소화기 ; 대전 지역에서 급성 A형 간염의 유전자형에 따른 임상 특성 고찰

이영우 ( Young Woo Lee ),양현웅 ( Hyeon Woong Yang ),이진아 ( Jin A Lee ),윤기호 ( Ki Ho Yun ),양성은 ( Seong Eun Yang ),이민지 ( Min Ji Lee ),박세영 ( Se Young Park ),김새희 ( Sae Hee Kim ),이향이 ( Hyang Ie Lee ),이윤정 ( Yun Ju 대한내과학회 2011 대한내과학회지 Vol.80 No.5

목적: B형 간염이나 C형 간염 등은 유전자형에 따른 차이가 알려져 있지만, 국내에서 증가하는 IIIA 유전자형과 기존의 IA 유전자형에 의한 간염의 차이가 거의 알려진 바 없다. 따라서 대전 지역에서 발생한 급성 A형 간염의 유전자형에 따른 차이를 알고자 한다. 방법: 2009년 11월부터 2010년 6월까지 급성 A형 간염으로 진단되면서 유전자형이 확인된 81명의 환자를 대상으로 임상적 소견들과 검사실 소견들을 전향적으로 연구하였다. 결과: 평균 나이는 32.6±7.4세이며, 평균 입원 기간은 7.7±2.4일이었다. 직업은 서비스직, 사무직 그리고 교육직이 가장 많았다. 유전자형 간의 급성 간염에 따른 증상들의 종류는 별다른 차이가 없었다. 유전자형에 따른 증상의 빈도는 IIIA 유전자형에서 구토와 설사가, IA 유전자형에서는 복통과 피부 반점이 상대적으로 많았다. 검사실 소견에서는 IIIA 유전자형에서 헤모글로빈의 평균, CRP 평균, AST 최대 수치 평균은 상대적으로 유의하게 높았다. 그리고 AST와 ALT 및 총 빌리루빈 최대 수치들과 INR의 수치가 IIIA 유전자형에서 상대적으로 높게 분포하는 경향을 보였다. 결론: 대전 지역에서 유행하는 급성 A형 간염에서 IIIA 유전자형에 따른 급성 간염은 기존의 IA 유전자형과 차이가 있을 것으로 보이며, 다기관 연구를 통한 심도 깊은 연구가 필요하겠다. Background/Aims: Acute viral hepatitis A is a major health problem in Korea and the influx of genotype IIIA is thought to be one reason. We examined the differences in the clinical characteristics and laboratory findings of genotypes IA and IIIA in Daejeon. Methods: From November 2009 to June 2010, 81 patients positive for IgM anti-HAV were enrolled prospectively. The hepatitis A was genotyped using real-time polymerase chain reaction. The clinical characteristics and laboratory results were compared on the Results: The mean patient age was 32.6±7.4 years. The mean hospitalization was 7.7±2.4 days. The patient occupation varied. Clinically, vomiting and diarrhea were relatively more prevalent in genotype IIIA than in IA. Abdominal pain and skin spots were relatively more prevalent in genotype IA than in IIIA. The hemoglobin, peak aspartate aminotransferase (AST) level, and C-reactive protein were statistically higher in genotype IIIA than in IA. The distributions of the peak AST, alanine aminotransferase (ALT) and total bilirubin values tended to be perched in genotype IIIA than in IA. The international normalized ratio (INR) tended to be slightly prolonged in genotype IIIA than in IA. Conclusions: Recently, genotype IIIA of acute viral hepatitis A has become prevalent in Daejeon. Hepatitis A genotype IIIA probably causes worse laboratory abnormalities than genotype IA.

원료 배합 및 소금 농도에 따른 대맥장의 품질 특성

강혜정 ( Hye Jeong Kang ),유진아 ( Jin A Yoo ),박정미 ( Jung Mi Park ),김상희 ( Sang Hee Kim ),송인규 ( In Gyu Song ),최혜선 ( Hye Sun Choi ),윤향식 ( Hyang Sik Yoon ) 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.2

