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Haneul Kwon,박병진 대한가정의학회 2020 Korean Journal of Family Medicine Vol.41 No.6
Background: High mean corpuscular volume (MCV) has been implicated in various health problems, such as anemia, liver disease, and thyroid disease. However, the clinical significance of borderline-high MCV is poorly understood in the primary care setting. This study aimed to investigate whether borderline-high MCV was related to arterial stiffness in Korean adults as measured by brachial-ankle pulse wave velocity (baPWV). Methods: This cross-sectional study comprised 582 participants aged >30 years who underwent routine health examinations. Borderline-high MCV was defined as over 95.0 fl (>90th percentile) after excluding participants with MCV of ≥100 fl or ≤80 fl, and high baPWV was defined as >1,600 cm/s (>90th percentile). The odds ratios (ORs) and 95% confidence intervals (CIs) for high baPWV according to borderline-high MCV were calculated using multiple logistic regression analyses after adjusting for the confounding variables. Results: The mean age of the study population was 47.8±11.7 years, and 56.9% of the participants were male. Compared to that in the control group, the OR (95% CI) of high baPWV in those with a borderline-high MCV was 3.68 (1.39–9.74) after adjusting for age, sex, body mass index, alcohol intake, smoking status, regular exercise, mean blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein cholesterol, C-reactive protein, γ-glutamyltransferase, uric acid, hypertension medication, and diabetes medication. Conclusion: Borderline-high MCV was independently associated with arterial stiffness among apparently healthy Korean individuals.
Kim, Haneul,Lee, Hyung Eun,Jung, In Ho,Jeon, Se Jin,Zhang, Jiabao,Kwon, Yubeen,Jang, Dae Sik,Ryu, Jong Hoon Elsevier 2018 Journal of Ethnopharmacology Vol.211 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>The seeds of <I>Ziziphus jujuba</I> var. <I>spinosa</I> (Bunge) Hu ex H.F Chow (Rhamnaceae) and the roots of <I>Codonopsis lanceolata</I> (Siedbold & Zucc.) Benth. & Hook. f ex Trautv. (Campanulaceae), contained in the DHP1402, have long been used for treating dementia or hypomnesia as folk medicine.</P> <P><B>Aim of the study</B></P> <P>It has been reported that <I>Z. jujuba</I> var. <I>spinosa</I> and <I>C. lanceolata</I> are effective in improving cognitive function, but via different mechanisms. Therefore, in the present study, we evaluated the synergistic effects of <I>Z. jujuba</I> var. <I>spinosa</I> and <I>C. lanceolata</I> on scopolamine-induced memory impairment.</P> <P><B>Materials and methods</B></P> <P>Scopolamine, a cholinergic muscarinic receptor antagonist, was used to induce cognitive dysfunction. We employed several behavioral tasks to estimate the synergistic effect of the seeds of <I>Z. jujuba</I> var. <I>spinosa</I> and the roots of <I>C. lanceolata</I>. In addition, we introduced the Western blotting, the antagonism passive avoidance task to investigate a synergistic effect of an herbal formulation.</P> <P><B>Results</B></P> <P>Synergistic effects of a combination of <I>Z. jujuba</I> var. <I>spinosa</I> and <I>C. lanceolata</I> at a 5:1 ratio [(w/w), DHP1402] were observed against cognitive dysfunction in the passive avoidance and Y-maze tasks. DHP1402 also ameliorated memory deficits in a dose-dependent manner in these behavioral tasks, as well as in the Morris water maze task. According to the Western blot results, the phosphorylation levels of protein kinase A (PKA), extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus were also increased in a synergistic manner after the administration of DHP1402. In addition, we found that the effects of DHP1402 on cognitive function were mediated by <I>N</I>-methyl-<I>D</I>-aspartate (NMDA) receptor signalling, based on the antagonism studies. Furthermore, we found that DHP1402 has inhibitory activity against acetylcholinesterase (AChE).</P> <P><B>Conclusion</B></P> <P>DHP1402 attenuates cholinergic blockade-induced cognitive dysfunction through NMDA receptor modulation, PKA-ERK-CREB pathway activation, and AChE inhibition. Therefore, DHP1402 could be a candidate for alleviating cognitive dysfunction.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hollow nanoparticles as emerging electrocatalysts for renewable energy conversion reactions
Park, Jongsik,Kwon, Taehyun,Kim, Jun,Jin, Haneul,Kim, Ho Young,Kim, Byeongyoon,Joo, Sang Hoon,Lee, Kwangyeol The Royal Society of Chemistry 2018 Chemical Society reviews Vol.47 No.22
<P>While the realization of clean and sustainable energy conversion systems primarily requires the development of highly efficient catalysts, one of the main issues had been designing the structure of the catalysts to fulfill minimum cost as well as maximum performance. Until now, noble metal-based nanocatalysts had shown outstanding performances toward the oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER). However, the scarcity and high cost of them impeded their practical use. Recently, hollow nanostructures including nanocages and nanoframes had emerged as a burgeoning class of promising electrocatalysts. The hollow nanostructures could expose a high proportion of active surfaces while saving the amounts of expensive noble metals. In this review, we introduced recent advances in the synthetic methodologies for generating noble metal-based hollow nanostructures based on thermodynamic and kinetic approaches. We summarized electrocatalytic applications of hollow nanostructures toward the ORR, OER, and HER. We next provided strategies that could endow structural robustness to the flimsy structural nature of hollow structures. Finally, we concluded this review with perspectives to facilitate the development of hollow nanostructure-based catalysts for energy applications.</P>
Catalytic pyrolysis of waste printed circuit boards
( Hyunjin Kim ),( Jihyeon Seo ),( Haneul Shim ),( Youngeun Kang ),( Young-min Kim ),( Sumin Pyo ),( Young-kwon Park ) 한국폐기물자원순환학회 2022 ISSE 초록집 Vol.2022 No.-
Owing to the increased amount of electrical and electronic equipment, caused by the usage amount increase and further accelerated the exchange period of hardware, such as personal computer, smart phone, display equipment, and so on, the amount of electronic waste (e-waste) had been largely increased in recent decades. Printed circuit board (PCB) is a main component of electrical and electronic equipment and difficult to be recycled due to its harmful effect caused by the high halogen contents. In addition, the multilayer structure of PCB, consisted with additives, polymers, paper, and inorganics, makes it difficult to use the simple pyrolysis product as fuel or chemical feedstocks. Therefore, the catalytic pyrolysis was applied to increase the selectivity toward to the value-added products in this study. For the experiments, the tandem micro reactor-gas chromatography/mass spectrometry was used for the simple pyrolysis in the 1<sup>st</sup> furnace and sequential catalytic upgrading of pyrolysis products in the 2<sup>nd</sup> furnace. The product distribution produced at different temperature and by the use of different catalysts was analyzed and discussed to optimize the process operation for the chemical recycling of PCB. The obtained results suggested that the product oil quality can be increased by applying catalytic pyrolysis process increasing the yield of aromatic hydrocarbons with the decrease oxygen contents.