구자가 卵巢摘出로 誘發된 흰쥐의 骨多孔症에 미치는 影響 (2)

徐富一,金先熙,卞晟僖,金美麗 대한본초학회 1998 大韓本草學會誌 Vol.13 No.2

This study was performed to investigate the effects of Allii Tuberosi Semen(菲子) on osteoporosis after ovariectomy in rats. Control group received a daily po administration of normal saline for 4 weeks after oophorectomy(OVX). The other experimental group received a daily po administration of water extract of Allii Tuberosi Semen for 4 weeks after oophorectomy(OVX-ATS). Therefore, we measured levels of calcium, phosphorus, ash weights in femur. These results were as follows : 1. In the level of bone phosphorus, the result of OVX was 63.85±1.86㎎/㎗, but the result of OVX-ATS was 68.18±0.85㎎/㎗. But there was no statistical significance. 2. In the level of bone calcium, the result of OVX was 141.66±2.19㎎/㎗, but the result of OVX-ATS group was 164.82±3.74㎎/㎗. And the result of OVX-ATS showed significant increase in comparison with OVX. 3. In the level of bone ash weight, the result of OVX was 0.31±0.005(g), but the result of OVX-ATS was 0.33±0.002(g). And the result of OVX-ATS showed significant increase in comparison with OVX. The observations from these studies and the past studies(=A study on the effects of Allii Tuberosi Semen in ovariectomized osteoporosis of rats) suggest possible protective effect of Alli Tuberosi Semen water extract against bone loss in ovariectomized rats.

비만 치료 및 예방에 대한 한약의 효능 연구(Ⅱ) : 4종 처방이 비만 흰쥐의 면역조직화학적 변화에 미치는 영향

金蓮燮,卞晟僖,徐富一,金相贊,國萬,趙應行 대한본초학회 2000 大韓本草學會誌 Vol.15 No.1

We had experiment with several prescriptions in order to find cure and prevention effects for an obesity. We fed control gmup rats high fat diet and administered normal saline for Bweeb. And we fed experimental gmup ram high fat diet and administered exmct of four prescriptions for Bweek. The result were as follows: 1. The size of the epididymal fat cell of rats in Bikam-whan, Chekamhanghyuluiyiin-rang and Chekambohyulansin-tang groups showed a significant decrease in comparison with control group. 2. The fat drops area in hepatic lobule of rats in Bikam-whan, Cheknmhanghyuluiyiin-rang, Chekambohyulonrin-tang, and Chekambangpungrongseong-san groups showed a significant decrease in comparison with control group. 3. The area of the insulin granuls in islet of rats in Bikam-who4 Chekamhnnghyuluiyiin-tang and Chekambohyulonrin-tong group showed a significant decrease in comparison with control group. According to above these results, Bikam-whan. Cheknmhonghyuluiviin-tnng and Chekambohyulonrin-tang have shown to be capable of cure and prevent for an obesty.

마우스에서 자외선조사에 의한 피부주름형성에 대한 생약추출물의 억제효과

구성근, 배부희, 허진주, 미가, 강봉수, 김준형, 남상윤, 윤영원, 김종수, 이범준 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.3

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牧楡湯이 人體 肺癌細胞의 變化에 미치는 影響에 關한 分子生物學的 硏究

李炯周,金相贊,徐富一,金先熙,卞晟僖 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

This experimental study was performed to investigate the effects of Mokyou-Tang on cell cycle and gene expressions of human lung cancer cell. I examined the cell cycle progression and cell cycle-related gene expression in A549 using a flow cytometry and a quantitative PT-PCR analysis. The treatment groups, in accordance with concentration of Mokyou-Tang were classified as 3 group(MYT 100㎕/㎖, MYT 500㎕/㎖, MYT 1,000㎕/㎖), and according to treatment time, were classified as 2 group(24hours, 48hours). The results were summarized as follows; 1. In cell cycle stage, MYT 100㎕/㎖(48hours) and 1000㎕/㎖(48hours) groups were increased as compared with control group, especially 1000㎕/㎖(48hours) group showed eminent increase. 2. In p53 gene, MYT 500㎕/㎖(48hours) and 1000㎕/㎖(48hours) groups showed eminent suppressive effect to cancer cell. 4. CDKNI gene was decreased in all treatment groups, this mean that MYT has suppressive effect to proliferation of cancer cell. 4. In GADD45 gene was decreased in all treatment groups, this mean that MYT has suppressive effect to proliferation of cancer cell. The results suggest that MYT promotes G1 cell cycle arrest and suppresses the proliferation of cancer cell. Thus, it seems likely that MYT has suppressive effect to proliferation of lung cancer cell.

