소아에서 간질발작의 임상양상과 뇌파검사의 관계

이승현(Seung Hyeon Lee),손동우(Dong Woo Son),은병욱(Byung Wook Eun),심소연(So Yeon Sim),최덕영(Deok Young Choi),선용한(Yong Han Sun),조강호(Kang Ho Cho0, 류 일(Eell Ryoo),전인상(In Sang Jeon0, 차 한(Hann Tchah) 대한소아신경학회 2009 대한소아신경학회지 Vol.17 No.2

목적:발작의 분류는 발작의 원인, 예후를 추정하거나 항경련제를 선택하는 데 있어 매우 중요하며 뇌파검사는 발작의 종류를 구분하고 적절한 치료를 하기 위해 시행하는 중요한 검사이다. 저자들은 소아에서 임상적 발작이 확실한 경우 간질발작의 임상양상과 뇌파검사 간의 일치 정도를 알아보고자 한다. 방법:2000년 1월 1일부터 2008년 9월 30일까지 1회 이상의 간질발작을 주소로 가천의대 길병원 소아청소년과에 방문한 환자 중 본원에서 처음으로 뇌파검사를 시행한 환자를 대상으로 하였다. 발작의 임상양상은 목격자와 본인의 설명을 기록한 의무기록지를 기준으로 하여 부분발작과 전신발작으로 분류하였고 뇌파검사는 발작간간질양방전을 기준으로 정상과 비정상으로 분류하였으며 각성과 수면상태 모두에서 시행하였다. 결과:총 461명의 환자의 뇌파검사 시의 평균 연령은 6.7세였고 남자는 247명, 여자는 214명이었다. 전체 환자에서 발작의 임상양상은 부분발작이 310명, 전신발작이 187명이었다. 각성뇌파검사에서 비정상은 158명으로 부분발작파가 118명, 전신발작파가 59명, 두 가지 발작파가 한 환자에서 나온 경우가 19명이었고, 수면뇌파검사에서는 비정상이 239명으로 부분발작파가 196명, 전신발작파가 77명, 두 가지 발작파가 한 환자에서 나온 경우가 34명이었으며 전체 환자에서는 비정상이 273명으로 부분발작파가 216명, 전신발작파가 97명, 두 가지 발작파가 한 환자에서 나온 경우가 40명이었다. 간질증후군은 전체 환자 중 90명에서 관찰되었다. 146명(41.5%)의 부분발작과 44명(23.4%)의 전신발작 및 79명(87.8 %)의 간질증후군이 뇌파소견과 일치하였다. 결론:영유아 및 소아에 있어 발작을 진단할 때에는 발작양상 분 아니라 정확한 뇌파소견을 세심하게 고려하여야 한다. Purpose:Electroencephalography(EEG) is an essential method carried out for classifying seizures and taking appropriate treatment. The aim of this study is to investigate the concordance between clinical findings of epileptic seizures and EEG in children. Methods:We enrolled 461 patients from those who visited Gil hospital from January 1, 2000 to September 30, 2008 with the chief complaint of epileptic seizure more than once and checked their first EEG at the same hospital. The clinical findings of seizure were based on the charts and interictal waking and sleep EEGs were done. Results:The mean age of the patients was 6.7 years old. 497 epileptic seizures occurred and its clinical finding included 310 of partial seizures and 187 of generalized seizures. In 315 waking EEG 158 were abnormal including 118 of partial seizures, 59 of generalized seizures and 19 of both seizures, in 431 sleep EEG 239 were abnormal including 196 of partial seizures, 77 of generalized seizures and 34 of both seizures, and in waking and/or sleep EEG 273 were abnormal including 216 of partial seizures, 97 of generalized seizures and 40 of both seizures. Epileptic syndromes were observed in 90 patients. 146(41.5%) of partial seizures, 44(23.4%) of generalized seizures, and 79(87.8%) of epileptic syndromes accorded with EEG. Conclusion:When diagnosing seizures in children, we must consider not only clinical findings but also accurate EEG findings.

