esthetic category, admission and operation of the patients of facial deformity have been changed with annual change. This study was conducted in the concept of helping the overall character of orthognathic surgery in future understood and being an important index in the establishment of better treatment course, through the patient, on whom was operated orthognathic surgery via sagittal split ramal osteotomy in our Dept. of Oral & Maxillofacial Surgery, Chonbuk National University Hospital from 1991. 1. 1 to 1995. 12. 31. The results were obtained as follows. 1. The ratio of male to female was 1 : 1.33 and the ages between 16 and 25 year was 73.6%, and the mean age was 20.4 years. 2. The ratio of setback amount between 6 to 15mm was 84.6% and the advancement amount between 1 to 10mm was 89% and the mean amount of movement was 9.0mm in setback, and 3.6mm in advancement. 3. After removal of maxillomandibular fixation(MMF), the distinction of sex was not statistically significant in ROM. 4. The ROM following methods of fixation was statistically significant in 3rd(P<0.05), 8th, and 12th week(each P<0.01), with faster rehabilitation in rigid fixation which had shorter MMF period. 5. The rehabilitation of ROM following the operation methods was statistically significant in 1st(P<0.05), 2nd, 3rd, 4th, 6th, 8th, and 12th week(each P<0.01) with faster rehabilitation in the case of SSRO than Lefort I / SSRO (Two jaw surgery). 6. The rehabilitation of ROM following directions of mandibular movement did not manifest a statistically significant difference in both setback and advancement.

포름알데하이드에 폭로된 해부학 실습 학생들의 임파구 자매염색분체교환

백두진,주수자,김기영,이수진,심상효,손정일,심성한,송재철,조율희 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

Sister-chromatid exchanges measured in the peripheral lymphocytes of 15 non-smoking medical students after exposure to formaldehyde during 24-week anatomy class showed a small but significant (p=0.0468) increase when compared with samples obtained from the same individuals immediately before exposure. Mean frequencies of sister-chromatid exchange of cultured peripheral lymphocytes were 5.40±0.24 from the samples before exposure and 5.87±0.22 from the same samples after exposure. Breathing-zone air samples collected by formaldehyde monitoring kit with digital colorimeter(SKC) showed a mean concentration of 0.72±0.02 ppm formaldehyde.

복강경을 이용한 부인과 수술의 임상적 고찰

조혜진,정효영,정혁 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives : To assess the advantages, disadvantages, appilcability, and complications of laparoscopy in gynecologic disease. Materials and Method: A retrospective study which includes 591 patients who underwent laparoscopic surgery from January, 1994 to February, 2005 for gynecologic diseases was done. Results: The patient's ages ranged from 19 to 65 years and their mean age was 40years. The indications of laparoscopy were myoma in 240 cases (40.6%), ovarian tumor, ectopic pregnancy, pelvic adhesion, primary infertility, secondary infertility, endometriosis, pelvic inflammatory disease, hemorrhagic corpus luteum and tubal obstruction in decreasing order. The operations performed were laparoscopic-assisted vaginal hysterectomy in 247 cases (41.8%), diagnostic laparoscopy, oophorectomy, salpingo-oophorectorny, ovarian cystectomy, pelvic adhesiolysis, salpingectomy, ovarian wedge resection and fulgarization in order. Operation times were from 10 to 240 minutes (mean 64 minutes). Postoperative hospital stays were from 0 day to 15 days (mean 3.9 days). There were 11 surgical complications including 1 trocar site hematoma, 11 incision site infection, 2 postoperative ileus and 1 patient underwent reoperation because of delayed ureteral fistula. Conclusion: We conclude that operative laparoscopy is useful in gynecologic diseases but need development of laparoscopic equipments, research of operative method, extension of operative indications, and skilled laparoscopic surgeons.