The effects of codon usage on the formation of secondary structures of nucleocapsid protein of peste des petits ruminants virus

Xiao‑xia Ma,Yi‑ning Wang,Xiao‑an Cao,Xue‑rui Li,Yong‑sheng Liu,Jian‑hua Zhou,Xue‑peng Cai 한국유전학회 2018 Genes & Genomics Vol.40 No.9

The nucleocapsid (N) protein of peste des petits ruminants virus (PPRV) with a conserved amino acid usage pattern plays an important role in viral replication. The primary objective of this study was to estimate roles of synonymous codon usages of PPRV N gene and tRNA abundances of host in the formation of secondary structure of N protein. The potential effects of synonymous codon usages of N gene and tRNA abundances of host on shaping different folding units (α-helix, β-strand and the coil) in N protein were estimated, based on the information about the modeling secondary structure of PPRV N protein. The synonymous codon usage bias was found in different folding units in PPRV N protein. To better understand the role of translation speed caused by variant tRNA abundances in shaping the specific folding unit in N protein, we modeled the changing trends of tRNA abundance at the transition boundaries from one folding unit to another folding unit (β-strand → coil, coil → β-strand, α-helix → coil, coil → α-helix). The obvious fluctuations of tRNA abundance were identified at the two transition boundaries (β-strand → coil and coil → β-strand) in PPRV N protein. Our findings suggested that viral synonymous codon usage bias and cellular tRNA abundance variation might have potential effects on the formation of secondary structure of PPRV N protein.

Treatment of fever with traditional Chinese medicine according to Zheng on cancer patients (based on case reports)

Peng Cao,Lan-Ying Liu,Xue-Ting Cai,Xiao-Ning Wang,Jie-Ge Huo,Zhong-Ying Zhou 셀메드 세포교정의약학회 2012 셀메드 (CellMed) Vol.2 No.2

Fever in cancer patients is often due to the following causes: evil qi and toxity stagnancy, disorders of qi and blood, deficiencies of zang and fu organs, and the disorder of yin and yang. The treatments given to cancer patients with a fever are according to five: (a) Excessive inner heat and toxicants: remove heat and the toxicant, induce purgation. We use Cheng-Qi-Tang plus Qing-Wen-Bai-Du-Yin. (b) Tangle of damp and heat, and qi stagnancy: remove damp and heat, smooth the qi channel. We use Gan-Lu-Xiao-Du-Dan or San-Ren-Tang. (c) Obvious blood and heat stagnancy: remove heat and blood stasis. We use Xue-Fu-Zhu-Yu-Tang. (d) Deficiency of spleen qi, inner heat caused by a yin deficiency: nourish spleen qi and yin to remove the inner heat. We use Bu-Zhong-Yi-Qi-Tang or Xiao-Jian-Zhong-Tang. (e) Prominent yin deficiency and hectic fever: replenish yin and remove inner heat. We use Qing-Hao-Bie-Jia-Tang or Chai-Qian-Mei-Lian-San. The pathogenesis of fever in cancer patients is complicated. We can see both deficiency and excess in one differentiation. Therefore, we must make sure of it, then we can get the most effective treatment.

Interval-valued Analytic Network Process and its Application in Risk Assessment of Dynamic Alliance

Xiao-Guang Zhou,Yan-Hui Zhou,Xiao-Xiao Cui 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.9

Analytic Network Process (ANP) has been widely used in solving many complicated decision making problems. An approach to acquire the comprehensive weights of interval-valued Analytic Network Process (IV-ANP) is proposed. Firstly, the independent local interval-valued weights are obtained by solving the goal programming for interval-valued pairwise comparison matrices. Based on the interaction and feedback relationships among criteria and/or indices, an unweighted interval-valued supermatrix is formed. To avoid loss of information, an extreme value method is developed for acquiring the global weights of IV-ANP. Secondly, the alternatives are ranked on the basis of interval-valued preference order. Finally, with the interaction and feedback relationships between criteria and/or indices being considered, an index system for assessing the risk of dynamic alliance is presented. With the uncertain and inaccurate information during the evaluation process being considered, the proposed IV-ANP method is applied for risk assessment of dynamic alliance, and sensitivity analyses for some key risk factors are performed to show their impacts on the risk levels of alliance enterprises.

Tailoring fabric geometry of plain-woven composites for simultaneously enhancing stiffness and thermal properties

Xiao-Yi Zhou,Neng-Wei Wang,Wen Xiong,Xin Ruan,Shao-Jin Zhang 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.42 No.4

This paper proposes a numerical optimization method to design the mesoscale architecture of textile composite for simultaneously enhancing mechanical and thermal properties, which compete with each other making it difficult to design intuitively. The base cell of the periodic warp and fill yarn system is served as the design space, and optimal fibre yarn geometries are found by solving the optimization problem through the proposed method. With the help of homogenization method, analytical formulae for the effective material properties as functions of the geometry parameters of plain-woven textile composites were derived, and they are used to form the inverse homogenization method to establish the design problem. These modules are then put together to form a multiobjective optimization problem, which is formulated in such a way that the optimal design depends on the weight factors predetermined by the user based on the stiffness and thermal terms in the objective function. Numerical examples illustrate that the developed method can achieve reasonable designs in terms of fibre yarn paths and geometries.

