흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향

최한곤,장보현,이종달,김정애,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

Drug interactions with food, on occasion, led to serious nutritional and functional changes in the body as well as alterations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increased risk of microvascular, macrovascular, and neuropathic complications. However, the precise mechanism of diabetes mellitus remins unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo-or hyperglycemia and preventing complications. Laminaria japonica is a brown macroalgae which can be used as a functional diet due to high content of diatery fiber. the purpose of this study was to investigate the effect of Laminaria japonica diet on the pharmacokinetics of metformin which are frequently used in the treatment of diabetes. Diabetic rats induced by strep-tozotocin were employed in this study. Blood concentrations of oral hypoglycemic agent, metformin, were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_(a), t_(1/2), C_(max), t_(max), and AUC, C_(max), and k_(a), and increase in t_(max), compared to those with normal diet. This oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of metformin caused by ong-term Laminaria japonica diet.

클렌부테롤의 피부투과에 미치는 경피흡수촉진제의 영향

최한곤,이종달,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.1

Clenbuterol, a selective β_2-adrenergic receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic obstructive bronchial disease, chronic bronchitis and pulmonary emphysema. The percutaneous permeation of clenbuterol was investigate in hairless mouse skin after application of 50/50 buffer(pH 10)/propylene glycol solvent mixture. The enhancing effects of various penetration enhancers such as terpenes, non-ionic surfactants, pyrrolidones, fatty acids and some other enhancers on the permeation of clenbuterol were evaluated using Franz diffusion cell. Among terpenes studied, 1,8-cineole was the most effective enhancer, which increase the permeability of clenbuterol approximately 39.33-fold compared with the control without penetration enhancer, followed by menthone with enhancement ratio of 23.57. Nonionic surfactants did not have significant enhancing effects. N-Lauryl-2-pyrrolidone increased the permeability of clenbuterol approximately 4.51-fold compared with the control. Lauric acid increased the permeability of clenbuterol approximately 35.57-fold with decreasing the lag time from 2.64 to 0.52 hr. Oleic acid, linoleic acid, the permeability of clenbuterol 9.24-fold compared with that without enhancer.

LED배열을 이용한 광Vector-Matrix 곱셈에 관한 연구

최평석,박한규 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.2

인코히어런트광은 이용하여 vector-matrix 곱셈기를 LED 배열 및 lens계, mask 등으로 구성하였다. 입력 vector 는 LED 배열로 나타내었으며 matrix 는 mask 상에 면적변조방식으로 부호화 하였다. 곱셈의 결과는 lens계를 통하여 photodiode 배열로 검출하였으며 하나의 채널로 출력을 관찰하기 위해 analog multiplexer를 사용하였다. vector 및 matrix의 원소가 양의 실수 및 복소수일 경우에 대하여 출력파형을 관찰하였으며 특히 복소수 data일 경우 mask 상에 부호화 하는 방법을 제시하였다. The vector-matrix multiplier using incoherent optical illumination is constructed with a LED array, lens system and mask. The input vector is represented by a LED array and the matrix is encoded on a film by the mask modulation method. The result of multiplication is detected by a photodiode array through the lens system, and an analog multiplexer is used for looking at output signal on the channel. When the elements of a vector and matrix are positive number and complex number, the output signal is observed. Finally an encoding method in case of complex data is suggested.

프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성

최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1

Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.

횡문근융해증과 급성 신부전 및 범발성 혈관내 응고장애를 동반한 열사병 1예

최대은,박수진,권오경,이한규,이영모,이상주,나기량,이강욱,신영태 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Heat stroke is a life-threatening illness characterized by an elevated core body temperature that rises above 40% and central nervous system dysfunctions that results in delirium, convulsions, or coma. Heat stroke is subdivided into two forms, classic and exertional. Since strenuous exercise is one of the major exacerbating and precipitating factors, the incidence of exertional heat stroke is high among young adult, especially military personnel undergoing military training. Exertional heat stroke commonly causes rhabdomyolysis, lactic acidosis, acute renal failure, shock and pulmonary edema. We report a case of heat stroke with rhabdomyolysis, acute renal failure, disseminated intravascular coagulopathy(DIC) after strenuous exercise. A 18 year old man was admitted to the hospital because of loss of consciousness. He was a wrestler and he had tried to lose 6kg in weight by jogging and strenuous exercise on that summer day with hot temperature. The development of this illness was favoured by much clothes inappropriate for that environmental condition with a purpose to enhance sweating, and by restricted intake of water and food. On admission, the blood pressure was 80/50mmHg, and body temperature was 39.4℃ with stuporous mentality. Laboratory finding were as follows : in complete blood cell count, hemoglobin was 16.7g/dL and platelet count was 158,000/ mm³. In blood chemistry, AST 1061U/L, ALT 201U/L, BUN 30mg/dL, Cr 2.2mg/dL, LDH 941IU/L, CK 696IU/L were resulted. In arterial blood gas analysis, pH 7.39, pCO₂ 30mmHg pO₂ 86mmHg, HCO₃ 18.4mEq/L, O₂ saturation 96.7% were resulted. In urinalysis, specific gravity 1.025, protein 3+, erythrocyte 2+ were resulted. In brain imaging study, brain CT finding was normal. After appropriate treatments with rapid cooling, hydration and supportive care, he improved with alert mental status. On 2nd hospital day, in laboratory result, thrombocytopenia and coagulopathy were appeared and renal insufficiency was aggravated. So he was treated with platelet concentrate and fresh frosen plasma for DIC, and enough hydration for appropriate urine volume preservation. After all, On 22nd hospital day, he fully recovered and discharged. Nowadays, with followed for some duration, he is wellbeing with no complications.

