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NF-κB in Cellular Senescence and Cancer Treatment
Jing, Hua,Lee, Soyoung Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.3
The NF-${\kappa}B$ pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-${\kappa}B$ in cancer cells, recent findings postulate that NF-${\kappa}B$ participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-${\kappa}B$. In this review, we discuss implications of the NF-${\kappa}B$ signaling pathway in cancer. Particularly, we emphasize the connection of NF-${\kappa}B$ with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-${\kappa}B$ produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.
영문 : 산동반도 블루 이코노미 지역의 산업구조 최적화
( Jing Hua Kim ),( Jung Ho Kim ) 국제지역학회 2013 국제지역연구 Vol.17 No.3
중국 해양경제 개발의 첫 시범지역인 산동반도 블루 이코노미 지역은 2011년 1월중국의 국가 경제개발 전략의 일환으로 수립된 미래지향적인 시도이다. 同 블루 이코노미 지역의 개발계획과 관련하여 어떻게 이 지역의 산업구조를 최적화하여 구성할 것인가, 그리고 어떻게 주도산업들을 선정할 것인가 하는 문제가 블루 이코노미 성공의 가장 중요한 요소라 할 수 있다. 본 논문에서는 Analytic Hierarchy Process(AHP) 기법을 적용하여 이 문제의 해결을 돕기 위한 모델을 제시하고 있다. 분석 결과 同 지역의 개발을 가속화하고 역내 여타 산업들의 개발을 촉진시키기 위해서 어업, 조선업, 운송업, 관광업 등을 주도산업으로 육성하여야 한다고 제시한다. 또한 산동반도 블루 이코노미 지역의 산업구조 최적화를 추진함에 있어서 중국의 관련분야 전문가들이 지속가능한 경제성장과 효율적인 자원의 활용을 환경보호나 사회적 조화의 추구보다 우선시하고 있음을 밝혀준다. 이는 향후 同 지역의 발전경로에 지대한 영향을 미치는 결과로서 중국 시장의 중요성을 고려할 때 우리나라 기업들의 진출에 많은 시사점을 제공한다. Establishment of the Shandong Peninsula Blue Economic Zone, the first pilot region for marine economy development in China, is a global and forward-looking proposal and has been made part of China`s national economic development strategy in January, 2011. In terms of planning the development of this Blue Economic Zone, how to optimize the industrial layout in this region and how to select the leading industries could be the critical components to the success of the blue economy. This study applies the Analytic Hierarchy Process (AHP) and introduces a model to help solve this problem. The analysis results indicate that fishery, shipbuilding, transportation and tourism should be cultivated as the leading industries so as to accelerate development and promote other industries to upgrade as well within this region. It also indicates that economic sustainability and efficient resource utilization seems to be more important to the Chinese experts than environmental protection and the pursuit of social harmony. This will undoubtedly have significant influence and implications for the future development path of the Shandong Peninsula Blue Economic Zone and for Korean firms operating in the area as well as for potential investors.
Jing-Lei Zhao,Xu Chen,Gui-Lin She,Yan Jing,Ru-Qing Bai,Jin Yi,Hua-Yan Pu,Jun Luo 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.43 No.6
This paper presents an investigation on the free vibration characteristics of functionally graded nanocomposite double-beams reinforced by single-walled carbon nanotubes (SWCNTs). The double-beams coupled by an interlayer spring, resting on the elastic foundation with a linear layer and shear layer, and is simply supported in thermal environments. The SWCNTs gradient distributed in the thickness direction of the beam forms different reinforcement patterns. The materials properties of the functionally graded carbon nanotube-reinforced composites (FG-CNTRC) are estimated by rule of mixture. The first order shear deformation theory and Euler-Lagrange variational principle are employed to derive the motion equations incorporating the thermal effects. The vibration characteristics under several patterns of reinforcement are presented and discussed. We conducted a series of studies aimed at revealing the effects of the spring stiffness, environment temperature, thickness ratios and carbon nanotube volume fraction on the nature frequency.
