Analysis of the Indexes on Early Childhood Education Environment Construction in Chinese Communities - Taking the Integration of Natural Attributes as an Example -

Han, Wen Jing(한원징),Seo, Han Sok(서한석) 한국전시산업융합연구원 2021 한국과학예술융합학회 Vol.39 No.3

This research is aimed at improving community environment where Chinese children engage themselves in daily play, communication, learning, fitness and other activities. At present, the natural environment that is truly suitable for children’s activities is lacking in Chinese communities, and there is no clear construction standard. In view of this, this research adopts the literature research method to study the relevant literature in South Korea, China and other countries, and integrates the child-friendly city action plan, the nature education theory for young children and the construction standard of Korean forest kindergarten. Through comparative analysis, this research attempts to unfold the current situation and existing problems of the natural environment for children"s activities in Chinese communities and reveal the analytical indexes suitable for community construction, so as to provide a basis for the construction of the Chinese community environment. The research findings and content summary are as follows: First, in terms of recreation, the environment shall satisfy young children with fun activities, provide rich construction areas, and set up facilities for young children to enjoy adventurous climbing or water. Second, in terms of naturalness, a quiet and diverse ecological environment shall be created, and natural materials as well as natural elements can be used as much as possible, besides, local materials shall be adopted in order to save energy. Third, in terms of education, an artistic and participatory environment shall be created to help children improve their aesthetic ability, and meanwhile help them experience the magic of life and establish a correct outlook on life. Fourth, in terms of sociality, space for children to interact with others shall be provided to help them quickly adapt to the environment and get a sense of belonging. Fifth, in terms of functionality, the characteristics of children"s physical and mental development shall be fully considered and the environment must be added with fun and diversity. Sixth, in terms of safety, maintaining hygienic environment, using environment-friendly materials, regularly inspecting and maintaining facilities, setting up barrier-free passages and facilities to cope with emergencies can add up to give children a sense of physical and psychological safety. It is hoped that the 6 elements, namely, recreation, naturalness, education, sociality, functionality, and safety, together with the 36 analysis indexes, will provide guidance and suggestions for the construction of the natural environment for children in Chinese communities.

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy

Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.

Nano-eutectic growth in Co-17.8 wt%Gd alloy ribbons and the magnetostrictive properties at different wheel speeds.

Yao, Wen-Jing,Sun, Wen,Wang, Nan,Han, Seung Zeon,Lee, Je-Hyun American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.11

<P>Under near-equilibrium solidification conditions, the Co-17.8 wt%Gd eutectic alloy forms rod-like eutectic microstructure of (αCo) solid solution and Co17Gd2 compound. When the solidification condition is far from the equilibrium, the rapid growth of nano-eutectic in Co-17.8 wt%Gd alloy ribbons is realized by the single-roller techniques. The average granular size (d) of nano-eutectic in the center of ribbons varies with the increase of wheel speed (V), d = 510.36-25.51 V+0.44 V2. XRD results of ribbons at different wheel speeds indicate that, with the rise of wheel speed, the main peak of Co17Gd2 compound becomes more and more notable, whereas the main peak of (αCo) solid solution tends to reduce. Along the length direction, the Co-17.8 wt%Gd alloy ribbons have the negative magnetostrictive strain. The magnetostrictive strain enhances with the increase of wheel speed. At the wheel speed of 40 m/s, the magnetostrictive coefficient of ribbons is measured to be - 733 ppm at the magnetic field of 6 kOe. The influence of the wheel speed and the magnetic field on the maanetostrictive coefficient is discussed.</P>

Selecting and Identifying Lactic Acid Bacteria in Sourdough and Their Effect on Sourdough Physical and Chemical Properties

( Jing Han Huang ),( Syue Fong Lai ),( Wen Fu Wu ),( Chen Wei Huang ),( Ying Chen Lu ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

Sourdough is traditionally used as the leavening agent for bread making and a potential source of probiotics. In this study, sourdoughs from seven restaurants in Taiwan were collected. The lactic acid bacteria strains were isolated and identified by 16S rDNA sequencing from these sourdoughs. The following lactic acid bacteria species were identified: Lactobacillus pentosus, Lactobacillus paracasei, Lactobacillus casei, Lactobacillus plantarum, Lactobacillus sanfranciscensis. Five lactic acid bacteria strains, Lactobacillus paracasei LYC1242, Lactobacillus casei LYC1244, Lactobacillus plantarum LYC1245 and Lactobacillus casei LYC1246, were selected and singly used to ferment wheat flour. The pH value of various sourdoughs decreased to pH3 from pH5 and kelp at pH3. The titratable acidity and viscosity of various sourdoughs increased significantly compared to spontaneous fermented flour. However, there is no significant difference in titratable acidity between various sourdoughs. The sourdough fermented with L. casei LYC1244 had highest cell count. These studies provided preliminary results for choosing the best lactic acid bacteria starter strain to develop probiotic sourdough bread.

