임신 40주와 출산 후 6주에 있는 20대 임산부 보행의 역학적 특성 비교

윤희중,문동안,정남주,금명숙,이경식,유실,김영란,한윤수 한국운동역학회 2000 한국운동역학회지 Vol.10 No.1

본 연구는 임신 40주와 출산후 6주간에 있는 임산부의 보행 동작의 특정을 규명함으로써 이와 관련된 연구자들에게 기초자료를 제공하고자 실시하였다. 이를 위해 임신 4주에 있는 임산부를 대상으로 1차 실험을 실시하였으며 동일한 대상자를 출산후 6주에 2차로 실험하여 자료를 수집하였다. 디지타이징 시 오차를 최소화하고 인체관절점의 분별을 위해 21개의 반사마커를 부착하였다. 10m의 보행주로를 걷는 동안 두 대의 비디오카메라를 이용하여60Hz로 자료를 수집하였으며 동시에 100Hz 지면반력자료를 수집하였다.수집되어진 자료는 DLT 방법을 사용하여 분석하였으며 이의 분석에 Kwon3d 프로그램을 활용하였다. 분석결과 다음과 같은 결론을 얻었다. 1. 임신 40주와 출산 후 6주의 보행 시 지지시간과 스윙시간의 비율이 다르게 나타났으며 보폭과 보간, 활보장은 임신 40주에서 더 큰 값을 보였다. 상체 전경각 역시 임신 40주에서 더 큰 값을 보였다. 힙관절, 무릎관절, 발목관절각도는 S1이 출산후 6주에서 큰 값을 보인반면 S2는 출산전후에 큰 변화를 보이지 않다. 2. 상하지면반력의 경우 FP1과 FP2는 임신 40주보다는 출산 6주에서 큰값을 보였지만 FP3는 임신 40주에서 보다 큰값을 보이고 있었다. 전후지면반력의 경우 출산전과 후 모두 Fy2에서 보다 큰 값을 보이고 있었다. This Study was to investigate kinematical characteristic comparison of the gait pregnant 40weeks and after delivery 6weeks 20´s women and provide the basic data. To accomplish this study, in the first, carry out an experiment with the pregnant women in the pregnant 40weeks on the videotape, and than the second, make an experiment with the kinematic data. Kinematic data were filtered with a low-pass, fourth-order Butterworth filter with an effective cut off frequency of 6Hz. The conclusions were drawn as follows; 1. Floor contact Periods(stance and swing rate) were differed from before and after the delivery and a pregnant 40 weeks was greater than after delivery 6 weeks in the step, width, stride. Also, a pregnant 40 weeks was greater than after delivery 6 weeks in the front angular. And the other angular components were represented similar pattern. 2. In the vertical load, delivery 6 weeks was grater than a pregnant 40 weeks in the FP1(first peak) and FP2(valley). And FP3(second peak)was represent that a pregnant 40 weeks was greater than delivery 6 weeks. Also, in the horizontal shear, Fy2(progressional force)was greater than Fy1(breaking force) about time of the delivery.

The study of fingerprint degradation and composition according to aging(Ⅱ)

Nam Yee Kim(김남이),Jong Shin Park,Woo-Yong Park,Geum Mun Nam,Sang Cheol Heo,Ji Eun Jung,Jihyuk Kim,Hee Sook Kim 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11

The latent fingerprint is one of the most important evidences for individualization at a crime scene. As crime becomes more intelligent, it is becoming increasingly important to determine when a latent fingerprint was deposited. This study was designed by modeling a real crime. There was a crime in which dozens of pottery pieces packed in polystyrene boxes and stored in an underground warehouse were stolen. A latent fingerprint developed in a polystyrene box at the crime scene by emulsion black technique, and the suspect was arrested. However, the suspect claimed that I had been hired to transport the pottery to the underground warehouse10 years ago. I’ve never been there since then. Fingerprint aging was studied by keeping fingerprint samples deposited by volunteers on polystyrene boxes in a dark room. Emulsion black technique (iron oxide) was used for fingerprint development. Even fingerprint samples stored from more than 6 months and up to 2 years were able to identify latent fingerprint. After identification of latent fingerprint by using the emulsion black technique, the sample was used to analyze the components by GC/MS with TMS derivatization for the fingerprint aging. The ratio of cholesterol and squalene(Ch/Sq) as aging indicator was calculated. The ratio was about 0.01 from the initial time to 1 month of storage, but after that, it gradually increased to more than 0.1 after 6 months, and also the absolute amount of cholesterol and squalene were decreased much more than initial time. Applying heat to the fingerprint sample or storing the developed fingerprint sample also affected the aging.

