Ginsenoside Rg1 alleviates A deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice

Han Zhang,Yong Su,Zhenghao Sun,Ming Chen,Yuli Han,Yan Li,Xianan Dong,Shixin Ding,Zhirui Fang,Weiping Li,Weizu Li 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.6

Background: Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, may be a potential agent for thetreatment of Alzheimer’s disease (AD). However, the protective effect of Rg1 on neurodegeneration in ADand its mechanism of action are still incompletely understood. Methods: Wild type (WT) and APP/PS1 AD mice, from 6 to 9 months old, were used in the experiment. The open field test (OFT) and Morris water maze (MWM) were used to detect behavioral changes. Neuronal damage was assessed by hematoxylin and eosin (H&E) and Nissl staining. Immunofluorescence,western blotting, and quantitative real-time polymerase chain reaction (q-PCR) were used toexamine postsynaptic density 95 (PSD95) expression, amyloid beta (Ab) deposition, Tau and phosphorylatedTau (p-Tau) expression, reactive oxygen species (ROS) production, and NAPDH oxidase 2(NOX2) expression. Results: Rg1 treatment for 12 weeks significantly ameliorated cognitive impairments and neuronaldamage and decreased the p-Tau level, amyloid precursor protein (APP) expression, and Ab generation inAPP/PS1 mice. Meanwhile, Rg1 treatment significantly decreased the ROS level and NOX2 expression inthe hippocampus and cortex of APP/PS1 mice. Conclusions: Rg1 alleviates cognitive impairments, neuronal damage, and reduce Ab deposition byinhibiting NOX2 activation in APP/PS1 mice.

Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-β/STAT3 Pathway

Fang, Zhenghuan,Jung, Kyung Hee,Yan, Hong Hua,Kim, Soo-Jung,Rumman, Marufa,Park, Jung Hee,Han, Boreum,Lee, Ji Eun,Kang, Yeo wool,Lim, Joo Han,Hong, Soon Sun S. Karger AG 2018 CELLULAR PHYSIOLOGY AND BIOCHEMISTRY Vol.47 No.5

<P><B><I>Background/Aims:</I></B> Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with poor prognosis. Conventional chemotherapies including gemcitabine have failed owing to weak response and side effects. Hence novel treatment regimens are urgently needed to improve the therapeutic efficacy. In this study, we aimed to assess the anticancer activity of melatonin and sorafenib as a novel therapy against PDAC. <B><I>Methods:</I></B> We used various apoptosis assay and PDAC xenograft model to assess anticancer effect <I>in vitro</I> and <I>in vivo</I>. We applied phospho-receptor tyrosine kinase (RTK) array and phospho-tyrosine kinase array to explore the mechanism of the combined therapy. Western blotting, proximity ligation assay, and immunoprecipitation assay were also performed for validation. <B><I>Results:</I></B> Melatonin synergized with sorafenib to suppress the growth of PDAC both <I>in vitro</I> and <I>in vivo</I>. The effect was due to increased apoptosis rate of PDAC cells that was accompanied by mitochondria dysfunction. The enhanced anticancer efficacy by the co-treatment could be explained by blockade of PDGFR-β/STAT3 signaling pathway and melatonin receptor (MT)-mediated STAT3. <B><I>Conclusions:</I></B> Melatonin reinforces the anticancer activity of sorafenib by downregulation of PDGFR-β/STAT3 signaling pathway and melatonin receptor (MT)-mediated STAT3. The combination of the two agents might be a potential therapeutic strategy for treating PDAC.</P>

Preventing Wrong-site Surgeiy by Universal Protocol to Promote Patient Safety

Fang-Chih Yeh,Hsien-Ju Chuang,Han-Ming Chen,Li,Fang Liu,Hsien-Hung Hung 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

A Study on Related Factors of Breastfeeding to Southeast Asian Immigrant Mothers After Delivery in Central Taiwan

