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      • UKF를 이용한 정전용량형 수동센서시스템의 파라메타 추정

        김경엽,이준탁 東亞大學校附設 淸報技術硏究所 2006 情報技術硏究所論文誌 Vol.13 No.2

        In this paper, a noisy passive telemetry sensor system using Unscented Kalman Filter (UKF) is proposed. To overcome these trouble problems such as a power limitation and a estimation complexity that the general passive telemetry sensor system IC chip has, the principle of inductive coupling was applied to the modelling of a passive telemetry sensor system (PTSS) and its noisy capacitive parameter was estimated by the UKF algorithm in time domain. Specially, to show the effective tracking performance of the UKF, we compared with the tracking performance of Recursive Least Square Estimation (RLSE) using linearization.

      • KCI등재후보

        실과 단정한 옷차림 단원의 CD-ROM 타이틀의 개발과 효과

        안준엽,김채복 韓國實科敎育硏究學會 1999 實科敎育硏究 Vol.5 No.2

        The purpose of this study is to develop CD-ROM title on Neat Dressing unit of practical arts for the third grade students of elementary school, and to compare and verify the academic achievement between the group received computer aid lesson by using the developed CD-ROM title and the group received the traditional lesson. The results of survey were as followings. 1. Computer aid lesson by using CD-ROM title improved the academic achievement scores on learning Neat Dressing unit of practical arts for the third grade students of elementary school. 2. The middle subgroup with lesson by using CD-ROM title scored higher than the middle subgroup with traditional lesson.

      • KCI등재후보

        병원단위의 임상진료지침 개발과정

        신영수,김창엽,오병희,한규섭,윤병우,한준구,강영호 한국의료QA학회 1997 한국의료질향상학회지 Vol.4 No.1

        Background : With increased concerns about variation among physician a practice pattern and their impact on the quality of care, clinical practice guidelines have been developed by many different organizations, with differing aims and incentives. From the same point of view, there is growing interest in the development of clinical practice guidelines in Korea, but with only a few examples. As a result, there is not much exploration on the incentive and barrier to development guidelines as well as description on the development process. The purposes of this study are to describe the process of the four different clinical practice guidelines in a hospital setting, and to identify incentives and barriers in the development of guidelines. Methods : For this research, a clinical practice guideline development committee and four clinical practice guideline development teams were organized in a university hospital which has more than 1,200 beds. Twenty eight doctors, three nurses, and one technician participated as members of development teams for eight months. Four to six meetings were held, and three to seven departments in the hospital were involved. Results : The topics which developed into clinical practice guidelines were cardiopulmonary resuscitation(CPR), blood transfusion, anticoagulation, and angiography. The main goals set by teams were education(CPR, angiography), risk management(blood transfusion), and to enhance quality of care(anticoagulation). Among four teams, only in the team for anticoagulation guideline medical record review and pilot-testing were performed. Also literature review was not carried out systematically. However, all the guidelines were developed by multidisciplinary participation by personnels of related departments. All the team expected guidelines to be used as standard protocols in the practice. Conclusion : Experience and skill in developing process has to be improved to have a more valid and useful practice guideline. In particular, literature review and problem identification by examining medical record should be emphasized. Also further studies of the clinical outcomes of the guidelines application and changes in physicians behaviors would be required.

      • Effects of N-acetyl Cysteine as Precursor of GSH in RA-induced Neuronal Differentiation of P19 ESCs

        Joon Yup Kim,Jiae Park,Yoo Hun Noh,Do Hee Kim,Ok Hyeon Kim,Yoon Hee Chung,Kyung Yong Kim,Seung Ho Han,Sung Su Kim,Won Bok Lee 중앙대학교 의과대학 의과학연구소 2013 中央醫大誌 Vol.38 No.2

        N-acetyl cysteine (NAC), estradiol and melatonin are well-known as antioxidant, and these reagents have a strong influence on many cellular events. Therefore, we compared effects of NAC in Retinoic acid (RA)-induced embryonic body's (EB) formation and neuronal differentiation of P19 embryonic stem cells (P19 ESCs) with estradiol and melatonin. NAC dramatically increased EB formation and neuronal differentiation in terms of neuronal marker, MAP-2, and neuronal maturation. However, in additional treated groups with estradiol and melatonin, no differences were founded as contrasted with NAC treatment. Furthermore, in NAC-enhanced neuronal differentiation, intracellular glutathione (GSH) contents was only increased, and co-treatment with buthionine sulphoximine (BSO), a GSH-synthesis inhibitor, effectively reduced the EB formation and neuronal differentiation. These results demonstrated that NAC increase EB formation and neuronal differentiation by up-regulation of intracellular GSH contents. NAC-enhanced neuronal differentiation effects may be as donor of GSH, not as antioxidant.

