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윤혜원,심기남,나선경,송도경,정정화,정가영 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2
Double primary cancers are two independently developed cancers in an individual. There have been some reports on double primary cancer since Billroth reported it for the first time in 1879. Double primary cancer of the stomach and esophagus has been revealed a very low incidence worldwide. The incidence of an esophageal cancer with another primary cancer is reported to be 9.5∼27%, but double primary cancers in the esophagus and stomach have been rarely reported to our knowledge. In this study, we present here a case of double primary esophageal and stomach cancer in a 66-year-old man because of progressive dysphagia.
이혜경,나운환 한국장애인고용촉진공단 고용개발원 2009 장애와 고용 Vol.19 No.2
20여년의 역사를 지닌 직업재활시설은 중증장애인을 위한 고용과 훈련의 장으로써 역할을 해오고 있으나, 직업재활시설 운영의 효율성에 대하여 실제적으로 연구된 적이 거의 없다. 지금까지 의 직업재활시설 운영에 대한 평가는 단순지표체계에 의한 평가로 정부 예산의 타당성이나 시설 운영에 바람직한 운영방향을 제시하는데에 제한이 있고, 시설 운영의 효율성에 대한 정확한 분석을 얻기 어렵다는 한계가 있다. 따라서 본 연구에서는 자료포락분석을 활용하여 직업재활시설의 상대적 효율성 분석을 통해 직업재활시설이 보다 효율적으로 운영될 수 있는 방안을 제시하고자 하였다. 연구결과 첫째, 종사자 수가 많은 시설일수록 근로장애인들의 월평균 임금이 높으며, 직업재활과정에 따른 사업을 수행하는 시설일수록 재활프로그램 실적, 취업알선 및 취업실적 등의 전반적 실적도 높았으나 상담 및 평가실적과 재활프로그램의 실적이 높을수록 근로장애인의 월평균 임금액은 줄어드는 음의 상관관계가 있는 것으로 분석되어, 생산활동 보다 상담과 평가 등의 재활훈련과 프로그램에 시간을 많이 투자할수록 생산력이 떨어지는 것으로 분석되었다. 둘째, 개별 직업재활시설 효율성 분석 결과 효율적인 시설이 더 많았으며, 비효율적인 시설의 공통점은 투입요인이 산출요인에 비하여 과잉공급되고 있기 때문인 것으로 나타나, 업재활시설이 보다 효율적으로 운영되기 위한 구체적 방안을 제시하였다. This study was designed to present efficient operational directions and the related tasks for vocational rehabilitation facilities via an analysis of their relative efficiency. In order to achieve the objectives of this study, first it was derived the efficiency factors by analyzing the operational status of the facilities. Then, it was analyzed the co-relationship among the factors and the efficiency of the facilities by using the DEA (Data Envelopment Analysis) method. The study outcome is summarized as follows: First, the input and output variable factors revealed that those facilities that perform more counseling or assessment activities have more rehabilitation programs. The vocational rehabilitation facilities perform their business operations according to a series of vocational rehabilitation service systems. However, it was found that facilities which have more rehabilitation programs pay less monthly average wages to the persons with disabilities, indicating that there exists a negative co-relationship between the two factors. Second, eleven out eighteen DMUs were classified as efficient vocational rehabilitation facilities through analysis of the efficiency of individual facilities. It was revealed that the common causes for their inefficiency were excessive input factors coupled with insufficient output factors. The variable factors that most affect the efficiency of vocational rehabilitation facilities are not their input budget or number of employees but their insufficient efforts and the lack understanding of their efficiency. Therefore, the vocational rehabilitation facilities cannot achieve efficiency simply on the basis of government input or the number of employees. Indeed, they need to strive to enhance their efficiency or output factors with limited input factors. nalysis(DEA)
Dansyl 유도체화와 역상 고성능액체크로마토그래피에 의한 아미노산의 정량
나혜경(Hye-Kyeong Na),전덕영(Deok-Young Jhon),홍윤호(Youn-Ho Hong) 한국식품영양과학회 1994 한국식품영양과학회지 Vol.22 No.6
