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황기환,고대식,전계석 慶熙大學校 材料科學技術硏究所 1992 材料科學技術硏究論集 Vol.5 No.-
In this paper, using the spectra and the reflection coefficient of surface acoustic wave:SAW, the surface breaking crack-depth is estimated by computer simulation and the experiment. In order to perform this experiment, two type shaped flows half-penny and rectangular of line-crack have been made in the surface of aluminium. Measuring results, for half-penny type, the reflection coefficient have been in proportion to the surface breaking crack-depth. When the spectrum analyzer was used, the spectra analysis method for line crack of rectangular type was measured the average deviation 8.7% to the surface breaking crack-depth.
황기현,문경준,김문수,원태현 동의공업대학 1998 論文集 Vol.24 No.1
In this paper, a reference model following control system using a fuzzy logic controller (FLC) is proposed. A reference model whose response does not overshoot and has a fast rise time is designed. A FLC is designed to follow as close as possible the response of the reference model. The proposed design method has the robustness and the optimal tracking property under modeling error, disturbance and parameter perturbations. The proposed designing method is compared using a PD controller throughout the experiment. The effectiveness of the proposed designing method is verified through computer simulation and experiments for the second-order and the first-order reference model.
Hwang, Ji Sun,Kim, Gi-Cheon,Park, EunBee,Kim, Jung-Eun,Chae, Chang-Suk,Hwang, Won,Lee, Changhon,Hwang, Sung-Min,Wang, Hui Sun,Jun, Chang-Duk,Rudra, Dipayan,Im, Sin-Hyeog The American Association of Immunologists, Inc. 2015 JOURNAL OF IMMUNOLOGY Vol.194 No.4
<P>IL-31 is a key mediator of itching in atopic dermatitis (AD) and is preferentially produced by activated CD4<SUP>+</SUP> T cells and Th2 cells. Although pathophysiological functions of IL-31 have been suggested in diverse immune disorders, the molecular events underlying <I>IL-31</I> gene regulation are still unclear. In this study we identified the transcription start site and functional promoter involved in <I>IL-31</I> gene regulation in mouse CD4<SUP>+</SUP> T cells. TCR stimulation–dependent IL-31 expression was found to be closely linked with in vivo binding of NFAT1 and JunB to the <I>IL-31</I> promoter. Although NFAT1 alone enhanced <I>IL-31</I> promoter activity, it was further enhanced in the presence of JunB. Conversely, knockdown of either NFAT1 or JunB resulted in reduced <I>IL-31</I> expression. NFAT1-deficient CD4<SUP>+</SUP> T cells showed a significant defect in <I>IL-31</I> expression compared with wild-type CD4<SUP>+</SUP> T cells. In agreement with these findings, mice subjected to atopic conditions showed much higher levels of IL-31, which were closely correlated with a significant increase in the number of infiltrated NFAT1<SUP>+</SUP>CD4<SUP>+</SUP> T cells into the AD ears. Amelioration of AD progression by cyclosporin A treatment was well correlated with downregulation of IL-31 expressions in CD4<SUP>+</SUP> T cells and total ear residual cells. In summary, our results suggest a functional cooperation between NFAT1 and JunB in mediating <I>IL-31</I> gene expression in CD4<SUP>+</SUP> T cells and indicate that interference with this interaction or their activity has the potential of reducing IL-31–mediated AD symptoms.</P>
Common ABCB1 SNP, C3435T could affect systemic exposure of dapagliflozin in healthy subject
Jun Gi Hwang,Sae Im Jeong,Yu Kyong Kim,Yujin Lee,Sang Chun Ji,SeungHwan Lee,Min Kyu Park 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.4
P-glycoprotein (P-gp) is a transporter that plays an excretory role in epithelial cells. It is encoded by ABCB1, and single nucleotide polymorphisms (SNPs) in this gene can affect systemic drug exposure. Dapagliflozin and sitagliptin, used in type 2 diabetes treatment, are P-gp substrates. Here, we aimed to investigate whether ABCB1 polymorphisms affect dapagliflozin and sitagliptin pharmacokinetics (PK) in healthy Korean subjects. The study population consisted of 100 healthy Korean subjects (94 men and 6 women) who participated in four different clinical trials and received dapagliflozin and sitagliptin doses of 10 and 100 mg, respectively. We determined ABCB1 genotypes for the C3435T, C1236T, and G2677T/A SNPs. The relationship between the genotypes and dapagliflozin PKs was examined. Dapagliflozin and sitagliptin PK parameters were not statistically significantly affected by ABCB1 SNP genotypes. However, homozygous 3435TT subjects showed higher dapagliflozin PK parameters than CT and CC subjects. In subjects with the 3435TT and those with 3435CC and 3435CT genotypes, mean C max , AUC inf , and AUC 0-1 values of dapagliflozin were 223.06 ng/ mL and 194.81 ng /mL (p = 0.2767), 673.58 ng*h/mL and 573.96 ng*h/mL (p = 0.0492), and 128.53 ng*h/mL and 104.61 ng*h/mL (p = 0.2678), respectively. In summary, dapagliflozin and sitagliptin PK parameters were not significantly different between individuals with C1236T and C2677T/A ABCB1 genetic polymorphisms. Dapagliflozin exhibited higher systemic exposure in 3435TT subjects than in CC/CT subjects.
안구 마우스를 이용한 전신마비 환자용 홈 네트워크 시스템
황기현 ( Ki-hyun Hwang ),김범준 ( Beom-jun Kim ),송준 ( Jun Song ),유우종 ( Woo-jong Yoo ),황성현 ( Sung-hyun Hwang ),이수원 ( Soowon Lee ),김병기 ( Byung-gi Kim ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.2
본 연구에서는 전신마비 환자들이 안구 마우스를 사용하여 전등,선풍기,창문 제어 및 침대 각도 조절을 할 수 있고,보호자에게 소변통 알림과 응급메시지 알림을 보낼 수 있는 홈 네트워크 시스템을 설계하고 구현한다. 또한 전신마비 환자들뿐만 아니라 일반 사용자들도 이용할 수 있도록 동일한 기능을 모바일 어플리케이션으로 구현한다. 본 연구의 입력장치인 안구 마우스는 삼성전자 창의개발연구소에서 개발한 eyeCm을 사용하였다. 전체적인 시스템은 Arduino를 사용하여 제어하고,무선 통신은 Xbee모듈을 사용하여 구현하였다. 기존의 홈 네트워크 시스템은 일반 사용자들만 이용할 수 있지만, 본 연구에서는 루게릭 환자처럼 전신을 움직이지 못하는 환자들에게 최적화된 홈 네트워크 시스템을 구축하여 소외계층의 스마트 기기에 대한 접근성을 높이고,자립심을 키울 수 있도록 도와준다는 점에서 의의가 있다.
Hwang, Jun-Seok,Kim, Jin-Nam,Wee, Young-Jung,Yun, Jong-Sun,Jang, Hong-Gi,Kim, Sun-Ho,Ryu, Hwa-Won The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.4
In this study, melamine-formaldehyde microcapsules were prepared via in situ polymerization using peppermint oil as a core material, melamine-formaldehyde as the wall material, Tween 20 as the emulsifier, and poly (vinyl alcohol) as a protective colloid. The melamine-formaldehyde microcapsules prepared in this study were then evaluated with regard to their structures, thermal properties, particle size distributions, morphologies, and release behaviors.