Association of Polymorphisms in Stress-Related TNFα and NPY Genes with the Metabolic Syndrome in Han and Hui Ethnic Groups

Bu, De-Yun,Ji, Wen-Wu,Bai, Dan,Zhou, Jian,Li, Hai-Xia,Yang, Hui-Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Background: Metabolic syndrome (MS) is a cluster of complicated disorders caused by the interactive influencing factors of heredity and environment, which predisposes to many cnacers. Results from epidemic research indicate that stress is tightly related to the pathogenesis of MS and neoplasia. This paper aims to investigate the association between psychological stress and MS with respect to the tumor necrosis factor alpha (TNF${\alpha}$) and neuropeptide Y (NPY) genes in the Han and Hui ethnic groups. Methods: All subjects for this case-control study matched strict enrollment criteria (nationality, gender and age) and lived in the city of Wu Zhong of Ningxia Province in China. The enrolled group contained 102 matched pairs of Hui ethnic individuals and 98 matched pairs of Han ethnic individuals. Enrolled subjects completed the general Symptom Checklist-90 (SCL-90). The TNF${\alpha}$-308G/A variant and NPYrs16147 polymorphism were detected in case (81 males, 119 females) and control (81 males, 119 females) groups by polymerase chain reaction (PCR) amplification. Results: Nine factors of the SCL-90 were found to be statistically different (p<0.05) between case and control groups. The homozygous mutant genotype (AA) and the mutant allele (A) of the TNF${\alpha}$-308G/A gene were less frequently observed in the control population compared to the case group. The odds ratio (95% confidence interval) in "Allele" for MS was 2.28 (1.47-3.53), p=0.0001, while "OR" was 1.11 (0.83-1.47), p=0.15, for the NPYrs16147 gene polymorphism. Conclusions: Psychological stress has been positively associated with MS. A previous study from our group suggested there were differences in the level of psychological stress between Hui and Han ethnic groups. Furthermore, we found that the stress-related TNF${\alpha}$ gene was associated with MS for both Han and Hui ethnic groups. In contrast, NPY may be a possible contributor to MS and associated cancer for the Han ethnic group.

The Stent-Assisted Coil-Jailing Technique Facilitates Efficient Embolization of Tiny Cerebral Aneurysms

Cong-Hui Li,Xian-Hui Su,Bo Zhang,Yong-Feng Han,Er-Wei Zhang,Lei Yang,Dong-Liang Zhang,Song-Tao Yang,Zhen-Quan Yan,Bu-Lang Gao 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.6

Objective: Tiny cerebral aneurysms are difficult to embolize because the aneurysm’s sac is too small for a single small coil, and coils within the aneurysm may escape from the confinement of a stent. This study was performed to introduce the stent-assisted coil-jailing technique and to investigate its effect on the coil embolization of tiny intracranial aneurysms. Materials and Methods: Sixteen patients with tiny intracranial aneurysms treated with the stent-assisted coil-jailing technique between January 2011 and December 2013 were retrospectively reviewed and followed-up. Results: All aneurysms were successfully treated with the coil-jailing technique, and at the end of embolization, complete occlusion of the aneurysm was achieved in 9 cases (56.3%), incomplete occlusion in 6 (37.5%), and partial occlusion in 1 (6.3%). Intraprocedural complications included acute thrombosis in one case (6.3%) and re-rupture in another (6.3%). Both complications were managed appropriately with no sequela. Follow-up was performed in all patients for 3–24 months (mean, 7.7 months) after embolization. Complete occlusion was sustained in the 9 aneurysms with initial complete occlusion, progressive thrombosis to complete occlusion occurred in the 6 aneurysms with initial near-complete occlusion, and one aneurysm resulted in progressive thrombosis to complete occlusion after initial partial occlusion. No migration of stents or coils occurred at follow-up as compared with their positions immediately after embolization. At follow-up, all patients had recovered with no sequela. Conclusion: The stent-assisted coil-jailing technique can be an efficient approach for tiny intracranial aneurysms, even though no definite conclusion regarding its safety can be drawn from the current data.

