http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hassan Ahmed Hassan Ahmed Ismail,강병훈,김재수,이재형,최인욱,차광호,육재민,이영하 대한기생충학ㆍ열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.6
IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these cytokines in T cells. Here, we investigated the roles of PI3K and MAPK pathways in IL-12 and IL-23 production in human Jurkat T cells in response to Toxoplasma gondii and LPS. IL-12 and IL-23 production was significantly increased in T cells after stimulation with T. gondii or LPS. T. gondii and LPS increased the phosphorylation of AKT, ERK1/2, p38 MAPK, and JNK1/2 in T cells from 10 min post-stimulation, and peaked at 30-60 min. Inhibition of the PI3K pathway reduced IL-12 and IL-23 production in T. gondii-infected cells, but increased in LPS-stimulated cells. IL-12 and IL-23 production was significantly reduced by ERK1/2 and p38 MAPK inhibitors in T. gondii- and LPS-stimulated cells, but not in cells treated with a JNK1/2 inhibitor. Collectively, IL-12 and IL-23 production was positively regulated by PI3K and JNK1/2 in T. gondii-infected Jurkat cells, but negatively regulated in LPS-stimulated cells. And ERK1/2 and p38 MAPK positively regulated IL-12 and IL-23 production in Jurkat T cells. These data indicate that T. gondii and LPS induced IL-12 and IL-23 production in Jurkat T cells through the regulation of the PI3K and MAPK pathways; however, the mechanism underlying the stimulation of IL-12 and IL-23 production by T. gondii in Jurkat T cells is different from that of LPS.
Ismail Hassan Ahmed Hassan Ahmed,차승만,김연,홍성태 대한기생충학ㆍ열대의학회 2023 The Korean Journal of Parasitology Vol.61 No.2
In several schistosomiasis-endemic countries, the prevalence has remained high in some areas owing to reinfection despite repeated mass drug administration (MDA) interventions; these areas are referred to as persistent hot spots. Identifying hotspots is critical for interrupting transmission. This study aimed to determine an effective means of identifying persistent hot spots. First, we investigated the differences between Schistosoma haematobium and Schistosoma mansoni prevalence among school-aged children (SAC) estimated by a community-based survey, for which local key informants purposively selected communities, and a randomly sampled school-based survey. A total of 6,225 individuals residing in 60 villages in 8 districts of North Kordofan, Blue Nile, or Sennar States, Sudan participated in a community-based survey in March 2018. Additionally, the data of 3,959 students attending 71 schools in the same 8 districts were extracted from a nationwide school-based survey conducted in January 2017. The community-based survey identified 3 districts wherein the prevalence of S. haematobium or S. mansoni infection among SAC was significantly higher than that determined by the randomly sampled school survey (e.g., S. haematobium in the Sennar district: 10.8% vs. 1.1%, P<0.001). At the state level, the prevalence of schistosomiasis among SAC, as determined by the community-based survey, was consistently significantly higher than that determined by the school-based survey. Purposeful selection of villages or schools based on a history of MDA, latrine coverage, open defecation, and the prevalence of bloody urine improved the ability for identifying persistent hot spots.
Inkjet-printed antenna on thin PET substrate for dual band Wi-Fi communications
Hassan, A.,Ali, S.,Hassan, G.,Bae, J.,Lee, C. H. Springer Science + Business Media 2017 Microsystem Technologies Vol.23 No.8
<P>In this paper, we propose a high gain antenna operating over dual band of 900 MHz and 2.4 GHz. The proposed antenna is designed by finite element method (FEM) based Ansys high frequency structure simulator (HFSS). We use conductive ink of silver nanoparticles (AgNPs) and commercial Dimatix material inkjet printer (DMP-3000) to print the proposed antenna on 50-micron thick, transparent and flexible polyethyleneterephthalate (PET) substrate. To characterize the fabricated antenna, we use vector network analyzer (VNA) and obtain reflection coefficients of -16.4 dB at 900 MHz and -26 dB at 2.4 GHz, which accord with the HFSS simulation results. HFSS simulated results provide antenna gains as high as 16.74 and 16.24 dBi at 900 MHz and 2.4 GHz, respectively and 23.33 and 11.66 % of -10 dB fractional bandwidth at 900 MHz and 2.4 GHz, respectively. These results suggest that the proposed high gain antenna can be used for dual band Wi-Fi and wearable devices as well.</P>
Chitosan effects on glass matrices evaluated by biomaterial. MAS-NMR and biological investigations