제주산 로즈마리와 라벤더(Rosmarinus officinalis L., Lavandula angustifolia Mill.)로부터 추출한 essential oil과 hydrosol의 성분 분석 및 항산화 활성

전덕현 ( Deok Hyeon Jeon ),문정용 ( Jeong Yong Moon ),현호봉 ( Ho Bong Hyun ),김소미 ( Somi Kim Cho ) 한국응용생명화학회(구 한국농화학회) 2013 Journal of Applied Biological Chemistry (J. Appl. Vol.56 No.3

제주도에서 생산된 로즈마리(Rosmarinus officinalis L.)와 라벤더(Lavandula angustifolia Mill.) 두 종의 허브 에센셜 오일과 하이드로졸 성분을 GC-MS로 분석하였다. 로즈마리 에센셜 오일에는 α-pinene (40.96%)의 함량이 가장 높았으며, 라벤더 에센셜 오일에는 camphor (34.44%)가 가장 높았다. 로즈마리 하이드로졸에는 verbenone이 (45.31%) 가장 높게 나타났으며, 라벤더 하이드로졸에서는 camphor (67.04%)로 가장 높게 나타났다. 또한 로즈마리와 라벤더 에센셜 오일과 하이드로졸의 항산화 효능을 검증해 본 결과, 두 종류의 에센셜 오일 모두 DPPH, ABTS 라디칼 소거능과, Fe2+ ion 킬레이팅 활성을 나타냈으나, alkyl 소거능은 거의 나타나지 않았다. DPPH 라디칼소거능은 로즈마리 에센셜 오일이 라벤더 에센셜 오일보다 우수한 반면, Fe2+ ion 킬레이팅 실험에서는 라벤더 에센셜 오일이 로즈마리 에센셜 오일보다 더 우수했다. 로즈마리, 라벤더하이드로졸 모두 alkyl 라디칼 소거능을 나타냈으나, 라벤더 하이드로졸만이 Fe2+ ion 소거능을 나타냈다. 특히 H2O2에 의해 유도된 Fibroblast와 HaCaT에서의 세포독성 실험에서 하이드로 졸이 에센셜 오일보다 우수한 세포사멸 억제능을 나타냈다. Constituents of the essential oil (EO)s and hydrosol of rosemary (Rosmarinus officinalis L.) and lavender (Lavandula angustifolia Mill.) were analyzed by gas chromatography-mass spectrometry (GC-MS). The identified major constituents were α- pinene (40.96%), camphor (34.44%), verbenone (45.31%), and camphor (67.04%) in rosemary EO, lavender EO, rosemary hydrosol, and lavender hydrosol, respectively. The antioxidant activity of EO and hydrosol extracted from rosemary and lavender were evaluated. Both EO showed di(phenyl)-(2,4,6-trinitrophenyl) iminoazanium (DPPH) and 2,2`-azino-bis(3-ethylbenzthiazoline- 6-sulphonic acid) free radical scavenging activities as well as Fe2+ ion chelating activity but no alkyl radical scavenging activity. Rosemary EO showed higher DPPH radical scavenging activity than lavender, whereas lavender EO showed higher Fe2+ ion chelating activity. Both rosemary and lavender hydrosols showed alkyl radical scavenging activity, but only lavender hydrosol showed an activity on Fe2+ chelating assay. Both rosemary and lavender hydrosols also protected the dermal fibroblast and the HaCaT keratinocytes against H2O2-induced cytotoxicity.

원자력 케이블용 가속열화된 CSPE의 특성에 미치는 해수 범람의 영향

신용덕(Yong-Deok Shin),전황현(Hwang-Hyeon jeon),강명균(Myeong-Kyun Kang),전준수(Jun-Soo Jeon),이승훈(Seung-Hoon Lee),김인용(In-Yong Kim),박현신(Hyun-Shin Park),이희승(Hee-Seung Lee),전안균(An-Gyun Jeon) 대한전기학회 2013 대한전기학회 학술대회 논문집 Vol.2013 No.10

Dual function of quaternary ammonium in Zn/Br redox flow battery: Capturing the bromine and lowering the charge transfer resistance

Jeon, Jae-Deok,Yang, Hyeon Sun,Shim, Joonmok,Kim, Hyun Sik,Yang, Jung Hoon Elsevier 2014 ELECTROCHIMICA ACTA Vol.127 No.-

During the charging of a Zn/Br redox flow battery, cyclic voltammetry and electrochemical impedance spectroscopy measurements were carried out in-situ. As the state of charge (SOC) increased, some polybromide complex accumulated on the Br-side electrode surface and showed a positive effect on the adsorption of bromide ion as well as bromine. The deposition of polybromide complex onto the electrode surface was identified by SEM, EDS, and Raman spectroscopy. As a result, the charge transfer resistance for bromine oxidation decreased from 2.13 ohm to 1.27 ohm as the SOC increased from 0.0% to 80.0%. This may be due to the amphiphilic characteristics of the polybromide complex. While the solution resistance for catholyte was independent of the SOC, that for anolyte sharply decreased with increasing SOC. This could be explained by the increase in zinc ion mobility and the anolyte thickness reduction by growth of zinc metal dendrites. (C) 2014 Elsevier Ltd. All rights reserved.