Fang-Chih Yeh,Hsien-Ju Chuang,Han-Ming Chen,Li, Fang Liu,Hsien-Hung Hung 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

The Role of Corporate Social Responsibility Engagement on the Relationship between Country-of-Origin Effect and Brand Awareness

Fang, Yuan Tao · Oh, Han-Mo 충북대학교 산업경영연구소 2019 産業과 經營 Vol.32 No.2

본문 참고

Cooperative Distribution Algorithm of Green Supply Chain Considering the Risk Aversion of Manufacturers

Han Fang,Yang Yongqiang 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.9

Considering production and marketing coordination between supply chain enterprises, this paper specifies a multi-agent supply chain concurrent negotiation model for two-stage supply chain in the supply chain environment. Coordinator is used to search optimal proposals based on particle swarm optimization (PSO) and send these proposals to other threads. Proposal strategies based on retention value and time are put forward by learning retention value of rivals through Parzen-window estimation. Simulation experiment is conducted to test negotiation performance of the model. Compared with ordinary models, the model makes two improvements as follows: (1)PSO is inserted into coordinator to improve negotiation efficiency; (2) Proposal strategies are effectively supported by Parzen-window estimation and enable agents to consider the retention values of rivals. Further researches need to be done to study trust relationship between agents and influence of external environment on supply chain negotiation solution.

RAMS evaluation for a steel-truss arch high-speed railway bridge based on SHM system

Zhao, Han-Wei,Ding, You-Liang,Geng, Fang-Fang,Li, Ai-Qun Techno-Press 2018 Structural monitoring and maintenance Vol.5 No.1

The evaluation theory of reliability, availability, maintainability and safety (RAMS) as a mature theory of state evaluation in the railway engineering, can be well used to the evaluation, management, and maintenance of complicated structure like the long-span bridge structures on the high-speed railway. Taking a typical steel-truss arch bridge on the Beijing-Shanghai high-speed railway, the Nanjing Dashengguan Yangtze River Bridge, this paper developed a new method of state evaluation for the existing steel-truss arch high-speed railway bridge. The evaluation framework of serving state for the bridge structure is presented based on the RAMS theory. According to the failure-risk, safety/availability, maintenance of bridge members, the state evaluation method of each monitoring item is presented. The weights of the performance items and the monitoring items in all evaluation levels are obtained using the analytic hierarchy process. Finally, the comprehensive serving state of bridge structure is hierarchical evaluated.

Clinicopathologic and Prognostic Significance of the Zinc Finger of the Cerebellum Family in Invasive Breast Cancer

Wei Han,Cong Zhang,Xiao-jiao Gao,Hua-bing Wang,Fang Chen,Fang Cao,Yong-wei Hu,Jun Ma,Xing Gu,Hou-zhong Ding 한국유방암학회 2018 Journal of breast cancer Vol.21 No.1

Purpose: Five members of the zinc finger of the cerebellum (ZIC) family—ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5—have been shown to be involved in various carcinomas. Here, we aimed to explore the clinicopathologic and prognostic roles of ZIC family members in invasive breast cancer patients using immunohistochemical analysis, western blotting analysis, and real-time quantitative polymerase chain reaction (RT-qPCR). Methods: A total of 241 female invasive breast cancer patients who underwent radical mastectomy between 2009 and 2011 were enrolled. ZIC proteins in 241 pairs of breast tumors and corresponding normal tissues were investigated using immunohistochemistry and the clinicopathologic roles of proteins were analyzed using Pearson’s chi-square test. Kaplan-Meier curves and Cox regression analysis were also used to analyze the prognostic value of the ZIC proteins. In addition, 12 pairs of fresh-frozen breast tumors and matched normal tissues were used in the western blotting analysis and RT-qPCR. Results: Only ZIC1 expression in normal tissues was obviously higher than that in tumors (p<0.001). On multivariate analysis, ZIC1 expression (in overall survival analysis: hazard ratio [HR], 0.405, 95% confidence interval [CI], 0.233–0.702, p=0.001; in disease-free survival analysis: HR, 0.395, 95% CI, 0.234–0.669, p=0.001) was identified as a prognostic indicator of invasive breast cancer. Conclusion: ZIC1, but not the other proteins, was obviously decreased in breast tumors and associated with clinicopathologic factors. Thus, ZIC1 might be a novel indicator to predict the overall and disease-free survival of invasive breast cancer patients.

