IMPROVED PERTURBATION BOUND FOR ROBUST STABILITY IN LINEAR SYSTEM

Zhang Zhao,Zhao Chan Gan,Hu Heng Zhang 대한전자공학회 1992 대한전자공학회 Conference Vol.1992 No.2

SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways

Zhang, Yan-Li,Li, Qing,Yang, Xiao-Mei,Fang, Fang,Li, Jun,Wang, Ya-Hui,Yang, Qin,Zhu, Lei,Nie, Hui-Zhen,Zhang, Xue-Li,Feng, Ming-Xuan,Jiang, Shu-Heng,Tian, Guang-Ang,Hu, Li-Peng,Lee, Ho-Young,Lee, Su-J American Association for Cancer Research 2018 Cancer research Vol.78 No.9

<P>Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P>Tumor-associated macrophages (TAM) represent key regulators of the complex interplay between cancer and the immune microenvironment. Matricellular protein SPON2 is essential for recruiting lymphocytes and initiating immune responses. Recent studies have shown that SPON2 has complicated roles in cell migration and tumor progression. Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis. SPON2-α4β1 integrin signaling activated RhoA and Rac1, increased F-actin reorganization, and promoted M1-like macrophage recruitment. F-Actin accumulation also activated the Hippo pathway by suppressing LATS1 phosphorylation, promoting YAP nuclear translocation, and initiating downstream gene expression. However, SPON2-α5β1 integrin signaling inactivated RhoA and prevented F-actin assembly, thereby inhibiting HCC cell migration; the Hippo pathway was not noticeably involved in SPON2-mediated HCC cell migration. In HCC patients, SPON2 levels correlated positively with prognosis. Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.</P><P><B>Significance:</B> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P><B>Graphical Abstract:</B> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg. <I>Cancer Res; 78(9); 2305–17. ©2018 AACR</I>.</P><P><B>Graphical Abstract</B></P><P> [Figure]</P>

An Improved Secure Semi-fragile Watermarking Based on LBP and Arnold Transform

Heng Zhang,Chengyou Wang,Xiao Zhou 한국정보처리학회 2017 Journal of information processing systems Vol.13 No.5

In this paper, we analyze a recently proposed semi-fragile watermarking scheme based on local binary pattern(LBP) operators, and note that it has a fundamental flaw in the design. In this work, a binary watermark isembedded into image blocks by modifying the neighborhood pixels according to the LBP pattern. However,different image blocks might have the same LBP pattern, which can lead to false detection in watermarkextraction process. In other words, one can modify the host image intentionally without affecting itswatermark message. In addition, there is no encryption process before watermark embedding, which bringsanother potential security problem. To illustrate its weakness, two special copy-paste attacks are proposed in thispaper, and several experiments are conducted to prove the effectiveness of these attacks. To solve theseproblems, an improved semi-fragile watermarking based on LBP operators is presented. In watermarkembedding process, the central pixel value of each block is taken into account and Arnold transform isadopted to guarantee the security of watermark. Experimental results show that the improved watermarkingscheme can overcome the above defects and locate the tampered region effectively.

Clinical Reference Strategy for the Selection of Treatment Materials for Maxillofacial Bone Transplantation: A Systematic Review and Network Meta-Analysis

Zhang Shuxin,Zhang Xinyi,Li Yanling,Mao Xuran,Liu Rui,Qi Yanxin,Lee Eui-Seok,Jiang Heng Bo 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3

Bone graft materials have mixed effects of bone repair in the field of oral maxillofacial surgery. The qualitative analyses performed by previous studies imply that autogenous odontogenic materials and autogenous bone have similar effects on bone repair in clinical jaw bone transplantation. This retrospective systematic assessment and network meta-analysis aimed to analyze the best effect of clinical application of autogenous odontogenic materials and autogenous, allogeneic, and xenogeneic bone grafts in bone defect repair. A systematic review was performed by searching the PubMed, Cochrane Library, and other journal databases using selected keywords and Medical Subject Headings search terms. 10 Papers (n = 466) that met the inclusion criteria were selected. The assessment of heterogeneity did not reveal any overall statistical difference or heterogeneity (P = 0.051 > 0.05), whereas the comparison between autogenous and allogeneic bone grafts revealed local heterogeneity (P = 0.071 < 0.1). Risk of bias revealed nine unclear studies and one high-risk study. The overall consistency was good (P = 0.065 > 0.05), and the local inconsistency test did not reveal any inconsistency. The publication bias was good. The confidence regarding the ranking of bone graft materials after GRADE classification was moderate. The effects on bone repair in the descending order were as follows: autogenous odontogenic materials, xenogeneic bone, autogenous bone, and allogeneic bone. This result indicates that the autogenous odontogenic materials displayed stronger effects on bone repair compared to other bone graft materials. Autogenous odontogenic materials have broad development prospects in oral maxillofacial surgery.

