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RISS 인기검색어
- 검색키워드
- 저자 : Han-chun Chen (검색결과 56 건)
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Effect of the Circle-Grid Electrodes on Concentrated GaAs Solar Cell Efficiency
Chen-Chen Chung,Binh Tinh Tran,Ming-Hung Han,Kung-Liang Lin,Hung-Wei Yu,Yen-Teng Ho,Chun-Yen Chang,Edward Yi Chang 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.5
In this study, we investigate the effect of the shading factor of the front grid pattern on concentrated solar cell efficiency, taking the trade-off between the series resistance of the electrodes and the amount of incident light into consideration. We examine the thermal effect with regard to five different circle-grid electrode patterns of the front contact. The front contacts with different grid patterns affect the characteristics of light-concentratedtype GaAs single-junction solar cells. The device parameters analyzed include the open-circuit voltage (Voc), short-circuit current (Isc), fill factor (FF) and conversion efficiency (η). The results of our study show that for a concentration ratio greater than 60x with AM1.5G, the device with a shading factor of 7.1% has the best cell efficiency of 27.05%, due to the smaller current crowding at the center spot. The results indicate that the conversion efficiency of solar cells can be improved by establishing a compromise between the shading effect and the series resistance effect.
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Han-Chun Hung,Chien-Wei Feng,Yen-You Lin,Chun-Hong Chen,Kuan-Hao Tsui,Wu-Fu Chen,Chieh-Yu Pa,Jyh-Horng Sheu,Chun-Sung Sung,Zhi-Hong Wen 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Atopic dermatitis (AD) is a chronic inflammatory skin disease, and its prevalence is increasing. AD usually elicits skin barrier dysfunction, dry skin and itching. As the mechanisms of AD remain unknown, there is an urgent need to find effective therapies. Because of the diversity and complexity of marine environments, the discovery of drugs from marine organisms as novel therapeutic agents for human diseases has seen renewed interest. Dihydroaustrasulfone alcohol (WA-25), the synthetic precursor of austrasulfone, which is a natural product isolated from a Formosan soft coral, has been shown to possess many therapeutic effects in our previous studies. However, the detailed mechanisms and therapeutic effects of WA-25 on AD are incompletely understood. We performed in vitro and in vivo studies to examine the effects of WA-25 on AD. We showed that WA-25 blocks inflammation and oxidative stress. Simultaneously, we also found that WA-25 reduces the AD scores and AD-induced transepidermal water loss (TEWL), scratching behavior, and alloknesis. WA-25 is more effective in cases of AD than are the drugs that are currently used clinically. Importantly, we also found that when nucleophosmin (NPM) was inhibited or when its expression was reduced, the anti-inflammatory and anti-AD effects of WA-25 were blocked. These data suggest that NPM plays dual roles in inflammation and AD. Overall, these results suggest that WA-25 is a potential anti-inflammatory and AD therapeutic agent that is modulated by NPM.
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Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.
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End-to-end Service Assurance in 5G Crosshaul Networks
Che-Chun Teng,Mei-Chun Chen,Min-Han Hung,Hong-Jie Chen 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09
More and more telecom operators around the world began to build and to deploy fifth-generation (5G) mobile networks. With the advent of 5G service scenarios, it brings new challenges and increases the complexity of management. To deliver good quality of experience of these 5G applications for customers, service assurance is important. In this paper, we propose an end-to-end service assurance solution for 5G crosshaul networks. The 5G crosshaul network architecture consists of fronthaul, midhaul, and backhaul networks. Our solution deployed in 5G trial network in Chunghwa Telecom in Taiwan. The solution focus on slicing service assurance and synchronization monitoring. Besides, our solution adjusts most of network management in the operation support system (OSS) to apply to 5G crosshaul network. Our goal is to provide stable 5G transport network and to assure quality of experience for customers.
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Pao-Huan Chen(Pao-Huan Chen),Chun-Ming Shih(Chun-Ming Shih),Chi-Kang Chang(Chi-Kang Chang),Chia-Pei Lin(Chia-Pei Lin),Yung-Han Chang(Yung-Han Chang),Hsin-Chien Lee(Hsin-Chien Lee),El-Wui Loh(El-Wui Lo 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: Predicting disease relapse and early intervention could reduce symptom severity. We attempted to identify potential indicators that predict the duration to next admission for an acute affective episode in patients with bipolar I disorder. Methods: We mathematically defined the duration to next psychiatric admission and performed single-variate regressions using historical data of 101 patients with bipolar I disorder to screen for potential variables for further multivariate regressions. Results: Age of onset, total psychiatric admissions, length of lithium use, and carbamazepine use during the psychiatric hospitalization contributed to the next psychiatric admission duration positively. The all-in-one found that hyperlipidemia during the psychiatric hospitalization demonstrated a negative contribution to the duration to next psychiatric admission; the last duration to psychiatric admission, lithium and carbamazepine uses during the psychiatric hospitalization, and heart rate on the discharge day positively contributed to the duration to next admission. Conclusion: We identified essential variables that may predict the duration of bipolar I patients’ next psychiatric admission. The correlation of a faster heartbeat and a normal lipid profile in delaying the next onset highlights the importance of managing these parameters when treating bipolar I disorder.