      • KCI등재

        근력 보조가 가능한 말단 장치 형태의 보행 재활 로봇의 개발

        김정준(Jung-Joon Kim),김명주(Myeong-Ju Kim),곽노식(No-Sik Kwak),김창휘(Chang-Hwi Kim),김형식(Hyeongsic Kim),김정엽(Jung-Yup Kim) 대한기계학회 2018 大韓機械學會論文集A Vol.42 No.8

        본 논문은 보행 재활이 필요한 환자들을 위해 하지 근력 보조가 가능한 보행 재활 로봇의 개발에 대하여 서술하였다. 최근 상용화된 대표적인 보행 재활 로봇들의 경우 비싼 가격, 큰 부피, 고 중량, 불편한 착용 등의 단점들로부터 대중화 및 시장성에 한계를 보여왔다. 이러한 한계점들을 해결하기 위하여 본 연구로부터 세 가지 전략이 적용된 새로운 보행 재활 로봇을 개발하였다. 첫째, 말단 장치의 위치 및 각도 궤적이 정상인의 발 보행 궤적과 일치하는 5절 링크 메커니즘 및 발 착지면을 최적화 설계하였다. 둘째, 두 개의 링크 메커니즘의 크랭크축을 단 하나의 기어드 모터 구동축으로 결합하여 전체 기구부를 구동시키도록 함으로써 비용, 무게 및 부피를 최소화하였다. 셋째, 환자의 장애 정도에 따른 세 가지 보행 재활 모드를 제안하였으며, 특히, 기구부에 장착된 센서들로부터 보행 의도를 인식하고 이로부터 하지 근력을 효과적으로 보조할 수 있도록 하였다. 최종적으로 EMG센서를 통해 각 보행 재활 모드에 따른 근력 보조 성능을 실험적으로 검증하였다. This paper describes the development of a walking rehabilitation robot capable of lower body power assistance. Recently commercialized walking rehabilitation robots have several drawbacks such as high price, large volume, heavy weight, and uncomfortable fit; hence, they still have limitations in terms of popularity and marketability. To resolve these issues, we developed a novel walking rehabilitation robot with three strategies. First, a five-link mechanism and curved foot landing surface were optimally designed so that the position and angle trajectories of the end-effector can coincide with the foot walking trajectory of a normal person. Second, the price, weight, and volume were minimized by connecting the two link mechanisms with a shaft and driving it using a single-gear motor. Third, we proposed three walking rehabilitation modes based on the degree of disability and walking intention. Finally, the power assist performance of each mode was experimentally verified through EMG measurement.

      • KCI등재

        Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke

        Kim Jun Yup,Lee Keon-Joo,Kang Jihoon,Kim Beom Joon,Han Moon-Ku,강규식,Park Jong-Moo,Park Tai Hwan,Park Hong-Kyun,Cho Yong-Jin,Hong Keun-Sik,Lee Kyung Bok,Jang Myung Suk,Lee Ji Sung,Lee Juneyoung,Bae Hee- 대한의학회 2022 Journal of Korean medical science Vol.37 No.13

        Background: Clinical implications of elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients. Methods: Using a multicenter prospective stroke registry, we identified AIS patients hospitalized within 24 hours of onset with available NFTG results. The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year. Results: This study analyzed 2,176 patients. The prevalence of fasting and non-fasting hypertriglyceridemia was 11.5% and 24.6%, respectively. Multivariate analysis revealed that younger age, diabetes, higher body mass index and initial systolic blood pressure were independently associated with both fasting and non-fasting hypertriglyceridemia (all P < 0.05). Patients with higher quartiles of NFTG were more likely to be male, younger, eversmokers, diabetic, and have family histories of premature coronary heart disease and stroke (all P < 0.05). Similar tendencies were observed for FTG. The composite outcome was not associated with FTG or NFTG quartiles. Conclusion: The fasting and non-fasting hypertriglyceridemia were prevalent in AIS patients and showed similar clinical characteristics and outcomes. High FTG and NFTG levels were not associated with occurrence of subsequent clinical events up to one year.

      • KCI등재

        In-hospital mortality of atrial fibrillation-associated acute ischemic stroke in the intensive care unit

        Kim Do Yeon,Kang Jihoon,Jeong Han-Gil,Park Chan-Young,Kim Jun Yup,Kim Beom Joon,Han Moon-Ku,Bae Hee-Joon,Kim Baik Kyun 대한신경집중치료학회 2022 대한신경집중치료학회지 Vol.15 No.2

        Background: Although atrial fibrillation (AF)-associated acute ischemic stroke (AIS) is on the rise, is devastating, and life-threatening, there is limited data on the clinical course and in-hospital mortality of patients treated in the intensive care unit (ICU). This study aimed to describe the clinical course and factors associated with in-hospital mortality in AF-associated AIS patients admitted to the ICU.Methods: This study was a retrospective analysis of a prospective nationwide multicenter cohort including non-valvular AF-AIS patients receiving ICU care admitted to 14 stroke centers in South Korea from 2017 to 2020. In-hospital outcomes, including in-hospital mortality and neurological deterioration (ND) have been described.Result: Amongst 2,487 AF-associated AIS patients, 259 (10.4%) were treated in the ICU. In-hospital mortality and ND occurred in 8.5% and 17.0% of the patients, respectively. Higher rates of initial National Institute for Health Stroke Scale scores, symptomatic steno-occlusive lesions, and CHA<sub>2</sub>DS<sub>2</sub>-VASc (Congestive Heart Failure, Hypertension, Age ≥75 [Doubled], Diabetes Mellitus, Prior Stroke or Transient Ischemic Attack [Doubled], Vascular Disease, Age 65–74, Female) scores were found in those with in-hospital mortality. The CHA<sub>2</sub>DS<sub>2</sub>-VASc score after admission increased the risk of in-hospital mortality (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.00–2.18) were associated with in-hospital mortality. Antithrombotic use within 48 hours was related to decreased in-hospital mortality (OR, 0.26; 95% CI, 0.10–0.67).Conclusion: ICU care in AF-associated AIS is common, and the establishment of optimal treatment strategies in the ICU may be needed.

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