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김두권,조성민,이동석,최성민,하경임 동국대학교 경주대학 1997 東國論集 Vol.16 No.1
용혈성 요독 증후군은 미세혈관성 용혈성 빈혈과 혈소판 감소증 및 급성 신부전을 특징으로 하는 질환으로 정확한 원인은 아직 밝혀지지 않고 있으며 발병기전에서 가장 중요한 것은 신미세혈관의 내피세포의 손상으로 알려져 있다. 이 질환은 1955년 Gasser등^1)에 의하여 처음 보고된 후 서구에서는 소아 급성 신부전의 주된 원인으로 알려져 있은, 국내에서는 1972년 이등^2)이 처음 보고한 이래 매우 드물게 1례씩 증례보고되었으나 최근에는 수례가 보고되는 등 증가추세에 있는 질환이다^3∼11). 저자들은 용혈성 요독 증후군으로 1세 여야에서 지주막하 출혈이 동반된 경우와 10세 여아에서 심한 신부전증으로 복막투석 및 보조요법으로 치료된 경우, 2개월된 남아에서 고나트륨혈증이 동반된 경우 및 14개월된 여아에서 경한 임상경과를 취한 증례를 포함한 4례를 치험하였기에 이를 문헌고찰과 함께 보고하는 바이다. The hemolytic uremic syndrome is a clinical state characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. The etiology varies and in the majority the cause remained unknowed. Whatever the cause, the end result is extensive endothelial injury of the renal microvasculature. We experience 4 cases of hemolytic uremic syndrome. Case 1 was accompanied with subarachnoid hemorrhage in a year of age, female. Case 2 with severe acute renal failure, which was treated with peritonial dialysis, dypiridamole and aspirin in 10 years of age, female. Case 3 with severe hypernatremia in 2 months of age, male. Case 4 had mild clinical manifestation in 14 months of age, female. The age at presentation ranged from 2 month to 10years. All cases were improved completely without any complication. The review of the literature was made briefly.
김민수,서해경 동의대학교 한의학연구소 2002 동의ㆍ경산 한의학 학술대회 Vol.6 No.-
Objectives : There were few case reports on the treatment of Transverse Myelitis by oriental medicine. We experienced two cases of patients of Transverse Myelitis, who had complaints; motor, sensory impairment and bowel and urinary dysfunction. Methods : There are a lot of similarities between Wejeung(Weizheng;위증) and Transverse Myelitis. We diagnosed that symptoms as Wejeung(Weizheng;위증), and employed Oriental medical treatments; herb-medication, acupuncture, electro-acupuncture, moxa and physical therapy. Results : After oriental medical treatments, clinical improvement of the neurologic impairment was noted. Conclusions : We expected that therapeutic value of treatment of Transverse Myelitis in the oriental medicine will be higher if more clinical studies and researches are accomplished.
Min Jee Kim,Man Il Kim,Ki Gyoung Kim,Iksoo Kim 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.10
Up to now only 17 coleopteran mitogenomes have been fully or near fully sequenced, but this chart does not include any complete mitogenome sequence of the coleopteran infraorder Scarabaeiformia, in which the monotypic Scarabaeoidea is included. In this study, we firstly present three scarabaeoid mitogenomes, two of which are completed and one is near completed. The complete nucleotide sequences of the white-spotted flower chafer, Protaetia brevitarsis (Scarabaeiformia: Scarabaeidae), was determined to be 20,319 bp, the two-spotted stag beetle, Metopodontus blanchardi (Scarabaeiformia: Lucanidae), was 21,678 bp, and the incomplete garden chafer, Polyphylla laticollis (Scarabaeiformia: Scarabaeidae), which lacks sequence information from whole A+T-rich region and a partial srRNA gene was 14,473 bp. Thus, the two complete mitogenome sequences are longest among the completely sequenced insect mitogenomes, followed by the 19,517 bp-long dipteran Drosophila melanogaster. Phylogenetic analysis using the concatenated 13 amino acid sequences of PCGs of the 13 coleopteran insects including three newly sequenced scarabaeoid successfully recovered a monophyly of suborder Polyphaga, a monophyly of infraorder Cucujiformia, a monophyly of infraorder Elateriformia, and also a monophyly of infraorder Scarabaeiformia within Polyphga. However, the Scarabaeiformia represented by three newly sequenced species was unexpectedly placed as a sister group to the Cucujiformia, instead of the placement to the sister to the Cucujiformia and Elateriformia group.