Hassane Oudadesse,Eric Wers,Xuang Vuong Bui,Claire Roiland,Imane Akhiyat,Amany Mostafa,Hassan Chaair,Hicham Benhayoune,Joel Fauré,Pascal Pellen-Mussi,Bruno Bureau 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.9
Bioactive glass 46S6 and biodegradable therapeutic polymer (Chitosan: CH) have been elaborated to form 46S6-CH composite by freeze-drying process. The kinetics of chemical reactivity and bioactivity at the surface were investigated by using physicochemical techniques, particularly solid-state MAS-NMR. Immortalized cell line used to construct multicellular spheroids was employed as three-dimensional (3D) cell cultures for in vitro studies. Obtained results showed a novel structure of the composite; the chemical treatment (ultrasound, magnetic stirring, freeze drying process and lyophilization) led the bioactive glass particles to be loaded in the chitosan-based materials. 29Si and 31P MAS-NMR results showed the emergence of two new species, QSi 3(OH) and QSi 4, which are characteristic of the vitreous network dissolution in simulated body fluid (SBF). MAS-NMR also confirmed the formation of amorphous calcium phosphate (ACP) at the surface of the initial 46S6-CH. Three-dimensional (3D) cell cultures highlighted the effect of chitosan, where the cell viability reached up to 78% in 46S6-CH composite and up to 67% in 46S6. The association of (CH) and bioactive glass (BG) matrix promotes a highly significant bioactivity, demonstrating surface bone formation and satisfactory behavior in biological environment.
Hassan, Syed Tauseef,Danish, Danish,khan, Salah-Ud-Din,Baloch, Muhammad Awais,Tarar, Zahid Hassan Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.12
Looking at the recent studies, nuclear energy and carbon dioxide (CO<sub>2</sub>) emissions nexus shows inconclusive result. To further explain nuclear energy-pollution nexuses this study is an attempt to analyze the impact of nuclear energy on pollution reduction for BRICS countries covering data for the period from 1993 to 2017. This study conducts advanced panel techniques such as Continuously-Updated Fully-Modified (CUP-FM) and Continuously-Updated Bias-Corrected (CUP-BC) for long run estimation. Our results support the notion that nuclear energy reduce CO<sub>2</sub> emissions. Also, renewable energy corrects environmental pollution in BRICS countries. The magnitude of the coefficient of nuclear energy is less as compared to renewable energy, implying that nuclear is less effective in reducing environmental pollution. The findings offer significant policy understandings and suggestions not only for BRICS economies but for developing countries as well in designing suitable nuclear energy-growth-carbon policies.
Clinical Findings of Sydenham Chorea in Pediatric Patients: A Single-Center Retrospective Study
Hassan Mottaghi Mohaddam Shahri,Ehsan Hassan Nejad,Mehran Beiraghi Toosi,Abdolreza Malek,Asma Payandeh 대한소아신경학회 2023 대한소아신경학회지 Vol.31 No.3
Purpose: Sydenham chorea is known for its rapid, irregular, and aimless involuntary movements and is considered a benign and self-limiting condition among the major manifestations of rheumatic fever. The current study reviewed the demographic, clinical, and paraclinical findings of pediatric patients with Sydenham chorea. Methods: This cross-sectional study was conducted among 22 patients with Sydenham chorea who were admitted to the pediatric wards of Mashhad Imam Reza and Ghaem Hospitals between 2006 and 2016. Data from these patients’ medical records were extracted, organized using checklist forms, and analyzed. Results: Eight patients were male and 14 were female. The average age was 10.09±3.53 years. In 31.8% of patients, chorea was the only sign of rheumatic fever. Chorea was unilateral in 21.1% of patients. The most common clinical findings were, in descending order, jerky movements, facial grimacing, gait disorders, mental disorders, speech disorders, muscle weakness, and milkmaid’s grip. Cardiac auscultation was normal in 76.2% of patients, while a holosystolic murmur was heard in 23.8%. In laboratory exams, 50% of patients were erythrocyte sedimentation rate (ESR)-positive, 31.2% were C-reactive protein (CRP)-positive, and 53.3% were anti-streptolysin O (ASO)-positive. Echocardiography showed the prevalence of mitral regurgitation (63.6%), aortic regurgitation (45.5%), tricuspid regurgitation (22.7%), pulmonary regurgitation (4.5%), and pericardial effusion (4.5%). Conclusion: This study showed that Sydenham chorea can be the only sign of rheumatic fever. This disease typically occurs in children between the ages of 7 and 12. ESR, CRP, and ASO can be the most effective laboratory tests for diagnosis.