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Estimated incidence of juvenile-onset recurrent respiratory papillomatosis in Korea
Jin-Kyoung Oh,Hwa Young Choi,Minji Han1,Yuh-Seog Jung,Sang Joon Lee,Moran Ki 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated the incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in Korea. METHODS: We conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits during which they received the International Classification of Diseases, 10th revision code for benign neoplasms of the larynx (D14.1). RESULTS: During 2002-2014, 123 children (74 boys and 49 girls) were diagnosed with RRP. The patients had a mean of 6.5 person-years of follow-up. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years (mean, 4.3). Thirty-six (29.3%) patients underwent surgery, including 23 patients (18.7%) who underwent 2 or more surgical procedures. Severe disease, measured by more frequent surgical procedures and shorter time intervals between consecutive operations, was associated with a younger age at diagnosis. CONCLUSIONS: The estimated incidence of juvenile-onset RRP in Korea was similar to that reported in other countries. The RRP burden should continue to be monitored using National Health Insurance Service claims data.
( Sung Won Lee ),( Hae Lim Lee ),( Nam Ik Han ),( Hee Yeon Kim ),( Chang Wook Kim ),( Chan Ran You ),( Sang Wook Choi ),( Se Hyun Cho ),( Joon-Yeol Han ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The aim of this study was to determine the factors associated with the development of major clinical adverse events in genotype 1 hepatitis C virus (HCV) infected Korean patients who received direct-acting antiviral (DAA) therapy in real clinical settings. Methods: A total of 648 genotype 1 HCV infected patients who received DAA therapy between May 2016 and January 2018 at the liver units of the Catholic University of Korea were analyzed. Primary endpoints were hepatic decompensation and/or treatment discontinuation due to adverse events and the development of de novo hepatocellular carcinoma (HCC). Results: The median follow-up period was 12.8 months (range, 1.3~34.8). 70.7% of the patients had chronic hepatitis and 29.3% compensated cirrhosis. Treatment discontinuation due to adverse events occurred in 2.8% (18/648), hepatic decompensation in 1.4% (9/648) and de novo HCC developed in 3.1% (19/620) of the patients. In multivariate analysis, baseline platelet count less than 150,000/㎣ (P=0.022), estimated glomerular filtration rate (eGFR) less than 50 mL/min/1.73㎡ (P=0.037) and baseline serum albumin less than 3.5g/dL (P=0.035) were independently associated with hepatic decompensation and/or treatment discontinuation due to adverse events. Also, platelet count less than 150,000/㎣ was independently associated with the development of de novo HCC (P=0.048). Conclusions: Patients with low platelet count and serum albumin level, which are indicators of portal hypertension, and patients with renal impairment were more likely to experience hepatic decompensation and/or treatment discontinuation due to adverse events. Low platelet count was associated with de novo HCC development. These patients should be meticulously followed up during and after the DAA therapy.
( Sang Hoon Lee ),( Joo Han Song ),( Kyung Soo Chung ),( Song Yee Kim ),( Eun Young Kim ),( Ji Jung ),( Young Ae Kang ),( Moo Suk Park ),( Se Kyu Kim ),( Joon Chang ),( Young Sam Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Chronic obstructive pulmonary disease (COPD) is a major health problem in many countries, and it is estimated to be the third common cause of death by 2020. However, there are few population-based studies to investigate the chest x-ray fi ndings in patients with COPD. Methods: We investigated the relationship of lung function and chest x-ray fi ndings using Korea National Health and Nutrition Examination Survey data. A total of 45,811 subjects were enrolled from July 2008 to December 2012. 13,602 subjects (5,878 male and 7,724 female) who undertook chest x-ray and PFT were analyzed in this study. Chest x-ray fi ndings were interpreted by one radiologist and four pulmonologists, and these readings were re-checked by six other doctors. Chest x-ray fi ndings are divided by 11 categories. PFT results are classifi ed as normal, obstructive, or restrictive pattern. All data analysis was done by SAS 9.2.Results: 10,342 (76.0%) subjects showed normal lung function; 1,776 (13.1%) obstructive pattern; 1,484 (10.9%) restrictive pattern. Inactive tuberculosis was the most common fi nding (7.9%) in this study. In subjects with airway obstruction, inactive tuberculosis (20.1%) was the most common fi nding and inactive other lung disease (6.3%) was the second. Like subject with obstructive lung pattern, inactive tuberculsis (11.3%) and inactive other lungdieseas (5.5%) were most common in subjects with restrictive lung function. Conclusions: To the best of our knowledge, there were no studies to investigate the association of lung function and chest x-ray fi ndings using population based study. In Korea, 20.1% of subjects with airway obstruction showed inactive tuberculosis on chest x-ray. Inactive tuberculosis and inactive other lung disease were most common chest x-ray fi ndings in both subjects with obstructive and restrictive lung function, but the proportion was different between two groups.
