Fenofibrate Increases Radiosensitivity in Head and Neck Squamous Cell Carcinoma via Inducing G2/M Arrest and Apoptosis

Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.

중국 중학생이 지각한 부모 및 교사의 자율성지지, 기본심리욕구, 사회정서역량 간의 관계 연구

( Yang Yue ),신태섭 ( Tae Seob Shin ) 인하대학교 교육연구소 2021 교육문화연구 Vol.27 No.1

본 연구의 목적은 자기결정성이론에 기반하여 부모 및 교사의 자율성 지지가 기본심리욕구를 매개로 중국 청소년의 사회정서역량에 미치는 영향을 살펴보는 데 있다. 이를 위해 중국 산동성 쯔보시 중학교 3학년 434명의 데이터를 사용하여 부모 및 교사의 자율성 지지와 중학생의 사회정서역량 간의 관계에서 중학생의 기본심리욕구의 매개효과를 확인하였다. 본 연구의 주요 결과는 다음과 같다. 첫째, 부모의 자율성 지지가 교사의 자율성 지지보다 중학생의 기본심리욕구 및 사회정서역량에 더 큰 영향을 미치는 것으로 나타났다. 둘째, 중학생의 기본심리욕구가 충족될수록 중학생의 사회정서역량 수준이 높아지는 것으로 나타났다. 셋째, 중학생이 지각한 부모 및 교사의 자율성 지지가 많을수록 중학생의 사회정서역량 수준이 높아졌다. 특히 중학생이 지각한 부모의 자율성 지지는 교사의 자율성 지지보다 중학생의 사회정서역량에 더 직접적인 영향을 주었다. 넷째, 부모와 교사의 자율성 지지는 중학생의 기본심리욕구를 충족시켜 사회정서역량에 긍정적 영향을 미쳤다. 이때 역시 부모의 자율성 지지는 교사의 자율성 지지보다 중학생의 기본심리욕구를 더 충족시키고 사회정서역량에 보다 큰 영향을 주는 것으로 나타났다. 연구 결과는 중학생의 사회·정서적 역량을 개발하기 위해 교사뿐만 아니라 부모의 역할이 필수적이고, 특히 중국에서 부모의 사회정서학습에 대한 인식 개선과 부모 교육 확대의 필요를 시사한다. Purpose of this study was intended to examine the effect of parent and teacher's autonomy support on adolescent's social and emotional competencies, focusing on the mediating effect of basic psychological needs based on self-determination theory. Data of 434 students in Zibo city in Shandong Province were used in the analysis of a structural equation modeling. The main results of this study are as follows. First, the more basic psychological needs of middle school students they were met, the higher level of social and emotional competencies of middle school students have. Second, the more parents and teachers' autonomy supported middle school students perceived, the higher level of social and emotional competencies of middle school students they had. In particular, parental autonomy support perceived by students had a more direct impact on the social and emotional competencies. Lastly, parents' autonomy support stimulated middle school students' basic psychological needs more than teachers' autonomy support, and has a greater influence on social and emotional competencies of middle school students. In conclusion, in order to develop the social and emotional competencies of middle school students, the role of parents as well as teachers is essential, suggesting the need to raise awareness of parent education in China and to expand and implement parent education at national level.

Bridge widening with composite steel-concrete girders: application and analysis of live load distribution

Yang, Yue,Zhang, Xiaoguang,Fan, Jiansheng,Bai, Yu Techno-Press 2015 Advances in concrete construction Vol.3 No.4

A bridge widening technology using steel-concrete composite system was developed and is presented in this paper. The widened superstructure system consists of a newly built composite steel-concrete girder with concrete deck and steel diaphragms attached to the existing concrete girders. This method has been applied in several bridge widening projects in China, and one of those projects is presented in detail. Due to the higher stiffness-to-weight ratio and the rapid erection of composite girders, this widening method reveals benefits in both mechanical performance and construction. As only a few methods for the design of bridges with different types of girders are recommended in current design codes, a more accurate analytical method of estimating live load distribution on girder bridges was developed. In the analytical model, the effects of span length, girder pacing, diaphragms, concrete decks were considered, as well as the torsional and flexural stiffness of both composite box girders and concrete T girders. The study shows that the AASHTO LRFD specification procedures and the analytical models proposed in this paper closely approximate the live load distribution factors determined by finite element analysis. A parametric study was also conducted using the finite element method to evaluate the potential load carrying capacities of the existing concrete girders after widening.

