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효과적인 뇌졸중 실험동물 모델 확립을 위한 시간에 따른 중대뇌동맥 폐색법
박지애 외 중앙대학교 의과대학 의과학연구소 2009 中央醫大誌 Vol.34 No.3/4
In this study, to establish effective model of middle cerebral artery occlusion (MCAO), we investigated the infarct size according to the occlusive duration. Middle cerebral artery of rats was temporarily ligated each for 0 min, 30 min, 60 min and 120 min. After each time for occlusion, rats were reperfused. As a result, rats in 60 min group and 120 min group showed the biggest infarct size than rats in any other group, where as rats in 30min group had the smallest infarct size. Unfortunately, lethality of rats in 120 min is almost 80%. However, lethality of rats in 60 min group was similar with rats in 30 min group. Therefore, occlusion of middle cerebral artery for 60 min is appropriate for establishment of effective stroke model.
A New Conceptual Framework for Designing Cloud Computing Business Model
Jiae Park(박지애),Youngho Lee(이영호),Gigyoung Park(박기경) 한국경영과학회 2009 한국경영과학회 학술대회논문집 Vol.2009 No.10
In this paper, we explore the cloud computing system that provides new business opportunities in IT industry. We clarify cloud computing environment and analyze key drivers of cloud service market. Motivated by the distribution process of cloud services, we design a set of cloud service models that pave the way for firm to identify profitable business cases. In addition, we propose revenue model for cloud service models according to services transaction system. Furthermore, we develop a modeling framework for selecting a suitable business model.
S-616 A rare case of myositis due to Campylobacter fetus bacteremia
( Jiae Park ),( Jong Hun Kim ),( Young Kyung Yoon ),( Jang Wook Sohn ),( Min Ja Kim ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Purpose: Myositis as an extraintestinal complication of Campylobacter bacteremia is rarely reported. Here, we present a rare case of myositis due to C. fetus bacteremia.?Summary: A 57-year-old man with a history of diabetes mellitus, chronic kidney disease, and liver cirrhosis presented with a 4-day history of fever, malaise, and pain of right thigh. Initial vital signs were BT 39.3℃, BP 90/60mmHg, HR 102/min, and RR 20/min. On physical examination, erythematous tender swollen right thigh without open wounds was noted. The lab results showed WBC 45200/uL and CRP 150.61mg/L. Two sets of blood cultures were obtained on admission and empiric antibiotic therapy of cefotaxime was started. Despite of empiric antibiotic therapy, his right thigh pain persisted with the report of isolation of gram negative bacilli from admission blood culture. Thus, antibiotic therapy was changed to meropenem. MRI performed on the 3rd hospital day showed diffuse swelling and edematous changes in the right adductor muscle compartment without abscess, consistent with myositis. Gram negative bacilli seen from admission blood cultures were later identified as C. coli by the VITEK2 system. Given infrequent association between bacteremia and C. coli, 16S ribosomal RNA gene sequencing test was performed, which confirmed the identification of C. fetus. Further antibiotic susceptibility testing by E-test method was done, which demonstrated susceptibility to meropenem and ampicillin. Meropenem treatment was continued based on the antibiotic susceptibility results and disease severity. He responded well to meropenem treatment with clearance of bacteremia and resolution of right thigh pain as well as normalization of CRP. Repeat MRI test on the 32nd hospital day showed significant improvement of myositis. He was discharged in stable condition to continue oral ampicillin/sulbactam antibiotic treatment for additional one month, which resulted in complete resolution of infection.?Conclusions: This is the first documented case of myositis due to C. fetus bacteremia. Particular attention is needed for the patient with underlying medical condition (s) affecting the immunity for detection of rare complication of C. fetus bacteremia.
( Jiae Park ),( Jong Hun Kim ),( Young Kyung Yoon ),( Jang Wook Sohn ),( Min Ja Kim ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background: Cytomegalovirus (CMV) and Clostridium difficile (CDIFF) co-infection in enterocolitis is uncommon. We present a pooled analysis of the reported cases to evaluate the epidemiology and outcome of concomitant CMV and CDIFF enterocolitis.?Methods: Pubmed was searched for English-written articles published up to May 2016. Articles that reported cases of concomitant CMV and CDIFF enterocolitis were reviewed.?Results: A total of 20 cases were identified. Median age was 57 years and there were 11 males. Significant underlying immunosuppressed conditions were noted in 8 patients (8/20, 40%; receipt of solid organ transplantation (SOT) in 5 patients, hematologic malignancy in 2 patients, advanced AIDS in 1 patient). No significant underlying medical condition was noted in 5 patients. There were 3 patients who had prior history of CDIFF infection (3/20, 15%). The majority of patients had recent use of antibiotics (15/20, 75%). Of note, median age for 5 patients who had no significant underlying medical conditions was 78 years. All patients had diarrhea with manifestation of bloody diarrhea in 11 patients (11/20, 55%). Diagnosis of CMV enterocolitis was made on the basis of positive biopsy result (20/20, 100%). CDIFF infection was diagnosed on positive toxin (16 patients), positive culture (3 patients), and morphology of pseudomembranous colitis (1 patient). Most of the patients (18/20, 90%) were treated for both CMV and CDIFF infection, except for 2 patients (one patient who was treated only for CDIFF infection and the other patient without available CDIFF treatment data). Anti-CMV therapy included ganciclovir, valganciclovir, and foscarnet. CDIFF treatment included metronidazole, vancomycin, and 1 case of fecal transplantation. Relapse of CDIFF infection was noted in 1 patient. There were 4 patients who underwent bowel resection surgery for treatment. Death (3/20, 15%) was noted in 2 SOT recipients and 1 elderly patient (83 years) without underlying medical condition.?Conclusions: CMV and CDIFF co-infection in enterocolitis is rare but has been increasingly noted for significant risks of morbidity and mortality, particularly for immunosuppressed patients and elderly patients.
Park, Hyeong Bin,Lee, Byoung-Doo,Lee, Chang Woo,Hwang, Jung Eun,Park, Hwan Joon,Kim, Seongjun,An, Jiae,Kim, Pyoung Beom,Kim, Nam Young National Institute of Ecology 2021 국립생태원회보(PNIE) Vol.2 No.4
Iris dichotoma Pall. found on Daechung Island in Korea has been designated as an endangered species. To aid in conservation efforts of this species, this study investigated its germination characteristics and seed dormancy type. Four sets of seeds were incubated at different temperatures (4/1℃, 15/6℃, 20/10℃, and 25/15℃). One set of seeds was cold stratified (4 weeks at 4/1℃). The final germination rate and mean germination time showed that the optimal germination temperature was 25/15℃. Final germination rates were ~70%, showing no significant difference among temperature treatments. However, mean germination time were significantly different among all temperature treatments except for 4/1℃. Mean germination time for seeds with temperature treatments of 15/6℃, 20/10℃, and 25/15℃ were 3.2, 2.1, and 1.5 weeks, respectively. At 25/15℃, the mean germination time was half of that at 15/6℃. Seeds of I. dichotoma had fully developed embryos at the time of dispersal. No additional growth of the embryo was observed. Cold stratification did not affect the final germination rate or the mean germination time. This study shows that seeds of I. dichotoma have no physiological or morphological dormancy, unlike other members of the Iris genus known to have seed dormancy that needs a relatively high incubation temperature (≥25/15℃) for mass propagation to occur. These results will be useful for understanding ecophysiological mechanisms related to the species' habitat. They are also useful for mass propagation of I. dichotoma for the purpose of conserving this endangered species.