Kim, Bo-Gyoung,Kim, Jin-Wook,Kim, Soo-Min,Go, Ryeo-Eun,Hwang, Kyung-A,Choi, Kyung-Chul MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.1
<P>Cyprodinil (CYP) is a pyrimidine amine fungicide that has been extensively used in agricultural areas. 3,3′-Diindolylmethane (DIM) is a derivative of the dietary phytoestrogen, indole-3-carbinol (I3C), which is derived from cruciferous vegetables and considered to be a cancer-preventive phytonutrient agent. In this study, the effects of CYP and DIM were examined on the cell viability, invasion, and metastasis of human endometrial cancer cells, Ishikawa, via epithelial mesenchymal transition (EMT). CYP increased the level of cell viability of Ishikawa cells compared to DMSO as a control, as did E2. Ishikawa cells lost cell-to-cell contact and obtained a spindle-shaped or fibroblast-like morphology in response to the application of E2 or CYP by the cell morphology assay. In the cell migration and invasion assay, CYP enhanced the ability of migration and invasion of Ishikawa cells, as did E2. E2 and CYP increased the expressions of N-cadherin and Snail proteins, while decreasing the expression of E-cadherin protein as EMT-related markers. In addition, E2 and CYP increased the protein expressions of cathepsin D and MMP-9, metastasis-related markers. Conversely, CYP-induced EMT, cell migration, and invasion were reversed by fulvestrant (ICI 182,780) as an estrogen receptor (ER) antagonist, indicating that CYP exerts estrogenic activity by mediating these processes via an ER-dependent pathway. Similar to ICI 182,780, DIM significantly suppressed E2 and CYP-induced proliferation, EMT, migration, and invasion of Ishikawa cancer cells. Overall, the present study revealed that DIM has an antiestrogenic chemopreventive effect to withdraw the cancer-enhancing effect of E2 and CYP, while CYP has the capacity to enhance the metastatic potential of estrogen-responsive endometrial cancer.</P>
( Min Jee Kim ),( Ki Gyoung Kim ),( Iksoo Kim ) 한국잠사학회 2013 International Journal of Industrial Entomology Vol.27 No.1
In this study, we present the nearly complete mitogenome sequences of the garden chafer, Polyphylla laticollis manchurica, which is listed as an endangered species in Korea. The P. l. manchurica mitogenome, which includes unfinished whole A+T-rich region and a partial srRNA was 14,473-bp long, possessing typical sets of genes (13 PCGs, 22 tRNA genes, and 2 rRNA genes). Gene arrangement of the P. l. manchurica mitogenome was identical to the common one found in the majority of insects. The 5 bp-long motif sequence (TAGTA) that has been suggested to be the possible binding site for the transcription termination peptide for the major-strand was also found in the P. l. manchurica mitogenome between tRNASer(UCN) and ND1. The start codon for COI gene and ATPase8 was designated as a typical TTG. All tRNAs of the P. l. manchurica showed a stable canonical clover-leaf structure of other mt tRNAs, except for tRNASer(AGN), DHU arm of which could not form stable stemloop structure. As has been previously determined, the high A/T content was unanimously observed in P. l. manchurica in terms of A/T bias in the third codon position (73.5%) compared with the first (66.4%) and second codon position (66.2%). The PCGs encoded in major-strands are slightly T-skewed, whereas those of the minor-strand are A-skewed, indicating strand asymmetry in nucleotide composition in the Coleoptera including P. l. manchurica.