A Theoretical Method to Predict Crack Initiation in Stabilizing Piles

Yang Yu,Yue-quan Shang,Hong-yue Sun 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.5

Stabilizing pile is a kind of underground structure, in which the crack initiation on the pile shaft is more dangerous than the crackon the interior concrete structure. A crack discriminant in displacement form was deduced by introducing the subgrade reactionmethod and reinforced concrete theory, in which the head displacement of stabilizing pile was the main parameter. Therefore, thehead displacement of stabilizing pile in critical state of cracking (critical head displacement) can be obtained according to the crackdiscriminant. Subsequently, the predicting crack initiation in stabilizing pile could be achieved by comparing measured headdisplacement with critical head displacement of the stabilizing pile. The crack discriminant was tested and verified in Hongyanlandslide project, Zhejiang province, China. Based on the field measurements at Hongyan landslide project, some stabilizing pileswere critically stressed to initiate the crack.

Sliding Mode Control of Three-Phase Four-Leg Inverters via State Feedback

Yang, Long-Yue,Liu, Jian-Hua,Wang, Chong-Lin,Du, Gui-Fu The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.5

To optimize controller design and improve static and dynamic performances of three-phase four-leg inverter systems, a compound control method that combines state feedback and quasi-sliding mode variable structure control is proposed. The linear coordinate change matrix and the state variable feedback equations are derived based on the mathematical model of three-phase four-leg inverters. Based on system relative degrees, sliding surfaces and quasi-sliding mode controllers are designed for converted linear systems. This control method exhibits the advantages of both state feedback and sliding mode control. The proposed controllers provide flexible dynamic control response and excellent stable control performance with chattering suppression. The feasibility of the proposed strategy is verified by conducting simulations and experiments.

A Novel Phase Locked Loop for Grid-Connected Converters under Non-Ideal Grid Conditions

Yang, Long-Yue,Wang, Chong-Lin,Liu, Jian-Hua,Jia, Chen-Xi The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.1

Grid synchronization is one of the key techniques for the grid-connected power converters used in distributed power generation systems. In order to achieve fast and accurate grid synchronization, a new phase locked loop (PLL) is proposed on the basis of the complex filter matrixes (CFM) orthogonal signal generator (OSG) crossing-decoupling method. By combining first-order complex filters with relation matrixes of positive and negative sequence voltage components, the OSG is designed to extract specific frequency orthogonal signals. Then, the OSG mathematical model is built in the frequency-domain and time-domain to analyze the spectral characteristics. Moreover, a crossing-decoupling method is suggested to decouple the fundamental voltage. From the eigenvalue analysis point of view, the stability and dynamic performance of the new PLL method is evaluated. Meanwhile, the digital implementation method is also provided. Finally, the effectiveness of the proposed method is verified by experiments under unbalanced and distorted grid voltage conditions.

Anti-fouling characteristic of carbon nanotubes hollow fiber membranes by filtering natural organic pollutants

Yue Yang,Sen Qiao,Ruofei Jin,Jiti Zhou,Xie Quan 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.4

Membrane fouling is a universal problem for conventional membrane filtration that usually causes a deterioration in membrane performance. We used electro-assisted carbon nanotubes hollow fiber membranes (CNTs-HFMs) to investigate the anti-fouling properties using natural organic pollutants. Benefiting from the electro-assistance, the permeation flux of humic acid solution using CNTs-HFMs was 190.20 L/(m2·h·bar), which was about 1.5- and 4.4- times higher than those of CNTs-HFMs without electro-assistance and traditional polyvinylidene fluoride hollow-fiber membranes (PVDF-HFMs). And the permeation fluxes of bovine serum albumin, sodium alginate and supernatant of anaerobic bioreactor also presented similar results. The average COD removal rate of CNTs-HFMs (66.8%) at 1.0 V was higher than that of CNTs-HFMs without electro-assistance and PVDF-HFMs, which can be attributed to the formation of electrostatic repulsive force. It could reduce the deposition of pollutants on membrane surface under electroassistance.