Protective Effect of Herbal Extracts against Skin Wrinkle Induced by UVB Irradiation in Hairless Mice

Jong Soo Kim, Bu-Hui Bae, Hyun Ji Park, Bong Su Kang, Dang-Young Kim, Seon-Young Hwang, Byung Kuk Ahn, Sang Yoon Nam, Young Won Yun, Beom Jun Lee 충북대학교 동물의학연구소 2010 Journal of Biomedical and Translational Research Vol.11 No.3

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Adaptive Robust Control based on RBF Neural Networks for Duct Cleaning Robot

Bu Dexu,Yu Hongshan,Sun Wei,Wang Cong,Zhang Hui 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.2

In this paper, a control strategy for duct cleaning robot in the presence of uncertainties and various disturbances is proposed which combines the advantages of neural network technique and advanced adaptive robust theory. First of all, the configuration of the duct cleaning robot is introduced and the dynamic model is obtained based on the practical duct cleaning robot. Second, the RBF neural network is used to identify the unstructured and dynamic uncertainties due to its strong ability to ap-proximate any nonlinear function to arbitrary accuracy. Using the learning ability of neural network, the designed controller can coordinately control the mobile plant and cleaning arm of duct cleaning ro-bot with different dynamics efficiently. The neural network weights are only tuned on-line without te-dious and lengthy off-line learning. Then, an adaptive robust control scheme based on RBF neural network is proposed, which ensures that the trajectories are accurately tracked even in the presence of external disturbances and uncertainties. Finally, based on the Lyapunov stability theory, the stability of the whole closed-loop control system, and the uniformly ultimately boundedness of the tracking errors are all strictly guaranteed. Moreover, simulation and experiment results are given to demonstrate that the proposed control approach can guarantee the whole system converges to desired manifold with well performance.

Preparation and Thermal Performance of Fullerene-Based Lead Salt

Hui-Juan Guan,Rufang Peng,Bo Jin,Hua Liang,Fengqi Zhao,Xing-Bing Bu,Wen-Jing Han,Shijin Chu 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.8

C60 is widely investigated because of its unique structure. But its applications in solid propellant seem to be relatively neglected. C60 has more outstanding features than carbon black which is widely used as a catalyst ingredient of solid propellant. To combine the advantages of fullerene and lead salts, another good composite in propellant catalysts, we synthesized a kind of fullerene phenylalanine lead salt (FPL) and explored its thermal performances by differential thermal analysis (DTA) and thermogravimetry analysis (TGA). The results show it undergoes four exothermic processes started from 408 K. Combined TGA and X-ray diffractometer (XRD), the decomposition mechanism of FPL was derived by TG-IR and comparing IR spectra of FPL and its residues after burned to 327 °C, 376 °C and 424 °C, respectively. Effect of FPL on the decomposition characteristic of hexogen (RDX), a type of explosive in propellant, has been investigated using DTA at different heating rate, which shows the decomposition temperatures of the explosive are all reduced by more than 20 K. The corresponding activation energy (Ea) is decreased by 30 kJ·mol−1. So FPL has potential application as a combustion catalyst in solid propellant.

FREQUENTLY CONVERGENT SOLUTIONS OF A DIFFERENCE EQUATION

Hui Li,Fanqiang Bu,Yuanhong Tao 충청수학회 2014 충청수학회지 Vol.27 No.2

In this paper, using the de¯nition and properties of frequency measurement, we describe the properties of solutions of a di??erence equation as the initial value belongs to di??erent intervals of the whole domain. We get the main result that if the initial value belongs to [¡1; 1] which is di??erent from ¡1§p52 , then the solutionde¯ned by initial value have two frequent limits 0 and 1 of the same degree 0.5.