Comparison between Field Test and Numerical Analysis for a Jacket Platform in Bohai Bay, China

HE-ZHEN YANG,HAN-IL PARK,KYUNG-SIK CHOI,HUA-JUN LI 한국해양공학회 2006 韓國海洋工學會誌 Vol.20 No.2

This paper presents a comparison between numerical analysis and field test on a real offshore platform in Bohai Bay, China. This platform is a steel jacket offshore platform with vertical piles. The field testing under wave-induced force and wind force etc. was conducted, in order to obtain the dynamic parameters of the structure, including the frequencies of the jacket platform, as well as the corresponding damping ratios and mode shapes. The natural excitation technology (NExT) combined with eigensystem realization algorithm (ERA) and the peak picking (PP) method in frequency domain are carried out for modal parameter identification under operational conditions. The three-dimensional finite element model (FEM) is constructed by ANSYS and an analytical modal analysis is performed to generate modal parameters. The analytical results were compared with experimental results. A good agreement was achieved between the finite element and analysis and field test results. It is further demonstrated that the numerical and experimental modal analysis provide a comprehensive study on the dynamic properties of the jacket platform. According to the analysis results, the modal parameters identification under ambient excitation can calibrate finite element model of the jacket platform structures, or can be used for the structural health monitoring system.

Advantages of Restoring miR-205-3p Expression for Better Prognosis of Gastric Cancer via Prevention of Epithelial-mesenchymal Transition

Zhen Zhang,Xujun He,Ji Xu,Genhua Zhang,Yue Yang,Jie Ma,Yuanshui Sun,Haibin Ni,Fengyong Wang 대한위암학회 2020 Journal of gastric cancer Vol.20 No.2

Purpose: miR-205 is a tumor suppressor and plays an important role in tumor invasiveness. However, the role of miR-205 in human gastric cancer (GC) epithelial-mesenchymal transition (EMT) remains unclear. The aim of this study was to investigate the molecular mechanism of miR-205 in the regulation of EMT in GC invasion. Materials and Methods: Quantitative polymerase chain reaction (qPCR) was used to detect the expression of miR-205 in GC. Further, the correlation between the pathological parameters and prognosis of GC was statistically analyzed. A transwell model was used to evaluate the effect of miR-205-3p on the invasion and migration of GC cells. qPCR, western blotting, and luciferase assay were performed to analyze the relationship and target effects between miR-205-3p and the expression of zinc finger electron box binding homologous box 1 (ZEB1) and 2 (ZEB2). Results: We found that the levels of miR-205-3p were significantly lower (P<0.05) in GC tissues than in matched normal tissues. Additionally, the expression of miR-205-3p was related to the tumor invasion depth, lymph node metastasis, lymph node invasion, and tumor, node, metastasis stage. Patients with lower miR-205-3p expression levels in the tumors had a poorer prognosis. The in vitro assays indicated that miR-205-3p could affect the invasion ability and EMT of GC cells by targeting the expression of both ZEB1 and ZEB2. Conclusions: miR-205-3p promotes GC progression and affects the prognosis of patients by targeting both ZEB1 and ZEB2 to directly influence EMT.

Strength criterion of plain recycled aggregate concrete under biaxial compression

Zhen-Jun He,Gan-Wen Liu,Wan-Lin Cao,Chang-Yang Zhou,Zhang Jia-Xing 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.2

This paper presents results of biaxial compressive tests and strength criterion on two replacement percentages of recycled coarse aggregate (RPRCA) by mass for plain structural recycled aggregate concrete (RAC) at all kinds of stress ratios. The failure mode characteristic of specimens and the direction of the cracks were observed and described. The two principally static strengths in the corresponding stress state were measured. The influence of the stress ratios on the biaxial strengths of RAC was also analyzed. The experimental results showed that the ratios of the biaxial compressive strength  3f to the corresponding uniaxial compressive strength c for the two RAC are higher than that of the conventional concrete (CC), and dependent on the replacement percentages of recycled coarse aggregate, stress states and stress ratios; however, the differences of tensile-compressive ratios for the two RAC and CC are smaller. On this basis, a new failure criterion with the stress ratios is proposed for plain RAC under biaxial compressive stress states. It provides the experimental and theoretical foundations for strength analysis of RAC structures subject to complex loads.