GC/MS 분석과 베이지안 분류 모형을 이용한 새 윤활유와 사용 엔진 오일의 동일성 추적과 분류

김남이(Nam Yee Kim),남금문(Geum Mun Nam),김유나(Yuna Kim),이동계(Dong-Kye Lee),박세연(Seh Youn Park),이경재(Kyoungjae Lee),이재용(Jaeyong Lee) 한국분석과학회 2014 분석과학 Vol.27 No.1

Kinematical Characteristics Comparison of the Pregnant Woman during the Walking -about the time of the delivery-

( Hee Joong Yoon ),( Nam Ju Chung ),( Myung Suk Geum ),( Kyung Sik Lee ),( Sil You ),( Young Nan Kim ),( Yoon Soo Han ),( Dong An Mun ) 한국운동역학회 2005 한국운동역학회 논문 영문초록집 Vol.2005 No.-

우주방사선측정용 조직등가비례계수관의 교정과 의료분야에서의 응용

김성환(Kim Sunghwan),남욱원(Nam Uk-Won),이재진(Lee Jaejin),표정현(Pyo Jeonghyun),박원기(Park Won-Kee),문봉곤(Moon Bong-Kon),김현수(Yeonsu Kim),백금문(Geum Mun Baek) 한국방사선학회 2014 한국방사선학회 학술대회 논문집 Vol.2014 No.추계

조직등가비례계수기는 우주에서의 복잡한 방사선 환경에서 방사선의 선에너지전이 스펙트럼을 측정하여 등가선량을 측정할 수 있는 검출기이다. 본 연구에서는 국제우주정거장에서 방사선량 모니터링에 활용할 수 있은 조직등가비례계수기를 개발하고 그 특성을 평가하였다. 소형 디지털화된 조직등가비례계수기는 미소선량측정을 위하여 직경 2 μm 크기의 선량을 모사하도록 설계 제작하였다. 개발된 검출기는 한국표준연구원의 252Cf 중성자 표준선원으로 교정하였으며, 채널- 선에너지전이 교정계수는 0.2 keV/μm-CH 이었다 Tissue equivalent proportional counter (TEPC) can measure the LET spectrum and calculate the equivalent dose for the complicated radiation field in space. In this paper, we developed and characterized a TEPC for radiation monitoring in International Space Station (ISS). The compact digital type TEPC which can simulate a 2 μm of the site diameter for micro-dosimetry has been tested with 252Cf neutron standard source in KRISS. The determined calibration factor of channel-LET was about 0.2 keV/μm-CH.

Characterization of Carbon Monoxide Fatalities by Metabolomics

Ju, Hyun Kyoung,Nam, Geum Mun,Min, Ji-Sook,Pyo, Jae Sung,Kang, Jae Seon Taylor Francis 2016 Analytical letters Vol.49 No.12

<P>Metabolite profiling of postmortem blood in carbon monoxide poisoning cases was performed with gas chromatography-mass spectrometry based on metabolomics. All data were processed with an automated mass spectral deconvolution and identification system and the metabolites were characterized using the National Institute of Standards and Technology library. Discriminant analysis was performed and the carbon monoxide-induced biomarkers were determined with a variable importance parameter in the projection plot obtained from partial least square discriminant analysis. This metabolomics approach, including global metabolites profiling, is useful in improving the interpretation of metabolism in carbon monoxide poisoning deaths.</P>