Tumor Markers for Diagnosis, Monitoring of Recurrence and Prognosis in Patients with Upper Gastrointestinal Tract Cancer

Jing, Jie-Xian,Wang, Yan,Xu, Xiao-Qin,Sun, Ting,Tian, Bao-Guo,Du, Li-Li,Zhao, Xian-Wen,Han, Cun-Zhi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

To evaluate the value of combined detection of serum CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS for the clinical diagnosis of upper gastrointestinal tract (GIT) cancer and to analyze the efficacy of these tumor markers (TMs) in evaluating curative effects and prognosis. A total of 573 patients with upper GIT cancer between January 2004 and December 2007 were enrolled in this study. Serum levels of CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS were examined preoperatively and every 3 months postoperatively by ELISA. The sensitivity of CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS were 26.8%, 36.2%, 42.9%, 2.84%, 25.4%, 34.6%, 34.2% and 30.9%, respectively. The combined detection of CEA+CA199+CA242+CA724 had higher sensitivity and specificity in gastric cancer (GC) and cardiac cancer, while CEA+CA199+CA242+SCC was the best combination of diagnosis for esophageal cancer (EC). Elevation of preoperative CEA, CA19-9 and CA24-2, SCC and CA72-4 was significantly associated with pathological types (p<0.05) and TNM staging (p<0.05). Correlation analysis showed that CA24-2 was significantly correlated with CA19-9 (r=0.810, p<0.001). The levels of CEA, CA19-9, CA24-2, CA72-4 and SCC decreased obviously 3 months after operations. When metastasis and recurrence occurred, the levels of TMs significantly increased. On multivariate analysis, high preoperative CA72-4, CA24-2 and SCC served as prognostic factors for cardiac carcinoma, GC and EC, respectively. combined detection of CEA+CA199+CA242+SCC proved to be the most economic and practical strategy in diagnosis of EC; CEA+CA199+CA242+CA724 proved to be a better evaluation indicator for cardiac cancer and GC. CEA and CA19-9, CA24-2, CA72-4 and SCC, examined postoperatively during follow-up, were useful to find early tumor recurrence and metastasis, and evaluate prognosis. AFP, TPA and TPS have no significant value in diagnosis of patients with upper GIT cancer.

Adaptive Controller Design for Switched Stochastic Nonlinear Systems Subject to Unknown Dead-zone Input via New Type of Network Approach

Wen-Jing He,Shan-Liang Zhu,Na Li,Yu-Qun Han 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.2

In this article, adaptive tracking control for a class of switched stochastic nonlinear systems subject to unknown dead-zone input using multi-dimensional Taylor network (MTN) is studied. Firstly, the characteristic function is introduced to convert the nonlinearity of the input dead-zone into a linear model. Secondly, a novel adaptive control method based on the backstepping recursive design technique is proposed, which combines MTN and common Lyapunov functions (CLFs). Significantly, a method to reduce the computational complexity of switched stochastic nonlinear systems is proposed for the first time, which introduces characteristic function and MTN technology. The result makes clear that the proposed controller can ensure all signals of the closed-loop system are bounded in probability, and the output of the system can track reference signal well. Finally, the effectiveness of proposed control method is verified by simulation results.

Turbulence-tolerant Manchester On-off Keying Transmission for Free-space Optical Communication

Qian-Wen Jing,Pei-Zheng Yu,Han-Lin Lv,Yanqing Hong 한국광학회 2023 Current Optics and Photonics Vol.7 No.4

We propose a turbulence-tolerant Manchester on-off keying (M-OOK) transmission for free-space optical (FSO) communication. At the transmitter end, a M-OOK signal featuring a spectrum with lowfrequency components absent is modulated and transmitted into a turbulent channel. At the receiver end, a low-pass filter (LPF) -based adaptive-threshold decision (ATD) with LPF-extracted channelstate information (CSI) and a high-pass filter (HPF)-based fixed-threshold decision (FTD) are employed to compensate for the effects of turbulence, owing to the low-frequency spectral characteristics of the turbulent channel. The performance of LPF-based ATD and HPF-based FTD are evaluated for various cutoff frequencies for the LPF and HPF. Besides, the proposed M-OOK transmission is compared to conventional non-return-to-zero OOK (NRZ-OOK) for different data rates. The proposed technique is verified in simulation. The simulation results show that the proposed M-OOK detection with optimized cutoff frequencies of LPF and HPF has better bit-error-rate (BER) performance compared to NRZOOK, and it is close to the theoretical ATD with the knowledge of precise CSI under various degrees of turbulence effects.