Comprehensive evaluation of high-temperature sintering behavior of sea sand vanadia-titania magnetite based on grey relational analysis

Zhen-xing Xing,Zhuang Huang,Gong-jin Cheng,He Yang,Xiangxin Xue,Guo-dong Zhang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.12

Sea sand vanadia-titania magnetite is difficult to pelletize, and it is difficult for iron and steel enterprises touse it as a raw material for ironmaking. In this paper, the high-temperature physicochemical characteristics and sinteringbehavior of sea sand vanadia-titania magnetite were comprehensively studied and systematically evaluated. Thehigh-temperature metallurgical physicochemical characteristics of different iron ore powders and under different experimentalconditions were studied by the micro-sintering experimental system. The high-temperature sintering indexeswere comprehensively evaluated by the grey correlation analysis, and the influence of sea sand ore on sintering performancewas investigated by sintering pot experiment. The research results show that the high-temperature sinteringcharacteristics of sea sand vanadia-titania magnetite were the worst, and the grey correlation degree was the lowest. The high-temperature sintering characteristics of sintered blocks with sea sand ore were affected by changing the basicityand the addition amount of sea sand ore. When the basicity was 0.8 and the addition amount of sea sand ore was15 wt%, the evaluation index of grey relational analysis was the best. The vertical sintering speed and tumble indexwere slightly reduced by adding sea sand ore, but the sinter yield was improved and the particle size distribution of sinterwas optimized. The experimental results provide a certain data reference for the actual production of sinter with seasand vanadia-titania magnetite.

Heavy Metal Contamination of Soils: a Global Challenge to Food Security

Zhenli He,Xiaoe Yang,Virupax C Baligar 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Critical review of bioelectrochemical systems integrated with membrane-based technologies for desalination, energy self-sufficiency, and high-efficiency water and wastewater treatment

Yang, Euntae,Chae, Kyu-Jung,Choi, Mi-Jin,He, Zhen,Kim, In S. Elsevier 2019 Desalination Vol.452 No.-

<P><B>Abstract</B></P> <P>Bioelectrochemical systems (BESs) are versatile electrochemical technologies that use microbial catalysts for simultaneously harvesting energy and treating wastewater. However, there is a consensus that practical energy applications and clean water production remain technically challenging for stand-alone BESs. To address these technological challenges, membrane-based technologies for water/wastewater treatment and energy production, such as electrodialysis, forward osmosis, reverse electrodialysis, and pressurized filtration (e.g., ultrafiltration), have been integrated into BESs. This integration has created new systems including microbial desalination cells, osmotic microbial fuel cells, pressurized filtration-microbial fuel cells, and microbial reverse-electrodialysis cells. This article aims to provide a comprehensive review on the recent progress in BESs integrated with membrane-based technologies, discuss advantages and limitations, and present outlooks toward further development of these technologies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Membrane-based processes have recently been integrated into bioelectrochemical systems. </LI> <LI> Current development and challenges of these technologies extensively are discussed. </LI> <LI> For desalination, microbial desalination cell and osmotic microbial fuel cell </LI> <LI> For energy self-sustenance, microbial reverse-electrodialysis cell </LI> <LI> For high efficient wastewater treatment, pressurized filtration microbial fuel cell </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

A Functional SNP in the MDM2 Promoter Mediates E2F1 Affinity to Modulate Cyclin D1 Expression in Tumor Cell Proliferation

Yang, Zhen-Hai,Zhou, Chun-Lin,Zhu, Hong,Li, Jiu-Hong,He, Chun-Di Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Background: The MDM2 oncogene, a negative regulator of p53, has a functional polymorphism in the promoter region (SNP309) that is associated with multiple kinds of cancers including non-melanoma skin cancer. SNP309 has been shown to associate with accelerated tumor formation by increasing the affinity of the transcriptional activator Sp1. It remains unknown whether there are other factors involved in the regulation of MDM2 transcription through a trans-regulatory mechanism. Methods: In this study, SNP309 was verified to be associated with overexpression of MDM2 in tumor cells. Bioinformatics predicts that the T to G substitution at SNP309 generates a stronger E2F1 binding site, which was confirmed by ChIP and luciferase assays. Results: E2F1 knockdown downregulates the expression of MDM2, which confirms that E2F1 is a functional upstream regulator. Furthermore, tumor cells with the GG genotype exhibited a higher proliferation rate than TT, correlating with cyclin D1 expression. E2F1 depletion significantly inhibits the proliferation capacity and downregulates cyclin D1 expression, especially in GG genotype skin fibroblasts. Notably, E2F1 siRNA effects could be rescued by cyclin D1 overexpression. Conclusion: Taken together, a novel modulator E2F1 was identified as regulating MDM2 expression dependent on SNP309 and further mediates cyclin D1 expression and tumor cell proliferation. E2F1 might act as an important factor for SNP309 serving as a rate-limiting event in carcinogenesis.