비인강암의 세기조절방사선치료기술을 이용한 동시차등조사가속치료의 예비성적

이상욱(Sang wook Lee),백금문(Geum Mun Back),이병용(Byong Yong Yi),최은경(Eun Kyung Choi),김종훈(Jong Hoon Kim),안승도(Seung Do Ahn),신성수(Seong Soo Shin),김상윤(Sang Yoon Kim),남순열(Soon Yuhl Nam),최승호(Seung Ho Choi),김성배(Sung 대한두경부종양학회 2003 대한두경부 종양학회지 Vol.19 No.1

Purpose: To introduce our early experience with intensity-modulated radiotherapy (IMRT) in the treatment of nasopharyngeal carcinoma. Methods and Materials: Eight patients who underwent IMRT for no disseminated nasopharyngeal carcinoma at the Asan Medical Center between September 2001 and November 2002 were evaluate by prospective analysis. According to the 1997 American Joint Committee on Cancer staging classification, 5 had Stage III, and 3 had Stage IVB disease. The IMRT plans were designed to be delivered as a 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) using the 'step and shoot' technique with a MLC (multileaf collimator). Daily fractions of 2.2-2.5Gy and 1.9-2Gy were prescribed and delivered to the GTV and CTV and clinically negative neck node, respectively. The prescribed dose was 70A-79.0Gy to the gross tumor volume (GTV), 60Gy to the clinical target volume (CTV) and metastatic nodal station, and 46Gy to the clinically negative neck. All patients also received weekly cisplatin during radiotherapy. Acute and late normal tissue effects were graded according to the Radiation Therapy Oncology Group (RTOG) radiation morbidity scoring criteria. Results: Follow-up period was ranging from 5 to 18 months. All patients showed complete response and loco-regional control rate was 100% but one patient died of malnutrition due to treatment related toxicity. There were no Grade 3 or 4 xerostomia and all patients had experienced improvement of salivary gland function. Conclusion: 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) boost intensity-modulated radiotherapy technique allows parotid sparing as evidenced both clinically and by dosimetry. Initial tumor response and loco-regional control was promising. It is clinically feasible. A larger population of patients and a long-term follow-up are needed to evaluate ultimate tumor control and late toxicity.

포도당 유도체 불소화합물(FDG)을 이용한 비소세포폐암의 Integrated PET/CT 전산화 모의치료기에 대한 유용성 평가

나종억,서정남,김진수,김대섭,홍동기,백금문,Na, Jong Eok,Suh, Jeong Nam,Kim, Jin Soo,Kim, Dae Seob,Hong, Dong Ki,Baek, Geum Mun 대한방사선치료학회 2013 대한방사선치료학회지 Vol.25 No.1

