유튜브와 인스타그램에서의 한국어교육 콘텐츠 분석

김규리 ( Kim¸ Gyuri ),김영주 ( Kim¸ Youngjoo ) 국제한국어교육학회 2021 한국어 교육 Vol.32 No.4

This study examines online KFL(Korean as a Foreign Language) content focused on Youtube and Instagram. The purpose of this paper is to analyze the educational value of Youtube and Instagram for Korean language education. To compare these two online platforms’ characteristics, this study investigates the way of composing content, interacting with users, and education content (pronunciation, vocabulary, grammar, reading, listening, speaking, writing, culture education). After a series of analyses of the collected content, students who learn the Korean language through Youtube or Instagram were surveyed. Through such research, it was confirmed that satisfaction with culture, speaking, and vocabulary education is high on Instagram, and culture, listening, grammar education is high on Youtube. In addition, students use various social media features and tools like live streaming, comments section, Instagram hashtags, Youtube community tab which allows them to interact with each other. (KyungHee University)

Increased Sclerostin Levels after Further Ablation of Remnant Estrogen by Aromatase Inhibitors

김원진,Yoon Jung Chung,Se Hwa Kim,Sehee Park1,Jae Hyun Bae,Gyuri Kim1,Su Jin Lee1,Jo Eun Kim1,박병우,임승길,이유미 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.1

Background: Sclerostin is a secreted Wnt inhibitor produced almost exclusively by osteocytes, which inhibits bone formation. Aromatase inhibitors (AIs), which reduce the conversion of steroids to estrogen, are used to treat endocrine-responsive breast cancer. As AIs lower estrogen levels, they increase bone turnover and lower bone mass. We analyzed changes in serum sclerostin levels in Korean women with breast cancer who were treated with an AI. Methods: We included postmenopausal women with endocrine-responsive breast cancer (n=90; mean age, 57.7 years) treated with an AI, and compared them to healthy premenopausal women (n=36; mean age, 28.0 years). The subjects were randomly assigned to take either 5 mg alendronate with 0.5 μg calcitriol (n=46), or placebo (n=44) for 6 months. Results: Postmenopausal women with breast cancer had significantly higher sclerostin levels compared to those in premenopausal women (27.8±13.6 pmol/L vs. 23.1±4.8 pmol/L, P<0.05). Baseline sclerostin levels positively correlated with either lumbar spine or total hip bone mineral density only in postmenopausal women (r=0.218 and r=0.233; P<0.05, respectively). Serum sclerostin levels increased by 39.9%±10.2% 6 months after AI use in postmenopausal women; however, no difference was observed between the alendronate and placebo groups (39.9%±10.2% vs. 55.9%±9.13%, P>0.05). Conclusion: Serum sclerostin levels increased with absolute deficiency of residual estrogens in postmenopausal women with endocrine-responsive breast cancer who underwent AI therapy with concurrent bone loss.

Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition

Kim, Soo Hyun,Kim, Gyuri,Han, Dai Hoon,Lee, Milim,Kim, Irene,Kim, Bohkyung,Kim, Kook Hwan,Song, Young-Mi,Yoo, Jeong Eun,Wang, Hye Jin,Bae, Soo Han,Lee, Yong-Ho,Lee, Byung-Wan,Kang, Eun Seok,Cha, Bong- LANDES BIOSCIENCE 2017 AUTOPHAGY Vol.13 No.10

<P>Impairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack of approved agents for treating NASH, drugs that can enhance autophagy and modulate inflammasome pathways may be beneficial. Here, we investigated the novel mechanism of ezetimibe, a widely prescribed drug for hypercholesterolemia, as a therapeutic option for ameliorating NASH. Human liver samples with steatosis and NASH were analyzed. For in vitro studies of autophagy and inflammasomes, primary mouse hepatocytes, human hepatoma cells, mouse embryonic fibroblasts with Ampk or Tsc2 knockout, and human or primary mouse macrophages were treated with ezetimibe and palmitate. Steatohepatitis and fibrosis were induced by feeding Atg7 wild-type, haploinsufficient, and knockout mice a methionine- and choline-deficient diet with ezetimibe (10mg/kg) for 4wk. Human livers with steatosis or NASH presented impaired autophagy with decreased nuclear TFEB and increased SQSTM1, MAP1LC3-II, and NLRP3 expression. Ezetimibe increased autophagy flux and concomitantly ameliorated lipid accumulation and apoptosis in palmitate-exposed hepatocytes. Ezetimibe induced AMPK phosphorylation and subsequent TFEB nuclear translocation, related to MAPK/ERK. In macrophages, ezetimibe blocked the NLRP3 inflammasome-IL1B pathway in an autophagy-dependent manner and modulated hepatocyte-macrophage interaction via extracellular vesicles. Ezetimibe attenuated lipid accumulation, inflammation, and fibrosis in liver-specific Atg7 wild-type and haploinsufficient mice, but not in knockout mice. Ezetimibe ameliorates steatohepatitis by autophagy induction through AMPK activation and TFEB nuclear translocation, related to an independent MTOR ameliorative effect and the MAPK/ERK pathway. Ezetimibe dampens NLRP3 inflammasome activation in macrophages by modulating autophagy and a hepatocyte-driven exosome pathway.</P>