검은콩 속성장인 대맥장의 실용화를 위해 검은콩과 보리 함량을 달리하여 메주를 만든 후, 소금 농도와 수분 첨가량을 다르게 하여 장을 담근 후 발효기간 중 품질 특성을 분석하였다. 대맥장이 발효되면서 pH는 점차 감소하였고, 총산은 증가하였다. 아미노태 질소 함량은 발효 중 현저하게 증가하였으며, 15% 염도에서 보다 10% 염도 조건에서 아미노태 질소 함량이 높은 것으로 나타났다. 대맥장 발효 70일째, 일반세균수는 발효기간에 따른 세균수의 차이를 보이지 않았으며, 유산균의 경우 10% 염도에서 발효기간이 증가함에 따라 2~3 log cycle 정도 감소하였고, 처리구 A와 15% 염도인 처리구 D에서는 유산균이 검출되지 않았다. 총 폴리페놀 함량은 발효 중 증가하였으며, 10% 염도 조건에서 15% 염도 조건에서 보다 높은 값을 나타내었다. DPPH 라디칼 소거 활성능은 발효기간에 따라 증가하였으며, 발효 70일째에는 처리구 간 차이가 없는 것으로 확인되었다. 발효 70일된 속성장의 관능평가를 실시한 결과, 전반적인 기호도는 검은콩과 보리를 5:5 또는 7:3의 비율로 메주를 만든 후, 10% 염도에서 메주의 1.5배의 수분을 첨가하여 제조한 B와 C처리구가 우수한 것으로 나타났다. This study investigated the quality characteristics of black soybean paste(Daemacjang) with black soybean content and salt concentration. The total acidity increased as the pH decreased during fermentation period. The amino-type nitrogen content of all samples increased significantly during fermentation time. Total cell counts was not significantly different during fermentation, and mold counts decreased at 3 log cycles. The cell counts of lactic acid bacteria decreased approximately 2 to 3 log cycles in 10% salt concentration (treat B and C), and were not detected in treat A and D. Total polyphenol contents of treat A, B, and C were 42.77%, 52.99% and 52.95% during fermentation up to 70days, respectively, which was higher than D (39.86%). In a sensory evaluation, treat B showed the highest scores for overall acceptability.

Estrogen Receptor-${\alpha}$ 유전자 5' 영역의 Single Nucleotide Polymorphism의 탐색과 한우와 Holstein에서 번식능력 및 산유능력과의 관계

염규태,전향아,박해금,김영신,김현,김재환,성환후,조영무,조재현,고응규,Yeom, Gyu-Tae,Jeon, Hyang-A,Park, Hae-Geum,Kim, Young Sin,Kim, Hyun,Kim, Jae Hwan,Seong, Hwan-Hoo,Cho, Young Moo,Cho, Jae-Hyeon,Ko, Yeoung-Gyu 한국동물번식학회 2014 Reproductive & developmental biology Vol.38 No.3

This study was conducted for SNPs in the 5'-regions of estrogen receptor-${\alpha}$ (ESR-${\alpha}$), and association with calving interval (CI), service per conception (SPC) and 305 days milk yield in Hanwoo and Holstein dairy cattle. The genetic improvement was incurred low reproduction performance. The objective of this study was to investigate connections between single nucleotide polymorphisms (SNP) of Estrogen receptor-${\alpha}$ (ESR-${\alpha}$) with reproduction performance (calving interval, service per conception, and 305 d milk yield) in Hanwoo and Holstein dairy cattle. Hanwoo and Holstein blood samples were collected from 183 and 124 dam of breeding farms and DNA was extracted. Primer design was based on NCBI GenBank (Accession No. AY340579). The PCR-RFLP method with Bgl I was used to genotype the cattle. The result showed two variants of the ESR-${\alpha}$ gene. The Bgl I cut the 492 bp amplification product into 322 bp and 170 bp fragments for allele G, while allele A remained uncut, resulting in two restriction fragments for homozygote G/G and three fragments for heterozygote A/G. We found two of different genotypes in these breeds, A/G and G/G. In Hanwoo, the A/G genotype frequency was 0.13, and G/G was 0.87. The CI of A/G was $382.18{\pm}10.03$ days, and G/G was $381.69{\pm}5.22$ days. The SPC of A/G was $1.62{\pm}0.16$, and G/G was $1.32{\pm}0.04$. While CI showed no significance difference, SPC exhibited significant difference (p<0.05). In Holstein cattle, the frequency of genotype A/G was 0.02 and G/G was 0.98. The 305 days milk yield of A/G was $7,253.00{\pm}936.00kg$ and of G/G was $8,747.51{\pm}204.88kg$, showing no significant difference.

Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing

Park, Sun-Im,Im, Sun-A,Kim, Ki-Hyang,Lee, Chong-Kil The Korean Association of Immunobiologists 2011 Immune Network Vol.11 No.6

Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the $H-2K^b$-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.

Phase Separating Bulk Metallic Glass: A Hierarchical Composite

Park, Byung Joo,Chang, Hye Jung,Kim, Do Hyang,Kim, Won Tae,Chattopadhyay, Kamanio,Abinandanan, T. A.,Bhattacharyya, Saswata American Physical Society 2006 Physical Review Letters Vol.96 No.24

<P>Phase separating systems present a unique opportunity for designing composites with hierarchical microstructure at different length scales. We report here our success in synthesizing phase separating metallic glasses exhibiting the entire spectrum of microstructural possibilities expected from a phase separating system. In particular, we report novel core shell and hierarchical structures of spherical glassy droplets, resulting from critical wetting behavior and limited diffusion. We also report synthesis of a bulk phase separating glass in a metallic glass system. The combination of unique core shell and hierarchical structures in metallic glass systems opens a new avenue for the microstructure design of metallic glasses.</P>

Evaluation of alloying effect on the formation of Ni-Fe nanosized powders by pulsed wire discharge

Park, Gyu-Hyeon,Lee, Gwang-Yeob,Kim, Hyeon-Ah,Lee, A-Young,Oh, Hye-Ryeong,Kim, Song-Yi,Kim, Do-Hyang,Lee, Min-Ha Elsevier 2016 Materials science and engineering B. Advanced Func Vol.212 No.-

<P>This study investigates the effects of varying the explosion time and charging voltage of pulsed wire discharge (PWD) on the mean particle size, dispersibility and alloying reliability of powders produced from pure Ni and Ni-plated Fe wires. It was found that with increasing charging voltage, the mean particle size of Ni powders is reduced from 40.11 +/- 0.23 to 25.63 +/- 0.07 nm, which is attributed to a change in the extent of super heating with particle size. Nanosized powders of Ni-Fe alloy with a mean particle size between 25.91 +/- 0.24 and 26.30 +/- 0.26 nm were also successfully fabricated and found to consist of particles with a gamma-(Ni/Fe) core and FeO shell. The reliability for the optimization of processing parameters to control particle sizes is also evaluated. (C) 2016 Elsevier B.V. All rights reserved.</P>

Pancreatic panniculitis in alcoholic pancreatitis with multiple pseudocysts

( A Reum Cho ),( Ki Hyun Rhyu ),( Young Woo Kang ),( Young Woo Choi ),( Kyu Chan Huh ),( Tae Hee Lee ),( Sun Moon Kim ),( Kyung Ho Song ),( Hoon Sup Koo ),( Moon Hyang Park ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Pancreatic panniculitis is a rare complication of pancreatic disease appearing in approximately 2-3%. Its pathogenesis is still not well understood, but the release of pancreatic enzymes may play role, leading to subcutaneous fat necrosis. Tender, inflammatory nodules typically develop on the lower legs. Pancreatic panniculitis is usually confirmed by skin biopsy. Clinicians with less experiences, may be unable to identify pancreatic panniculitis. We report the case of a pancreatic panniculitis associated with pancreatitis. A 46-year-old man was admitted to our hospital with a 2 weeks history of abdominal pain after heavy drinking. He also presented with loss of appetite and fever. Physical examination on admission did not inspect any skin lesions. The results of laboratory tests were as follows: white blood cell count 20.9 × 109/L, lipase 2,144 U/L, pancreatic amylase 1,787 U/L and C-reactive protein 27 mg/dL. Liver function tests were normal. Computed tomography revealed multiple pseudocysts, fluid collection and underlying chronic pancreatitis (Fig. A). He was treated supportively for acute alcoholic pancreatitis and administered empirical antibiotics. Abdominal pain and fever relievedafter 5 days. On hospital day ten, multiple tender nodules on both legs (Fig. B). Histopathological examination showed lobular panniculitis without vasculitis, with fat necrosis, ghost adipocytes (anucleate adipocytes) and saponification (Fig. C). The nodules resolved over the course of 2 weeks.