State Feedback H∞ Control for a Class of Nonlinear Systems Using Partition of Unity Method

Dong-Fang Han,Yin-He Wang 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.1

The system model is nonlinear with respect to all its variables while the output model is linear. The nonlinear system model is firstly converted into an equivalent linear model with error by using partition of unity method. The stability with decay rate and the disturbance attenuation for the nonlinear system are discussed based on the equivalent model. A state feedback H∞ controller is then proposed in terms of linear matrix inequalities (LMIs).

A Study on the Application of VR Technology in the Field of Electronic Commerce

Yuan Han Fang 한국경영실무학회 2021 한국경영실무학회지 Vol.7 No.1

4차산업혁명이 시작되면서 사회의 모든 산업이 변화하고 있고, 기술개발, 인공지능, 빅데이터, VR 기술 등 응용분야가 발전하고 있으며, 기술도 시간과 인건비를 크게 절약했다. 이 단계에서 컴 퓨터와 휴대폰의 사용이 보편화되고 있으며, 인터넷 쇼핑과 인터넷 구매는 우리의 삶을 더 쉽고 빠 르게 만든다. 비록 온라인 쇼핑은 저렴하지만, 그것은 당신에게 맞지 않을 수도 있고, 그리고 나서 사용자 경험에 영향을 미치는 환불을 신청할 수도 있다. 따라서 VR 기술을 적용함으로써 소비자 는 경험과 만족도를 높이고 자신이 직접 만든 제품을 더 정확하게 구매할 수 있다. 반면에 2020년 COVID-19는 우리에게 많은 불편함을 야기시켰다. 소비자들은 집을 보러 현장에 갈 수 없다. VR 기술은 이 문제를 쉽게 해결할 수 있다. VR안경을 가정이나 부동산 내 지정된 장소에서 VR안경 을 사용하면 실제 주택의 배치와 장식 효과를 시뮬레이션을 하여 시간을 절약할 뿐 아니라 감염위험도 예방할 수 있다. 우리의 삶과 건강은 COVID-19의 영향을 받고 있지만 하루빨리 VR 기술 이 전자상거래에 적용돼야 한다는 의미를 담고 있다. VR 기술이 전자상거래에 적용된다는 장점도 많지만 단점도 많다. 우리는 이 기술을 개선하고 발전시켜야 한다. 본 논문은 VR 기술의 적용에 대해 논의하고 VR 기술의 적용에 대해 설명한다. With the start of the Fourth Industrial Revolution, every industry in society is changing, technological development, artificial intelligence, big data, VR technology, and other applications, and technology has also greatly saved time and human costs. At this stage, the use of computers and cell phones is becoming more common, and Internet shopping and Internet buying make our lives easier and faster. Although shopping online is cheap, it may not be suitable for you and then apply for a refund that affects the user experience. Therefore, by applying VR technology, consumers can increase their experience and satisfaction and buy their own products more accurately. On the other hand, in 2020 COVID-19 has caused us a lot of inconveniences. Consumers can't go to the scene to see the house. VR technology can solve this problem easily. Using VR glasses, at home, or designated locations in real estate, through VR glasses, simulates the layout and decorating effects of real houses, saving not only time but also preventing the risk of infection. Our lives and health are affected by COVID-19, but it implies that VR technology should be applied to e-commerce as soon as possible. Although VR technology has many advantages in being applied to e-commerce, there are many disadvantages as well. We should improve and develop this technology. This paper discusses the application of VR technology and explains the application of VR technology.