간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

Gilbert 증후군에서 열량 제한 시험과 Phenobarbital 자극 시험의 의의(14예)

이헌영,채경훈,정재훈,강윤세,김연수,문희석,박기오,이엄석,김선문,김석현,성재규,이병석,이강욱 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Gilbert 증후군은 인구의 7%에서까지 나타날 수 있는 매우 흔한 증후군으로서 비진행성인 양성의 만성적 경과를 치하며, 간질환의 증상과 징후가 없는 경한 비포합형 고빌리루빈혈증이 특징인 일종의 체질적인 증상으로서 혈장 빌리루빈 농도에 대한 사춘기의 영향 때문에 10대와 20대에 자주 진단이 된다. 따라서 임상적인 중요성은 미약하지만 높은 빈도가 예상되는 점에 그 중요성이 부여되어야 할 것이다. 따라서 적정한 임상적 진단법으로 기왕에 소개된 열량제한 시험과 phenobarbital 유도 시험을 시행하고 이들의 진단적 가치를 알아보기 위하여 본 연구를 시행하였다. 1990년 7월부터 1999년 4월까지 충남대학교병원에 내원하여 HBsAg, IgG anti-HBc 및 anti-HCV가 음성이고, 간 초음파 스캔에서 이상이 없으며, 혈청 AST, ALT 및 AP가 정상인 비음주자에서 경한 비포합형 고빌리루빈혈증이 있는 14예의 환자들을 대상으로 ^(99m)Tc-DISID 스캔을 시행하였으며, 기저 치 총빌리루빈 및 포합형 빌리루빈 치를 측정한 다음에 하루에 400Kcal로 48시간동안 제한한 열량 제한 시험을 시행하였고, phenobarbital을 하루 60mg씩 5일간 투여한 후에도 각각 총빌리루빈과 포합형 빌리루빈 치를 검사하여 비포합형을 구하였다. 대상 환자들은 모두 14예로서 남자가 11예(78.6%)였고 여자가 3예(21.4%)여서 3.7:1로 남자에서 많았으며, 20대가 6예(42.9%), 30대가 역시 6예(42.9%) 및 40대가 2예(14.2%)로서 2,30대가 대부분(85.8%)이었다. 열량 제한 시험 후의 총빌리루빈 치, 비포합형 및 포합형 빌리루빈 치들은 평균 각각 5.5±2.7, 4.2±2.3 및 1.3±10mg/dL 로서, 시험 전 치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg/dL 보다 유의하게(p=0.001, p=0.001, p=0.023) 상승하였다. 포합형 빌리루빈 치도 유의하게 상승하였으나 비포합형의 상승보다는 훨씬 낮아서 주로 비포합형이 증가하였다. phenobarbital 투여 중 설사가 발생하여 중단한 1예를 제외한 13예에서 열량 제한 시험 후에 상승하였던 총, 비포합형 및 포합형 빌리루빈 치가 phenobarbital 유도 시험후에는 2.0±1.1, 1.5±0.8 및 0.5±0.4mg/dL로서 열량 제한 시험 결과보다 유의하게 낮아졌고(p=0.00, p=0.000, p=0.001), 열량 제한 시험 전의 기초치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg.dL 보다도 더욱 낮아졌으며 유의한 차이(p=0.001, p=0.02, p=0.005)를 나타내었다. 14예에서 시행한 ^(99m)-Tc DISIDA 스캔에서 9예(64.3%)가 정상이었고, 5예(35.7%)에서는 심장 및 신장으로의 간외 섭취가 3예였고, 60분까지 소장 배출이 없는 배설 지연 예와 담낭 수축 불량 예가 각각 1예 씩 발견되었다. Phenobarbital 투여시험에서 민감도가 열량제한시험에 비해 더 높았다(92.3%와 50.0%). Gilbert 증후군에서 1일 400 Kcal로 48시간의 열량제한 시험과 1일 60mg의 phenobarbital을 5일간 투여하는 유도 시험은 편리하고 유용한 임상적인 진단법으로 이용할 수 있다고 생각된다. 그러나 열량 제한 시험에서는 증가 기준의 통일이 필요하다고 유추되며 phenobarbital 유도 시험이 민감도가 더 높은 것으로 생각된다. Gilbert's syndrome is very frequent and benign chronic process characterized by mild, intermittent, unconjugated hyperbilirubinemia without any symptom and sign of liver disease. Previously intoduced caloric restriction test and phenobarbital stimulation test as two appropriate clinical tests had been examined and their diagnostic values were reevaluated. Fourteen patients with mild, persistent, unconjugated hyperbilirubinemia were included. Subsequently caloric restriction has been applicated by 400 Kcal/day for 48 hours and phenobarbital has been prescribed by 60 mg/day for 5 days. Therafter serum levels of total and direct bilirubin were measured. Most of the patients were third and fourth decade(85.8%) and male predominant. Each basal serum levels of total, indirect and direct bilirubin were 3.0±0.8, 2.2±0.8 and 0.7±0.4 mg/dL. After caloric restriction test, each levels were increased significantly to 5.5±2.7, 4.2±2.3 and 1.3±1.0 mg/dL(p=0.001, p=0.001, p=0.023). After phenobarbital stimulation test for 13 patients had been practiced, increased levels of each bilirubin after caloric restriction test were decreased significantly to 2.0±1.0, 1.5±0.8 and 0.5±0.4 mg/dL(p=0.000, p=0.000, p=0.001) and these levels were significantly lower than basal levels(p=0.001, p=0.02, p=0.005). The sensitivities of caloric restriction test were 85.7%, 50.0%, and 71.4%, 35.7%(1.0, 1.5 mg increase of total bilirubin and 1.0, 1.5 mg/dL increase of indirect bilirubin). The sensitivities of phenobarbital stimulation test were 93.2% and 92.3% at criteria of 1.5 mg/dL increase of total bilirubin and indirect bilirubin. On the diagnosis of Gilbert syndrome, caloric restriction test and phenobarbital stimulation test are convenient and useful diagnostic tools in clinical face. And also phenobarbital stimulation test has higher sensitivity than caloric restriction test. Furthermore, standardization of bilirubin increment would be necessary in caloric restriction test.