Jing Hua,Zhipeng Lu,Hengbo Yin,Wuping Xue,Aili Wang,Lingqin Shen,Shuxin Liu 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.40 No.-
Aldol condensation of acetic acid with formaldehyde to acrylic acid was catalyzed by the SiO2-, SBA-15-,and HZSM-5-supported vanadium phosphorous oxide (V-P-O) catalysts prepared by the incipientwetness impregnation. The supports obviously increased the surface areas and changed the acid–baseproperties of the as-prepared catalysts. V-P-O/SBA-15 catalysts with high acid and alkali quantitiesexhibited high catalytic activities for the aldol condensation of acetic acid with formaldehyde to acrylicacid. When the V-P-O/SBA-15 catalyst with the P/V mole ratio of 2.0:1 catalyzed the reaction at 330–370 8C, the acrylic acid selectivities were 90.8–70.2% at the formaldehyde conversions of 14.3–68.7%.
Jing Si,Jian-hui Wang,Li-jing Zhang,Hua Zhang,Ya-jie Liu,Li-zhe An 한국식물학회 2009 Journal of Plant Biology Vol.52 No.6
Rapid amplification of cDNA ends was performed to isolate cold-regulated CbCOR15 (EF208112) from Chorispora bungeana. This alpine species is distributed in subnival areas. Transcripts were detected in the leaves, but not the roots, of plants acclimated to cold temperatures. Expression was induced at high levels at both 4°C and −4°C. In comparing its deduced protein sequence to that of AtCOR15a (cold-regulated 15a in Arabidopsis thaliana), the N terminus had less homology than the C terminus while still containing a region analogous to the chloroplast-targeted signal peptide of AtCOR15a. We also introduced CbCOR15, with the CaMV 35S promoter, into tobacco. Second-generation (T1) plants had significantly increased tolerance to chilling, as determined by their electrolyte leakage, chlorophyll content, and relative water content. Further freezing-stress experiments showed that the tolerance of transgenic lines was significantly greater than that of the nontransgenics. Although the degree of chilling and freezing tolerance in the transgenic plants was not directly correlated with the accumulated levels of CbCOR15, we could conclude that this gene confers cold tolerance.
Impairment of AMPK-α2 augments detrusor contractions in bladder ischemia
Jing-Hua Yang,Wanting Niu,Yedan Li,Kazem M. Azadzoi 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.5
Purpose: Ischemia disrupts cellular energy homeostasis. Adenosine monophosphate-activated protein kinase alpha-2 (AMPK-α2) is a subunit of AMPK that senses cellular energy deprivation and signals metabolic stress. Our goal was to examine the expression levels and functional role of AMPK-α2 in bladder ischemia. Materials and Methods: Iliac artery atherosclerosis and bladder ischemia were engendered in apolipoprotein E knockout rats by partial arterial endothelial denudation using a balloon catheter. After eight weeks, total and phosphorylated AMPK-α2 expression was analyzed by western blotting. Structural integrity of AMPK-α2 protein was assessed by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Functional role of AMPK-α2 was examined by treating animals with the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-D ribofuranoside (AICAR). Tissue contractility was measured in the organ bath and bladder nerve density was examined by immunostaining. Results: Total AMPK-α2 expression increased in bladder ischemia, while phosphorylated AMPK-α2 was significantly downregulated. LC-MS/MS suggested post-translational modification of AMPK-α2 functional domains including phosphorylation sites, suggesting accumulation of catalytically inactive AMPK-α2 in bladder ischemia. Treatment of rats with AICAR diminished the force of overactive detrusor contractions and increased bladder capacity but did not have a significant effect on the frequency of bladder contractions. AICAR diminished contractile reactivity of ischemic tissues in the organ bath and prevented loss of nerve fibers in bladder ischemia. Conclusions: Ischemia induces post-translational modification of AMPK-α2 protein. Impairment of AMPK-α2 may contribute to overactive detrusor contractions and loss of nerve fibers in bladder ischemia. AMPK activators may have therapeutic potential against detrusor overactivity and neurodegeneration in bladder conditions involving ischemia.