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박금자,이지현,배경의,강양희,송후승 노인간호학회 2007 노인간호학회지 Vol.9 No.1
Purpose: The purpose of this study was to identify levels of self-esteem and depression in the elders who are residents in welfare facilities and to provide basic data for developing nursing intervention programs for these people. Methods: The participants in this study were 192 older people who scored 24 or higher on the K-MMSE (Korean-Mini Mental State Examination), and have lived for three months or more in one of 4 institutions located in B Metropolitan City. The data were collected by structured questionnaire from August 1 to 20 2006 and frequency, percentage, mean and standard deviation, and Pearson correlation coefficient were used to analyze the data with the SPSS/12.0 program. Results: 1. The score for self-esteem of the participants was 33.70± 7.20 (tool range: 10-50), and for depression, 6.57±3.98 (tool range: 0-15). 2. There was a slightly negative correlation between self-esteem and depression (r=-.388, p=.000). 3. There were significant differences in self-esteem according to education level (F=4.486, p= .012), and level of intention to be admitted to facility (F=7.504, p=-.000). 4. There was significant difference in depression according to education level (F=3.832, p=.023), type of religion (F=3.837, p= .005), level of intention to be admitted to facility (F=7.987, p=.000). Conclusion: This study might help in developing nursing intervention programs to improve self-esteem and reduce depression these elders.
Isolation and Identification of Secondary Metabolites from the Ovary of Nelumbo nucifera
Seung-Heon Ji(지승헌),Jae-Won Lee(이재원),Seung-Eun Lee(이승은),Young-Seob Lee(이영섭),Geum-Soog Kim(김금숙),Young-Sup Ahn(안영섭),Nam-In Baek(백남인),Yi Lee(이이),Heung-Bin Lim(임흥빈),Dae Young Lee(이대영) 한국생명과학회 2016 생명과학회지 Vol.26 No.10
연꽃의 자방으로부터 80% MeOH로 추출하고, 얻어진 추출물을 n-hexane, ethyl acetate, n-butanol 및 H₂O으로 용매 분획하였다. 이 중 n-hexane 분획물에 대해 silica gel과 octadecyl silica gel column chromatography 및 Prep-HPLC system을 반복 수행하여 5 종의 물질을 분리 하였다. 각 화합물의 화학구조는 NMR, GC/MS및 ESI/MS 등의 분광학적 스펙트럼을 측정하고, 해석하여 1-eicosanol (1), cycloartenol (2), trans-squalene (3), pentadecanoic acid (4) 및 β-sitosterol (5)으로 동정하였다. 이 화합물들은 연꽃 자방추출물에서 처음으로 분리하고 동정하였으며 앞으로 이 화합물들에 대한 다양한 생리적 및 약리적 활성을 검토함으로써 건강기능성 식품 또는 의약품의 소재로서의 충분한 가치가 있다고 여겨진다. The ovary parts of Nelumbo nucifera were extracted in 80% methanol (MeOH), and the concentrated extract was then partitioned using n-hexane, ethyl acetate (EtOAc), n-butanol (n-BuOH), and H₂O, successively. Using an octadecyl silica gel (ODS) column, silica gel (SiO2) column chromatography, and a HPLC purification system, five compounds were isolated from the n-hexane fraction obtained from the extract of N. nucifera ovary. The chemical structures of the metabolites were determined using several spectroscopic methods, including NMR and GC/MS and MS of 1-eicosanol (1), cycloartenol (2), trans-squalene (3), pentadecanoic acid (4), and β-sitosterol (5). This study is a first attempt to isolate and identify secondary metabolites from the ovary of N. nucifera. The results indicated that the extract of N. nucifera ovary has biological effects, such as antibacterial and -tumor activity. Therefore, it could decrease the risk of HIV transmission through breastfeeding.
( Geum Jin Kim ),( Hyun Gyu Choi ),( Ji Hyang Kim ),( Sang Hyun Kim ),( Jeong Ah Kim ),( Seung Ho Lee ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
A methanol extract of the seed of Prunus persica (Rosaceae) was found to inhibit histamine release in human mast cells. Activity-guided fractionation of the methanol extract yielded three cyanogenic glycosides (1-3) and other phenolic compounds (4-8). To evaluate their anti-allergic and anti-inflammatory activities, the isolates (1-8) were tested for their inhibitory effects on histamine release and on the gene expressions of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in human mast cells. Of these, phenolic glycosides 7 and 8 suppressed histamine release and inhibited the pro-inflammatory cytokines TNF-alpha and IL-6. These results suggest that isolates from P. persica are among the anti-allergic inflammatory principles in this medicinal plant.