Triterpenoids and Sterones from the Stem Bark of Ailanthus altissima

Xiao-Jiang Zhou,Min Xu,Xue-Song Li,Yue-Hu Wang,Ye Gao,Rui Cai,Yong-Xian Cheng 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.1

One new tirucallane-type triterpenoid, alianthusaltinin A (1), one new C29 sterone, alianthaltone A (2), and 12 known compounds have been isolated from the stem bark of Ailanthus altissima. The structures of new compounds were identified by means of spectroscopic methods. Compound 3 was isolated from natural sources for the first time, and compounds 4, 5, and 9 were isolated from this plant for the first time.

A new reconfigurable liquid-metal-antenna-based sensor

Xiao-Ping Zhou,Yihui Fu,Hantao Zhu,Zihao Yu,Shanyong Wang 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.30 No.4

In this paper, a new sensor chip with frequency reconstruction range of 2.252 GHz ~ 2.450 GHz is designed and fabricated. On this basis, a self-designed "T-shaped" shell is added to overcome the disadvantage of uneven deformation of the traditional steel shell, and the range of the sensor chip is expanded to 0 kN ~ 96 kN. The liquid metal antenna is used to carry out a step-by-step loading test, and the relationship between the antenna resonance frequency and the pressure load is analyzed. The results show that there is a good linear relationship between the pressure load and the resonant frequency. Therefore, the liquid metal antenna can be regarded as a pressure sensor. The cyclic loading and unloading experiments of the sensor are carried out, and different loading rates are used to explore the influence on the performance of the sensor. The loading and unloading characteristic curves and the influence characteristic curves of loading rate are plotted. The experimental results show that the sensor has no residual deformation during the cycle of loading and unloading. Moreover, the influence of temperature on the performance of the sensor is studied, and the temperature correction formula is derived.

Triterpenoids and Sterones from the Stem Bark of Ailanthus altissima

Zhou, Xiao-Jiang,Xu, Min,Li, Xue-Song,Wang, Yue-Hu,Gao, Ye,Cai, Rui,Cheng, Yong-Xian Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.1

One new tirucallane-type triterpenoid, alianthusaltinin A (1), one new $C_{29}$ sterone, alianthaltone A (2), and 12 known compounds have been isolated from the stem bark of Ailanthus altissima. The structures of new compounds were identified by means of spectroscopic methods. Compound 3 was isolated from natural sources for the first time, and compounds 4, 5, and 9 were isolated from this plant for the first time.

F-LBQA : Fair Load Balancing QOS Algorithm in Overlay Network

ZHOU Xiao-Yan,Zhao Kai 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.3

Due to the traditional overlay network QOS routing algorithm fails to consider the effects of the resource bottleneck on the routing selection, it results in the local congestion of the system. Therefore, this paper proposes a fair load-balancing QOS overlay routing F-LBQAR algorithm. The algorithm introduces the resource fairness index, sets up a new load-balancing utility function, and adopts the adaptive weighted method in the system’s load state to correct the weight restriction of QOS. The experimental results show that the algorithm in this paper can reduce the probability of network congestion caused by resources bottleneck and improve the QOS service success rate and the throughput of the system.

Couple-group L2-L∞ Consensus of Nonlinear Multi-agent Systems with Markovian Switching Topologies

Xiao Li,Cancan Zhou,Jianping Zhou,Zhen Wang,Jianwei Xia 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.3

The paper is devoted to the couple-group L2-L∞ consensus problem of nonlinear multi-agent systemsaffected by external disturbances. The interaction topologies among agents obey a continuous-time Markovianprocess with unknown transition probabilities. By a system transformation, the problem of couple-group L2-L∞ consensus is converted into a L2-L∞ control issue. Then, by Lyapunov stability theory and graph theory, sufficientconditions for the couple-group L2-L∞ consensus are obtained. The control gains can be acquired via the solutionsof a group of linear matrix inequalities. Moreover, the present method is extended to the multi-group L2-L∞consensus. Finally, an example is provided to illustrate the effectiveness of the results.

Humanized Murine Model for HBV and HCV Using Human Induced Pluripotent Stem Cells

Xiao-Ling Zhou,In-Hyun Park,Gareth J. Sullivan,Pingnan Sun 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.2

Infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) results in heterogeneous outcomes from acute asymptomatic infection to chronic infection leading to cirrhosis and hepatocellular carcinoma (HCC). In vitro models using animal hepatocytes, human HCC cell lines, or in vivo transgenic mouse models have contributed invaluably to understanding the pathogenesis of HBV and HCV. A humanized mouse model made by reconstitution of human primary hepatocytes in the liver of the immunodeficient mouse provides a novel experimental opportunity which mimics the in vivo growth of the human hepatocytes. The limited access to primary human hepatocytes necessitated the search for other cellular sources, such as pluripotent stem cells. Human embryonic stem cells (hESCs) have the features of self-renewal and pluripotency and differentiate into cells of all three germ layers, including hepatocytes. Humaninduced pluripotent stem cells (iPSCs) derived from the patient’s or individual’s own cells provide a novel opportunity to generate hepatocyte-like cells with the defined genetic composition. Here, we will review the current perspective of the models used for HBV and HCV study,and introduce the personalized mouse model using human iPSCs. This novel mouse model will facilitate the direct investigation of HBV and HCV in human hepatocytes as well as probing the genetic influence on the susceptibility of hepatocytes to HBV and HCV.