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Isolation and Identification of Secondary Metabolites from the Ovary of Nelumbo nucifera
Seung-Heon Ji(지승헌),Jae-Won Lee(이재원),Seung-Eun Lee(이승은),Young-Seob Lee(이영섭),Geum-Soog Kim(김금숙),Young-Sup Ahn(안영섭),Nam-In Baek(백남인),Yi Lee(이이),Heung-Bin Lim(임흥빈),Dae Young Lee(이대영) 한국생명과학회 2016 생명과학회지 Vol.26 No.10
연꽃의 자방으로부터 80% MeOH로 추출하고, 얻어진 추출물을 n-hexane, ethyl acetate, n-butanol 및 H₂O으로 용매 분획하였다. 이 중 n-hexane 분획물에 대해 silica gel과 octadecyl silica gel column chromatography 및 Prep-HPLC system을 반복 수행하여 5 종의 물질을 분리 하였다. 각 화합물의 화학구조는 NMR, GC/MS및 ESI/MS 등의 분광학적 스펙트럼을 측정하고, 해석하여 1-eicosanol (1), cycloartenol (2), trans-squalene (3), pentadecanoic acid (4) 및 β-sitosterol (5)으로 동정하였다. 이 화합물들은 연꽃 자방추출물에서 처음으로 분리하고 동정하였으며 앞으로 이 화합물들에 대한 다양한 생리적 및 약리적 활성을 검토함으로써 건강기능성 식품 또는 의약품의 소재로서의 충분한 가치가 있다고 여겨진다. The ovary parts of Nelumbo nucifera were extracted in 80% methanol (MeOH), and the concentrated extract was then partitioned using n-hexane, ethyl acetate (EtOAc), n-butanol (n-BuOH), and H₂O, successively. Using an octadecyl silica gel (ODS) column, silica gel (SiO2) column chromatography, and a HPLC purification system, five compounds were isolated from the n-hexane fraction obtained from the extract of N. nucifera ovary. The chemical structures of the metabolites were determined using several spectroscopic methods, including NMR and GC/MS and MS of 1-eicosanol (1), cycloartenol (2), trans-squalene (3), pentadecanoic acid (4), and β-sitosterol (5). This study is a first attempt to isolate and identify secondary metabolites from the ovary of N. nucifera. The results indicated that the extract of N. nucifera ovary has biological effects, such as antibacterial and -tumor activity. Therefore, it could decrease the risk of HIV transmission through breastfeeding.
Analytical Method Validation for the Major Metabolites of Acanthopanax sessiliflorus Fruits
Bo Ram Choi(최보람),Seung Heon Ji(지승헌),Young Seob Lee(이영섭),Ye Joo Lee(이예주),Jae Suk Ban(반재숙),Nam In Baek(백남인),Tae Joon Choi(최태준),In Ho Jung(정인호),Seung Eun Lee(이승은),Geum Soog Kim(김금숙),Dae Young Lee(이대영) 한국약용작물학회 2016 한국약용작물학회 학술대회논문집 Vol.2016 No.2
전대근,송재격,김석곤,지승헌,Jeon, Dae-Geun,Song, Jaegyok,Kim, Seok-Kon,Ji, Seung-Heon 대한치과마취과학회 2013 Journal of Dental Anesthesia and Pain Medicine Vol.13 No.2
A 30-year-old man with morbid obesity (height: 176 cm, body weight: 100 kg, body mass index: 32.28) was scheduled for reconstruction of the mandibular fracture. During induction of general anesthesia and nasotracheal intubation, we experienced massive epistaxis, hypoxemia and difficult airway management. Fortunately, we performed oro-tracheal intubation with direct laryngoscopy and it barely succeeded. He recovered without any residual complications and rescheduled seven days later and we successfully performed awake fiberoptic nasotracheal intubation. The patient discharged on the fourth postoperative day.