Sung Chul Cha,Heon Joon Park,Jin Han Lee,Kwang Yool Ko,Chang Hyun Shin 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.3
The objective is to develop the complex coating technique with high quality and homogeneity of coating for spherical parts with diameter of 2 ~ 4 mm and stable mass production shall be secured with consideration of coating material, process and jig design. Silicon oxide-diamond like carbon (SiO-DLC) complex coating chemistry is expected to enhance the high temperature stability as opposed to DLC. Currently, the spherical part is first welded and then assembled with other parts, finally they are coated with DLC. However in this manner, the maximum charging in one coating batch is limited due to the very big size of the whole component which increases cost. Therefore the spherical part is to be coated before welding. Overall, reactive sputtering with high precision fixturing and masking technique resulted in the best overall properties for modern powertrain fuel system. The jig design was optimized with consideration of coating properties (height, width, thickness, inserting distance) and spherical parts were fixed at the jig with magnet plate. Coating material and process were determined with several trials. In conclusion the PVD+PACVD coated parts is developed and coatings with high quality, homogeneity and 30,000 inserting amount are secured. Coated parts are minimum 100 % more durable than non-coated parts.
Effects of N-acetyl Cysteine as Precursor of GSH in RA-induced Neuronal Differentiation of P19 ESCs
Joon Yup Kim,Jiae Park,Yoo Hun Noh,Do Hee Kim,Ok Hyeon Kim,Yoon Hee Chung,Kyung Yong Kim,Seung Ho Han,Sung Su Kim,Won Bok Lee 중앙대학교 의과대학 의과학연구소 2013 中央醫大誌 Vol.38 No.2
N-acetyl cysteine (NAC), estradiol and melatonin are well-known as antioxidant, and these reagents have a strong influence on many cellular events. Therefore, we compared effects of NAC in Retinoic acid (RA)-induced embryonic body's (EB) formation and neuronal differentiation of P19 embryonic stem cells (P19 ESCs) with estradiol and melatonin. NAC dramatically increased EB formation and neuronal differentiation in terms of neuronal marker, MAP-2, and neuronal maturation. However, in additional treated groups with estradiol and melatonin, no differences were founded as contrasted with NAC treatment. Furthermore, in NAC-enhanced neuronal differentiation, intracellular glutathione (GSH) contents was only increased, and co-treatment with buthionine sulphoximine (BSO), a GSH-synthesis inhibitor, effectively reduced the EB formation and neuronal differentiation. These results demonstrated that NAC increase EB formation and neuronal differentiation by up-regulation of intracellular GSH contents. NAC-enhanced neuronal differentiation effects may be as donor of GSH, not as antioxidant.
( Sung Jun Ko ),( Sun Mi Choi ),( Jin Woo Lee ),( Young Sik Park ),( Chang Hoon Lee ),( Jae Joon Yim ),( Chul Gyu Yoo ),( Young Whan Kim ),( Sung Koo Han ),( Sang Min Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Adipose tissue is recently recognized as not only energy reservoir but also endocrine organ producing proin ammatory cytokines. Especially the impact o visceral adipose tissue(VAT) in critical illnesses has been proposed, but researches on the association between VAT and sepsis were scarce and quantitative measurement of VAT had not been used. Methods: In this retrospective cohort study, we enrolled patients with sepsis who examined abdominal computed tomography(A-CT) within 1 month of occurrence of sepsis, among the patients admitted to intensive care unit(ICU). Age, sex, anthropometric values, comorbidities and APACHE II score were reviewed. The areas of VAT and total adipose tissue(TAT) on the section of A-CT image of the umbilicus level were measured by calculating pixels presenting fat density. Results: Among 287 patients admitted to ICU due to sepsis, 178 patients were included for this study. Median age was 65 and 59.0% were men. In-hospital mortality rate was 57.9%. Women had higher TAT and subcutaneous adipose tissue, lower VAT/TAT ratio compared to men. The amount of VAT and VAT/TAT ratio were higher in in-hospital mortality group than in survivor group(90.41cm2 vs. 63.83cm2 and 45.88% vs. 32.79%, p=0.001 and <0.001, respectively). After adjusting age, sex, APACHE II score and comorbidities, multivariate logistic regression analysis revealed that the amount of VAT and VAT/TAT ratio were independent prognostic factors of sepsis with obvious dose-dependent relationship(VAT/TAT ratio quartile 3: OR 8.832, p<0.001 and quartile 4: OR 29.477, p<0.001, compared to quartile 1 respectively). Conclusion: The amount of VAT and VAT/TAT ratio quantitatively measured by A-CT were positively correlated with mortality in sepsis, and this association was dose-dependent. Visceral obesity should be considered as the poor prognostic factor of sepsis.