http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Chen Guoliang,Li Xianlong,Zhu Hongzhang,Wu Huachuan,He Dacheng,Shi Liangyu,Wei Fuxin,Liu Xizhe,Chen Ningning,Liu Shaoyu 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
The poor survival and low efficiency of neuronal differentiation limits the therapeutic effects of transplanted neural stem cells in the treatment of spinal cord injury. Neurofibromatosis-1 (NF-1) is a tumor suppressor gene that restricts the rapid and abnormal growth and differentiation of neural cells. In the present study, lentiviral vectors were used to knock out NF-1, Ricotr (the core member of mTORC2) or NF-1+Ricotr in neural stem cells in vitro, and the NF-1, Ricotr or NF-1+Ricotr knockout neural stem cells were transplanted at the lesion site in a rat model of spinal cord injury (SCI). We first demonstrated that targeted knockout of NF-1 had an antiapoptotic effect and improved neuronal differentiation by enhancing the mTORC2/Rictor pathway of neural stem cells in vitro. Subsequently, transplanting NF-1 knockout neural stem cells into the injured site sufficiently promoted the tissue repair and functional recovery of rats with spinal cord injury by enhancing the survival and neuronal differentiation of grafted neural stem cells. Collectively, these findings reveal a prominent role of NF-1 in neural stem cell biology, which is an invaluable step forward in enhancing the benefit of neural stem cell-mediated regenerative cell therapy for spinal cord injury and identifies the transplantation of NF-1 knockout neural stem cells as a promising strategy for spinal cord injury.
Chen Guoliang,Wei Fuxin,Li Jiachun,Shi Liangyu,Zhang Wei,Wang Xianxiang,Xu Zuofeng,Liu Xizhe,Zou Xuenong,Liu Shaoyu 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.7
Objective: To analyze the correlations between intraoperative ultrasound and MRI metrics of the spinal cord in degenerative cervical myelopathy and identify novel potential predictive ultrasonic indicators of neurological recovery for degenerative cervical myelopathy. Materials and Methods: Twenty-two patients who underwent French-door laminoplasty for multilevel degenerative cervical myelopathy were followed up for 12 months. The Japanese Orthopedic Association (JOA) scores were assessed preoperatively and 12 months postoperatively. Maximum spinal cord compression and compression rates were measured and calculated using both intraoperative ultrasound imaging and preoperative T2-weight (T2W) MRI. Signal change rates of the spinal cord on preoperative T2W MRI and gray value ratios of dorsal and ventral spinal cord hyperechogenicity on intraoperative ultrasound imaging were measured and calculated. Correlations between intraoperative ultrasound metrics, MRI metrics, and the recovery rate JOA scores were analyzed using Spearman correlation analysis. Results: The postoperative JOA scores improved significantly, with a mean recovery rate of 65.0 ± 20.3% (p < 0.001). No significant correlations were found between the operative ultrasound metrics and MRI metrics. The gray value ratios of the spinal cord hyperechogenicity was negatively correlated with the recovery rate of JOA scores (ρ = -0.638, p = 0.001), while the ventral and dorsal gray value ratios of spinal cord hyperechogenicity were negatively correlated with the recovery rate of JOA-motor scores (ρ = -0.582, p = 0.004) and JOA-sensory scores (ρ = -0.452, p = 0.035), respectively. The dorsal gray value ratio was significantly higher than the ventral gray value ratio (p < 0.001), while the recovery rate of JOA-motor scores was better than that of JOA-sensory scores at 12 months post-surgery (p = 0.028). Conclusion: For degenerative cervical myelopathy, the correlations between intraoperative ultrasound and preoperative T2W MRI metrics were not significant. Gray value ratios of the spinal cord hyperechogenicity and dorsal and ventral spinal cord hyperechogenicity were significantly correlated with neurological recovery at 12 months postoperatively.
THE GENERALIZED WEIGHTED MOORE-PENROSE INVERSE
Sheng, Xingping,Chen, Guoliang 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.25 No.1
In this paper, we definite a generalized weighted Moore-Penrose inverse $A^{+}_{M,N}$ of a given matrix A, and give the necessary and sufficient conditions for its existence. We also prove its uniqueness and give a representation of it. In the end we point out this generalized inverse is also a prescribed rang T and null space S of {2}-(or outer) inverse of A.
Exposure Assessment for RCC Dam Construction Integrated Real-Time Location Information
Xiazhong Zheng,Jiali Zhou,Guoliang Chen,Shu Chen 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.3
Roller compacted concrete (RCC) dam projects are generally initiated in dynamic environment, where space conflicts occur frequently. Construction workers are often exposed to dangers posed by activities performed by teams other than their own. Therefore, it’s critical for construction security to conduct fairly precise exposure assessment. Several research studies have been proposed to address this site safety issue. Despite their valuable contributions, few of them have noticed that, for some construction processes, their hazard scope may exceed the work space. Another limitation is that most traditional methods expound space factor and time factor separately rather than comprehensively. Accordingly, the present paper proposes a novel method to quantify exposure frequency integrated with the real-time location information of three-dimensional cross activities. Combined with the construction process cycle and the operation time characteristics, conflicts between impact space and work space are determined in real time, which is more accurate as the interaction between construction activities is certain at each moment. With a reliable assessment of hazard exposure levels, construction managers will be able to provide solutions to reduce hazards to acceptable levels.
Helin Fu,Jie Li,Guoliang Li,Jingjun Chen,Pengtao An 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.6
The Sejila tunnel, part of the Sichuan–Tibet railway, is in a complex geostress environment because of its deep burial depths and tectonic movement. Based on the measured stress data combined with the structural history and features, the stress characteristics of the Sejila area are preliminarily identified. Then, a three-dimensional numerical model that can provide real topographic features is established, and a distribution law of stress boundary conditions is proposed according to compilations of much measured stress data. By means of support vector regression (SVR), the stress field of the whole Sejila region is determined and finds a reasonable accordance with the measured stress data. Results show that the vertical stress in deep buried stratum can be approximately regarded as one of the principal stresses, and it is reasonable to apply the lateral stress to the model boundary according to a linear function with burial depth. The in situ stress in the tunnel site exhibits that σH > σV > σh, and the σHdirection deflects when it encounters faults or strata interfaces; the larger that the intersecting angle between fault strike and σH is, the smaller the deflection. Compared to the entrance, the rear of the tunnel is subjected to a high maximum principal stress with a high angle; moreover, most sections of the tunnel are estimated to suffer from severe rockbursts, except for a range of 5 km away from the tunnel entrance and 2.5 km away from the exit, according to the Russense criterion. This paper can provide the basis for the prediction and prevention of rockbursts in the Sejila tunnel.