코골음 및 무호흡증 환자에서 구개인두 성형술의 효과

강성호,홍석찬,이광희 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-

코골음 및 수면 무호흡증은 비중격 만곡, 편도비대, 비인강 협착 및 인두내 종물, 늘어진 구개 수나 연구개, 거대설, 후두낭종 등에 의한 해부학적 이상 소견으로 상기도 폐쇄를 일으켜서 나타 나는 것으로서 구개인두 성형술을 시행함으로써 상기도 폐쇄로 인해 생길 수 있는 합병증의 발생을 예방함과 동시에 코골음과 수면 무호흡증을 치료하는 데 기여할 것으로 사료된다. Sleep disorders as new disease entities continue to increase clinical experiences and increase their significance. Obstructive Sleep apnea syndrome is a disorder characterizd by subjective symptoms including daytime hypersomnolence, headache, altered mention, and snoring. Objective measurement using polysomnography documents episodes of apnea and desaturation level that provides more important information. In this study, we analyzed the changes of snoring and sleep apnea after uvulopalatopharyngoplasty. Postoperatively, snoring was shown to have been cured or improved in 92% of cases, while sleep apnea was improved in 69% of cases. This means that uvulopalatopharyngoplasty is mandatory to relieve the upper airway obstruction caused by anatomical abnormalities.

초임계 이산화탄소를 이용하는 친환경 공정에 의한 다공성 고분자의 제조

강세란,홍성수,이민규,이석희,천재기,주창식 한국환경과학회 2004 한국환경과학회지 Vol.13 No.3

An experimental study on the preparation of monolithic porous polymers by environmentally friend process in supercritical carbon dioxide has been carried out. Polymerization mixture composed of a cross-linking monomer, initiator and functional co-polymer was charged in the reactor with sapphire window. After the system was purged with a flow of CO₂ for 15 min, the reactor was pressurized with liquid CO₂ up to 100 bars. The reactor was isolated from and placed back to the system via quick connector for shaking until the mixture had become fully homogeneous. The reactor was then heated and pressurized to the required reaction conditions and left overnight. After cooling and CO₂ evacuation, the polymer was removed from the reactor as dry, white, continuous monoliths. The effect of experimental conditions on the physical properties of porous polymer was systematically examined, and it was found that monomer content had a major effect on the physical properties of the polymers.

삭골(Bone shaving)한 골의 재생에 골막이 미치는 영향

강진성,권건영,송중원,오석희,한기환 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

Many orientals have a more prominent malar eminence and mandibular angle than westerners so their faces often look rough and unattracive. In recent years more people want to have a more attractive and beautiful face due to economic prosperity and westernization. Therefore people receiving bone shavings or osteotomies for cosmetic purposes are increasing. The effects of the periosteum on lay bone grafts were investigated but the effect of the periosteum after bone shaving or osteotomy is little known. The authors investigated the effect of the periosteum on the regeneration of bone in membranous and endochondral bone of rabbits. Bony defects each measuring about 5.0×5.0×1.5mm were made on the left and right sides of the parietal bones of 15 rabbits and femurs of 15 other rabbits respectively. The periosteum was preserved on the left and removed on the right. The following results were obtained: 1) The average thickness of the regenerated bones in groups 2 δ4 were thinner than those in groups 1 δ 3 at 4, 8 and 12 weeks postoperatively but the differences of thickness were statistically significant at onl 4weeks postoperatively(P<0.05). 2) The histological findings in groups 2 δ 4 showed lesser regeneration of the shaved bone than those in groups 1 δ 3 at 4, 8 and 12weeks postoperatively. 3) There was no significant increase in the thickness of the regenerated bone after 8 weeks postoperatively in all groups. 4) At 12 weeks postoperatively, the thickness of the regenerated bone in all groups was over 70% of the thickness of the resected bone. In summary, the authors found that it is important to perform overcorrection and resect the periosteum simultaneously in bone shaving to prevent the unwanted regeneration.

