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      • KCI등재

        정상 및 원추각막에서 각막 전, 후면의 융기 및 시상면만곡도의 비교분석

        이종수,이승욱,이승민,이미현,Jong Soo Lee,Seung Wook Lee,Seung Min Lee,Mi Hyun Lee 대한안과학회 2012 대한안과학회지 Vol.53 No.10

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Purpose: To compare changes of anterior and posterior corneal elevation, and sagittal curvature according to the severity of keratoconus and to compare differences between keratoconus and normal cornea. Methods: A total of 81 eyes diagnosed with keratoconus and 20 eyes of normal subjects were evaluated with a Pentacam Scheimpflug camera. The keratoconus eyes were divided into 3 groups according to mean keratometer (K): mild (K ≤ 47.0 diopters (D)), moderate (47.0 to 52.0 D), and severe (52.0 D≥). The following parameters were obtained to evaluate the correlation of keratoconus: corneal thickness, anterior and posterior corneal elevation, and sagittal curvature. Results: Out of 81 keratoconus eyes, 56 eyes were mild, 12 eyes were moderate, and 13 eyes were severe keratoconus. The mean central corneal keratometer, anterior and posterior corneal elevation, and sagittal curvature of the keratoconus eyes were 49.7 D, 22.07 μm, 38.16 μm, 52.76 D and the values increased statistically compared to the normal eyes. Furthermore, the values increased significantly with the severity of keratoconus. ROC curve analysis showed the estimated meaningful value for anterior and posterior corneal elevation and sagittal curvature of keratoconus for diagnosis; there were no diagnostic values for corneal thickness and refractive power. Conclusions: The index of 5.5 μm for mean anterior elevation, 12.5 μm for mean posterior elevation, and 44.5 μm for mean sagittal curvature using the PentacamⓇ are useful to diagnose keratoconus. Variation of anterior and posterior elevation, and sagittal curvature measured by PentacamⓇ are useful in understanding the process of keratoconus. J Korean Ophthalmol Soc 2012;53(10):1432-1437

      • 몇종의 세균과 Saccharomyces cerevisiae에 대한 식품첨가물의 향균 특성

        이종수,오준세,김나미,금종화,이석건,Lee, Jong-Soo,Oh, Jun-Sei,Kim, Na-Mi,Keum, Jong-Hwa,Lee, Suk-Kun 배재대학교 자연과학연구소 1996 自然科學論文集 Vol.8 No.2

        현재 식품첨가물로 많이 사용되고 있는 유기산과 안정제 및 색소 등의 각종 세균과 Sacch. cerevisiae 에 대한 향균 특성을 조사하였다. 산도 조절용으로 사용되고 있는 젖산, 사과산, 호박산 및 주석산은 L. acidophilus와 Sacch. cerevisiae에 대하여 향균성이 없었으나 B. subtilis등의 세균에 대하여는 향균성이 있었고 특히 사과산은 P. aeruginosa에 대하여 강한 향균력이 있었다.(최소생육저지농도 : 0.05%). 안정제로서의 알긴산과 펙틴은 B. subtilis, E. coli, P. aeruginosa에 대하여 비교적 강한 향균성을 보였고 L. acidophilus에 대하여는 향균성이 없었다. 황색 색소(홍화엘로우)와 적색 색소(Red powder-N)는 향균성이 없었고 표백제인 $NaHSO_3$의 세균에 대한 최소생육저지농도는 0.05%, Sacch. cerevisiae에 대하여는 0.5%로 향균성이 있었다. In order to survey the safety of some food additives, antimicrobial activity of acidulants, stabilizers, antioxidants, natural coloring materials and bleaching agents against 5 strains of bacteria and Sacch. cerevisiae were investigated by dilution method and minimal inhibitory concentration(MIC) method. Malic acid as acidulants displayed the effective antimicrobial activity in vitro against P. aeruginosa and its MIC is 0.05%. Alginic acid and pectin as stabilizer also displayed strong antimicrobial activity against B. subtilis, E. coli and P. aeruginosa, and tannin(antioxidants) and $NaHSO_3$ displayed antimicrobial activity against all bacteria tested. However gums(Arabia, Xanthan, Gua) and natural coloring materials(Hongwha Yellow, Red powder-N) were not affected to growth of bacteria and Sacch. cerevisiae.

      • KCI등재

        익상편조직의 섬유모세포에 미치는 사이클로스포린의 영향

        이종수,이승욱,이상준,김나미,Jong Soo Lee,Seung Wook Lee,Sang Jun Lee,Na Mi Kim 대한안과학회 2012 대한안과학회지 Vol.53 No.3