Advantages of Restoring miR-205-3p Expression for Better Prognosis of Gastric Cancer via Prevention of Epithelial-mesenchymal Transition

Zhang, Zhen,He, Xujun,Xu, Ji,Zhang, Genhua,Yang, Yue,Ma, Jie,Sun, Yuanshui,Ni, Haibin,Wang, Fengyong The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol.20 No.2

Purpose: miR-205 is a tumor suppressor and plays an important role in tumor invasiveness. However, the role of miR-205 in human gastric cancer (GC) epithelial-mesenchymal transition (EMT) remains unclear. The aim of this study was to investigate the molecular mechanism of miR-205 in the regulation of EMT in GC invasion. Materials and Methods: Quantitative polymerase chain reaction (qPCR) was used to detect the expression of miR-205 in GC. Further, the correlation between the pathological parameters and prognosis of GC was statistically analyzed. A transwell model was used to evaluate the effect of miR-205-3p on the invasion and migration of GC cells. qPCR, western blotting, and luciferase assay were performed to analyze the relationship and target effects between miR-205-3p and the expression of zinc finger electron box binding homologous box 1 (ZEB1) and 2 (ZEB2). Results: We found that the levels of miR-205-3p were significantly lower (P<0.05) in GC tissues than in matched normal tissues. Additionally, the expression of miR-205-3p was related to the tumor invasion depth, lymph node metastasis, lymph node invasion, and tumor, node, metastasis stage. Patients with lower miR-205-3p expression levels in the tumors had a poorer prognosis. The in vitro assays indicated that miR-205-3p could affect the invasion ability and EMT of GC cells by targeting the expression of both ZEB1 and ZEB2. Conclusions: miR-205-3p promotes GC progression and affects the prognosis of patients by targeting both ZEB1 and ZEB2 to directly influence EMT.

CT-Guided Microcoil Localization of Small Peripheral Pulmonary Nodules to Direct Video-Assisted Thoracoscopic Resection without the Aid of Intraoperative Fluoroscopy

Huang Zhen-guo,Wang Cun-li,Sun Hong-liang,Li Chuan-dong,Gao Bao-xiang,Chen He,Yang Min-xing 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.7

Objective: To evaluate the feasibility, safety, and effectiveness of CT-guided microcoil localization of solitary pulmonary nodules (SPNs) for guiding video-assisted thoracoscopic surgery (VATS). Materials and Methods: Between June 2016 and October 2019, 454 consecutive patients with 501 SPNs who received CTguided microcoil localization before VATS in our institution were enrolled. The diameter of the nodules was 0.93 ± 0.49 cm, and the shortest distance from the nodules to the pleura was 1.41 ± 0.95 cm. The distal end of the microcoil was placed less than 1 cm away from the nodule, and the proximal end was placed outside the visceral pleura. VATS was performed under the guidance of implanted microcoils without the aid of intraoperative fluoroscopy. Results: All 501 nodules were marked with microcoils. The time required for microcoil localization was 12.8 ± 5.2 minutes. Microcoil localization-related complications occurred in 179 cases (39.4%). None of the complications required treatment. A total of 463 nodules were successfully resected under the guidance of implanted microcoils. VATS revealed 38 patients with dislocated microcoils, of which 28 underwent wedge resection (21 cases under the guidance of the bleeding points of pleural puncture, 7 cases through palpation), 5 underwent direct lobectomy, and the remaining 5 underwent a conversion to thoracotomy. In 4 cases, a portion of the microcoil remained in the lung parenchyma. Conclusion: CT-guided microcoil localization of SPNs is safe and reliable. Marking the nodule and pleura simultaneously with microcoils can effectively guide the resection of SPNs using VATS without the aid of intraoperative fluoroscopy.

High alcohol-soluble MoOx gel for interfacial layer in organic solar cells

Jian Xiong,Zhen He,Shiping Zhan,Bingchu Yang,Xiaowen Zhang,Ping Cai,Cong Xu,Xiaogang Xue,Jian Zhang 한국물리학회 2017 Current Applied Physics Vol.17 No.8

Water-free solvent soluble, low-temperature processed metal oxides are important for preparing efficient and stable electronic devices, as well as the convenience in simplifying the device production process. Here we reported a facile approach with the features of low-temperature and solution-based process for the formation of a MoOx (s-MoOx) film as interface layer in polymer solar cells (PSCs). The absorbability, elementary composition, electronic property and surface microstructure of the s-MoOx are investigated in detail by ultravioletevisible spectrophotometer (UVevis), X-ray photoelectron spectrometry (XPS), ultraviolet photo-electron spectrometer (UPS) and atomic force microscopy (AFM). These investigations confirmed that such MoOx xerogel has high solubility in the organic alcohol solvents, such as ethanol and methanol. Meanwhile, this s-MoOx can be applied as the interfacial layer in organic solar cells via a low-temperature treatment (about 100 C) due to its proper physical properties, and a power conversion efficiency (PCE) over 3% was achieved. In addition, the devices with s-MoOx shows excellent air-stability, and the PCE efficiency can maintain about 84% of its initial value after 100 h exposure in air, which is dramatically enhanced comparing with the common devices with PEDOT:PSS layer.