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Hyaluronate - parathyroid hormone peptide conjugate for transdermal treatment of osteoporosis
Cho, Minsoo,Han, Seulgi,Kim, Hyemin,Kim, Ki Su,Hahn, Sei Kwang Informa UK (TaylorFrancis) 2018 Journal of Biomaterials Science. Polymer Edition Vol. No.
<P>Human parathyroid hormone 1-34 fragment (PTH1-34) has been used as a FDA-approved therapeutics to treat osteoporosis by daily subcutaneous injection. In this work, we successfully developed PTH1-34 conjugated hyaluronic acid (HA) for the transdermal treatment of osteoporosis with improved patient compliance. HA-PTH1-34 conjugate was synthesized by the coupling reaction between aldehyde group introduced to HA and amine group of PTH1-34. After characterization by gel permeation chromatography (GPC) and ELISA, the biological effect of HA-PTH1-34 conjugate on the proliferation of human osteoblast cells was confirmed by in vitro calcium colorimetric assay and cAMP assay. Two-photon microscopy clearly visualized the effective skin penetration of FITC modified HA-PTH1-34 conjugate. The transdermally delivered HA-PTH1-34 conjugates elevated the blood calcium concentration for more than 2days, reflecting the feasibility for the treatment of osteoporosis.</P>
Exploration of Novel 2-Alkylimino-1,3-thiazolines: T-Type Calcium Channel Inhibitory Activity
Han, Minsoo,Nam, Kee Dal,Shin, Dongyun,Jeong, Nakcheol,Hahn, Hoh-Gyu American Chemical Society 2010 Journal of combinatorial chemistry Vol.12 No.4
<P>We have developed combinatorial libraries of new 2-alkylimino-1,3-thiazolines with four diversity points, consisting of more than 500 compounds, in a parallel synthetic fashion. The synthetic strategy was based on the construction of a large library aimed at the discovery of new compounds with T-type calcium channel inhibitory activity through structure modifications of hit compound <B>2</B>. The syntheses of the compounds of Chemset A with four diversity points were accomplished by the condensation of thioureas <B>5</B> with α-haloketones <B>6</B>{<I>1−66</I>} having two diversity points each. A library of phthalimidyl 1,3-thiazolines <B>24</B> was synthesized to provide Chemset B, which allowed the introduction of other diversity points through the nucleophilic character of the amino nitrogen. A sublibrary, Chemset C, was constructed from the libraries of Chemset A and Chemset B by functionalization of the C-4 position of the 1,3-thiazoline ring. The products containing ester or acid groups at the C-4 position of the 1,3-thiazoline ring were used in amide synthesis to give a new sublibrary within Chemset C. Deprotection of the phthalimidyl moiety of <B>24</B> followed by the reaction with benzoyl chloride gave the corresponding sublibrary in Chemset C. Another sublibrary which includes secondary amino derivatives was obtained by reduction of the amide moiety or reductive amination of <B>23</B> with phenyl aldehyde. The selected compounds from the generated libraries were evaluated with respect to inhibition of T-type calcium channels, where some of them have exhibited promising activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jcchff/2010/jcchff.2010.12.issue-4/cc100041m/production/images/medium/cc-2010-00041m_0022.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P>
이산적 선택실험을 통한 온ㆍ오프라인 쇼핑채널의 소비자 후생효과와 경쟁 분석
박민수 ( Minsoo Park ),한종희 ( Jong-hee Hahn ) 한국산업조직학회 2024 産業組織硏究 Vol.32 No.1