慢性 氣管支喘息 患者에 있어서의 N-(3',4'-dimethoxycinnamoyl) anthranilic acid의 臨床的 效果

康晳榮,金有瑩,文熙範 최신의학사 1985 最新醫學 Vol.28 No.1

Assessment of In Vitro Assay System for Thyroid HormoneDisruptors Using Rat Pituitary GH3 Cells

Hee Jin Kim1,Hae Young Park1,Jeonga Kim1,Il Hyun Kang2,Tae Sung Kim2,Soon Young Han2,Tae Seok Kang2,Kui Lea Park2,Hyung Sik Kim1 한국독성학회 2006 Toxicological Research Vol.22 No.4

The development of in vitro assays has been recommended to screening and test-ing the potential endocrine disruptors (EDs). These assay systems focus only on identifying thethe thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detectTH disruptors using rat pituitary tumor GH3 cells. The test system is based on the TH-dependentincrease in growth rate. As expected, L-3,5,3-triiodothyronine (T3) markedly induced a morphologicalchange in GH 3 cells from flattened fibroblastic types to rounded or spindle-shaped types. T3 stimu-lated GH3 cell growth in a dose-dependent manner with the maximum growth-stimulating effect9 M. In addition, T3 increased the release of growth hor-mone and prolactin into the medium of the GH3 cells culture. Using this assay system, the TH-dis-rupting activities of bisphenol A (BPA) and its related compounds were examined. BPA,dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH3 cells in therange of 1 × 10-5M to 1 × 10-6M concentrations. In conclusion, this in vitro assay system might bestandardization before it can be used as a broad-based screening tool.

초음파상 지방간 정도와 간기능 수치의 연관 관계

강희태,한석희,남정수,김미영 한국건강관리협회 2000 건협 Report Vol.3 No.-

카르복시 폴리술폰 아이오노머의 기계적 성질

유지강,이용혁,김희석,김준섭,박기주,D. Nguyen,A. Eisenberg 조선대학교 생산기술연구소 1997 生産技術硏究 Vol.19 No.1

The dynamic mechanical properties of carboxylated polysulfone ionomers were studied by using DMTA. It was found that at 25 mol% of ions, the ionomer shows two glass transitions: one at ca. 200 ℃ and the other at ca. 235 ℃. It was also found that with increasing an ion content to ca. 37 mol%, a matrix T_(g) shifts to ca. 210 ℃, but a cluster T_(g) remains at the same temperature; however, the sizes of tan δ peaks for each transitions do not change with the ion content. This result means that even at those high ion contents, there is sufficient amount of a unclustered material in the samples, and the increase in the ion content does not increase the volume fraction of a cluster phase. In addition, the difference in two T_(g)s of this ionomer system was found to be ca. 40 ℃, which is smaller than that in poly(styrene-co-methacrylate) ionomer system. This finding implies that in the polysulfone ionomers weak ionic interactions in a multiplet resulting from steric hindrance due to the bulkiness of benzene ring to which the ionic group is attached and the tension on polymer chains surrounding the multiplet due to chain rigidity affect the size and stability of the multiplet significantly.

회분식 생물반응기를 이용한 BDOC_(rapid)와 BDOC_(slow) 결정

손희종,노재순,강임석 한국물환경학회 2004 한국물환경학회지 Vol.20 No.4

In this study, biodegradable organic matter was divided into a rapidly biodegradable fraction(BDOC_(rapid)) and a slowly biodegradable fraction(BDOC_(slow)) for various waters with different types of DOC. These fractions(BDOC_(rapid) and BDOC_(siow)) were defined by using a shaking incubation method modified from Carlson's method. Also, in this study, optimum incubation time and accuracy were investigated to determine BDOC_(rapid) and BDOC_(slow). When suspended bacteria obtained from raw water and BAC effluent, or attached bacteria from BAC was respectively used as an inoculum, the difference in total BDOC(BDOC_(total)) was minimal. Therefore, total BDOC was determined in 7~8 days by the shaking method, which is comparable with Servais's method by which BDOC was determined in 28 days. In addition, the difference of BDOC between these two methods was within 7%. Although BDOC_(rapid) and BDOC_(slow) were effectively determined by a method defined by Klevens, the difference in optimal incubation time was significant for different water samples. However, when using the shaking method, optimal incubation time for BDOC_(rapid) was found to be 3 days, therefore, the BDOC_(rapid) was defined as the difference between DOC_0 and DOC_(3days), and BDOC_(slow) was defined as the difference between BDOC_(total) and BDOC_(rapid). As a conclusion, for determining the fraction of BDOC using the shaking method, the concentrations of an inoculums and optimal incubation times used in this study were very effective.