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Purpose: To evaluate the response and cellular damage of cultured human pterygial cells according to the concentration and exposure time of topical cyclosporin. Methods: Human pterygial cells were exposed to a cyclosporin A concentrations of 0.1 μg/ml (0.0001%), 1 μg/ml (0.0001%), 10 μg/ml (0.001%), 100 μg/ml (0.01%), or 500 μg/ml (0.05%) for 5 or 10 minutes. An MTT-based colorimetric assay was performed to assess the metabolic activity of cellular proliferation, and a lactate dehydrogenase (LDH) leakage assay was used to determine cellular damage. The extra-cellular matrix of PIP, laminin and MMP were evaluated, and the measurement of pro-inflammatory cytokine, TNF-α and IL-1b. IL-6, IL-8 was performed using ELISA kits. Results: The pterygial cellular inhibitory effect of cyclosporin was similar to that of the control according to the concentration and exposure time (p > 0.05). Compared with the control, the level of LDH did not show a statistically significant difference between concentration and exposure time (p > 0.05). There was no significant difference of inhibitory effects by PIP, laminin, or MMP between the experimental and control groups (p > 0.05). The production of TNF-α and IL from the experimental pterygial cells due to the effect of cyclosporin was not significantly different from that of the control at a longer exposure time or stronger concentration (p > 0.05). Conclusions: The response of pterygial cells to topical cyclosporin A at concentrations less than 0.05% for less than 10 minutes of exposure time showed no prevention of pterygial recurrence. With regard to cellular damage, little effects on inhibition of PIP, laminin, MMP, IL, and TNF-α were observed compared with that of the control. J Korean Ophthalmol Soc 2012;53(3):466-472

      • KCI등재

        겔형태 인공누액이 각막실질세포 및 결막상피세포에 미치는 영향

        이종수,김은희,김수진,이지은,김나미,Jong Soo Lee,Eun Hee Kim,Soo Jin Kim,Ji Eun Lee,Na Mi Kim 대한안과학회 2010 대한안과학회지 Vol.51 No.12

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Purpose: To evaluate the biological effects and cytotoxicity of gel-type artificial tears on human corneal keratocytes and conjunctival cells in vitro. Methods: Human corneal keratocytes and conjunctival epithelial cells were exposed to Soothe® and Systane® at variable concentrations. Evaluations were conducted through an MTT-based calorimetric assay to measure the metabolic activity and through a lactate dehydrogenase (LDH) assay to assess cellular damage. Apoptotic response was examined using fluorescent microscopy and flow cytometric analysis, and cellular morphologic results were evaluated with a transmission electron microscope. Results: The inhibitory effects of corneal keratocyte and conjunctival cell proliferations increased at higher concentrations and longer exposure times to Soothe® and Systane®. The LDH titers increased after Soothe® exposure, but showed no significant difference after Systane® exposure. Soothe® and Systane® treatments both produced fluorescence, representing apoptotic cells. In flow cytometry, the maximal apoptotic response was observed for both types of artificial tears, although Systane® showed less edema, as well as reduced cytoplasmic and nuclear cell degeneration compared to those of Soothe®. Conclusions: The apoptotic responses of Soothe® and Systane® are associated with inhibitory effects of human corneal keratocyte and conjunctival epithelial cell proliferations. To inhibit the cellular proliferation of human corneal keratocytes and conjunctival epithelial cells, Systane® may be less severe than Soothe® at higher concentrations and longer exposure times. J Korean Ophthalmol Soc 2010;51(12):1643-1651

      • KCI등재

        실사적인 3차원 물체 모델링 기법 개선

        이종수,Lee, Jong-Soo 한국정보처리학회 2003 정보처리학회논문지B Vol.10 No.2

        본 논문에서는 실사적인 3D 물체 모델링을 위해 제안된 기법들을 고찰하고, 보다 정확한 모델링을 위한 방안들을 제시하고 있다. F-행렬 추정기법의 개선과 스테레오 영상 평행화기법을 적용함으로 물체 모델링의 정확도를 높히는데 필수적임을 보여준다. In this paper, in-depth considerations are given to various techniques suggested for photographic 3D modelling and possible enhancements of the techniques are discussed. It is found that both the improvement of fundamental matrix estimation techniques and the stereo image rectification processing stage are necessary for more accurate 3D modelling.

      • KCI등재후보

        시민의 사법참여에 관한 헌법적 검토 : anhand von Einfu¨hrungsmo¨glichkeiten des Jurysystems oder der Scho¨ffengerichtsbarkei

        이종수 법과사회이론학회(구 법과사회이론연구회) 2003 법과 사회 Vol.25 No.-

        Es handelt sich in diesem Aufsatz um eine Mo¨glichkeit der Einfu¨hrung des anglo-amerikanishen Jurysysterms oder der deutschen Scho¨ffengerichtsbarkeit. In diesen La¨ndern haben sich diese Institutionen traditionell herausgebildet, hauptsa¨chlich um die rechtsprechende Gewalt zu kontrollieren. In Korea gibt es noch keine solche Institution. Dementsprechend hat die koreanishce Justiz an der Vertrauenskrise gelitten. Sie wird nach wie vor kein vertrauen der bu¨rger gewinnen ko¨nnen, solange sie keine Justizreform erfolgreich durchfu¨hren kann. Ich gehe davon aus, dass die Einfu¨hrung des Jurysystems oder der Scho¨ffengerichtsbarkeit zur Verwirklichung der Bu¨rgerbeteiligung an der Justiz nicht durch eine Verfassungsa¨nderung, sondern lediglich durch Gesetzesa¨nderungen mo¨glich ist.