고성능 액체크로마토그래피를 이용하여 간편하고 신속하며 경제적인 아미노산의 정량방법을 연구한 결과, Nova-Pak C_(18) 역상컬럼을 통한 아미노산 Dansyl유도체의 분리조건을 결정하였다. 용매 A(인산 완충용액(200mM, PH 6.8) 15%, 아세토니트릴 11%, 물 74%)와 용매 B (아세토니트릴 65%, 메탄올 28%, 물 7%)를 각각 88%, 12%에서 시작하여 20%, 80%까지 50분 동안 linear하게 용매를 전개 시킨 결과 Asn과 Gln을 포함한 단백질을 구성하는 20개 아미노산의 완전한 분리가 50분내에 이루어졌으며, 최대 감지 수준은 picomole 정도로 해상력 또한 우수하였고, 머무름 시간의 재현성은 평균±0.05분 이하였다. 이러한 조건으로 글루타민 합성효소의 산 가수분해물의 아미노산 조성을 분석하여 아미노산 정량의 타당성을 검토하였다. 그리고 혈청, 간장, 두유, 우유 그리고 요구르트 중의 유리 아미노산 조성을 조사한 결과, 사람의 혈처에서는 Ala이 가장 높게 검출되었고, 간장에서는 Asp와 Glu, 두유의 경우 Ala과 Thr 그리고 우유와 요구르트에서는 Pro이 가장 높게 나타났다. This experiment was carried out to determine the separation condition of 1-dimethylaminonaphthalene-5-sulfonyl(Dansyl) derivatives of amino acids by reverse-phase high performance liquid chromatography with Nova-Pak C_(18) column. Determined solvent system was solvent A (200mM phosphate buffer pH 6.8 15%, acetonitrile 11%, water 74%) and solvent B(acetonitrile 65%, methanol 28%, water 7%). Linear gradient of solvent B was applied from 12% to 80% for 50min. Complete separation of 20 amino acids including asparagine and glutamine which constitute protein was achieved within 50min. As the detection limit was the range of picomole, the resolution power was excellent. Reproducibility of the retention time was less than mean±0.05min. According to the above optimum chromatographic conditions, the amino acid composition of some food and human blood was examined. The most affluent amino acid was alanine in human blood, aspartic acid and glutamic acid in soy sauce, alanine and threonine in soy milk and proline in milk and yoghurt.
Study on the Distribution of Carbapenem-Resistant Enterobacteriaceae (CRE) in Busan, 2022
Kyeong-A Kim,Hye-sook Heo,Hye-jun Kim,Su-Jin Shin,Young-Ran Na 대한미생물학회 2023 Journal of Bacteriology and Virology Vol.53 No.2
This study was conducted on the incidence of as carbapenemase-resistant Entero-bacteriaceae (CRE) infection and carbapenemase-producing Enterobacteriaceae(CPE) gene distribution in Busan to prepare basic data for preventing the spreadof CRE infection by confirming the regional characteristics of CRE infection. Thetotal of 2,429 strains from 92 clinics were obtained from rectal swab, sputum,stool, urine, blood, wound, bile, transtracheal aspiration, pus, ascetic fluid, bronchialwashing, catheter tip, genital, skin, sore, tissue, from January to December 2022. The CRE infection was tested by the method tested by the Korea Disease Controland Prevention Agency (KDCA). Species identification was confirmed by VITEK 2. Klebsiella pneumoniae which was detected in 1,698 (70.2%), was the mostcommon isolated CRE, followed by Escherichia coli in 430 (17.8%), Enterobactercloacae 90 (3.7%) and Citrobacter freundii 44 (1.8%). Among the identifiedCREs, 2,029 (83.5%) strains were identified as CPE. More than half of the detectedCPE types were 1,680 (69.2%) of KPC-2 (Klebsiella pneumonia carbapenases-2),followed by 166 (6.8%) of NDM-1 (New Delhi metallo-β-lactamase-1), 58 (2.4%)of KPC-3, and 51 (2.4%) of NDM-5. These findings provide good basic data forcomprehensive surveillance of CREs, suggesting that KPC and NDM are widespreadin Busan. In the analyzed CRE samples, Ertapenem resistance was the most com-mon at 99.5%, imipenem resistance 72.3%, meropenem resistance 67.9%, anddoripenem resistance 48.7%. It is expected that this study can be used as basicdata for preparing suitable countermeasures against CRE infection in the com-munity in the future.