계란의 음향진동 모드분석

최완규,조한근 충북대학교 농업과학기술연구소 2001 農業科學硏究 Vol.18 No.-

Surface crack detection is an important aspect in the quality control process of egg markets. The acoustic vibration of an egg could be used as a critical factor in evaluating the eggshell quality. The mode shape indicates the egg vibration behavior at different locations with respect to the input impulse and provides important information for the optimum sensor location to obtain the desired acoustic measurements. Theoretical analysis and experimental measurements were conducted to determine the acoustic vibration modes in eggs. The resonant frequencies of the first and second resonance mode of intact eggs were found to be distributed between 2kHz and 7kHz range. The measured mode shapes of an egg were similar to theoretical shapes of homogeneous, elastic spheres. An elliptical deformation at the equator ring of the egg was observed. The frequency peak of this mode was dominantly present in the frequency spectrum of an intact egg impacted at its sharp position. The mode shapes related to the first resonant frequency of an egg showed that the optimum location for the measuring sensor was the 180 degrees position. A optimum location for the egg support was found to be the 90 degrees position having the smallest vibration magnitude.

내린천 유역의 HEC-HMS 모형 적용에 관한 연구

최한규,백효선,정병하 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A

HEC-HMS model should be calibrated to be applied to these basins in Gangwon-do unlike the general basins. In the study, it is investigated whether the HEC-HMS model may be applied or not to Naerinchon basin where is the typical basin of Gangwon-do Additionally, the straightforword module of HEC-HMS for simulating the hydrologic characteristic of Gangwon-do basins well will be suggested by comparison of the numerical results with the observed data. The hydrologic results estimated by several modules such as Clark, SCS and Snyder methods in HEC-HMS model have been compared with the observed data for 1999~2000 storm events. It is concluded that Clark method are relatively applicable to the basins in Gangwon-do rather than the others methods. The parametric studies for HEC-HMS model should be studied further in order to apply to Gangwon-do basins more accurately.

雙極形 트랜지스터를 利用한 高周波 增幅器에 관한 硏究

최상준,朴漢奎 연세대학교 산업기술연구소 1977 논문집 Vol.7 No.1

. In this paper, the historical background and physical characteristic of bipolar transistor is explained, and S-parameters of two-port network are measured with HP 8410 network analyzer system. As a ploting the measured values of S-parameters and the constant gain circle on the Smith chart, the amplifier can be designed to have a nearly constant power gain in U.H.F. A trial and error process is followed to find the proper matching element to provide the required output or input matches at frequncy. To measure S-parameters insert 2 SC 1673 NPN silicon bipolar transistor in the HPK02-8405 A transistor fixture and the HP8410 network analyzer system used to measure the characteristics. In this experiment, the amplifier is designed with S-parameters data and operates from 400 MHz to 800 MHz with a typical gain of 13 dB and flat to within 1 dB across the band.

백서의 원위부 피편에 동맥유입의 중요성에 관한 실험적 연구

최규남,최희윤,강희문,김한중 大韓成形外科學會 1983 Archives of Plastic Surgery Vol.10 No.2

Microsurgery and myocutaneous flap have been developed recently for wide employment in plastic and reconstructive surgery. Therefore, the delay procedure has been declined in its use recently, because it has many difficult problems. If the flap is longer and larger, it should be delayed for complete survival, but delay requires considerable time. Therefore, as a substitute for delay, vascular anastomosis in the distal part of a flap will theoretically give the same effect. In this study, we investigated the importance of arterial inflow in the distal side of a flap in rats. The experiment was done in 3 different groups according to the design of flaps and in each group 3 subgroups were made. In A flap, the superficial epigastric artery was preserved or anastomosis. In V flap. the superficial epigastric vein was preserved or anastomosis. In C flap, as a control flap, both artery and vein were severed. In result, A flaps in all 3 groups were completely survived. Both V and C flaps in all 3 groups were showed distal necrosis. But C flaps were showed more necrosis than V flaps. In conclusion, we suggest the possibility that a large flap may be transposed in one stage with vascular anastomosis in the distal part-preferably artery and vein, or artery only.

N₂O₃계 거대고리 리간드와 전이금속 이온과의 착물 형성에 관한 연구

최규성,박휴범,유한준 慶南大學校 附設 基礎科學硏究所 1992 硏究論文集 Vol.4 No.-

The stability constants of the complexes of transition metal ions(Co²+, Ni²+, Cu²+, and Zu²+) with N₂O₃-donor macrocyclic lignads such as 1,15-diaza-3,4 : 12,13-dibenzo-5,8,11-trioxacy-cloheptadecane(NenOdienH₄)and 1,15-diaza-3,4 :12, 13-dibenzo-5, 8, 11-trioxacyclooctade-cane( NtnOdieH₄)have been determined by polarographic method in MeOH solution at 25℃. From the results, the followings have been obstained, 1. In MeOH solution, transition metal ions from a 1:1 complex with these ligands. 2. The order complex stability constants of transition metal ions these ligands is Co(II) < Ni(II) <Cu(II) < Zn(II), the same as the natural order of stability proposed by Williams-Irving. 3. The order of stability constants of Ni(II), Cu(II) ions is NenOdienH₄> NtnOdienH₄, of Co(II), Zn(II) ions is NenOdienH₄< NtnOdienH₄.