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Chen, Xiaoqiang,Lee, Kyung-Ah,Ha, Eun-Mi,Lee, Kyung Mi,Seo, You Yeong,Choi, Han Kyoung,Kim, Ha Na,Kim, Min Jung,Cho, Chun-Seok,Lee, Soo Young,Lee, Won-Jae,Yoon, Juyoung Royal Society of Chemistry 2011 Chemical communications Vol.47 No.15
<P>A specific and sensitive fluorescence-based method was developed for the imaging of microbe-induced HOCl production. Furthermore, we demonstrate dual oxidase (DUOX)-mediated HOCl generation in the mucosa of live animals providing a novel insight into mucosal innate immunity.</P> <P>Graphic Abstract</P><P>A specific and sensitive fluorescence-based method was developed for the imaging of microbe-induced HOCl production. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc10589b'> </P>
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CHEN, JITAO,CHOUGH, SUNG KWUN,CHUN, SEUNG SOO,HAN, ZUOZHEN Blackwell Publishing Ltd 2009 Sedimentology Vol.56 No.4
<P>Abstract</P><P>This paper focuses on the formative processes of limestone pseudoconglomerates in the Gushan and Chaomidian Formations (Late Cambrian) of the North China Platform, Shandong Province, China. The Gushan and Chaomidian Formations consist mainly of limestone and shale (marlstone) interlayers, wackestone to packstone, grainstone and microbialite as well as numerous limestone conglomerates. Seventy-three beds of limestone pseudoconglomerate in the Gushan and Chaomidian Formations were analysed based on clast and matrix compositions, internal fabric, sedimentary structures and bed geometry. These pseudoconglomerates are characterized by oligomictic to polymictic limestone clasts of various shapes (i.e. flat to undulatory disc, blade and sheet), marlstone and/or grainstone matrix and various internal fabrics (i.e. intact, thrusted, edgewise and disorganized), as well as transitional boundaries. Limestone pseudoconglomerates formed as a result of soft-sediment deformation of carbonate and argillaceous interlayers at a shallow burial depth. Differential early cementation of carbonate and argillaceous sediments provided the requisite conditions for the formation of pseudoconglomerates. Initial deformation (i.e. burial fragmentation, liquefaction and injection) and subsequent mobilization and disruption of fragmented clasts are two important processes for the formation of pseudoconglomerates. Burial fragmentation resulted from mechanical rupture of cohesive carbonate mud, whereas subsequent mobilization of fragmented clasts was due to the injection of fluid materials (liquefied carbonate sand and water-saturated argillaceous mud) under increased stress. Storm-wave loading was the most probable deformation mechanism, as an external triggering force. Subsequent re-orientation and rounding of clasts were probably prolonged under normal compactional stress. Eventually, disrupted clasts, along with matrix materials, were transformed into pseudoconglomerates by progressive lithification. Soft-sediment deformation is prevalent in alternate layers of limestone and mud(marl)stone and/or grainstone, regardless of their depositional environments.</P>
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Development of Phalaenopsis Flowering Quality Prediction Models
( Han-chun Hsu ),( Suming Chen ),( Chao-yin Tsai ),( Yung-huei Chang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Phalaenopsis is an important exported flower in Taiwan and its flowering quality was reported to be correlated to its leaves’ carbohydrate contents and external traits. Phalaenopsis Sogo Yukidian 'V3' was used as the experimental samples in this research. A hand-held spectrometer and a hyperspectral system were used to build the carbohydrate content prediction models (CC model) respectively first, and then combined with leaves’ external traits obtained from hyperspectral imaging to build the flowering quality prediction model (FQ model). The advantage and application of FQ models built by both devices were compared. The results showed that the CC models built with MPLSR for glucose, fructose, sucrose, total soluble sugar, starch and total carbohydrates by hyperspectral system were all better than those by hand-held spectrometer. The results of FQ models with PLSDA and SVM also showed that the performance of hyperspectral system to discriminate quality levels was better. As for the ANN models’ results to predict the total number of flowers, the errors using both devices were all lower than 0.87. The research proved that using spectral technique to predict the interior contents in Phalaenopsis leaves or flowering quality were both feasible. Although the performance of hyperspectral imaging system is better than that of hand-held spectrometer, it was expensive and not as convenient as hand-held spectrometer. We can adopt some other ways such as using multispectral imaging system or optimize the performance of hand-held spectrometer if we want to apply the results to the Phalaenopsis industry.
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Chun-Chieh Fu,Hai Nguyen Tran,Xing-Han Chen,Ruey-Shin Juang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.83 No.-
In this study, novel polyethylenimine (PEI)-grafted chitosan (CS) core-shell (called as Fe3O4/CS/PEI)magnetic nanoparticles were synthesized and applied for adsorbing phosphate in water. The magneticand physicochemical properties of as-synthesized nanoparticles werefirst analyzed by means of asuperconducting quantum interference device, X-ray diffractometer, X-ray photoelectron spectroscope,Fourier-transform infrared spectroscope, transmission electron microscope, zeta potential analyzer, andnitrogen sorptiometer. The followed experiments indicated that the amount of phosphate adsorbedincreased with increasing equilibrium pH to near 4.0 and then decreased when the pH was furtherincreased. The adsorption isotherms of phosphate on Fe3O4/CS/PEI particles were wellfit by the Langmuirequation, and its maximum adsorption was 48.2 mg g 1 at an equilibrium pH of 3.0 and 25 C. Theprimary mechanism for phosphate adsorption on Fe3O4/CS/PEI particles was electrostatic attraction. Thepreferential adsorption of phosphate in the presence of other excess anions including chloride, nitrate,carbonate, and sulfate was presented. Under the conditions studied, more than 90% of phosphate wasdesorbed from the laden Fe3O4/CS/PEI particles by 0.05 mol L 1 of NaOH solution. The remainedadsorption efficiency obtained in thefive-cycle reusability tests has demonstrated the promisingapplication potential of Fe3O4/CS/PEI particles.
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