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Lee, Jee-San,Kim, Mi-Yeun,Park, Eun-Ran,Shen, Yan Nan,Jeon, Ju-Yeon,Cho, Eung-Ho,Park, Sun-Hoo,Han, Chul Ju,Choi, Dong Wook,Jang, Ja June,Suh, Kyung-Suk,Hong, Jungil,Kim, Sang Bum,Lee, Kee-Ho D.A. Spandidos 2018 Oncology Reports Vol.40 No.3
<P>Transmembrane protein 165 (TMEM165), a Golgi protein, functions in ion homeostasis and vesicular trafficking in the Golgi apparatus. While mutations in <I>TMEM165</I> are known to cause human ‘congenital disorders of glycosylation’, a recessive autosomal metabolic disease, the potential association of this protein with human cancer development has not been explored to date. In the present study, we revealed that <I>TMEM165</I> is overexpressed in HCC and its depletion weakens the invasive activity of cancer cells through suppression of matrix metalloproteinase-2 (MMP-2) expression. Levels of <I>TMEM165</I> mRNA and protein were clearly increased in HCC patient tissues and cell cultures. Quantitative real-time RT-PCR analysis of fresh HCC tissues (n=88) revealed association of <I>TMEM165</I> overexpression with more frequent macroscopic vascular invasion, microscopic serosal invasion and higher α-fetoprotein levels. Notably, depletion of <I>TMEM165</I> led to a marked decrease in the invasive activity of two different HCC cell types, Huh7 and SNU475, accompanied by downregulation of MMP-2. Our collective findings clearly indicated that TMEM165 contributed to the progression of HCC by promoting invasive activity, supporting its utility as a novel biomarker and therapeutic target for cancer.</P>
0.5% 고비중 Bupivacaine 과 Tetracaine을 사용한 척추 마취의 비교
이후전,류지한,심규호,전병돈,이신우,태일산 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.1
Several methods for the management of intractable pain for various conditions including malignant disorders, herpes zoster, and low back pain and/or sciatica in 80 patients were described and analyzed. Neurolytic blocks of celiac plexus were given to the patients suffering from intra-abdominal pain from malignant origin or chronic pancreatitis. Herpes zoster was treated mainly by chemical sympathectomy via paravertebral route and occassionaly corticosteroid was administered epidurally with the local anesthetic, bupivacaine. All the patients with low back pain and/or sciatica were given epidural corticosteroid one to three times. Other peripheral verve blocks and regional corticosteroid therapy were given to the rest of the patients. Fair to excellent result was obtainde in 71% of the patients but the response was poor in the remaining 28% of the patients. It seems that earlier the patients were referred to the pain clinic, the better the results were.
지속적 액와부 상완신경총 차단술 - I. 카테테르 삽입방법의 변형 -
이후전(Hoo Jeon Lee),태일산(Il San tae) 대한통증학회 1997 The Korean Journal of Pain Vol.10 No.2
N/A Background: Authors modified the traditional continuous axillary brachial plexus block technique of Selander for purpose of increasing success rate and decreasing complications by use of commercial epidural anesthesia set. Method: Thirty-nine patients scheduled for upper extremity operations were injected with 40 ml of anesthetic solution by axillary perivascular technique, using 23-25G immobile needle at 2 cm from the pectoralis major. Tuohy needle was immediately introduced at 4 cm from the pectoralis major and pierced the expanded neurovascular sheath at an angle of 30 degree to the skin. The pop was well noted. Needle was advanced 0.5 to 3.0 cm and epidural catheter introduced through the needle. After removal of needle, occlusive dressing was done. Tip of catheter and spread of solution were demonstrated by fluoroscopy with contrast dye after completion of procedure. Result: Catheter insertion was successful at first attempt for all case. Total length of insertion was from 6 to 13(10.0+1.7) cm. Tip of catheter was placed in infraclavicular space(66.7%), about the humeral head(17.9%) and in upper arm in 3 cases as U-shape(7.9%). Catheters were maintained for 6.7+ 2.6(3-12) days. There were no complications such as: perforation of major vessels, needle trauma to nerve, infection, bleeding or hematoma. Conclusion: This study demonstrated continuous axillary brachial plexus block with epidural anesthesia set is safe, easy and convenient modification of technique of Selander.
