http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Suh, Hyewon,Choi, Ko-Woon,Kim, Myung Sic,Kim, Jeong Hyeon,Noh, Sun Young,Sung, Moon-Hee,Lee, Chul-Hoon The Korean Society for Microbiology and Biotechnol 2012 Journal of microbiology and biotechnology Vol.22 No.11
We previously isolated a novel compound, HY251, with the molecular structure of 3-propyl-2-vinyl-1,2,3,3a,3b,6,7,7a,8,8a-decahydrocyclopenta[a]indene-3,3a,7a,8a-tetraol from the roots of Aralia continentalis. The current study was designed to evaluate the detailed molecular mechanisms underlying the apoptotic induction by HY251 in human ovarian cancer PA-1 cells. TUNEL assay and Western blot analyses revealed an appreciable apoptotic induction in PA-1 cells treated with $60{\mu}M$ of HY251 for 24 h. This apoptotic induction was associated with caspase-8-dependent Bid cleavage, which in turn resulted in the formation of pro-apoptotic truncated Bid (tBid), and activation of caspase-9 and -3, as well as the cleavage of poly(ADP-ribose) polymerase (PARP). Moreover, we found that this death event was also associated with the significant up-regulation and activation of the p53 tumor-suppressor protein through phosphorylation at Ser15. Therefore, we suggest that HY251 may be a potent cancer chemotherapeutic candidate for the treatment of ovarian cancer.
직선 및 Spectral Clustering을 사용한 장소 단위 영상 분류
문혜원(Hyewon Moon),이진한(Jin Han Lee),서일홍(Il Hong Suh) 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.11
In this paper, we propose a scene grouping algorithm where each resulting group can represent certain concept of a place. We consider each scene as a set of line features and calculate similarities between scenes using a vocabulary tree and TFIDF weighting scheme. Then using the scenes as nodes and their similarities as weighted edges, a similarity graph is constructed. By cutting the sparse edge parts of this graph using spectral clustering, this graph is partitioned into ĸ groups which correspond to ĸ places.
Comparison of Swallowing Characteristics in Normal Controls and Patients with Dysphagia
Baekhee Lee,Hyewon Lee,Myeongeun Yun,Mee Kyung Suh,Duk L. Na,Heecheon You 대한인간공학회 2013 대한인간공학회 학술대회논문집 Vol.2013 No.5
Objective: The present study is intended to compare swallowing characteristics between normal controls and patients with dysphagia through quantification of the pharyngeal movement. Background: The existing diagnoses of swallowing have been qualitatively conducted by a clinician referring to results of the VideoFluorocopic Swallowing Study (VFSS) or the Fiberoptic Endoscopic Evaluation of Swallowing (FEES); therefore, a quantitative methodology for assessment of the swallowing is required to diagnose dysphagia more accurately. Method: A three-step approach was applied in the study: (1) development of a swallowing measurement device consisting of an ultrasonic Doppler sensor to measure the pharyngeal movement, (2) establishment of five swallowing quantification measures (peak amplitude, duration, number of peaks, peak interval, and impulse of swallowing) by a swallowing signal preprocessing, (3) evaluation of the swallowing in 120 normal controls and 36 dysphagic patients by three-step protocol (S1. informed consent, S2. exercise, S3. swallowing session; type and volume: dry saliva, thin liquid 1, 3, 9 ml, and thick liquid 1, 3, 9 ml). Results: Swallowing signals of normal controls and dysphagic patients classified into 2 types (short-single: 39%; short-double: 43%) and 3 types (short-double: 58%; long-double: 33%; long-multiple: 9%), respectively. Dysphagic patients had difficulties in swallowing of 9 ml regardless of swallowing type. Highest peak amplitude, duration, number of peaks, average peak interval, and impulse of dysphagic patients were 1.3 times higher (t = 4.31, p < .001), 3 times longer (t = -11.15, p < .001), 2 times more (t = -6.73, p < .001), 2 times longer (t = -9.23, p < .001), and 1.3 times lower (t = 8.94, p < .001) than those of normal controls, respectively. Application: The swallowing characteristics of dysphagic patients can be applied to develop a diagnostic model which can evaluate quantitatively the existence and severity for dysphagia.
Jongheon Jung,Hyewon Lee,Yang-Gun Suh,Hyeon-Seok Eom,Eunyoung Lee 대한의학회 2021 Journal of Korean medical science Vol.36 No.8
Total body irradiation (TBI) is included in the conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT), with unique advantages such as uniform distribution over the whole body and decreased exposure to cytotoxic chemotherapeutic agents. For individuals who lack matched sibling or matched unrelated donors, the use of haploidentical donors has been increasing despite challenges such as graft rejection and graft-versus-host disease (GVHD). Although a limited number of studies have been performed to assess the clinical role of TBI in haploidentical HSCT, TBI-based conditioning showed comparable results in terms of survival outcomes, rate of relapse, and GVHD in diverse hematologic malignancies such as leukemia, lymphoma, and multiple myeloma. Advances in supportive care, along with recent technical improvements such as restriction of maximum tolerated dose, appropriate fractionation, and organ shielding, help to overcome diverse adverse events related to TBI. Post-transplantation cyclophosphamide was used in most studies to reduce the risk of GVHD. Additionally, it was found that post-transplantation rituximab may improve outcomes in TBI-based haploidentical HSCT, especially in patients with B-cell lymphoma. Along with the advances of techniques and strategies, the expansion of age restriction would be another important issue for TBI-based haploidentical HSCT considering the current tendency toward increasing age limitation and lack of matched donors. This review article summarizes the current use and future perspectives of TBI in haploidentical HSCT.