Clinical Characteristics of COVID-19: Clinical Dynamics of Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection Detected by Early Active Surveillance

Hyeon Jeong Suh,Kim Deok Hee,허은영,이현우,이정규,이창섭,Kim Mijeong,Jeon Yong Duk,정진원,김영근,Pyo Jin Shin,이미숙,강진숙,이명진,김백남,박상원 대한의학회 2020 Journal of Korean medical science Vol.35 No.32

Background: There is limited information describing the presenting characteristics and dynamic clinical changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosed in the early phase of illness. This study is a case series of patients with coronavirus disease 2019 (COVID-19) admitted to 11 hospitals in Korea. Methods: Patients with confirmed SARS-CoV-2 infection by positive polymerase chain reaction (PCR) testing of respiratory specimens by active surveillance that were finally discharged between February 20 and April 30, 2020 were included. Patients were classified into mild and non-mild groups on initial admission according to oxygen demand and Sequential Organ Failure Assessment score, and the mild group was followed up and subgrouped into non-aggravation and aggravation groups. Results: A total of 161 patients with SARS-CoV2 infection were enrolled. Among the mild group of 136 patients, 11.7% of patients experienced clinical aggravation during hospitalization, but there was no initial clinical parameter on admission predicting their aggravation. Fever (odds ratio [OR], 4.56), thrombocytopenia (OR, 12.87), fever (OR, 27.22) and lactate dehydrogenase (LDH) > 300 U/L (OR, 18.35), and CRP > 1 mg/dL (OR, 11.31) significantly indicated aggravation in the 1st, 2nd, 3rd, and 4th 5-day periods, respectively. PCR positivity lasted for a median of 22 days and 32 days after the onset of illness in the non- aggravation and aggravation groups, respectively. Conclusion: Old age was associated with early severe presentation. Clinical aggravation among asymptomatic or mild patients could not be predicted initially but was heralded by fever and several laboratory markers during the clinical course.

마운팅부 영향인자에 따른 래치의 예상수명 시뮬레이션과 개발기간 개선에 대한 연구

박현태(Hyeon-Tae Park),전남규(Nam-Kyu Jeon),여덕종(Deok-Jong Yeo),윤성민(Sung-Min Yoon),허상범(Sang-Bum Hur) 한국자동차공학회 2022 한국자동차공학회 학술대회 및 전시회 Vol.2022 No.11

Mostly automotive latch fatigue has been proved by predict stiffness analysis and breaking strength test or direct durability test. Durability test needs dozens of days by design lifecycle and same by changing various factors. We use MSM(Modal Superposition Method) which predicts fatigue by adapting modal stress & modal displacement in Fe-Safe, after stiffness and modal analysis using Abaqus. In addition, We proved analysis accuracy by compare direct endurance test data, expecting to be able to reduce development time by predicting design lifecycle of brand new latch system through the result.

해양 플랜트용 고압 다단 Water Injection Pump의 수치 해석적 연구

김덕수(Deok Su Kim),전상규(Sang Gyu Jeon),박원규(Warn Gyu Park),최현철(Hyeon Cheol Choi) 한국유체기계학회 2014 유체기계 연구개발 발표회 논문집 Vol.2014 No.11

사매 에탄올 추출물의 항산화 및 항염증 효과

이덕재(Deok Jae Lee),전인화(In Hwa Jeon),김현수(Hyeon Soo Kim),조일영(Il Young Cho),장선일(Seon Il Jang) 한의병리학회 2012 동의생리병리학회지 Vol.26 No.1

L1/L2 이중-밴드 GPS 수신기용 RF 전단부 설계

김현덕(Hyeon-Deok Kim),오태수(Tae-Soo Oh),전재완(Jae-Wan Jeon),김성균(Seong-Kyun Kim),김병성(Byung-Sung Kim) 한국전자파학회 2010 한국전자파학회논문지 Vol.21 No.10