GC–MS analysis of chemical constituents and determination of the total antioxidant capacity of adult powder of Periplaneta americana

Yang Zhen,Xie Jiqin,Huang Feiyun,Yang Yu,Zhang Xiuyue,Yue Bisong 한국곤충학회 2022 Entomological Research Vol.52 No.2

Edible insects are alternative sources of high protein. Southeast Asia, South America, Africa, and Europe have recorded edible insects and, especially in Europe and America, there are factories that produce insects as food. In some areas of China, there has also been the habit of eating insects since ancient times. Periplaneta americana is an insect with the homology of medicine and food. In recent years, its medicinal and nutritional functions have attracted extensive attention and research. Its adult powder has been certified as a health product. It not only contains a variety of proteins but also is rich in fatty acids. The composition and antioxidant function of adult powder extract was analyzed in this study. Using adult P. americana powder as the raw material, it was extracted with n-Hexane, dichloromethane, and ethyl acetate, respectively. Gas chromatography–mass spectrometry (GC–MS) removed a total of 60 compounds, and many active components were extracted from P. americana powder for the first time. The parts and relative content of each extracted sample were obtained, and the total antioxidant capacity (T-AOC) of each extracted piece was determined, among which the antioxidant activity of ethyl acetate was the highest.

Spatiotemporal expression patterns of thymosin and its immune regulation after bacterial stimulation in American cockroach (Periplaneta americana)

Yang Zhen,Xie Jiqin,Yang Yu,Sun Xiaohong,Jing Jie,Shen Yongmei,Yue Bisong,Zhang Xiuyue 한국곤충학회 2021 Entomological Research Vol.51 No.12

Thymosin is a physiologically active polypeptide hormone which has many functions involved in promoting wound healing, promoting hair growth, and accelerating tissue and organ regeneration. American cockroach (Periplaneta americana) has three subtypes thymosin (THY1, THY2, THY3) which are different splices from the same thymosin gene. Real-time PCR was used to detect and analyze the expression differences of THY1 and THY2 in different stages, sexes, tissues and after stimulation by bacteria. Thymosins were expressed in adult, eclosion, and ootheca, and their expression levels were significantly up-regulated during the eclosion period, showing the thymosin might be involved in the eclosion process. The expression levels of thymosins in females were higher than males, and the differences in eclosion stages were more significant (P < 0.01), indicating that they were closely related to development and female reproduction. The expressions of THY1 and THY2 in hemolymph were significantly higher (P < 0.01) than that in other tissues. The up-regulated expression of thymosin in two immune-related tissues (Hemolymph and adipose) after Escherichia coli stimulation further confirmed its involvement in the immune response. Our research would provide a basis for screening of novel pesticides target genes.

Critical effects of long non-coding RNA on fibrosis diseases

Yue Zhang,Gang Luo,Yi Zhang,Mengjie Zhang,Jian Zhou,Weiwu Gao,Xiuyun Xuan,Xia Yang,Di Yang,Zhiqiang Tian,Bing Ni,Jun Tang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

The expression or dysfunction of long non-coding RNAs (lncRNAs) is closely related to various hereditary diseases, autoimmune diseases, metabolic diseases and tumors. LncRNAs were also recently recognized as functional regulators of fibrosis, which is a secondary process in many of these diseases and a primary pathology in fibrosis diseases. We review the latest findings on lncRNAs in fibrosis diseases of the liver, myocardium, kidney, lung and peritoneum. We also discuss the potential of diseaserelated lncRNAs as therapeutic targets for the clinical treatment of human fibrosis diseases.