      • 유두체가 손상된 횐쥐 암컷의 난소와 자궁 무게

        이종수,강일영,Lee, Jong-Soo,Kang, Il-Yung 대한생리학회 1967 대한생리학회지 Vol.1 No.2

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        흰쥐 암컷 29 마리를 세 무리로 나누어 한 무리에서는 유두체에 둔 전극을 거쳐 직류전류를 흘림으로써 유두체를 파괴하였으며 (유두체군), 다른 한 무리에서는 모든 조작을 유두체군에서와 마찬가지로 시행하였으나 전류는 흘리지 않았고 (수술대조군), 나머지 한 무리는 정상대조군으로 삼았다. 수술이 끝난 한 달후 세무리의 난소와 자궁을 떼어 조사하였으나 위축된 모습을 나타낸 개체는 없었으며, 유두체군, 수술대조군 및 정상대조군 사이에 난소와 자궁의 무게에 있어서 유의한 차이가 없었다. 그러므로 유두체가 여성의 성선자극 호르몬 생산에 관여한다는 증거는 찾을 수 없었다. In order to see whether the mamillary bodies participate in the control of female gonadotrophic function, 12 female rats in which the mamillary bodies were damaged by passing 0.3 ma direct cur-rent through stereotaxically implanted electrodes, 8 rats which received the same treatment except passage of current, and 9 normal rats were prepared. One month after the operation, all animals were sacrificed and their brain lesions checked histologically, their ovaries and uteri examined and weighed. The ovaries and uteri showed neither atrophic changes in any animal, nor significant differences in the weight among the 3 groups. Thus the results do not support the idea that the mamillary bo-dies are implicated in the control of female gonadotrophic function.

      • 여성의 뇌졸중후 골다공증에 대한 조경론적(調經論的) 기초연구

        이종수,윤상협,Lee, Jong-Soo,Yoon, Sang-Hyub 척추신경추나의학회 2000 대한추나의학회지 Vol.1 No.1

        the aim of this study was to investigate whether osteoporosis can be advanced after cerebral infarction Of not and role of female sex hormone. all animals were classified 4 groups; group of ovariectomy (OVXgroup) group of cerebral infarction( INF group), group of combination ovariectomy and cerebral infarction(OVX + INF group), naturally intact group for control data (NOR group ). cerebral infarction was made by Chen,s method with some modification and ovariectomy was performed by Wayforth,s method. experimental data was collected at 15 days, 1 month, 3 months and 6months after starting observation. serum 17 ${{\beta}-estradiol\;(E_2)}$ was determined by radioimmunoassay, for comparision of osteoporosis formation, bone density, serum osteocalcin, Serum total calcium and phosphorus, Serum AST Concentration, Serum ALT Concentration, Creatinine Concentration were also calculated. we have found that cerebral ischemia decreases not only the serum concentration of 17 ${{\beta}-estradiol\;(E_2)}$ and inhibits but also the physiologically compensatory function of the ovariectomized rats and that the decreased estrogen concentration followed by cerebral infarction have not produced osteoporosis, regretfully.

      • 잉어 내장중의 Mouse 치사성분 Cyprinol Sulfate의 분리 및 생리 활성

        이종수,Lee, Jong-Soo 생화학분자생물학회 1994 한국생화학회지 Vol.27 No.5

        양식산 잉어(Cyprinidae, Cyprinus carpio) 내장의 MeOH 추출물로부터 mouse의 치사성분을 분리 정제하였다. 이 성분은 HRFABMS로부터 분자식은 $C_{27}H_{48}O_{8}S$로 판명되었으며 NMR 등 각종 기기 분석 자료를 검토한 결과, 잉어과 어류의 담낭 중에 존재한다고 알려진 독특한 성분인 cyprinol sulfate($5{\alpha}-cholestane$ $3{\alpha}$, $7{\alpha}$, $12{\alpha}$, 26, 27-pentol, 26-sulfate)로 동정되었다. Cyprinol sulfate의 mouse치사량은 2.0~3.0mg/MU 이었고, 약한 용혈성($500{\mu}g/ml$)과 prolyl endopeptidase 활성 저해작용($IC_{50}$ > $200{\mu}g/ml$)을 나타내었으나 Bacillus subtilis와 Aspergillus niger에 대한 항균성이나 L1210 세포에 대한 독성은 나타내지 않았다. A toxic component to mice was isolated from the viscera of cultivated carp (Cyprinus carpio) as white powder. Molecular formula was obtained to be $C_{27}H_{48}O_{8}S$ on the basis of the HRFABMS data. NMR spectra of the isolated compound were corresponded with those of $5{\alpha}-cyprinol$ except the $C_{26}$ sulfated carbon. Therefore, it was identified as cyprinol sulfate ($5{\alpha}-cholestane$ $3{\alpha}$, $7{\alpha}$, $12{\alpha}$,26,27-pentol 26-sulfate). It showed toxicity to mice (2~3 mg/MU, i.p.), hemolytic activity ($500{\mu}g/ml$) and prolyl endopeptidase inhibition ($IC_{50}$ > $200{\mu}g/ml$), but, had no antibacterial, antifungal and cytotoxic activity to L1210 cells.

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