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RISS 인기검색어
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- 저자 : Guangyu He (검색결과 4 건)
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Guangyu Zhang,Fangfang He,Chunli Fu,Youzhong Zhang,Qiuan Yang,Jianbo Wang,Yufeng Cheng 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.1
Objective: To assess the toxicity of delivering extended field intensity-modulated radiotherapy (EF-IMRT) and concurrent cisplatin chemotherapy for locally advanced cervical carcinoma. Methods: Forty-five patients who underwent EF-IMRT and concurrent cisplatin chemotherapy for the treatment of stage IB2 to IIIB cervical cancer were retrospectively reviewed. The clinical target volume included all areas of gross and potentially microscopic disease and regional lymph node regions. All patients underwent high-dose-rate brachytherapy. The acute and late toxicity were scored using the Common Terminology Criteria for Adverse Events and the Radiation Therapy Oncology Group late radiation morbidity scoring criteria, respectively. Results: The median follow-up was 28 months (range, 5 to 62 months). Forty-two patients had a complete response, and three had a persistent disease. Of those 42 patients, 15 patients (35.7%) had recurrence. The regions of recurrence were in-field in 2 patients and out-field in 13 patients. Acute grade ≥3 gastrointestinal, genitourinary and hematologic toxicity occurred in 3, 1, and 9 patients, respectively. Three patients (6.7%) suffered from late grade 3 toxicities. Seven patients experienced ovarian transposition, 5 of those patients (71%) maintained ovarian function. Thirty-eight patients (84.4%) were alive at the last follow-up. Conclusion: Concurrent cisplatin chemotherapy with EF-IMRT was safe. The acute and late toxicities are acceptable. EF-IMRT provides an opportunity to preserve endocrine function for patients with ovarian transposition.
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Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage
Wang Guangyu,Wang Yongsi,Jiang Shaofeng,Fan Wentao,Mo Chune,Gong Weiwei,Chen Hui,He Dan,Huang Jinqing,Ou Minglin,Hou Xianliang 한국유전학회 2022 Genes & Genomics Vol.44 No.7
Background: The current pandemic of coronavirus disease 2019 (COVID-19), transmitted person-to-person by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2), poses a threat to global public health. Objective: In this study, we performed the comprehensive analysis of the T cell receptor (TCR) repertoire may contribute to a more in-depth understanding of the pathogenesis of COVID-19. Methods: A comprehensive immunological analysis was performed to explore the features of the TCR repertoire and identified TCR sequences correlated with SARS-CoV-2 viral antigens. Results: we analyzed the COVID-19 patients' TCR repertoires in peripheral blood mononuclear cells (PBMC) which obtained before (baseline), during (acute), and after rehabilitation (convalescent) by ImmunoSEQ-technology, and found that repertoire features of TCRβ-chain (TCRβ) complementary-determining region 3 (CDR3) in COVID-19 patients were remarkable difference, including decreased TCR diversity, abnormal CDR3 length, difference of TRBV/J gene usage and higher TCR sequence overlap. Besides, we identified some COVID-19 disease-associated TCRβ clones, and the abundance of them changed with the progression of the disease. Importantly, these disease-associated TCRβ clones could be used to distinguish COVID-19 patients from healthy controls with high accuracy. Conclusions: We provide a clear understanding of the TCR repertoire of COVID-19 patients, which lays the foundation for better diagnosis and treatment of COVID-19 patients.
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A polymeric composite protective layer for stable Li metal anodes
Guo Suogang,Wang Li,Jin Yuhong,Piao Nan,Chen Zonghai,Tian Guangyu,Li Jiangang,Zhao Chenchen,He Xiangming 나노기술연구협의회 2020 Nano Convergence Vol.7 No.21
Lithium (Li) metal is a promising anode for high-performance secondary lithium batteries with high energy density due to its highest theoretical specific capacity and lowest electrochemical potential among anode materials. However, the dendritic growth and detrimental reactions with electrolyte during Li plating raise safety concerns and lead to premature failure. Herein, we report that a homogeneous nanocomposite protective layer, prepared by uniformly dispersing AlPO 4 nanoparticles into the vinylidene fluoride-co-hexafluoropropylene matrix, can effectively prevent dendrite growth and lead to superior cycling performance due to synergistic influence of homogeneous Li plating and electronic insulation of polymeric layer. The results reveal that the protected Li anode is able to sustain repeated Li plating/stripping for > 750 cycles under a high current density of 3 mA cm −2 and a renders a practical specific capacity of 2 mAh cm −2 . Moreover, full-cell Li-ion battery is constructed by using LiFePO 4 and protected Li as a cathode and anode, respectively, rendering a stable capacity after 400 charge/discharge cycles. The current work presents a promising approach to stabilize Li metal anodes for next-generation Li secondary batteries.
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Jingrui Ye,Mengjuan Teng,Xingyue Qian,Chao Wan,Guangyu He,Haiqun Chen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
Hydrogen evolution reactions (HER) via water splitting is of significance for electricity-to-fuel conversion. The pursuits of rationally design and facile synthesis method for efficient HER catalysts have long been asubject of interest. In this work, a bimetallic MOF-derived strategy was constructed to realize doping andalloying of transition metal in parallel and Pd-CuCeOx catalyst was prepared, in which Cu served as dopingelement in CeO2 and secondary metal in Pd-Cu alloy. For the as-synthesized Pd-CuCeOx, an overpotentialof 109 mV is needed to reach a current density of 10 mA cm2 with a Tafel slope of only 30.9 mVdec1. With the low content of precious metal, Pd-CuCeOx exhibited a high TOF value of 6.99 s1, which isabout 3.5 times higher than that of commercial Pt/C. The improved HER performance is attributed to thed-band structure modified by alloying and the enhanced electronic coupling caused by doping.
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