( Ji Eun Na ),( Dong Hyun Sinn ),( Jeong-hoon Lee ),( Wonseok Kang ),( Geum-youn Gwak ),( Young-han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Observational studies suggested tenofovir may have favorable efficacy for the prevention of (HCC) development compared to entecavir. However, mechanism of both drugs is suppression of hepatitis B virus (HBV) replication and whether class effect exist despite same mechanism of action remains controversial, and data from randomized controlled trial are lacking. As a results, whether change in therapy is required for those who shows good virological response to entecavir treatment in order to further reduce HCC risk remains unknown. Methods: A retrospective cohort of 1,336 treatment-naïve chronic HBV mono-infected adults patients without malignancy or organ transplantation at baseline who started entecavir or tenofovir treatment between June 2012 to December 2015, and showed maintained virological response during follow-up were analyzed. Primary outcome was comparison of entecavir and tenofovir on incident HCC during follow-up. Results: During a median 4.4 years of follow-up (range: 1.0- 7.4 years) after achieving virological response, 99 patients developed HCC. The 5-years cumulative HCC incidence rate was 7.3% and 6.3% for entecavir and tenofovir group, with similar risk of HCC between two groups (adjusted hazard ratio: 0.82; 95% confidence interval 0.52 to 1.28; P=0.39). The risk of HCC was similar in in propensity score-matched cohort (entecavir = 570; tenfovir =570; hazard ratio 1.02; 95% confidence interval 0.68 to 1.52; P=0.94). In subgroup analysis, HCC risk was similar between two drugs in both patients with and without cirrhosis. Conclusions: In patients who showed good virological response, we observed no difference in the risk of HCC between two drugs. This observation suggest class effect may not exist and imply entecavir is equally effective as tenofovir for the prevention of HCC among those with good virological response.
Acute Toxicity of the BKCa Channel Opener LDD175
( Ji Young Choi ),( Jong Hyun Choi ),( Geum Seon Lee ),( Hong Sook Ko ),( Chul Seung Park ),( Yong Chul Kim ),( Jae Hoon Cheong ) 한국응용약물학회 2006 Biomolecules & Therapeutics(구 응용약물학회지) Vol.14 No.4
LDD175 (4-choloro-7-trifluoromethyl-l0H-benzo[4,5]furo[3,2-b]indole-1- carboxylic acid) is one of benzofuroindole derivatives that act as a potent BKCa channel openers. In the process of testing LDD175 as a new drug candidate, an acute toxicity study was carried out in mice. The mice were administered LDD175 intraperitoneally at dose of 0.2, 1, 10, 50, 100, 200, 400, 800 mg/kg and orally at dose of 10, 100, 400, 800 mg/kg body weight. After administering LDD175, the vital organs such as the liver, kidney and spleen were carefully observed for any significant pathological features or differences from the norm over a 14-day period. LDD175 did not induce any short-term toxicity at doses less than 100 mg/kg. A LD50 of LDD175 was 2493 mg/kg in male mice and 4908 mg/kg in female mice. Weight reduction was observed at a dose of 800 mg/kg in male, and 400 and 800 mg/kg in female. The kidney weight decreased in females after an intraperitoneal injection of LDD 175 high dose (> 400 mg/kg, i.p.), and the spleen weight increased in the male (800 mg/kg, i.p.) and female (400mg/kg, i.p.) mice. Inspite of the change in organ weights, there were neither histopathological changes nor any gross morphological abnormalities detected in any organ. LDD175 did not produce significant changes in the general behavior at doses of < 200 mg/kg, but decreased locomotor activity was observed at an intraperitoneal dose of 400 mg/kg. Its effects on the locomotor activity and activity on the rotarod were tested and compared with the effects of diazepam 5 mg/kg. The decrement in the locomotor activity and the activity on the rotarod induced by LDD175 was less serious than it by diazepam.