Use of a Diabetes Self-Assessment Score to Predict Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

Kim, Gyuri,Lee, Yong-ho,Park, Young Min,Kim, Jungghi,Kim, Heesuk,Lee, Byung-Wan,Kang, Eun Seok,Cha, Bong-Soo,Lee, Hyun Chul,Kim, Dae Jung Williams & Wilkins Co 2015 Medicine Vol.94 No.27

<▼1><P>Supplemental digital content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are strongly associated with obesity, insulin resistance, and type 2 diabetes. We recently developed and validated a self-assessment score in the Korean population to identify people at high risk for diabetes. The objective of this study was to evaluate whether the self-assessment risk score for diabetes can also be used to screen for the presence of NAFLD or NASH.</P><P>The study population included 15,676 subjects (8313 men and 7363 women) over 20 years old who visited the National Health Insurance Service Ilsan Hospital in Korea between 2008 and 2010. Anthropometric, clinical, and laboratory data were analyzed during regular health checkups. Fatty liver disease was diagnosed using ultrasound, discrimination capability was assessed based on the area under the receiver operating characteristic curve (AUC), and evaluation measures, including sensitivity and specificity, were calculated. Multiple logistic analyses were also performed.</P><P>We calculated a self-assessed risk score for diabetes (range: 0–11), and a cutoff of ≥5 identified 60% (50%) of men (women) at high risk for NAFLD, reflecting a sensitivity of 79% (85%), a specificity of 60% (66%), a positive predictive value (PPV) of 68% (51%), and a negative predictive value (NPV) of 73% (91%), with an AUC of 0.75 (0.82) for men (women). A cutoff point of ≥6 identified 43% (31%) of men (women) at high risk for NASH, reflecting a sensitivity of 80% (86%), a specificity of 64% (75%), a PPV of 30% (28%), and a NPV of 94% (98%), with an AUC of 0.77 (0.86) for men (women). The odds ratios that a 1-point increase in the diabetes risk scores would be associated with an increased risk for NAFLD and NASH were 1.20 [95% confidence interval (CI): 1.16–1.25] and 1.57 (95% CI: 1.49–1.65), respectively, in men, and 1.28 (95% CI: 1.21–1.34) and 1.89 (95% CI: 1.73–2.07), respectively, in women.</P><P>The present study indicates that our self-assessment risk score for diabetes could be an effective primary screening tool for the presence of NAFLD or NASH.</P></▼2>

Portal Vein Thrombosis in Minimal Change Disease

Gyuri Kim,Gyuri Kim,Su Jin Heo,Yoen Kyung Kee,Seung Hyeok Han 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2

Among the possible venous thromboembolic events in nephrotic syndrome, renal vein thrombosis and pulmonary embolism are common, while portal vein thrombosis (PVT) is rare. This report describes a 26-year-old man with histologically proven minimal change disease (MCD) complicated by PVT. The patient presented with epigastric pain and edema. He had been diagnosed with MCD five months earlier and achieved complete remission with corticosteroids, which were discontinued one month before the visit. Full-blown relapsing nephrotic syndrome was evident on laboratory and clinical findings, and an abdominal computed tomography revealed PVT. He immediately received immunosuppressants and anticoagulation therapy. An eight-week treatment resulted in complete remission, and a follow-up abdominal ultrasonography showed disappearance of PVT. In conclusion, PVT is rare and may not be easily diagnosed in patients with nephrotic syndrome suffering from abdominal pain. Early recognition of this rare complication and prompt immunosuppression and anticoagulation therapy are encouraged to avoid a fatal outcome.