본 논문의 목적은 가격과 비가격 요소들을 포괄한 쇼핑채널 특성들이 소비자 선택에 미치는 영향을 추정하고 쇼핑채널의 비가격 전략이 경쟁구조에 어떤 영향을 미치는지 정량적으로 살펴보는 것이다. 이를 위해 본 연구는 소비자를 대상으로 한 이산적 선택실험을 통해 온라인 쇼핑채널과 오프라인 쇼핑채널에 대한 수요를 추정하고, 이로부터 쇼핑채널의 전략이 채널 간 경쟁에 미치는 영향을 시뮬레이션을 통해 예측한다. 분석 결과 소비자들은 쇼핑채널 선택 시가격뿐만 아니라 제품의 다양성, 배송시간, 이동시간, 제품체험 가능 여부와 같은 비가격요인들에 대해서도 상당한 가치를 부여하는 것으로 나타났다. 이에 따라 쇼핑채널들의 물류망 투자경쟁, 간접 네트워크 효과(브랜드 수), 배송시간, 이동시간 등 비가격적 속성을 둘러싼 경쟁이 시장의 경쟁구조에 주요한 영향을 미칠 것으로 예측되었으며, 오프라인과 온라인 쇼핑채널의 결합 시 나타날 시너지 효과도 상당한 것으로 나타나, 가격 외의 측면에서도 온라인 쇼핑채널과 오프라인 쇼핑채널 간 경쟁관계가 존재함을 확인했다. The purpose of this paper is to analyze the impact of shopping channel characteristics, including price and non-price factors, on consumer choice and to quantitatively examine how shopping channels’ non-price strategies affect the competitive structure. To this end, we estimate the demand for online and offline shopping channels through a discrete choice experiment with consumers, and use simulations to predict the impact of shopping channel strategies on inter-channel competition. The analysis shows that consumers place significant value on non-price factors such as product variety, delivery time, travel time, and product experience when choosing a shopping channel. Based on the demand estimation results, we predict the magnitudes of impacts that firms’ non-price strategies would have on the competitive structure of the market under various scenarios. The synergy effects of combining offline and online shopping channels are also significant, confirming that there is competition between online and offline shopping channels in aspects other than price.
Speech Enhancement Using a Two-Stage Network for an Efficient Boosting Strategy
Kim, Juntae,Hahn, Minsoo IEEE Signal Processing Society 2019 IEEE signal processing letters Vol.26 No.5
<P>A novel neural network architecture, called two-stage network (TSN), with a multi-objective learning (MOL) method for an efficient boosting strategy (BS) is proposed for speech enhancement. BS is an ensemble method using multiple base predictions (MBPs) for better final prediction. Because of the necessity for MBPs, the computational cost and model size of BS-based methods are greater than those of a single model. In overcoming this, TSN first obtains MBPs from a single deep neural network. Then, to obtain better final prediction, the convolution layers of TSN aggregate not only MBPs but also some auxiliary information such as contextual information, while adaptively filtering out some unnecessary information, e.g., poor base predictions. At the training phase, the MOL enables all stages of TSN to learn jointly, whereas allowing the TSN framework to embed a BS. Our experimental results confirm that the embedded BS leads TSN to outperform other baseline methods with a reasonably low computational cost and model size.</P>
스펙트럼의 변동계수를 이용한 잡음에 강인한 음성 구간 검출
김영민,한민수,Kim Youngmin,Hahn Minsoo 대한음성학회 2003 말소리 Vol.48 No.-
This paper deals with a new parameter for voice detection which is used for many areas of speech engineering such as speech synthesis, speech recognition and speech coding. CV (Coefficient of Variation) of speech spectrum as well as other feature parameters is used for the detection of speech. CV is calculated only in the specific range of speech spectrum. Average magnitude and spectral magnitude are also employed to improve the performance of detector. From the experimental results the proposed voice detector outperformed the conventional energy-based detector in the sense of error measurements.
박태선,한민수,Park Taesun,Hahn Minsoo 대한음성학회 2003 말소리 Vol.47 No.-
This paper describes the use of pitch information for speaker identification. The recognition system is a GMM based one with 4 connected Korean digits speech database. The mean of the pitch period in voiced sections of speech are shown to be ,useful at discriminating between speakers. Utilizing this feature with Gaussian mixture model in the speaker identification system gave a marked improvement, maximum 6% improvement comparing to the baseline Gaussian mixture model.