Purpose: To evaluate the usefulness of Integrated PET/CT and compare the gloss tumor volume (GTV) identified on CT, PET, PET/CT to that obtained from fluorodeoxyglucose (FDG). Materials and Methods: This experimental study was obtained using GE Discovery 690 (General Electric Healthcare, Milwaukee, MI, USA) PET/CT simulator with Gammex Laser System for five non-small cell lung cancer (NSCLC) patients. In order to increase the reproducibility of the patient setup, We have to fixed to patients using the Extended Wing Board. GTV delineation was painted using the EclipseTM ver.10 contouring program for CT, PET, PET/CT images. And then, We were to compare the changes in the GTV. Results: These results are drawn from 5 patients who have atelectasis or pneumonitis. Compared to CT defined GTV, PET was decreased by 10.5%, 11.8% and increased by 67.9%, 220%, 19.4%. PET/CT was decreased by 7.7%, 6.7%, 28% and increased by 232%, 24%. Conclusion: We were able to determine the usefulness of PET/CT simulator for NSCLC. PET/CT simulator in radiation therapy is useful to define the target volume and It is possible to delineate Objective and accurate target volume. It seems to be applicable to other areas in the near future. 목 적: 최근 Integrated PET/CT (GE Discovery 690, General Electric Healthcare, Milwaukee, MI, USA, 이하 PET/CT) 전산화 모의치료기가 방사선치료에 적용되면서 정확한 표적용적(Target Volume, TV)의 묘사가 가능하게 되었다. 본 연구에서는 포도당 유도체 불소화합물(F-18 fluoro-2-deoxyglucose, FDG)을 이용한 비소세포폐암 환자의 육안적표적용적(Gloss Target Volume, GTV)을 비교하여 유용성을 평가하고자 한다. 대상 및 방법: 가멕스 레이져 시스템(GAMMEX INC, Middleton, WI, USA)이 설치된 PET/CT를 이용하여 비소세포폐암 환자 5명을 대상으로 입체모의치료를 실시하였다. 환자 위치잡이의 재현성을 높이기 위하여 바로누운자세(supine)에서 환자고정용구(Extended Wing Board)를 사용하여 환자를 고정하였다. 획득한 영상은 치료계획시스템(Eclipse V10. Varian, USA)에서 CT, PET, 융합한 PET/CT에 GTV를 묘사하여 비교하였다. 결 과: 무기폐(atelectasis)나 폐렴(Pneumonitis)과 같은 합병증을 동반한 비소세포폐암 환자 5명에 대해 CT에 대한 PET의 GTV는 각각 10.5%, 11.8% 감소하였으나 67.9%, 220%, 19.4% 증가하였다. CT에 대한 PET/CT의 GTV는 각각 7.7%, 6.7%, 28% 감소하였으나 232%, 24%증가하였다. 결 론: FDG를 이용한 비소세포폐암 환자의 PET/CT 전산화 모의치료기는 GTV 묘사를 통하여 종양의 경계를 명확히 해주고 불확실한 표적체적을 정의하는데 CT보다 유용하여 앞으로 다른 부위에 추가 적용 가능할 것으로 보인다.

3D 프린팅 기법을 통한 전립샘암 환자의 내부장기 팬텀 제작 및 생체내선량측정(In-vivo dosimetry)에 대한 고찰

서정남,나종억,배선명,정동민,윤인하,배재범,곽정원,백금문,Seo, Jung Nam,Na, Jong Eok,Bae, Sun Myung,Jung, Dong Min,Yoon, In Ha,Bae, Jae Bum,Kwack, Jung Won,Baek, Geum Mun 대한방사선치료학회 2015 대한방사선치료학회지 Vol.27 No.1

