Nucleation behavior of glutathione polymorphs in water

Hongyuan Wei,Zhi Chen,Leping Dang,Shuai Li 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.10

Nucleation behavior of glutathione (GSH) polymorphs in water was investigated by experimental method combined with classical nucleation theory. The solubility of α and β forms GSH in water at different temperatures,and the nucleation induction period at various supersaturations and temperatures were determined experimentally. The results show that, in a certain range of supersaturation, the nucleation of β form predominates at relatively higher temperature,while α form will be obtained at lower temperature. The nucleation kinetics parameters of α and β form were then calculated. To understand the crucial role of temperature on crystal forms, “hypothetic” nucleation parameters of β form at 283.15 K were deduced based on extrapolation method. The results show that the interfacial tension, critical free energy, critical nucleus radius and nucleus number of α form are smaller than that of β form in the same condition at 283.15 K, which implies that α form nucleates easier than β form at low temperature. This work may be useful for the control and optimization of GSH crystallization process in industry.

An Integrated Nomogram Combining Clinical Factors and Microtubule-Associated Protein 1 Light Chain 3B Expression to Predict Postoperative Prognosis in Patients with Intrahepatic Cholangiocarcinoma

Liang Chen,Hongyuan Fu,Tongyu Lu,Jianye Cai,Wei Liu,Jia Yao,Jinliang Liang,Hui Zhao,Jiebin Zhang,Jun Zheng,Yingcai Zhang,Yang Yang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose Microtubule-associated protein 1 light chain 3B (LC3B) serves as a key component of autophagy, which is associated with the progression of carcinoma. Yet, it is still unclear whether LC3B is also an independent risk factor for intrahepatic cholangiocarcinoma (ICC). We aim to explore the predictive value of LC3B on prognosis of ICC, and to establish a novel and available nomogram to predict relapse-free survival (RFS) and overall survival (OS) for these patients after curative-intent hepatectomy. Materials and Methods From August 2004 to March 2017, 105 ICC patients were eligibly enrolled in the Third Affiliated Hospital of Sun Yat-sen University. Preoperative clinical information of enrolled patients was collected. Expression LC3B in the ICC specimen was detected by immunohistochemistry. Results The 5-year RFS and OS in this cohort were 15.7% and 29.6%, respectively. On multivariate Cox regression analysis, independent risk factors for 5-year OS were cancer antigen 125, microvascular invasion, LC3B expression and lymph node metastasis. Except for the above 4 factors, neutrophil/lymphocyte ratio and tumor differentiation were independent factors for 5-year RFS. The area under the curve of nomograms for OS and RFS were 0.820 and 0.747, respectively. Conclusion The nomograms based on LC3B can be considered as effective models to predict postoperative survival for ICC patients.

Tough antifouling organogels reinforced by the synergistic effect of oleophobic and dipole–dipole interactions

Liangpeng Zeng,Hongyuan Cui,Yi Liu,Xinxing Lin,Ziang Wang,Hui Guo,Wei-Hua Li 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-

Slippery organogels have gained increasing interest as competitive candidates for antifouling applications. However, it remains challenging to develop tough organogels suitable for fouling resistance indynamic and flexible application scenarios. Herein, a kind of physically crosslinked organogels with acombination of desirable properties, including high toughness, transparency, surface slipperiness, andfouling resistance is developed. The representative pAL organogels, constructed by poly(acrylonitrileco-lauryl acrylate) (pAL) copolymer and infiltrated with n-hexadecane as a lubricating solvent, possesshigh tensile fracture stress, fracture strain, Young’s modulus, and toughness of 4.28 MPa, 517%,2.52 MPa, and 11.19 MJ m3. In the organogels, the polar cyano groups from the pAN segments serveas physical cross-linking points, where the synergistic effects played by oleophobic and dipole–dipoleinteractions significantly toughen the materials. Meanwhile, the soft oleophilic poly(lauryl acrylate)chains offer considerable solvent content, giving rise to satisfactory surface slipperiness. Therefore, theorganogels bring about a 57.16% and 81.50% reduction of protein and bacteria adhesion in comparisonto the control. The satisfactory antifouling performance has been further confirmed with Spirulina platensis. It is deemed that this organogel may provide great potential for various applications in the future suchas anti-adhesion materials and self-cleaning coating.

Comparison of cavitation prediction for a centrifugal pump with or without volute casing

Xianwu Luo,Wei Wei,Bin Ji,Zaibing Pan,Wenchao Zhou,Hongyuan Xu 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.6

Cavitation may not only cause head and efficiency breakdown of hydraulic machines but also generate other unfavorable phenomena such as noise and vibration. Therefore, the accurate prediction of cavitation development is important for various pump applications. In this paper, two numerical models, namely, models A and B, are applied to simulate the turbulent cavitating flows inside a centrifugal pump to investigate the effect of calculation domain on the prediction accuracy of cavitation performance for hydraulic machines. Model A has a calculation domain with volute casing, whereas model B has a single blade-to-blade flow passage without volute casing. Steady simulations of cavitating flow in the pump have been conducted based on the shear stress transport k-ω turbulence model and the homogeneous cavitation model. Both models A and B predicted that the pump performance decreases with decreasing cavitation number. Experimental results show that model B can predict better the critical cavitation number at the best efficiency point compared with model A, which is the full flow passage model. Internal flow investigations indicate that an asymmetrical feature of cavitating flow exists when the calculation domain with volute casing is applied. The asymmetrical cavitation development in different blade-to-blade flow passages for model A results in an over-estimation of the decrease in pump performance because of the interaction between the impeller blade and the tongue of the volute casing. A simple calculation domain without volute casing is preferred for steady cavitation prediction in pumps rather than the full flow passage with volute casing because the former has better convergence, less resource requirements, and lower time consumption.

Current Evidence on the Association between rs3757318 of C6orf97 and Breast Cancer Risk: a Meta-Analysis

Hong, Yuan,Chen, Xue-Qin,Li, Jiao-Yuan,Liu, Cheng,Shen, Na,Zhu, Bei-Bei,Gong, Jing,Chen, Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: A common genetic variant rs3757318, located in intron of C6orf97, was firstly identified to be associated with breast cancer (BC) risk by a genome-wide association (GWA) study. However, subsequent validation studies with different ethnicities have yielded conflicting results. Materials and Methods: We performed a meta-analysis to synthesize all available data for evaluating the precise effect of this variant on BC susceptibility. Results: A total of 8 articles containing 11 studies with 62,891 cases and 65,635 controls were included in this meta-analysis. When compared to the G allele, the rs3757318-A allele was significantly associated with BC risk with the pooled OR of 1.21 (95% CI=1.15 - 1.29, P<0.001) but with obvious between-study heterogeneity (P=0.040). Stratified analysis suggested that diversity of ethnicity along with control source may explain part of the heterogeneity. Similarly, significant associations were also identified in heterozygote, homozygote, dominant and recessive genetic models. Sensitivity and publication bias analyses indicated robust stability of our results. Conclusions: Our present meta-analysis demonstrated that the variant rs3757318 is associated with increased BC risk. Nevertheless, further studies are needed to clarify the underlying biological mechanisms.