http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A New Moving-magnet Type Linear Actuator utilizing Flux Concentration Permanent Magnet Arrangement
Akira Goto,Takuya Okamoto,Atsushi Ikariga,Takashi Todaka,Masato Enokizono 대한전기학회 2012 Journal of Electrical Engineering & Technology Vol.7 No.3
This paper presents a moving-magnet type linear actuator designed by using flux concentration type permanent magnet arrangement, which can generate higher magnetic flux density in air-gap. In this construction, detent force which is induced by both slot-effect and end-effect becomes larger due to strong attractive forces. To reduce cogging force we have employed a modular mover structure of two magnetic pole sections connected with a center yoke. The improved motor performance is demonstrated with the prototype machine.
Historical Perspective on Fluid Machinery Flow Optimization in an Industry
Akira Goto 한국유체기계학회 2016 International journal of fluid machinery and syste Vol.9 No.1
Fluid-dynamic design of fluid machinery had heavily relied on empiricism and experimental observations for many years. Since 1980s, thanks to the advancements in Computational Fluid Dynamics (CFD), a variety of flow physics have been revealed. The contribution by CFD is indispensable; however, the challenge is required not only on the advancements in CFD technologies but also innovation of “ design (optimization) technologies ” because of the complex interactions between 3-D flow fields and the complex 3-D flow passage configurations, etc. This paper presents historical perspective on fluid machinery flow optimization in an industry with some messages for the future.
Historical Perspective on Fluid Machinery Flow Optimization in an Industry
Goto, Akira Korean Society for Fluid machinery 2016 International journal of fluid machinery and syste Vol.9 No.1
Fluid-dynamic design of fluid machinery had heavily relied on empiricism and experimental observations for many years. Since 1980s, thanks to the advancements in Computational Fluid Dynamics (CFD), a variety of flow physics have been revealed. The contribution by CFD is indispensable; however, the challenge is required not only on the advancements in CFD technologies but also innovation of "design (optimization) technologies" because of the complex interactions between 3-D flow fields and the complex 3-D flow passage configurations, etc. This paper presents historical perspective on fluid machinery flow optimization in an industry with some messages for the future.
A New Moving-magnet Type Linear Actuator utilizing Flux Concentration Permanent Magnet Arrangement
Goto, Akira,Okamoto, Takuya,Ikariga, Atsushi,Todaka, Takashi,Enokizono, Masato The Korean Institute of Electrical Engineers 2012 Journal of Electrical Engineering & Technology Vol.7 No.3
This paper presents a moving-magnet type linear actuator designed by using flux concentration type permanent magnet arrangement, which can generate higher magnetic flux density in air-gap. In this construction, detent force which is induced by both slot-effect and end-effect becomes larger due to strong attractive forces. To reduce cogging force we have employed a modular mover structure of two magnetic pole sections connected with a center yoke. The improved motor performance is demonstrated with the prototype machine.
Akira Kishimoto,Yurie Goto,갠지하시모토 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.3
Post-traumatic stress disorder (PTSD) is a pathological response to trauma characterized by frequent recollections, recurrentnightmares, and flashbacks of the traumatic event(s). To date, the precise mechanisms underlying the development of PTSDremain unknown. Several studies have suggested that antiepileptic drugs, such as gabapentin and lamotrigine, may be effectivein the treatment of PTSD symptoms. We report on a 15-year-old Japanese female junior high school student who developedPTSD symptoms following repeated teasing from male classmates. Additionally, we underscore the beneficial effects of treatmentwith gabapentin and lamotrigine on flashbacks and nightmares. This patient developed PTSD symptoms after repeated teasingfrom male classmates at school. Her flashbacks and nightmares were treated with a combination of gabapentin and lamotrigine. After recovery, treatment with lamotrigine alone controlled her symptoms. Our observations suggest that a process of sensitizationmay be involved in the development of PTSD symptoms. Additionally, gabapentin and/or lamotrigine were effective in the treatmentof flashbacks and nightmares in this patient. Thus, doctors should consider using these anti-epileptic drugs as an alternativeapproach to treating PTSD symptoms.