Inpatients' Knowledge about Primary Liver Cancer and Hepatitis

He, Wen-Jing,Xu, Ming-Yan,Xu, Rui-Rui,Zhou, Xiao-Qiong,Ouyang, Jun-Jie,Han, Hui,Chen, Geng-Zhen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Objective: To assess the level of an inpatient population's awareness about hepatitis and primary liver cancer (PLC), the most common type of which is hepatocellular carcinoma (HCC), and then to initiate education of this group. Methods: A survey was conducted with 1300 participants within the inpatient unit in representative tertiary hospitals in the Chaoshan area of China. Structured questionnaires contained demographic data and statements about different aspects of liver cancer and hepatitis. The questionnaires were completed by trained medical practitioners after they had conducted the interviews. Results: One way ANOVA showed that the sample population lacked adequate knowledge about HCC and hepatitis. Stepwise multiple regression analysis demonstrated that the participant's level of education had the greatest impact on their total knowledge score when other variables remained constant. Conclusions: The study demonstrated: a general lack of awareness amongst the participants about the preventative strategies, and the management options available for people with primary liver cancer and hepatitis; education level was an important factor affecting knowledge levels. The demonstrated deficiencies in people's knowledge about hepatitis and HCC, and their lack of subsequent protective behaviours are likely to play an important role in HCC and hepatitis transmission or prevention.

Research on soil net nitrogen mineralization in Stipa grandis grassland with different stages of degradation

Wanyu Wen,Xiaobing Li,Lihong Chen,Dandan Wei,Han Wang,Meng Zhang,Jing Yu 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.4

Net nitrogen mineralization is one of the nitrogen cycling process, and it is very important to understand nitrogen mineralization characteristics in degradation grassland. In the upper 0–10 cm soil layer of Stipa grandis P. A. Smirn. grassland in the Xilin river basin, Inner Mongolia, we studied the soil net nitrogen mineralization and nitrification among three varying stages of degradation grassland and analyzed the relationship between the mineralization rate of the soil net nitrogen and environmental factors, using the resin-core incubation method. Our results demonstrated that, from May to October 2012, the accumulated net nitrogen mineralization was 21.620 mg kg–1, 12.486 mg kg–1, and 48.053 mg kg–1 in the slightly, medium, and heavily degraded grasslands, respectively and varied greatly among the three stages of degradation shown by the S. grandis grassland plots. During the cultivation period, the variation of net nitrogen mineralization and nitrification was similar to the variation of soil mineral nitrogen. The higher soil mineral nitrogen content indicated higher mineralization of net nitrogen. In July and August, soil moisture was positively correlated with the net nitrogen mineralization rate, and the correlation coefficients between these two factors of 0.73, 0.58, and 0.79 for the slightly, medium, and heavily degraded plots, respectively. The rates of net nitrogen mineralization and nitrification were negatively correlated with soil total nitrogen, but positively correlated with C/N ratio, and weakly correlated with other physicochemical properties.

Urchin-like alkaline nickel–cobalt carbonate derived Ni3S4/Co3S4 nanoparticles anchored on rGO for lithium/sodium-ion batteries with enhanced capacity

Bo-Han Zhang,Yu-Qian Wang,Fen Gao,Hua-Ying Wang,Wan-Xin Wen,Yun-Lei Hou,Jing-Zhou Chen,Dong-Lin Zhao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

Transition metal sulfides (TMS) have emerged as promising anode materials for lithium and sodium ionbatteries due to their high theoretical capacity and low cost. However, the severe volume expansion duringthe conversion reaction causes rapid collapse inevitability when used as anode material. Herein, wepertinently fabricated nanoscale Ni3S4/Co3S4 with uniform particle size homogeneously dispersedbetween pleated graphene (Ni3S4/Co3S4@rGO) through facile hydrothermal assisted by cationic surfactants. The construction of 3D nanocomposites significantly shortens ion migration distances and enricheselectronic pathways, accelerating charge transfer kinetics while maintaining good stability. Uniformlydistributed bimetallic sulfides and rGO limit each other’s aggregation, allowing the excellent structuralproperties of the material to be maintained over time. Thus, the Ni3S4-Co3S4@rGO electrodes deliver ahigh reversible capacity of 972.5 mAh/g upon 200 cycles at 100 mA g1 in Lithium-ion battery and487.5 mAh/g upon 150 cycles at 100 mA g1 in Sodium-ion battery, as well as excellent rate capacityin both. These excellent properties show the potential for expansion of this simple synthetic methodin the field of alkali metal batteries.