목 적 : 본 연구는 3D 프린터를 이용하여 전립샘부위 팬텀을 제작하고 생체내선량측정(In-vivo dosimetry)을 통해 그 유용성을 평가하고자 한다. 대상 및 방법 : 전립샘암 환자의 3차원 치료체적을 바탕으로 3D 프린터(3D EDISON+, Lokit, KOREA)를 이용하여 전립샘과 직장의 체적을 동일하게 모사한 팬텀을 제작하고, 컴퓨터단층촬영(Lightspeed CT, GE, USA)을 통해 팬텀영상을 획득하였다. 전립샘암 환자의 체적과 팬텀의 체적을 비교 한 후, 전산화치료계획시스템(Eclipse version 10.0, Varian, USA)을 이용하여 치료계획을 설계하였다. 팬텀 내 측정지점인 방광(Bladder), 전립샘(Prostate), 직장 위벽(Rectal anterior wall), 직장 아래벽(Rectal posterior wall)의 임의의 지점에 모스펫검출기(Metal OXIDE Silicon Field Effect Transistor, MOSFET)를 위치시켜 선량 측정값과 치료계획을 비교분석 하였다. 결 과 : 전립샘과 직장풍선의 환자체적은 각각 30.61 cc, 52.19 cc 이고, 팬텀체적은 31.12 cc, 53.52 cc로 각 체적의 차이는 3% 미만으로 확인되었다. 모스펫검출기의 정밀도는 3%이내로 측정되었고 선량의 변화에 따라 상관계수 R2 = 0.99 ~ 1.00 의 선형성을 보였다. 네 곳의 측정 지점을 치료계획된 선량과 비교한 결과 방광 1.4%, 전립샘 2.6%, 직장 위벽 3.7%, 직장 아래벽 1.5%로 나타났고 모스펫검출기의 정밀도를 고려한 선량측정의 정확성은 5% 이내로 평가되었다. 결 론 : 본 실험을 통해 3D 프린터를 이용하여 제작한 전립샘 부위 팬텀은 체적의 차이 3% 미만으로, 인체를 모사하는데 효과적으로 사용될 수 있음을 확인하였다. 제작된 팬텀을 이용한 생체내선량측정은 모스펫검출기의 정밀도를 고려하더라도 방광, 전립샘, 직장 위벽, 직장 아래벽의 모든 측정점에서 5% 이내의 정확도로 수행 할 수 있었다. 따라서 3D 프린트를 이용해 제작된 전립샘 부위 팬텀은 생체선량측정을 하는데 있어 매우 유용하였으며 향후 환자에게 직접 적용하기 어려운 부위를 팬텀으로 대체 제작하여 생체내선량측정이 가능할 것으로 사료된다. Purpose : The purpose of this study is to evaluate the usefulness of a 3D printed phantom for in-vivo dosimetry of a prostate cancer patient. Materials and Methods : The phantom is produced to equally describe prostate and rectum based on a 3D volume contour of an actual prostate cancer patient who is treated in Asan Medical Center by using a 3D printer (3D EDISON+, Lokit, Korea). CT(Computed tomography) images of phantom are aquired by computed tomography (Lightspeed CT, GE, USA). By using treatment planning system (Eclipse version 10.0, Varian, USA), treatment planning is established after volume of a prostate cancer patient is compared with volume of the phantom. MOSFET(Metal OXIDE Silicon Field Effect Transistor) is estimated to identify precision and is located in 4 measuring points (bladder, prostate, rectal anterior wall and rectal posterior wall) to analyzed treatment planning and measured value. Results : Prostate volume and rectum volume of prostate cancer patient represent 30.61 cc and 51.19 cc respectively. In case of a phantom, prostate volume and rectum volume represent 31.12 cc and 53.52 cc respectively. A variation of volume between a prostate cancer patient and a phantom is less than 3%. Precision of MOSFET represents less than 3%. It indicates linearity and correlation coefficient indicates from 0.99 ~ 1.00 depending on dose variation. Each accuracy of bladder, prostate, rectal anterior wall and rectal posterior wall represent 1.4%, 2.6%, 3.7% and 1.5% respectively. In- vivo dosimetry represents entirely less than 5% considering precision of MOSFET. Conclusion : By using a 3D printer, possibility of phantom production based on prostate is verified precision within 3%. effectiveness of In-vivo dosimetry is confirmed from a phantom which is produced by a 3D printer. In-vivo dosimetry is evaluated entirely less than 5% considering precision of MOSFET. Therefore, This study is confirmed the usefulness of a 3D printed phantom for in-vivo dosimetry of a prostate cancer patient. It is necessary to additional phantom production by a 3D printer and In-vivo dosimetry for other organs of patient.

전립선 암 환자의 영상유도 방사선 치료 시 Fiducial Marker를 이용한 2D/2D Match의 유용성에 대한 연구

배선명,양오남,송흥권,백금문,Bae, Sun-Myung,Yang, Oh-Nam,Song, Heung-Kwon,Back, Geum-Mun 대한방사선치료학회 2010 대한방사선치료학회지 Vol.22 No.1

Purpose: To study the efficacy of marker match with using kilovoltage (KV) X-ray among multiple image guidance that referring tree fiducial marker in radiation therapy for prostate cancer patients. Materials and Methods: KV two-dimantional images (anterior-posterior, right-left) and cone-beam CT volumetric images were acquired after setup for patients with three fiducial markers. Compare the position of the fiducial marker of reference plan computed tomography (CT) and of KV, CBCT images; then decide the shift score of X, Y, and Z. This study executed 5 times on 10 patients and analyzed the shift value. Results: In the radiation therapy using fiducial marker, The function of marker match showed the same direction tendency as the CBCT, and showed X, Y, Z difference of about 0.6, 0.7, and 0.8 (unit: mm). Conclusion: Comparing to this, the result of shift value using 2D marker match showed less than 1.0 mm difference. The function of marker match is considered more useful in time-wise and effective dose rather than CBCT. Therefore, Both methods are used to treat patients for prostate cancer.