본 논문에서는 L1/L2 이중-밴드 GPS(Global Positioning System) 수신기용 RF 전단부를 설계하였다. 수신기는 Low IF 구조이며, 인덕터를 사용하지 않는 광대역 저잡음 증폭기(Low Noise Amplifier: LNA)와 이미지 제거를 위하여 다상 여과기(poly-phase filter)를 포함하는 quadrature 하향 변환 주파수 혼합기(quadrature down-conversion mixer) 및 전류 모드 논리(Current Mode Logic: CML) 주파수 분배기로 구성되어 있다. 저잡음 증폭기와 이미지 제거 주파수 혼합기는 높은 이득과 헤드룸 문제를 해결하기 위하여 전류 블리딩 기술을 이용하였으며, 광대역 입력 정합을 구현하기 위하여 공통 드레인 피드백을 이용하였다. 0.18 ㎛ CMOS 공정을 이용해 제작된 RF 전단부는 L1 밴드에서 38 ㏈ 그리고 L2 밴드에서 41 dB의 이득을 보이며, IIP3는 L1 밴드에서 ?29 ㏈m, L2 밴드에서는 ?33 ㏈m이다. 입력 정합은 50 ㎒에서 3 ㎓까지 ?10 ㏈ 이하를 만족하며, 잡음 지수(Noise Figure: NF)는 L1 밴드에서는 3.81㏈, L2 밴드에서는 3.71 ㏈를 보인다. 이미지 주파수 제거율은 36.5 ㏈이다. 설계된 RF 전단부의 칩 사이즈는 1.2×1.35 ㎟이다. The RF front-end for L1/L2 dual-band Global Positioning System(GPS) receiver is presented in this paper. The RF front-end(down-converter) using low IF architecture consists of a wideband low noise amplifier(LNA), a current mode logic(CML) frequency divider and a I/Q down-conversion mixer with a poly-phase filter for image rejection. The current bleeding technique is used in the LNA and mixer to obtain the high gain and solve the head-room problem. The common drain feedback is adopted for low noise amplifier to achieve the wideband input matching without inductors. The fabricated RF front-end using 0.18㎛ CMOS process shows a gain of 38 ㏈ for L1 and 41 ㏈ for L2 band. The measured IIP3 is ?29 ㏈m in L1 band and ?33 ㏈m in L2 band, The input return loss is less than ?10 ㏈ from 50 ㎒ to 3 ㎓. The measured noise figure(NF) is 3.81 ㏈ for L1 band and 3.71 ㏈ for L2 band. The image rejection ratio is 36.5 ㏈. The chip size of RF front end is 1.2×1.35 ㎟.

Increase in the Contents of Ginsenosides in Raw Ginseng Roots in Response to Exposure to 450 and 470 nm Light from Light-Emitting Diodes

박상언,Deok-Jong Ahn,Hyeon-Jeong Jeon,Tae Ryong Kwon,Hyoun-Sub Lim,Bo-Seong Choi,백광현,Hanhong Bae 고려인삼학회 2012 Journal of Ginseng Research Vol.36 No.2

An light-emitting diode (LED)-based light source was used as a monochromatic light source to determine the responses of raw ginseng roots (Panax ginseng Meyer) to specifi c emission spectra with respect to the production of ginsenosides. The ginsenoside content in the ginseng roots changed in response to the LED light treatments at 25 relative to the levels in the control roots that were treated in the dark or at 4 for 7 d. Ginseng roots were exposed to LEDs with four different peak emission wavelengths,380, 450, 470, and 660 nm, in closed compartments. Compared with the control 4-treated roots, roots that were treated with 450 and 470 nm light showed a signifi cantly increased production of ginsenosides (p<0.05), with increases of 64.9% and 74.1%,respectively. The contents of the ginsenosides Rb2, Rc, and Rg1 were signifi cantly higher (p<0.05) in the 450 and 470 nm-treated root samples. The ratio of protopanaxadiol ginsenosides (Rb1, Rb2, Rc, and Rd) to protopanaxatriol ginsenosides (Rg1, Rg2, Re,and Rf) was signifi cantly higher (p<0.05) in the 450 and 470 nm-treated root samples than in the control 4-treated roots. This is the fi rst report that demonstrates the increase and conversion of ginsenosides in raw ginseng roots in response to exposure to LED light.