Amorphous Materials : THE FORMATION ABILITY AND THERMAL PROPERTIES OF Cu - P BASED AMORPHOUS ALLOYS

Zhang Bangwei,Shu Xiaolin,Tan Zhaosheng,Zhang Heng 대한금속재료학회 ( 구 대한금속학회 ) 1995 Advanced Material and Processing Vol.2 No.-

Expression and Clinical Significance of REPS2 in Human Esophageal Squamous Cell Carcinoma

Zhang, Hang,Duan, Chao-Jun,Zhang, Heng,Cheng, Yuan-Da,Zhang, Chun-Fang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Objective: REPS2 plays important roles in inhibiting cell proliferation, migration and in inducing apoptosis of cancer cells, now being identified as a useful biomarker for favorable prognosis in prostate and breast cancers. The purpose of this study was to assess REPS2 expression and to explore its role in esophageal squamous cell carcinoma (ESCC). Methods: Protein expression of REPS2 in ESCCs and adjacent non-cancerous tissues from 120 patients was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patient outcome. Additionally, thirty paired ESCC tissues and four ESCC cell lines and one normal human esophageal epithelial cell line were evaluated for REPS2 mRNA and protein expression levels by quantitative RT-PCR and Western blotting. Results: REPS2 mRNA and protein expression levels were down-regulated in ESCC tissues and cell lines. Low protein levels were significantly associated with primary tumour, TNM stage, lymph node metastasis and recurrence (all, P < 0.05). Survival analysis demonstrated that decreased REPS2 expression was significantly associated with shorter overall survival and disease-free survival (both, P < 0.001), especially in early stage ESCC patients. When REPS2 expression and lymph node metastasis status were combined, patients with low REPS2 expression/lymph node (+) had both poorer overall and disease-free survival than others (both, P < 0.001). Cox multivariate regression analysis further revealed REPS2 to be an independent prognostic factor for ESCC patients. Conclusions: Our findings demonstrate that downregulation of REPS2 may contribute to malignant progression of ESCC and represent a novel prognostic marker and a potential therapeutic target for ESCC patients.

Fragile Watermarking Based on LBP for Blind Tamper Detection in Images

( Heng Zhang ),( Chengyou Wang ),( Xiao Zhou ) 한국정보처리학회 2017 Journal of information processing systems Vol.13 No.2

Nowadays, with the development of signal processing technique, the protection to the integrity and authenticity of images has become a topic of great concern. A blind image authentication technology with high tamper detection accuracy for different common attacks is urgently needed. In this paper, an improved fragile watermarking method based on local binary pattern (LBP) is presented for blind tamper location in images. In this method, a binary watermark is generated by LBP operator which is often utilized in face identification and texture analysis. In order to guarantee the safety of the proposed algorithm, Arnold transform and logistic map are used to scramble the authentication watermark. Then, the least significant bits (LSBs) of original pixels are substituted by the encrypted watermark. Since the authentication data is constructed from the image itself, no original image is needed in tamper detection. The LBP map of watermarked image is compared to the extracted authentication data to determine whether it is tampered or not. In comparison with other state-of-the-art schemes, various experiments prove that the proposed algorithm achieves better performance in forgery detection and location for baleful attacks.

A Green Deep Eutectic Solvent-Based Ultrasound-Assisted Method to Extract Astaxanthin from Shrimp Byproducts

Zhang, Heng,Tang, Baokun,Row, Kyung Ho Taylor Francis 2014 Analytical letters Vol.47 No.5

An Improved Secure Semi-fragile Watermarking Based on LBP and Arnold Transform

Zhang, Heng,Wang, Chengyou,Zhou, Xiao Korea Information Processing Society 2017 Journal of information processing systems Vol.13 No.5

In this paper, we analyze a recently proposed semi-fragile watermarking scheme based on local binary pattern (LBP) operators, and note that it has a fundamental flaw in the design. In this work, a binary watermark is embedded into image blocks by modifying the neighborhood pixels according to the LBP pattern. However, different image blocks might have the same LBP pattern, which can lead to false detection in watermark extraction process. In other words, one can modify the host image intentionally without affecting its watermark message. In addition, there is no encryption process before watermark embedding, which brings another potential security problem. To illustrate its weakness, two special copy-paste attacks are proposed in this paper, and several experiments are conducted to prove the effectiveness of these attacks. To solve these problems, an improved semi-fragile watermarking based on LBP operators is presented. In watermark embedding process, the central pixel value of each block is taken into account and Arnold transform is adopted to guarantee the security of watermark. Experimental results show that the improved watermarking scheme can overcome the above defects and locate the tampered region effectively.

Fragile Watermarking Based on LBP for Blind Tamper Detection in Images

Zhang, Heng,Wang, Chengyou,Zhou, Xiao Korea Information Processing Society 2017 Journal of information processing systems Vol.13 No.2

Nowadays, with the development of signal processing technique, the protection to the integrity and authenticity of images has become a topic of great concern. A blind image authentication technology with high tamper detection accuracy for different common attacks is urgently needed. In this paper, an improved fragile watermarking method based on local binary pattern (LBP) is presented for blind tamper location in images. In this method, a binary watermark is generated by LBP operator which is often utilized in face identification and texture analysis. In order to guarantee the safety of the proposed algorithm, Arnold transform and logistic map are used to scramble the authentication watermark. Then, the least significant bits (LSBs) of original pixels are substituted by the encrypted watermark. Since the authentication data is constructed from the image itself, no original image is needed in tamper detection. The LBP map of watermarked image is compared to the extracted authentication data to determine whether it is tampered or not. In comparison with other state-of-the-art schemes, various experiments prove that the proposed algorithm achieves better performance in forgery detection and location for baleful attacks.