Influence of Signal Intensity Non-Uniformity on Brain Volumetry Using an Atlas-Based Method
Masami Goto,Osamu Abe,Tosiaki Miyati,Hiroyuki Kabasawa,Hidemasa Takao,Naoto Hayashi,Tomomi Kurosu,Takeshi Iwatsubo,Fumio Yamashita,Hiroshi Matsuda,Harushi Mori,Akira Kunimatsu,Shigeki Aoki,Kenji Ino,K 대한영상의학회 2012 Korean Journal of Radiology Vol.13 No.4
Objective: Many studies have reported pre-processing effects for brain volumetry; however, no study has investigated whether non-parametric non-uniform intensity normalization (N3) correction processing results in reduced system dependency when using an atlas-based method. To address this shortcoming, the present study assessed whether N3 correction processing provides reduced system dependency in atlas-based volumetry. Materials and Methods: Contiguous sagittal T1-weighted images of the brain were obtained from 21 healthy participants, by using five magnetic resonance protocols. After image preprocessing using the Statistical Parametric Mapping 5 software, we measured the structural volume of the segmented images with the WFU-PickAtlas software. We applied six different bias-correction levels (Regularization 10, Regularization 0.0001, Regularization 0, Regularization 10 with N3, Regularization 0.0001 with N3, and Regularization 0 with N3) to each set of images. The structural volume change ratio (%) was defined as the change ratio (%) = (100 x [measured volume - mean volume of five magnetic resonance protocols] / mean volume of five magnetic resonance protocols) for each bias-correction level. Results: A low change ratio was synonymous with lower system dependency. The results showed that the images with the N3 correction had a lower change ratio compared with those without the N3 correction. Conclusion: The present study is the first atlas-based volumetry study to show that the precision of atlas-based volumetry improves when using N3-corrected images. Therefore, correction for signal intensity non-uniformity is strongly advised for multi-scanner or multi-site imaging trials. Objective: Many studies have reported pre-processing effects for brain volumetry; however, no study has investigated whether non-parametric non-uniform intensity normalization (N3) correction processing results in reduced system dependency when using an atlas-based method. To address this shortcoming, the present study assessed whether N3 correction processing provides reduced system dependency in atlas-based volumetry. Materials and Methods: Contiguous sagittal T1-weighted images of the brain were obtained from 21 healthy participants, by using five magnetic resonance protocols. After image preprocessing using the Statistical Parametric Mapping 5 software, we measured the structural volume of the segmented images with the WFU-PickAtlas software. We applied six different bias-correction levels (Regularization 10, Regularization 0.0001, Regularization 0, Regularization 10 with N3, Regularization 0.0001 with N3, and Regularization 0 with N3) to each set of images. The structural volume change ratio (%) was defined as the change ratio (%) = (100 x [measured volume - mean volume of five magnetic resonance protocols] / mean volume of five magnetic resonance protocols) for each bias-correction level. Results: A low change ratio was synonymous with lower system dependency. The results showed that the images with the N3 correction had a lower change ratio compared with those without the N3 correction. Conclusion: The present study is the first atlas-based volumetry study to show that the precision of atlas-based volumetry improves when using N3-corrected images. Therefore, correction for signal intensity non-uniformity is strongly advised for multi-scanner or multi-site imaging trials.
Yagi Kiyoshi,Goto Yuta,Kato Kenji,Suzuki Nobuyuki,Kondo Akira,Waseda Yuya,Mizutani Jun,Kawaguchi Yohei,Joyo Yuji,Waguri-Nagaya Yuko,Murakami Hideki 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.6
Study Design Human ligamentum flavum–derived cells (HFCs) were obtained from surgical samples for a basic experimental study. Purpose We sought to evaluate the inflammatory response of human ligamentum flavum cells to investigate hypertrophic changes occurring in the ligamentum flavum. Overview of Literature Lumbar spinal stenosis (LSS) is a disease commonly observed in the elderly. The number of patients with LSS has increased over time, yet the pathomechanisms of LSS still have not been fully elucidated. One of the clinical features of LSS is hypertrophy of the ligamentum flavum, which results in narrowing of the lumbar spinal canal. Some reports have suggested that ligamentum flavum hypertrophy is associated with inflammation and fibrosis; meanwhile, the p38 mitogen-activated protein (MAP) kinase is involved in the hypertrophy of human ligamentum flavum cells. Methods HFCs were obtained from patients with LSS who underwent surgery. HFCs were stimulated by tumor necrosis factor-α (TNF-α) and a p38 MAP kinase inhibitor, SB203580. Phosphorylation of the p38 MAP kinase was analyzed by western blotting. The concentration of interleukin-6 (IL-6) in the conditioned medium was measured by enzyme-linked immunoassay and IL-6 messenger RNA expression levels were determined by real-time polymerase chain reaction. Results TNF-α induced the phosphorylation of p38 MAP kinase in a time-dependent manner, which was suppressed by the p38 MAP kinase inhibitor, SB203580. TNF-α also stimulated IL-6 release in both a time- and dose-dependent manner. On its own, SB203580 did not stimulate IL-6 secretion from HFCs; however, it dramatically suppressed the degree of IL-6 release stimulated by TNF-α from HFCs. Conclusions This is the first report suggesting that TNF-α stimulates the gene expression and protein secretion of IL-6 via p38 MAP kinase in HFCs. A noted association between tissue hypertrophy and inflammation suggests that the p38 MAP kinase inflammatory pathway may be a therapeutic molecular target for LSS.