강신삼,이길홍,이근후,장동산 중앙대학교 의과대학 의과학연구소 1990 中央醫大誌 Vol.15 No.3
In this study, the author has attempted to set up guideline of prevention and early therapeutic intervention of psychiatrically illed female workers by analyzing the effect of psychosocial role conflicts originated from home and occupation on the mental disorders. Among psychiatric inpatients, the employed females were selected as study group, while the unemployed females and employed males were selected as control groups. The author had tried to extract sociopsychiatric variables of female employment. The sampling was performed through the three stage clustered random sampling method and questionnaires were finally applied to a total of 303 psychiatric inpatients including 124 men and 179 women at march, 1988. The major findings were as follows; 1. The employed female patients showed higher rates of working at professional, technical or administrative part, and more frequently having western religion and graduating college. 2. The employed female patients showed higher rates of divorce, and specifically the rates of divorce were higher in person of engage in upper class occupation such as professional or administrative manager. 3. It showed higher rates that the employed female patients showed the compulsive, passive-aggressive or dependent personality traits, and tended to dissatisfy in their sexual life. 4. The employed female patients showed higher life change scores and had many difficulties in their occupational adjustment, but they showed lower rates of doing serious maladaptive behaviors such as working off several jobs or loss of work than employed males patients. 5. The father of the employed female patients showed higher rates of working at non-professional part and having lower educational level. And the employed female patients were more perceived that the economical level of their family was relatively poor. 6. Among the familial psychological variables, the mother's rearing attitude was more closely related with female employment. Particularly, in employed female patients, adultcentered and punish oriented maternal care were prominent. 7. The employed female patients showed relatively lower rates of friction in spouse-parent relations or in spouse-children relations, and lower rates of children's dissatisfaction at home than unemployed female patients. In conclusion, the employed female patients had many psychiatric problems in their home environment, developmental process, and personality development. And they tended to suffer from various psychosocial stressor-s originated from role conflicts in their job and home environment after employment. Therefore, it is necessary that we must concrete the counter-plan for relieving from psychosocial stresses and have psychiatric consideration for unconscious motivation of employment, for promoting mental health of employed female workers.
한방병원에 입원한 요통 환자의 요추 전만각, 요천각 변화의 심각도에 따른 예후 분석 연구
한수빈 ( Su-bin Han ),김은산 ( Eun-san Kim ),김효준 ( Hyo-jun Kim ),조후인 ( Hoo-in Jo ),김미혜 ( Mi-hye Kim ),이남우 ( Nam-woo Lee ),한정훈 ( Jeong-hun Han ),박병학 ( Byung-hak Park ),손재민 ( Jae-min Son ),강도현 ( Do-hyeon Kang 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.4
Objectives To analyze the prognosis of patients with low back pain according to the severity of abnormal lumbar lordotic angle and Ferguson's angle. Methods Data from electronic medical record of a total of 199 patients hospitalized in Korean medicine hospital were analyzed. With the sagittal view of lumbar spine X-ray, lumbar lordotic angle was defined as the angle between the superior endplate of L1 with the inferior endplate of L5. Ferguson’s angle was defined as the angle between the superior surfaces of the sacral with a horizontal line. ‘Measure Cobb’s Angle Tool’ of ‘INFINITT PACS’ was used to measure both angles. Lumbar lordotic angle and Ferguson's angle were subdivided into five sections. The number of days from onset and the duration of hospitalization were analyzed in each section. Results Severe hypolordotic lumbar lordotic angle group were found to have longer medical history and hospitalization duration than the control group. The ratio of long-term hospitalization (over 15 days) and chronic medical history (over 180 days) of patients with severe hypolordotic Ferguson’s angle were significantly higher than the control group. The ratio of patients with chronic medical history (over 180 days) was significantly higher in severe hyperlordotic Ferguson's angle group than the control group. Conclusions Severe hypolordotic lumbar lordotic angle was related to patient’s prognosis. Both severe hyperlordotic and severe hypolordotic Ferguson’s angle were found to be related to patient’s prognosis. However, a moderate loss of lumbar lordotic angle and Ferguson’s angle was not related to prognosis of low back pain patients. (J Korean Med Rehabil 2020;30(4):143-154)
The role of Egr-1 in IL-17F-induced psoriasin expression in human keratinocytes
( Sang Hoon Jeong ),( Min Gun Yoo ),( Seong Kyu Jeong ),( San Geun Lee ),( Hee Hoo Kim ),( Kyung Goo Lee ),( Sang Min Yi ),( Eun Young Lee ),( Yoon Hee Park ),( Hyun Cheol Bae ),( Sang Wook Son ) 대한피부과학회 2011 초록집 Vol.49 No.20