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Noh, Geun-Woong,Ji, Eun-Jung,Park, Jung-Nan,Kim, Kyung-Hee,Do, Min-Hee,Lee, Eung-Kyung,Lee, Sang-Sun The Korean Nutrition Society 1999 Nutritional Sciences Vol.2 No.2
Food allergies play an important role in Atopic Dermatitis (AD). Dietary manipulation is essential in the management of AD. However, there has been a paucity of data reporting the prevalence of food allergies in AD patients in Korea. In this study, the Food Open Challenge Tests (FOCT) were conducted to investigate food allergies in AD patients. The skin-prick test and the detection of specific IgE, as well as allergy history of patient were used to detect food allergies in all AD patients. Elimination diet was conducted for two weeks prior to FOCTs. The prevalence of food allergies by FOCT is as follows: milk (67.3%); chicken (64.2%); pork (62.8%); eggs (61.0%); beef(55.4%) ; wheat (52.0%) and soybean (45.2%). Allergenic food items in Korean AD patients were different from people in other foreign countries. The seven major foods those tested positively by FOCTs were completely eliminated from the replaced diets for two weeks, and were subsequently reintroduced one at a time. Results from FOCTs were not comparable with allergy history or skin-prick tests or specific IgE detection. The sensitivity and specificity of skin-prick tests and specific IgE detection were lower than FOCTs. Allergy history, skin-prick tests, and specific IgE detection are useful for the identification of food allergen but its clinical significance differed according to food items. Therefore, we conclude that even though a 10-day delay was necessary after food challenge, FOCT is a useful and valid method to confirm food allergies and may be essential for the effective control of food allergies for treatment of AD.
노건웅(Geun Woong Noh),이우길(Woo Gill Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1997 소아알레르기 및 호흡기학회지 Vol.7 No.2
N/A Purpose: Atopic dermatitis is characterized by immunologic abnormalities including evidence for reduced IFN-γ production with increased IL-4 production. Previous open trials have suggested efficacy for recombinant IFN-γ in treatment of severe atopic dermatitis. Here we report the results of treatment with IFN-γ in 5 patients with moderate to severe atopic dermatitis. Methods: Atopic dermatitis was diagnosed according to typical clinical symptoms. Patients were treated with IFN- r for 6 weeks. Patients received 2×10(6) units/m IFN-γ by subcutaneous injection. Serum IgE levels, total eosinophil counts with hemoglobin(Hb) concentrations, hematocrit(Hct)s, white blood cell counts(WBC), lymphocyte fractions, eosinophil fractions and platelet counts were examined before treatment and 1 week and 6 week after treatment. Results: The skin lesions of all patients begun to be improved after 3 times of injection. As estimated by patients, responses showed significant improvement. Three of five patients were resolved completely who showed complete clearance of skin manifestation. And remained two patients show dramatic improvement with mild some skin lesions. WBC counts, Hemoglobins, Hematocrits, lymphocyte fractions, eosinophil fractions and platelet counts was not significantly changed before and after IFN-γ treatment. Serum IgE levels were not markedly elevated and not reduced after IFN-γ treatment. But total eosinophil counts were decreased 1 week after treatment and reduced to normal range 6 weeks after treatment. Conclusions: Five severe atopic dermatitis patients who did not respond to previous treatment, who had showed complication to loeal steroid treatment and who had severe skin lesions were treated with IFN-γ. They showed marked improvement in skin lesions after IFN-γ treatment and three of them showed complete clearance of skin lesions. Total eosinophil count was regarded as an excellent indicator for diagnosis, evaluation of therapeutic effects of IFN-γ. IFN-γ may be a suitable immunotherapy modality in the treatment of atopic dermatitis and futher studies for the action mechanism of IFN-γ in atopic dermatitis might be needed.
Isolation and characterization of the Citrobacter freundii phage EF1 from earthworm (Eisenia andrei)
Geun Jung,Jung Seok Lee,Hong Jae Shin,Jung Yeol Bae,Ae Rin Lee,Sam woong Kim,Byung Jin Lee,Chi Won Noh,Tae Sung Jung 한국예방수의학회 2016 예방수의학회지 Vol.40 No.4
Earthworms, especially Eisenia andrei, are cultivated for a variety of purposes including waste disposal and compost production. In this study, bacteria from earthworm gut were cultured and the dominant species identified. Subsequently, we isolated bacteriophages able to lyse the isolated gut bacteria. Two dominant genera of gut bacteria, Aeromonas sp. and Citrobacter sp. were identified by using MALDI-TOF MS analysis and a library was constructed to find lytic phages. Phage EF1 showed lytic activity for C. freundii and two Citrobacter isolates, C. braakii and C. murliniae. These 3 species have similar sensitivities to EF1. Several aspects of the life cycle of EF1 were investigated by using C. freundii under optimal growth conditions. EF1 infects C. freundii with a moderate latent period, approximately 25 min, and a large burst size averaging 5 × 10 9 per infected cell. Moreover, the antimicrobial activity of EF1 was well maintained under diverse conditions including a broad temperature range of 40°C to 50°C and a wide pH range of 4 to 11. In conclusion, the results indicate that earthworm casting contain a wide range of bacteria species, for which there are various corresponding bacteriophages
Noh, Joon-Yong,Choi, Wahn-Soo,Noh, Geun-Woong,Lee, Jae-Ho The Korean Association of Immunobiologists 2010 Immune Network Vol.10 No.6
Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs and were found to consist of $8.5{\pm}3.5%$ of CD19(+)CD5(+) B cells. CD19(+)CD5(+)Foxp3(+) B cells showed spontaneous apoptosis. Rare CD19(+)CD5(+) Foxp3(+) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.