여러 CNN 애플리케이션에서 Systolic Array 성능의 해석적 모델링

김규리(Gyuri Kim),이수홍(Suhong Lee),김보열(Boyeal Kim),김종찬(Jongchan Kim),이혁재(Hyuk-Jae Lee) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.6

Highly Angiogenic, Nonthrombogenic Bone Marrow Mononuclear Cell–Derived Spheroids in Intraportal Islet Transplantation

Oh, Bae Jun,Jin, Sang-Man,Hwang, Yoonha,Choi, Jin Myung,Lee, Han-Sin,Kim, Gyuri,Kim, Geunsoo,Park, Hyo Jun,Kim, Pilhan,Kim, Sung Joo,Kim, Jae Hyeon American Diabetes Association 2018 Diabetes Vol.67 No.3

<P>Highly angiogenic bone marrow mononuclear cell-derived spheroids (BM-spheroids), formed by selective proliferation of the CD31(+) CD14(+) CD34(+) monocyte subset via three dimensional (3D) culture, have had robust angiogenetic capacity in rodent syngeneic renal subcapsular islet transplantation. We wondered whether the efficacy of BM-spheroids could be demonstrated in clinically relevant intraportal islet transplantation models without increasing the risk of portal thrombosis. The thrombogenic potential of intraportally infused BM-spheroids was compared with that of mesenchymal stem cells (MSCs) and MSC-derived spheroids (MSC-spheroids). The angiogenic efficacy and persistence in portal sinusoids of BM-spheroids were examined in rodent syngeneic and primate allogeneic intraportal islet transplantation models. In contrast to MSCs and MSC-spheroids, intraportal infusion of BM-spheroids did not evoke portal thrombosis. BM-spheroids had robust angiogenetic capacity in both the rodent and primate intraportal islet transplantation models and improved post-transplant glycemic outcomes. MRI and intravital microscopy findings revealed the persistence of intraportally infused BM-spheroids in portal sinusoids. Intraportal cotransplantation of allogeneic islets with autologous BM-spheroids in nonhuman primates further confirmed the clinical feasibility of this approach. In conclusion, cotransplantation of BM-spheroids enhances intraportal islet transplantation outcome without portal thrombosis in mice and nonhuman primates. Generating BM-spheroids by 3D culture prevented the rapid migration and disappearance of intraportally infused therapeutic cells.</P>

편의점 무인 키오스크를 위한 IoT 제품 개발

Kim TaeKyoung,Heo GyuRi,Kim TaeKyun 한국서비스디자인학회 2019 한국서비스디자인학회 학술대회자료집 Vol.2019 No.1

S-401 : A Case of Portal vein thrombosis in Minimal change disease

( Gyuri Kim ),( Jung Yeon Lee ),( Sang Eun Lee ),( Su Jin Heo ),( Seung Hyeok Han ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Thromboembolic events are considered critical complications of the nephrotic syndrome. Renal vein and deep veins of the lower limbs are most frequently involved, which often lead to acute kidney injury and pulmonary embolism, respectively. However, portal vein is a rare site where thrombus forms in patients with nephrotic syndrome. This report describes a case of histologically proven minimal change disease complicated by portal vein thrombosis. A 26-year-old male visited our hospital due to suddenly developed nausea, vomiting, and epigastric pain. Five months prior to the visit, he was diagnosed with minimal change disease by renal biopsy. Complete remission was achieved after treatment with oral corticosteroids at an initial dose of 1 mg/kg/day, followed by a slow taper over the next 4 months. Physical examination revealed pitting edema, ascites, and direct tenderness in epigastric abdominal area without rebound tenderness. Initial laboratory tests showed the following values: serum creatinine, 1.39 mg/dL (corresponding to eGFR 67 ml/min/1.73 m2); BUN, 13.9 mg/dL; total protein, 4.4 g/dL; albumin, 1.7g/dL; urine 24-h protein, 25.2 g. Abdominal CT showed thrombosis involving main and right portal vein without cavernous transformation suggesting an acute phase of thrombosis. The patient immediately started anticoagulation therapy with intravenous heparin infusion, followed by oral warfarin. In addition, high dose oral prednisolone at a dose of 60 mg/day was administered for relapsing of nephrotic syndrome. However, two-week corticosteroid treatment failed to achieve remission and 24-h proteinuria was 19 g/day, cyclosporine at a dose of 5 mg/kg was added. A month later, 24-h proteinuria decreased to 0.52 g/day and his kidney function recovered (eGFR≥90 ml/min/1.73 m2). Follow-up abdominal ultrasound showed a patent portal vein without thrombus. Complete remission was achieved after the use of cyclosporine for 6 weeks. In conclusion, portal vein thrombosis is rare and may not be easily diagnosed in patients with nephrotic syndrome who have abdominal pain. Early recognition of this rare complication and prompt anticoagulation therapy and immunosuppression should be emphasized to avoid fatal outcome.

Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study

Kim, Gyuri,Jang, Suk-Yong,Nam, Chung Mo,Kang, Eun Seok Elsevier 2018 Journal of hepatology Vol.68 No.3

<P>Conclusions: Statin use may have a beneficial inhibitory effect on HCC development, particularly in patients with DM or LC, at high risk of HCC. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</P>