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권선옥,김우식,오명기,나종천,이홍기,조욱현,최석구 인제대학교 2006 仁濟醫學 Vol.27 No.-
The use of critical pathways for a variety of clinical conditions has grown rapidly in recent years, particularly pathways for patients with acute myocardial infarction. We intend to determine the impact of a clinical pathway on ST-elevation myocardial infarction (STEMI) and to evaluate the efficacy and safety of facilitated percutaneous coronary intervention (PCI) compared with primary PCI. Low risk STEMI patients (ST elevation >0.1mV in more than 2 limb leads or ST elevation >0.2mV in contiguous precordial lead, chest pain lasting more than 30 min without response to nitroglycerin) will be included. All patients will be also treated medically according to critical pathway. STEMI is one of the common diseases in emergency medicine and so it is necessary to establish realistic treatment guidelines. The use of critical pathways will improve the quality of care.
Koo, Gi-Bang,Morgan, Michael J,Lee, Da-Gyum,Kim, Woo-Jung,Yoon, Jung-Ho,Koo, Ja Seung,Kim, Seung Il,Kim, Soo Jung,Son, Mi Kwon,Hong, Soon Sun,Levy, Jean M Mulcahy,Pollyea, Daniel A,Jordan, Craig T,Yan Springer Science and Business Media LLC 2015 Cell research Vol.25 No.6
<P>Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is an essential part of the cellular machinery that executes 'programmed' or 'regulated' necrosis. Here we show that programmed necrosis is activated in response to many chemotherapeutic agents and contributes to chemotherapy-induced cell death. However, we show that RIP3 expression is often silenced in cancer cells due to genomic methylation near its transcriptional start site, thus RIP3-dependent activation of MLKL and downstream programmed necrosis during chemotherapeutic death is largely repressed. Nevertheless, treatment with hypomethylating agents restores RIP3 expression, and thereby promotes sensitivity to chemotherapeutics in a RIP3-dependent manner. RIP3 expression is reduced in tumors compared to normal tissue in 85% of breast cancer patients, suggesting that RIP3 deficiency is positively selected during tumor growth/development. Since hypomethylating agents are reasonably well-tolerated in patients, we propose that RIP3-deficient cancer patients may benefit from receiving hypomethylating agents to induce RIP3 expression prior to treatment with conventional chemotherapeutics.</P>
백서에서 도서형 피판 작성시 덱사메타손 투여가 세포 자멸사에 미치는 영향
홍기웅,김한구,김승홍 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1
In order to prevent the damages of the flap tissues due to ischemia following a flap surgery, numerous studies have been conducted for the physiochemical, hemodynamic, and metabolic changes in ischemic flap. There had also been many discussions on the use of different drugs to prevent such damages. Recently apoptosis has been regarded as an important tissue injury mechanism as well as tissue necrosis in flap surgery. In acute tissue injury that can be caused by different reasons, some cells die of tissue necrosis while others may go through a time period, which will determine whether die of apoptosis or not. So survival of certain tissues will depend on the degree of apoptosis. In the post flap surgery period, the degree of apoptosis may influence the survival of ischemic flap with tissue necrosis. The author studied the effects of steroids (dexamethasone) on apoptosis in ischemic skin flap after a flap surgery. Steroids are known to increase the survival of flap by increasing tissue tolerance against tissue necrosis of ischemic flap. For the control group (N=15), after elevating an island skin flap with inferior epigastric vessels as pedicle on the abdominal area of a rat, the pedicle is clamped to create an ischemic state. Microscopical observations confirmed apoptosis as well as tissue necrosis of the flap. For the experimental group (N=l5), dexamethasone, a steroid matter was administered before the the clamping of the pedicle. As a result of microscopic observations and comparison of the effects of dexamethasone on the apoptotic area of ischemic flap between the control and experimental group, apoptosis increased significantly in the experimental group. In this respect, steroids, that are known to increase the survival of flap by reducing tissue necrosis, seem to weaken the survival of a flap by increasing the number of dead cells from apoptosis since they stimulate apoptosis of ischemic flap. Results of this study call for related studies on other drugs that can influence apoptosis of ischemic flap.
구홍모 ( Hong Mo Koo ),구인모 ( In Mo Ku ),고영채 ( Young Chae Ko ),이희 ( Hei Lee ),양기원 ( Gi Won Yang ),이영일 ( Young Il Lee ),조태일 ( Tae Il Cho ),강유미 ( You Mee Kang ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.9
To our knowledge, implantation into the uterine muscle wall is one of the rare form of ectopic pregnancy, with only 16 cases reported until 1995. The early diagnosis depends upon the sonographic finding of intramural gestational sac-like growth and persis
구기동 ( Koo Gi-dong ),홍정의 ( Hong Jung-yee ),장용원 ( Jang Yong-won ) 한국경영공학회 2020 한국경영공학회지 Vol.25 No.1
Population shift is a key factor in understanding the demographic situation of a country or region and is affected by its relative distance and location. The outflow of Koreans has been shifting from student studying abroad in the 1980s to advanced technology manpower since the 2000s. The number of foreign workers continued to expand due to the implementation of the industrial trainee system and the employment permission system. This study analyzed the trend of international migration of Koreans since 2000 and the flow of foreign laborers in Korea. Although the number of outbound travelers is higher than that of immigrants, the number of immigrants and outbound Koreans is similar in 2007. However, outbound Koreans have a similar trend, but the number of arrivals is increasing significantly. The number of immigrants has been much larger, but since 2008, the number of arrivals and departures has been in balance. The number of immigrants is higher than the number of outbound foreigners and the scale is continuously increasing. The main factors of Korean migrants are job search, family reunion, and housing. The scarce workforce in part was supplemented by the foreign labor force. In conclusion, the migration of Koreans is balanced between inflows and outflows starting from 2008, while foreigners are steadily increasing in inflows more than inflows. However, the size of the flow of Koreans could utilize the data, but could not be analyzed due to the lack of data on the working population and type of employment.