머신러닝을 이용한 데이터 기반 ESS 최적 운영 계획 수립에 관한 연구

박향아(Hyang-A Park),변길성(Gil-Sung Byeon),손완빈(Wan-Bin Son),조형철(Hyung-Chul Cho),조경희(Kyeong-Hee Cho),김종율(Jong-Yul Kim) 대한전기학회 2020 대한전기학회 학술대회 논문집 Vol.2020 No.7

개별 작업치료와 통합된 집단회상프로그램이 장기요양시설 노인의 심리적 건강과 인지기능에 미치는 효과

이향숙 ( Hyang Sook Lee ),윤정애 ( Joung Ae Yoon ),노종수 ( Jong Su Noh ),차정진 ( Jung Jin Cha ),강선애 ( Sun Ae Kang ),강현아 ( Hyun A Kang ),김은미 ( Eun Mi Kim ),박종현 ( Jong Hyun Park ),이보람 ( Bo Ram Lee ) 고령자·치매작업치료학회 2012 고령자.치매작업치료학회지 Vol.6 No.2

목적: 본 연구는 개별 작업치료와 통합된 집단회상프로그램이 장기요양시설 노인의 심리적 건강과 인지능력에 미치는 효과를 알아보고자 하였다, 연구방법: 대상자는 장기시설 노인 중 18명을 각 9명씩 무작위로 실험군과 대조군에 배정하였다. 실험군은 8주간 주 1회 30분씩 개인 작업치료를 실시하고, 집단회상프로그램은 주 2회씩 총16회(30~40)를 실시하였다. 사전·사후검사는 심리적 건강상태(우울, 삶의 질)를 알아보기 위해 한국형 노인우울검사(KGDS)와 삶의 질 척도(SF-8)를 사용하였고, 인지기능은 한국판 간이정신상태 판별검사(MMSE-K)와 신경행동학적 인지상태검사(NCSE)의 기억 항목을 사용하였다. 분석방법은 실험군과 대조군 각각의 중재 전, 후의 차이를 알아보기 위해 월콕슨 부호순위검정을 사용하였고, 두 군 간의 중재 후 변화량의 차이를 알아보기 위해 Mann-Whitney 검정을 사용하였다, 연구결과: 중재 전, 후 비교에서 실험군은 심리적 건강상태인 우울과 삶의 질에서 통계적으로 유의한 차이를 보여 향상되었으나, 인지기능은 통계적으로 유의한 차이가 없었다. 대조군은 우울과 삶의 질, 인지기능에 통계학적 차이를 보이지 않았다. 두 군 간의 중재 전, 후 변화량의 차이비교에서는 한국 판간이 정신상태 판별검사(MMSE-K)변화량에서만 실험군이 대조군에 비해 변화량이 통계학적으로 유의한 차이를 보였다, 결론: 개별 작업치료와 통합된 집단회상 프로그램은 장기시설 노인들에게 심리적 안정과 인지기능 변화에 긍정적인 효과가 있었다. 따라서 장기요양시설에서 개별 작업치료와 통합된 집단회상프로그램을 작업치료의 효과적인 방법으로 제안하고자 한다. Purpose: This study aims to investigate the effect of individual occupational therapy and the integrated group reminiscence counseling on psychological health and cognitive function of the elderly at long-term care facilities, Methods :Among the elderly at long-term care facilities, each eight people were randomly selected as experimental and control groups, respectively. Individual occupational therapy and group remi?niscence counseling were given to experimental group for 30minutes once a week and 30-40 minutes twice a week (total 16 times) for 8 weeks, respectively. Pre-and post-tests were per?formed using KGDS and SF-8 for psychological health(depression and quality of life), MMSE-K and memory item of NCSE for cognitive function, respectively. Wilcoxon sign?ed-ranks tests was used to examine the difference before and after the intervention in two groups, respectively. Mann-Whitney test was used to examine the difference in changes be?tween two groups after the intervention, Results: Experimental group sh wed statistically significant difference in depression and quality of life which were psychological health after intervention, but control group showed no statistically significant difference. Changes of MMSE-K after the intervention between two groups showed statistically significant difference, Conclusion: Individual occupational therapy and group reminiscence counseling gave the positive impact on psychological health and changes in cognitive function of the elderly at care facilities. Therefore, I would like to propose the development of individual occupational therapy and in?tegrated group reminiscence counseling as an effective method of occupational therapy.

자바 기반의 태양광 출력 예측 프로그램 개발

박향아(Hyang-A Park),김종율(Jong-Yul Kim),김응상(Eung-Sang Kim) 대한전기학회 2014 대한전기학회 학술대회 논문집 Vol.2014 No.7